Person: ÖZDER, ACLAN
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Publication Metadata only Anxiety levels among Turkish public transportation drivers: a relation to restless legs syndrome?(2014-01-01) Ozder, ACLAN; Eker, Hasan Huseyin; ÖZDER, ACLANThe aim of this study was to estimate the prevalence of individuals who are at high risk for state and trait anxiety as well as to investigate the relationship of anxiety levels of urban transportation drivers from Istanbul, Turkey with restless legs syndrome (RLS). The data was gathered between April 2013 and June 2013 by the use of a questionnaire prepared for the purpose of this study, completed anonymously. Restless leg syndrome and anxiety level were evaluated in the group; data obtained was analyzed using the SPSS version 16. Chi-square, correlation and student-t tests were used. Restless leg syndrome symptoms were determined by a self-assessment questionnaire, including the International Restless Legs Syndrome Study Group (IRLSSG) diagnostic criteria, to determine RLS symptoms and Spielberger State-Trait Anxiety Inventory (STAI) to determine anxiety levels of the participants. In the present study, the four RLS criteria were reported in 31.2%. STAI-state and STAI-trait scores were 40.82 +/- 9.55 and 42.99 +/- 8.54 respectively. The state and trait anxiety mean scores were different among participants with RLS in this study (p < 0.05). It was found a significant difference between tobacco usage and state anxiety (p < 0.05). There were a significant difference between RLS and age, number of cigarettes daily consumed and employment time (p < 0.05). The state and trait anxiety scores were found high among bus drivers with RLS in this study.Publication Metadata only Association between nutritional status and Modic classification in degenerative disc disease(2016-04-01) TASPINAR, Ozgur; Seyithanoglu, Hakan; CAMLI, Adil; KIZILTAN, Huriye; HOCAOGLU, Ilknur Turk; Aydin, TEOMAN; Keskin, YAŞAR; Ozder, ACLAN; Eris, ALİ HİKMET; DENIZLI, Ebru; KEPEKCI, Muge; SEYİTHANOĞLU, MEHMET HAKAN; AYDIN, TEOMAN; ERİŞ, ALİ HİKMET; ÖZDER, ACLAN; KESKİN, YAŞAR[Purpose] This study was conducted to examine the association between Modic classification and the eating habits in patients with degenerative disc disease (DDD) and to determine the influence of nutrition on disease severity. [Subjects and Methods] Sixty patients with DDD visiting a low back pain outpatient clinic were enrolled. Through face-to-face interviews, they completed questionnaires regarding their demographics, disease activity, smoking and alcohol use, concomitant diseases, disease duration, and nutritional status. Exclusion criteria were age 65 years, other comorbidities, missing MRI data, and inability to speak Turkish. [Results] Forty patients were finally included in the study. The frequency with which they consumed water, salt, fast food, eggs, milk, yogurt, cheese, whole wheat bread, white bread, butter, and margarine was recorded. A weak negative correlation was observed between the Modic types and fish and egg consumption. [Conclusion] Modic changes, which indicate the severity of DDD, seem to be correlated to patients- dietary habits. However, studies with comparison groups and larger samples are needed to confirm our promising results before any cause-and-effect relationship can be proposed.Publication Open Access Investigation of mean platelet volume in patients with type 2 diabetes mellitus and in subjects with impaired fasting glucose: a cost-effective tool in primary health care?(2014-01-01) Ozder, ACLAN; Eker, Hasan Huseyin; ÖZDER, ACLANThe aim of this study was to compare mean platelet volume (MPV) in patients with type 2 diabetes mellitus (T2DM), in subjects with impaired fasting glucose (IFG), and in non-diabetic controls. A total of 201 adults with T2DM and 201 subjects with IFG from the Family Medicine out-patient clinic as well as 201 healthy controls were included in the study. We measured blood fasting glucose, complete blood count and LDL-cholesterol and compared the results between the groups enrolled. In the patients with diabetes and subjects with IFG, MPV was significantly higher (10.66 ± 0.94 fL and 10.49 ± 0.96 fL, respectively ) as compared to the non-diabetic group (10.04 ± 1.01 fL) (p = 0.000). Among the diabetic subjects, a positive statistical Pearson correlation was seen between MPV and HbA1c levels (r = 0.357; p = 0.000) and fasting blood glucose (FBG) levels (r = 0.306; p = 0.000). The mean MPV in patients having HbA1C < 7.5% was 10.17 ± 0.83 fL and significantly lower than that of patients with HbA1c ≥ 7.5% (10.80 ± 0.92 fL) (p = 0.001). MPV could be used as a simple and cost-effective tool to monitor the progression and control of T2DM and thereby in preventing vascular events in primary health care.Publication Open Access Determination of Genetic Changes of Rev-erb beta and Rev-erb alpha genes in Type 2 Diabetes Mellitus by Next-Generation Sequencing(2020-08-13T00:00:00Z) Tokat, B; Kanca-Demirci, D; Gul, N; Satman, I; Ozturk, O; Ozder, ACLAN; Kucukhuseyin, O; Yilmaz-Aydogan, H; ÖZDER, ACLANBackground: The nuclear receptors Rev-erb alpha and Rev-erb beta are transcription factors that regulate the function of genes in glucose and lipid metabolism, and they also form a link between circadian rhythm and metabolism. We evaluated the variations in Rev-erb alpha and Rev-erb beta genes together with biochemical parameters as risk factors in type 2 diabetic (T2DM) patients. Methods: Molecular analyses of Rev-erb alpha and Rev-erb beta genes were performed on genomic DNA by using next-generation sequencing in 42 T2DM patients (21 obese and 21 non-obese) and 66 healthy controls. Results: We found 26 rare mutations in the study groups, including 13 missense mutations, 9 silent mutations, 3 5'UTR variations, and a 3'UTR variation, of which 9 were novel variations (5 missense and 3 silent and 1 5'UTR). Six common variations were also found in the Rev-erb genes; Rev-erb beta Chr3:24003765 A > G, Rev-erb beta rs924403442 (Chr3:24006717) G > T, Rev-erb alpha Chr17:38253751 T > C, Rev-erb alpha rs72836608 C > A, Rev-erb alpha rs2314339 C > T and Rev-erb alpha rs2102928 C > T. Of these, Rev-erb beta Chr3:24003765 A > G was a novel missense mutation (p.Q197R), while others were identified as intronic variants. T2DM patients with Rev-erb beta rs924403442 T allele had lower body surface area (BSA) than noncarriers (GG genotype) (p = 0.039). Rev-erb alpha rs72836608 A allele and Rev-erb alpha rs2314339 CC genotype were associated with decreased serum HDL-cholesterol levels in T2DM patients (p = 0.025 and p = 0.027, respectively). In our study, different effects of Rev-erbs polymorphisms were found according to gender and presence of obesity. Rev-erb alpha rs72836608 (C > A) and rs2314339 (C > T) and Rev-erb alpha rs2102928 (C > T) were associated with low HDL-C levels in male T2DM patients. In female patients, Rev-erb alpha rs2102928 (C > T) was associated with high microalbuminuria and Rev-erb beta rs9244403442 G > T was associated with low HDL and high BSA values. In addition, Rev-erb alpha Chr17: 38,253,751 (T > C), rs72836608 (C > A), and rs2314339 (C > T) and Rev-erb beta Chr3:24003765 (A > G) were associated with increased serum GGT levels in obese T2DM patients. In non-obese patients, Rev-erbs SNPs had no effect on serum GGT levels. Conclusion: Our findings indicate that variations in the Rev-erb alpha and Rev-erb beta genes can affect metabolic changes in T2DM and these effects may vary depending on gender and obesity.Publication Metadata only Nutritional Evaluation of Patients with Disk Hernia(2014-01-01T00:00:00Z) Seyithanoglu, Hakan; AYDIN, Teoman; Taspinar, Ozgur; Camli, Adil; Kiziltan, Huriye; ERİŞ, ALİ HİKMET; Hocaoglu, Ilknur Turk; Ozder, ACLAN; Denizli, Ebru; Kepekci, Muge; Kilic, Ilknur Zeynep; AYDIN, TEOMAN; ERİŞ, ALİ HİKMET; ÖZDER, ACLANPublication Metadata only METABOLIC SYNDROME IN COLLECTION AND DISPOSAL OF SOLID WASTE SECTOR(2012-01-01T00:00:00Z) Eker, Hasan Huseyin; BAYRAKTARLI, Recep Yilmaz; Issever, Halim; Ulas, Tumer; Erelel, Mustafa; ESER, ALİ; OZDILLI, Kursat; Ozder, ACLAN; ESER, ALİ; ÖZDER, ACLANObjectives: This study aims to assess the frequency and factors relevant to metabolic syndrome in workers employed in the collection and disposal of solid waste sector. Materials and Methods: This cross-sectional study was conducted in the major solid waste collecting and disposal company named ISTAC AS (Istanbul Environmental Protection and Waste Processing Corporation) in Istanbul, Turkey. All 715 male employees of the company were included in the study without sampling. The study was completed with 619 subjects. Since it was a small group, female workers were not taken into account in the study. Metabolic syndrome