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ÖZDER, ACLAN

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ÖZDER
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ACLAN
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Now showing 1 - 10 of 18
  • Publication
    Metadata only
    Anxiety levels among Turkish public transportation drivers: a relation to restless legs syndrome?
    (2014-01-01) Ozder, ACLAN; Eker, Hasan Huseyin; ÖZDER, ACLAN
    The aim of this study was to estimate the prevalence of individuals who are at high risk for state and trait anxiety as well as to investigate the relationship of anxiety levels of urban transportation drivers from Istanbul, Turkey with restless legs syndrome (RLS). The data was gathered between April 2013 and June 2013 by the use of a questionnaire prepared for the purpose of this study, completed anonymously. Restless leg syndrome and anxiety level were evaluated in the group; data obtained was analyzed using the SPSS version 16. Chi-square, correlation and student-t tests were used. Restless leg syndrome symptoms were determined by a self-assessment questionnaire, including the International Restless Legs Syndrome Study Group (IRLSSG) diagnostic criteria, to determine RLS symptoms and Spielberger State-Trait Anxiety Inventory (STAI) to determine anxiety levels of the participants. In the present study, the four RLS criteria were reported in 31.2%. STAI-state and STAI-trait scores were 40.82 +/- 9.55 and 42.99 +/- 8.54 respectively. The state and trait anxiety mean scores were different among participants with RLS in this study (p < 0.05). It was found a significant difference between tobacco usage and state anxiety (p < 0.05). There were a significant difference between RLS and age, number of cigarettes daily consumed and employment time (p < 0.05). The state and trait anxiety scores were found high among bus drivers with RLS in this study.
  • Publication
    Open Access
    Determination of Genetic Changes of Rev-erb beta and Rev-erb alpha genes in Type 2 Diabetes Mellitus by Next-Generation Sequencing
    (2020-08-13T00:00:00Z) Tokat, B; Kanca-Demirci, D; Gul, N; Satman, I; Ozturk, O; Ozder, ACLAN; Kucukhuseyin, O; Yilmaz-Aydogan, H; ÖZDER, ACLAN
    Background: The nuclear receptors Rev-erb alpha and Rev-erb beta are transcription factors that regulate the function of genes in glucose and lipid metabolism, and they also form a link between circadian rhythm and metabolism. We evaluated the variations in Rev-erb alpha and Rev-erb beta genes together with biochemical parameters as risk factors in type 2 diabetic (T2DM) patients. Methods: Molecular analyses of Rev-erb alpha and Rev-erb beta genes were performed on genomic DNA by using next-generation sequencing in 42 T2DM patients (21 obese and 21 non-obese) and 66 healthy controls. Results: We found 26 rare mutations in the study groups, including 13 missense mutations, 9 silent mutations, 3 5'UTR variations, and a 3'UTR variation, of which 9 were novel variations (5 missense and 3 silent and 1 5'UTR). Six common variations were also found in the Rev-erb genes; Rev-erb beta Chr3:24003765 A > G, Rev-erb beta rs924403442 (Chr3:24006717) G > T, Rev-erb alpha Chr17:38253751 T > C, Rev-erb alpha rs72836608 C > A, Rev-erb alpha rs2314339 C > T and Rev-erb alpha rs2102928 C > T. Of these, Rev-erb beta Chr3:24003765 A > G was a novel missense mutation (p.Q197R), while others were identified as intronic variants. T2DM patients with Rev-erb beta rs924403442 T allele had lower body surface area (BSA) than noncarriers (GG genotype) (p = 0.039). Rev-erb alpha rs72836608 A allele and Rev-erb alpha rs2314339 CC genotype were associated with decreased serum HDL-cholesterol levels in T2DM patients (p = 0.025 and p = 0.027, respectively). In our study, different effects of Rev-erbs polymorphisms were found according to gender and presence of obesity. Rev-erb alpha rs72836608 (C > A) and rs2314339 (C > T) and Rev-erb alpha rs2102928 (C > T) were associated with low HDL-C levels in male T2DM patients. In female patients, Rev-erb alpha rs2102928 (C > T) was associated with high microalbuminuria and Rev-erb beta rs9244403442 G > T was associated with low HDL and high BSA values. In addition, Rev-erb alpha Chr17: 38,253,751 (T > C), rs72836608 (C > A), and rs2314339 (C > T) and Rev-erb beta Chr3:24003765 (A > G) were associated with increased serum GGT levels in obese T2DM patients. In non-obese patients, Rev-erbs SNPs had no effect on serum GGT levels. Conclusion: Our findings indicate that variations in the Rev-erb alpha and Rev-erb beta genes can affect metabolic changes in T2DM and these effects may vary depending on gender and obesity.
