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ÖZDER, ACLAN

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  • PublicationMetadata only
    Tip 2 Diyabetes Mellitus hastalarında 25-(OH) D vitamini düzeyi mikroalbüminüri ve diyabetin seyri ile ilişkili midir?
    (2022-10-13) Yüksel Salduz Z. İ.; Özder A.; YÜKSEL SALDUZ, ZEYNEB İREM; ÖZDER, ACLAN
    SS-18 TIP 2 DIYABETES MELLITUS HASTALARINDA 25-(OH) D VITAMINI DÜZEYI MIKROALBÜMINÜRI VE DIYABETIN SEYRI ILE ILIŞKILI MIDIR? ZEYNEB İREM YÜKSEL SALDUZ, ACLAN ÖZDER BEZMIALEM TIP FAKÜLTESI AILE HEKIMLIĞI ANABILIM DALI Amaç: 25-(OH) D vitamini (VD) eksikliği birçok çalışmada Tip 2 Diyabetes Mellitusun (Tip 2 DM) ortaya çıkan komplikas yonları için önemli bir risk faktörü olarak tanımlanmıştır (1,2). Çalışmamızın amacı VD düzeyleri ile Tip 2 DM seyrinde ortaya çıkan albuminüri seviyesi arasındaki ilişkinin değerlendirilmesidir. Gereç-Yöntem: Çalışma kesitsel, tek merkezli, retrospektif olarak planlandı. Temmuz 2019-Aralık 2019 tarihleri arasında Bezmialem Tıp Fakültesi Hastanesi Aile Hekimliği polikliniğine ayaktan başvuran Tip 2 DM hastalarının sosyodemografik ve laboratuvar verileri elektronik hasta sisteminden tarandı. 148 hasta çalışmaya alındı. Hastalar VD düzeylerine göre ikiye ayrıldı. 25-(OH) D vitamini 20 ng/mL’ nin altında olanlar VD eksikliği olan grup; grup 1, 25-(OH) D vitamini 20 ng/mL’ nin üzerinde olanlar VD eksikliği olmayan grup; grup 2 olarak sınıflandırıldı. Hastaların Glukoz, Üre, Kreatinin, Kan üre azotu (BUN), Glomeruler filtrasyon hızı (GFR), Alanin aminotransferaz (ALT), Aspartat aminotransferaz (AST), LDL koles terol (LDL-C), HDL kolesterol (HDL-C), Trigliserid (TG), Total kolesterol, HbA1c ve hemogram parametre değerleri olarak Lökosit sayısı (WBC), Eritrosit sayısı (RBC), Trombosit sayısı (PLT), Hemoglobin (Hgb), Hematokrit (Hct), Nötrofil mutlak sayısı (Neut), Lenfosit mutlak sayısı (Lymph), Ortalama eritrosit hacmi (MCV), Ortalama trombosit hacmi (MPV), Vitamin B 12 (Vit B12), Ferritin, Tiroid stimülan hormon (TSH), 25-(OH) D vitamini, mikroalbüminüri düzeyi grup 1 ve grup 2 arasında karşılaştırıldı. Vitamin D seviyeleri ve albüminüri arasındaki ilişki incelendi. Bulgular: Çalışmaya 148 hasta dahil edildi. Hastaların yaş ortalaması 56,58±9,76 idi. 70 hasta erkek, 78 hasta kadındı. Tüm hastaların VD ortalaması 22,80±17,84 ve HbA1c ortalaması 7,56±1,65 bulundu. D vitamini 20 ng/mL’ nin altında 76, üzerinde 72 hastamız vardı. D vitamini 20 ng/mL’ nin altındaki grup 1 hastalarımızda; LDL-C, Total Kol, HbA1c, Lenfosit sayısı, mikroalbuminüri düzeyi anlamlı derecede yüksek bulundu. (p<0.05) (Tablo 1) Sonuç: Çalışmamızda D vitamini seviyesi düşük olan hastalarda mikroalbüminüri ve HbA1c düzeyi yüksek tespit edilmiş tir. Bu durum VD eksikliğinin Tip 2 DM hastalığının kontrolsüz seyrinde ve böbrek fonksiyon bozukluğunda etkili olduğunu düşündürtmektedir. Aile hekimliği kapsamında koruyucu hekimliğin önemi düşünüldüğünde VD desteği diyabetin kont rollü seyrinde ucuz ve etkili bir yöntem olarak gündemde olmalıdır. Kaynaklar 1. Kostoglou-Athanassiou, Ifigenia, et al. \"Vitamin D and glycemic control in diabetes mellitus type 2.\" Therapeutic ad vances in endocrinology and metabolism 4.4 (2013): 122-128. 2. Herrmann, Markus, et al. \"Serum 25-hydroxyvitamin D: a predictor of macrovascular and microvascular complicati ons in patients with type 2 diabetes.\" Diabetes care 38.3 (2015): 521-528. Anahtar Kelimeler:D vitamini, Mikroalbüminüri, Tip 2 diyabetes mellitus