frequency was investigated according to the NCEP-ATP III criteria including the levels of systolic and diastolic blood pressure, waist perimeter, HDL, triglyceride, fasting blood glucose values. Results: Metabolic syndrome was present in 40.9% of participating employees. Metabolic syndrome was more common in those working in the excavation field (54.0%), such as caterpillar operators (56.5%), and less common in employees working in administrative offices, such as office staff or managers, who were under 35 years old and who had been working for less than 10 years (p < 0.05). Employees working in work stations other than administrative offices had a 2.60 times higher risk compared to those working in administrative offices. Conclusions: Metabolic syndrome may be related to work station, job, age and period worked by the subjects.Publication Open Access THE PREVALENCE OF EXCESSIVE DAYTIME SLEEPINESS AMONG ACADEMIC PHYSICIANS AND ITS IMPACT ON THE QUALITY OF LIFE AND OCCUPATIONAL PERFORMANCE(2015-01-01) Ozder, ACLAN; Eker, Hasan Huseyin; ÖZDER, ACLANObjectives: Sleep disorders can affect health and occupational performance of physicians as well as outcomes in patients. The purpose of this study was to assess the prevalence of excessive daytime sleepiness (EDS) measured by the Epworth Sleepiness Scale (ESS) among academic physicians at a tertiary academic medical center in an urban area in the northwest region of Turkey, and to establish a relationship between the self-perceived sleepiness and the quality of life using the EuroQol-5 dimensions (EQ-5D). Material and methods: A questionnaire prepared by the researchers after scanning the literature on the subject was e-mailed to the academic physicians of a tertiary academic medical center in Istanbul. The ESS and the EQ-5D were also included in the survey. The e-mail database of the institution directory was used to compile a list of active academic physicians who practiced clinical medicine. Paired and independent t tests were used for the data analysis at a significance level of p < 0.05. Results: Three hundred and ninety six academic physicians were e-mailed and a total of 252 subjects replied resulting in a 63.6% response rate. There were 84 (33.3%) female and 168 (66.7%) male academic physicians participating in the study. One hundred and eight out of 252 (42.8%) academic physicians were taking night calls (p < 0.001). Ninety study subjects (35.7%) felt they had enough sleep and 84 (33.3%) reported napping daily (p < 0.001). In our sample, 28.6% (N = 72) of the physicians felt sleepy during the day (ESS score > 10) (p < 0.001). In the case of the EQ-5D index and visual analogue scale of the EQ-5D questionnaire (EQ-5D VAS), the status of sleepiness of academic physicians was associated with a poorer quality of life (p < 0.001). Conclusions: More than a 1/4 of the academic physicians suffered from sleepiness. There was an association between the poor quality of life and daytime sleepiness. There was also a positive relationship between habitual napping and being sleepy during the day.Publication Metadata only Investigation of the General Life Conditions of Elderly (Age 85 and Over) Living At Home in Province of Afyonkarahisar(2016-01-01) Sise, Sengul; Ozder, ACLAN; ÖZDER, ACLANObjective: This study was carried out to determine the general life conditions of elderly over 85 years old in Afyonkarahisar.Publication Metadata only ABO and Rh Blood Group Distribution in Istanbul Province (Turkey)(2015-09-01) SALDUZ, Zeyneb Irem Yuksel; Cetin, GÜVEN; KARATOPRAK, CUMALİ; Ozder, ACLAN; BILGINC, Mesut; GULTEPE, Ilhami; GUL, Omer; YÜKSEL SALDUZ, ZEYNEB İREM; ÇETİN, GÜVEN; KARATOPRAK, CUMALİ; ÖZDER, ACLANObjective: An understanding of the distribution of blood groups in a city is useful for individuals in need. In this study, we aimed to determine the distribution rates of ABO and Rh blood groups in Istanbul Province.Publication Metadata only EXCESSIVE DAYTIME SLEEPINESS AMONG TURKISH PUBLIC TRANSPORTATION DRIVERS: A RISK FOR ROAD TRAFFIC ACCIDENTS?(2014-01-01) Ozder, ACLAN; Gunay, Ersin; Eker, Hasan Huseyin; Ulasli, Sevinc Saris; ÖZDER, ACLANAims.. This study evaluated the prevalence of, and the risk factors for, obstructive sleep apnoea syndrome (OSAS) and excessive day time sleepiness (EDS) as well as it relation to road traffic accidents (RTA) among Turkish Public transportation drivers.