  • Publication
    Metadata only
    Association between nutritional status and Modic classification in degenerative disc disease
    (2016-04-01) TASPINAR, Ozgur; Seyithanoglu, Hakan; CAMLI, Adil; KIZILTAN, Huriye; HOCAOGLU, Ilknur Turk; Aydin, TEOMAN; Keskin, YAŞAR; Ozder, ACLAN; Eris, ALİ HİKMET; DENIZLI, Ebru; KEPEKCI, Muge; SEYİTHANOĞLU, MEHMET HAKAN; AYDIN, TEOMAN; ERİŞ, ALİ HİKMET; ÖZDER, ACLAN; KESKİN, YAŞAR
    [Purpose] This study was conducted to examine the association between Modic classification and the eating habits in patients with degenerative disc disease (DDD) and to determine the influence of nutrition on disease severity. [Subjects and Methods] Sixty patients with DDD visiting a low back pain outpatient clinic were enrolled. Through face-to-face interviews, they completed questionnaires regarding their demographics, disease activity, smoking and alcohol use, concomitant diseases, disease duration, and nutritional status. Exclusion criteria were age 65 years, other comorbidities, missing MRI data, and inability to speak Turkish. [Results] Forty patients were finally included in the study. The frequency with which they consumed water, salt, fast food, eggs, milk, yogurt, cheese, whole wheat bread, white bread, butter, and margarine was recorded. A weak negative correlation was observed between the Modic types and fish and egg consumption. [Conclusion] Modic changes, which indicate the severity of DDD, seem to be correlated to patients- dietary habits. However, studies with comparison groups and larger samples are needed to confirm our promising results before any cause-and-effect relationship can be proposed.
  • Publication
    Metadata only
    METABOLIC SYNDROME IN COLLECTION AND DISPOSAL OF SOLID WASTE SECTOR
    (2012-01-01T00:00:00Z) Eker, Hasan Huseyin; BAYRAKTARLI, Recep Yilmaz; Issever, Halim; Ulas, Tumer; Erelel, Mustafa; ESER, ALİ; OZDILLI, Kursat; Ozder, ACLAN; ESER, ALİ; ÖZDER, ACLAN
    Objectives: This study aims to assess the frequency and factors relevant to metabolic syndrome in workers employed in the collection and disposal of solid waste sector. Materials and Methods: This cross-sectional study was conducted in the major solid waste collecting and disposal company named ISTAC AS (Istanbul Environmental Protection and Waste Processing Corporation) in Istanbul, Turkey. All 715 male employees of the company were included in the study without sampling. The study was completed with 619 subjects. Since it was a small group, female workers were not taken into account in the study. Metabolic syndrome frequency was investigated according to the NCEP-ATP III criteria including the levels of systolic and diastolic blood pressure, waist perimeter, HDL, triglyceride, fasting blood glucose values. Results: Metabolic syndrome was present in 40.9% of participating employees. Metabolic syndrome was more common in those working in the excavation field (54.0%), such as caterpillar operators (56.5%), and less common in employees working in administrative offices, such as office staff or managers, who were under 35 years old and who had been working for less than 10 years (p < 0.05). Employees working in work stations other than administrative offices had a 2.60 times higher risk compared to those working in administrative offices. Conclusions: Metabolic syndrome may be related to work station, job, age and period worked by the subjects.
  • Publication
    Metadata only
    EXCESSIVE DAYTIME SLEEPINESS AMONG TURKISH PUBLIC TRANSPORTATION DRIVERS: A RISK FOR ROAD TRAFFIC ACCIDENTS?
    (2014-01-01) Ozder, ACLAN; Gunay, Ersin; Eker, Hasan Huseyin; Ulasli, Sevinc Saris; ÖZDER, ACLAN
    Aims.. This study evaluated the prevalence of, and the risk factors for, obstructive sleep apnoea syndrome (OSAS) and excessive day time sleepiness (EDS) as well as it relation to road traffic accidents (RTA) among Turkish Public transportation drivers.
  • Publication
    Metadata only
    STATUS OF VITAMIN D AMONG TURKISH ADULTS WITH TYPE 2 DIABETES MELLITUS IN PRIMARY HEALTH CARE
    (2015-01-01) Ozder, ACLAN; Eker, Hasan Huseyin; BILGINC, Mesut; ÖZDER, ACLAN
    Aims: The aim of our study was to investigate the prevalence and correlates of 25-hydroxy vitamin D (25(OH)D) deficiency and the relationship between 25(OH)D and the type 2 diabetes mellitus (T2DM) in primary health care.