  • PublicationOpen Access
    Determination of Genetic Changes of Rev-erb beta and Rev-erb alpha genes in Type 2 Diabetes Mellitus by Next-Generation Sequencing
    (2020-08-13T00:00:00Z) Tokat, B; Kanca-Demirci, D; Gul, N; Satman, I; Ozturk, O; Ozder, ACLAN; Kucukhuseyin, O; Yilmaz-Aydogan, H; ÖZDER, ACLAN
    Background: The nuclear receptors Rev-erb alpha and Rev-erb beta are transcription factors that regulate the function of genes in glucose and lipid metabolism, and they also form a link between circadian rhythm and metabolism. We evaluated the variations in Rev-erb alpha and Rev-erb beta genes together with biochemical parameters as risk factors in type 2 diabetic (T2DM) patients. Methods: Molecular analyses of Rev-erb alpha and Rev-erb beta genes were performed on genomic DNA by using next-generation sequencing in 42 T2DM patients (21 obese and 21 non-obese) and 66 healthy controls. Results: We found 26 rare mutations in the study groups, including 13 missense mutations, 9 silent mutations, 3 5'UTR variations, and a 3'UTR variation, of which 9 were novel variations (5 missense and 3 silent and 1 5'UTR). Six common variations were also found in the Rev-erb genes; Rev-erb beta Chr3:24003765 A > G, Rev-erb beta rs924403442 (Chr3:24006717) G > T, Rev-erb alpha Chr17:38253751 T > C, Rev-erb alpha rs72836608 C > A, Rev-erb alpha rs2314339 C > T and Rev-erb alpha rs2102928 C > T. Of these, Rev-erb beta Chr3:24003765 A > G was a novel missense mutation (p.Q197R), while others were identified as intronic variants. T2DM patients with Rev-erb beta rs924403442 T allele had lower body surface area (BSA) than noncarriers (GG genotype) (p = 0.039). Rev-erb alpha rs72836608 A allele and Rev-erb alpha rs2314339 CC genotype were associated with decreased serum HDL-cholesterol levels in T2DM patients (p = 0.025 and p = 0.027, respectively). In our study, different effects of Rev-erbs polymorphisms were found according to gender and presence of obesity. Rev-erb alpha rs72836608 (C > A) and rs2314339 (C > T) and Rev-erb alpha rs2102928 (C > T) were associated with low HDL-C levels in male T2DM patients. In female patients, Rev-erb alpha rs2102928 (C > T) was associated with high microalbuminuria and Rev-erb beta rs9244403442 G > T was associated with low HDL and high BSA values. In addition, Rev-erb alpha Chr17: 38,253,751 (T > C), rs72836608 (C > A), and rs2314339 (C > T) and Rev-erb beta Chr3:24003765 (A > G) were associated with increased serum GGT levels in obese T2DM patients. In non-obese patients, Rev-erbs SNPs had no effect on serum GGT levels. Conclusion: Our findings indicate that variations in the Rev-erb alpha and Rev-erb beta genes can affect metabolic changes in T2DM and these effects may vary depending on gender and obesity.
  • PublicationOpen Access
    A novel indicator predicts 2019 novel coronavirus infection in subjects with diabetes
    (2020-08-01T00:00:00Z) ÖZDER, ACLAN; ÖZDER, ACLAN
    Aims: Diabetes mellitus (DM) is associated with significant morbidity and mortality. The disease severity in 2019 novel coronavirus (Covid 19) infection has varied from mild self-limiting flu-like illness to fulminant pneumonia, respiratory failure and death. Since DM and Covid 19 infection are closely associated with inflammatory status, mean platelet volume (MPV) was suggested to be useful in predicting Covid infection onset. This study aimed to evaluate the diagnostic role of MPV in Covid patients with diabetes. Methods: A total of 640 subjects (160 Covid patients with type 2 diabetes, 160 healthy controls, 160 patients with non-spesific infections and 160 Covid patients without type 2 diabetes) enrolled in the study. Results: MPV was significantly higher (11.21 ± 0.61 fL) as compared to the results from the last routine visits of the the same individuals with diabetes (10.59 ± 0.96 fL) (p = 0.000). Conclusions: MPV could be used as a simple and cost-effective tool to predict the Covid infection in subjects with diabetes in primary care.
  • PublicationMetadata only
    FAMILY FUNCTIONING AMONG PATIENTS WITH TYPE 2 DIABETES MELLITUS IN PRIMARY CARE IN TURKEY
    (2020-01-01T00:00:00Z) ÖZDER, ACLAN; Salduz, Zeyneb; ÖZDER, ACLAN; YÜKSEL SALDUZ, ZEYNEB İREM
    Introduction: To examine the effects of family functioning on glycaemic control among adults with type 2 diabetes mellitus (T2DM) in primary health care.
  • PublicationMetadata only
    Ev izolasyonuna alınan hastaların covid-19 enfeksiyonu ve temas ile ilgili bilgi, tutum ve davranışları
    (2021-03-25T00:00:00Z) Baktır Altuntaş, Sibel; Yüksel Salduz, Zeyneb İrem; Altuntaş, Bülent; Özder, Aclan; YÜKSEL SALDUZ, ZEYNEB İREM; ÖZDER, ACLAN
  • PublicationOpen Access
    Glycosylated hemoglobin A1c predicts coronary artery disease in non-diabetic patients
    (2020-10-01T00:00:00Z) Kayali, Yildiz; ÖZDER, ACLAN; ÖZDER, ACLAN
    Background In primary care, there is a need for simple and cost-effective tool that will allow the determination of the risk of coronary artery disease (CAD). We aimed to research the value of glycosylated hemoglobin (HbA1c) in the prediction of coronary artery disease. Methods Patients admitted to the outpatient clinic of the Cardiology for angiography were retrospectively screened. Patients with diabetes or with HbA1c of 6.5 or above were excluded. Comparative HbA1c data were obtained according to the stenosis groups. Logistic regression analysis was used to investigate the risk factors affecting stenosis positivity. Results Of the study group, 120 patients were without any stenosis in any coronary artery, 56 patients were with >50% stenosis in one coronary artery, and 71 patients were with >50% stenosis in more than one coronary artery. There was a statistically significant difference between HbA1c measurements according to the degree of stenosis (P = .001 andP < .01, respectively). The odd ratio for HbA1c was 6.260 (95% CI: 3,160-12,401). According to the stenosis positivity, the cutoff point for HbA1c was found to be 5.6 and above. In the regression analysis, HbA1c was an independent risk factor for CAD. One unit increase in HbA1c level increases the risk of stenosis up to 12.4-fold (95% CI: 5,990-25,767). Conclusion The study showed HbA1c can be used as an independent marker in determining the probability and severity of coronary artery disease in non-diabetic individuals and as a useful marker in primary care predicting CAD.