  • Publication
    Open Access
    THE PREVALENCE OF EXCESSIVE DAYTIME SLEEPINESS AMONG ACADEMIC PHYSICIANS AND ITS IMPACT ON THE QUALITY OF LIFE AND OCCUPATIONAL PERFORMANCE
    (2015-01-01) Ozder, ACLAN; Eker, Hasan Huseyin; ÖZDER, ACLAN
    Objectives: Sleep disorders can affect health and occupational performance of physicians as well as outcomes in patients. The purpose of this study was to assess the prevalence of excessive daytime sleepiness (EDS) measured by the Epworth Sleepiness Scale (ESS) among academic physicians at a tertiary academic medical center in an urban area in the northwest region of Turkey, and to establish a relationship between the self-perceived sleepiness and the quality of life using the EuroQol-5 dimensions (EQ-5D). Material and methods: A questionnaire prepared by the researchers after scanning the literature on the subject was e-mailed to the academic physicians of a tertiary academic medical center in Istanbul. The ESS and the EQ-5D were also included in the survey. The e-mail database of the institution directory was used to compile a list of active academic physicians who practiced clinical medicine. Paired and independent t tests were used for the data analysis at a significance level of p < 0.05. Results: Three hundred and ninety six academic physicians were e-mailed and a total of 252 subjects replied resulting in a 63.6% response rate. There were 84 (33.3%) female and 168 (66.7%) male academic physicians participating in the study. One hundred and eight out of 252 (42.8%) academic physicians were taking night calls (p < 0.001). Ninety study subjects (35.7%) felt they had enough sleep and 84 (33.3%) reported napping daily (p < 0.001). In our sample, 28.6% (N = 72) of the physicians felt sleepy during the day (ESS score > 10) (p < 0.001). In the case of the EQ-5D index and visual analogue scale of the EQ-5D questionnaire (EQ-5D VAS), the status of sleepiness of academic physicians was associated with a poorer quality of life (p < 0.001). Conclusions: More than a 1/4 of the academic physicians suffered from sleepiness. There was an association between the poor quality of life and daytime sleepiness. There was also a positive relationship between habitual napping and being sleepy during the day.
  • Publication
    Metadata only
    Precision Diagnosis of Maturity-Onset Diabetes of the Young with Next-Generation Sequencing: Findings from the MODY-IST Study in Adult Patients.
    (2022-03-23T00:00:00Z) Aydogan, Hulya Yilmaz; Gul, Nurdan; Demirci, Deniz Kanca; Mutlu, Ummu; Gulfidan, Gizem; Arga, Kazim Yalcin; Ozder, ACLAN; Camli, Ahmet Adil; Tutuncu, Yildiz; Ozturk, Oguz; Cacina, Canan; Darendeliler, Feyza; Poyrazoglu, Sukran; Satman, Ilhan; ÖZDER, ACLAN
  • Publication
    Metadata only
    Sarcopenia Assessment in Patients with Type 2 Diabetes Mellitus
    (2014-01-01T00:00:00Z) AYDIN, Teoman; Taspinar, Ozgur; Camli, Adil; Ozder, ACLAN; Kiziltan, Huriye; ERİŞ, ALİ HİKMET; Hocaoglu, Ilknur Turk; Kepekci, Muge; Denizli, Ebru; Posul, Sevde; Gok, Murat; Guler, Mustafa; AYDIN, TEOMAN; ÖZDER, ACLAN; ERİŞ, ALİ HİKMET
  • Publication
    Open Access
    Lipid profile abnormalities seen in T2DM patients in primary healthcare in Turkey: a cross-sectional study
    (2014-12-06) Ozder, ACLAN; ÖZDER, ACLAN
    Background: Diabetes is characterized by chronic hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism. We aimed to research association between serum lipid profile and blood glucose, hypothesizing that early detection and treatment of lipid abnormalities can minimize the risk for atherogenic cardiovascular disorder and cerebrovascular accident in patients with type 2 diabetes mellitus. Methods: Fasting blood glucose (FBG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), triglyceride (TG) and glycated haemoglobin (HbA1c) levels were evaluated. A hepatic ultrasound was performed for every diabetic to evaluate hepatosteatosis. The study was done from January 2014 to June 2014 among 132 patients with T2DM who were admitted to outpatient clinic of Family Medicine department in a university hospital. The patients whose taking multi-vitamin supplementation or having hepatic, renal or metabolic bone disorders (including parathyroid related problems) were excluded from the study for the reason that those conditions might affect the carbohydrate and lipid metabolism in diabetes. Test of significance was calculated by unpaired student's t test between cases and controls. Correlation studies (Pearson's correlation) were performed between the variables of blood glucose and serum lipid profile. Significance was set at p<0.05. Results: Results of serum lipid profile showed that the mean values for TC, TG, HDL and LDL in female patients were 227.6 ± 57.7 mg/dl, 221.6 ± 101.1 mg/dl, 31.5 ± 6.7 mg/dl and 136.5 ± 43.7 mg/dl, respectively. The mean values for TC, TG, HDL and LDL in male patients were 219.1 ± 34.7 mg/dl, 250.0 ± 100.7 mg/dl, 30.2 ± 7.4 mg/dl and 125.7 ± 21.4 mg/dl, respectively. Significantly higher mean serum levels of TC, TG and LDL and significantly lower mean serum levels of HDL were noted in patients with diabetes (p<0.001). FBG showed significant positive correlation with TC (p<0.05) and TG (p<0.05). Significant correlations were observed between serum levels of TC, TG, LDL and hepatosteatosis and HbA1c (p<0.05). Conclusions: The study showed widespread lipid abnormalities in the course of diabetes triggered dyslipidemia as hypercholesterolemia, hypertriglyceridemia, elevated LDL and decreased HDL. This study proposes the predominance of hyperlipidemia over increased prevalence of diabetic dyslipidemia.