  • PublicationMetadata only
    The prevalence of dysmenorrhea and its effects on female university students- quality of life: what can we do in primary care?
    (2020-01-01T00:00:00Z) ÖZDER, ACLAN; Salduz, Zeyneb; ÖZDER, ACLAN; YÜKSEL SALDUZ, ZEYNEB İREM
    This study aimed to estimate the prevalence of dysmenorrhea among Turkish university students studying in the field of health sciences and to evaluate the effects of the students- socio-demographic characteristics on the condition. A cross-sectional survey of 658 students was conducted by questionnaire at a health sciences university in Turkey. A structured questionnaire was used to collect data on dysmenorrhea. Health related quality of life (HRQoL) was assessed using the generic 36-Item Short Form Health Survey (SF-36), and depressive symptoms were assessed with the BDI included in the survey. A visual analogue scale was used to assess the severity of dysmenorrhea. Data were analyzed using chi-square tests and logistic regression analysis. The prevalence of dysmenorrhea was 79.7% (524 out of 658 students). Age of menarche (P = 0.001), menstrual flow (P = 0.000), drinking coffee (P = 0.001) and having a family history of dysmenorrhea were significantly associated with dysmenorrhea in a multivariable analysis. Furthermore, 42.7% of the students with dysmenorrhea missed at least one day of school and 5.3% missed at least one exam. The high prevalence of dysmenorrhea among Turkish university students is a significant health problem requiring attention, and the need for on-the-job training of primary care physicians on the management of primary dysmenorrhea should be considered.
  • PublicationOpen Access
    COVİD-19 PANDEMİSİNDE Hastalık/Hastane Yönetimi- Pandemide Aile Hekimliği
    (2021-09-01T00:00:00Z) Özder, Aclan; ÖZDER, ACLAN
  • PublicationMetadata only
    Precision Diagnosis of Maturity-Onset Diabetes of the Young with Next-Generation Sequencing: Findings from the MODY-IST Study in Adult Patients.
    (2022-03-23T00:00:00Z) Aydogan, Hulya Yilmaz; Gul, Nurdan; Demirci, Deniz Kanca; Mutlu, Ummu; Gulfidan, Gizem; Arga, Kazim Yalcin; Ozder, ACLAN; Camli, Ahmet Adil; Tutuncu, Yildiz; Ozturk, Oguz; Cacina, Canan; Darendeliler, Feyza; Poyrazoglu, Sukran; Satman, Ilhan; ÖZDER, ACLAN
  • PublicationMetadata only
    TIP DALLARINDAKİ GELİŞMELERİN TARİHİ
    (2021-12-01T00:00:00Z) Yüksel, Zeyneb İrem; Özder, Aclan; YÜKSEL SALDUZ, ZEYNEB İREM; ÖZDER, ACLAN
    Aile Hekimliğinin Dünyadaki GelişimiTıp ilmi kimi zaman bilimsel, kimi zamansa meydana gelen sosyal süreçlere cevaben gelişmiştir. Teknolojik gelişmelere paralel olarak tıpta yeni uzmanlık dallarının ortaya çıktığı görülmektedir. Diğer tüm uzmanlık dalları gibi, Aile Hekimliği (AH)’nin doğuşu da bir gereksinim sonucu olmuştur. AH’ye duyulan bu gereksinim ilk kez Amerikalı bir iç hastalıkları hekimi olan Francis Peabody tarafından 1923 yılında dile getirilmiştir. Tıpta gelişen aşırı uzmanlaşmanın ortaya çıkardığı sorunlar nedeniyle, hastaları biyopsikososyal yaklaşım çerçevesinde bir bütün olarak değerlendirecek bir uzmanlık dalının gerekliliğini savunan Peabody’nin bu görüşü, yıllar sonra 2. Dünya savaşı ertesi dönemde İngiltere’de yankı bulmuş ve 1952 yılında Genel Pratisyenlik Kraliyet Koleji (Royal College of General Practitioners) kurulmuştur.