Person: ONSUN, NAHIDE
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Publication Open Access Ambulatory Blood Pressure Monitoring Could Unmask Hypertension in Patients with Psoriasis Vulgaris(2013-10-29) BACAKSIZ, AHMET; Erdogan, Ercan; Sonmez, Osman; Sevgili, Emrah; Tasal, Abdurrahman; ONSUN, NAHİDE; Topukcu, Bugce; Kulac, Beytullah; UYSAL, ÖMER; Goktekin, Omer; BACAKSIZ, AHMET; ONSUN, NAHIDE; UYSAL, ÖMERBackground: Psoriasis vulgaris is one of the most prevalent chronic, inflammatory skin disorders. Patients with psoriasis have excess risk of essential hypertension. Masked hypertension (MH), defined as normal office blood pressure (BP) with elevated ambulatory BP (ABPM), has been drawing attention recently due to its association with increased risk of developing sustained hypertension, cardiovascular morbidity, and mortality. The aim of this study was to investigate the prevalence of MH in psoriatic patients. Material and Methods: On hundred and ten middle-aged, normotensive, non-obese patients with psoriasis vulgaris and 110 age- and sex-matched normotensive controls were included in the study. ABPM was performed in all participants over a 24-h period. The clinical severity of the disease was determined according to current indexes. Results: The prevalence of MH among subjects with psoriasis vulgaris was 31.8% and increased compared to control subjects (p<0.01). Predictors of MH in patients with psoriasis vulgaris were detected as male sex, smoking, obesity-related anthropometric measures, and disease activity. Male sex, waist circumference, and diffuse psoriatic involvement were detected as independent predictors of MH. Conclusions: MH is prevalent in patients with psoriasis vulgaris. Assessment with ABPM and close follow-up for development of hypertension is reasonable.Publication Open Access The HLA-Cw12 Allele Is an Important Susceptibility Allele for Psoriasis and Is Associated with Resistant Psoriasis in the Turkish Population(2019-01-01T00:00:00Z) ONSUN, NAHİDE; Pirmit, Serpil; Ozkaya, Dilek; Çelik, Şirin; Rezvani, Aylin; CENGİZ, Fatma Pelin; Kekik, Cigdem; ONSUN, NAHIDE; REZVANİ, AYLİN; CENGİZ, FATMA PELINBackground. Psoriasis is a multifactorial immune-mediated infammatory disease triggered by both genetic and environmental factors. Te strong association between psoriasis and HLA-C∗06 allele has been demonstrated in various races. Te HLAC∗12 allele is closely related to the HLA-C∗06 family of alleles and shares identical sequences. To the best of our knowledge, there is no information about the relationship between HLA-C∗12 and psoriasis in the Turkish population. Te present study aims to determine this relationship. Methods. Tis case control study involved 150 patients with plaque-type psoriasis and 145 age- and gender-matched healthy individuals. Severity of psoriasis was measured using the PASI scores of all patients and joint involvement was investigated with CASPAR criteria. HLA-C alleles were determined with a Tepnel-Lifecodes system. Results. HLA-C∗06, HLA-C∗12, and HLA-C∗04 alleles were most commonly observed in psoriasis patients. HLA-C∗06 and HLA-C∗12 were signifcantly more frequent in the psoriasis group. HLA-C∗06 was 4.11 times more common in psoriasis patients. An increase in PASI (Psoriasis Area Severity Index) scores was compatible with HLA-C∗12 positivity. A need for systemic treatment was highly noticeable in patients with the HLA-C∗12 allele. Conclusions. HLA-C∗12 was found as the second most frequent allele with psoriasis in Turkish population and was associated with severe psoriasis. Our study is limited as we could not investigate other potentially related alleles other than HLA-C alleles and risk factors increasing severity of psoriasis.Publication Metadata only Verrucous Bowen’s disease on groin with dermoscopic and siascopic images(2017-05-06T00:00:00Z) CENGİZ, FATMA PELİN; EMİROĞLU, NAZAN; SU KÜÇÜK, ÖZLEM SU; ONSUN, NAHİDE; CENGİZ, FATMA PELIN; EMİROĞLU, NAZAN; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDEPublication Open Access Demographic characteristics, aetiology, and assessment of treatment options in leukocytoclastic vasculitis.(2017-04-01) CAKıTER, AU; Kucuk, OS; OZKAYA, DB; TOPUKÇU, B; ONSUN, NAHİDE; SU KÜÇÜK, ÖZLEM; BIYIK ÖZKAYA, DİLEK; ONSUN, NAHIDEIntroduction: Vasculitides are a heterogeneous group of diseases characterized by inflammation of the blood vessel walls. Etiological factors include infections, drugs, connective tissue diseases, and malignancies. Aim: To examine the demographic characteristics, etiological factors, and treatment options in 75 patients with leukocytoclastic vasculitis. Material and methods: The study included 75 patients diagnosed with leukocytoclastic vasculitis at our clinic. The patients’ medical records were reviewed to determine their age, sex, presence of systemic symptoms, possible etiological factors, laboratory results, types of cutaneous lesions, locations of the lesions, treatment options, and disease course. Results: There were 43 women and 32 men. Cutaneous lesions affected only the lower limbs in 60 of the 75 patients (80%) and usually presented as palpable purpura (64%, n = 48). Arthralgia (26.7%, n = 20) was the most frequent extracutaneous symptom. Of the patients with secondary vasculitis, the most common causes were infections and drugs. The mean age of the patients with Henoch-Schönlein purpura was 26.8 years. There was no significant association between age and renal, gastrointestinal, or joint involvement. Conclusions: The most common form of vasculitis in our study was cutaneous leukocytoclastic vasculitis. In most of the patients it appeared to be idiopathic. Among drugs, antibiotics were the most common etiological factor. In 4 patients, the cutaneous leukocytoclastic vasculitis behaved like the paraneoplastic syndrome.Publication Metadata only The associations between peer victimization, psychological symptoms and quality of life in adolescents with acne vulgaris(2016-12-01) BAHALI, A. G.; BAHALI, K.; OZKAYA, D. Biyik; Bilgic, A.; Su, O.; ONSUN, NAHİDE; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDEPublication Metadata only Correlation of clinical, dermoscopical and histopathological features of all subtypes of basal cell carcinoma(2017-06-01) DIZMAN, DİDEM; OZKAYA, D. B.; BAHALI, A. G.; DIZMAN, B. T.; YILDIZ, PELİN; TOSUNER, ZEYNEP; Demirkesen, C.; ONSUN, NAHİDE; SU, O.; DİZMAN, DİDEM; YILDIZ, PELİN; TOSUNER, ZEYNEP; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDEPublication Metadata only Verrucous Bowen’s disease on groin with dermoscopic and siascopic images(2017-05-06T00:00:00Z) CENGİZ, FATMA PELİN; EMİROĞLU, NAZAN; SU KÜÇÜK, ÖZLEM SU; ONSUN, NAHİDE; CENGİZ, FATMA PELIN; EMİROĞLU, NAZAN; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDEPublication Open Access Frequency and risk factors for secondary malignancies in patients with mycosis fungoides(2016-08-01) EMIROGLU, NAZAN; CENGIZ, F. P.; BAHALI, A. Gulsel; Su, O.; ONSUN, NAHİDE; CENGİZ, FATMA PELIN; EMİROĞLU, NAZAN; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDEMycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma (CTCL), has an incidence of 6.4 per million people [1]. Patients with CTCL have an increased risk of the development of secondary malignancies, particularly lymphomas [2,3]. We conducted a 20-year population-based cohort study to assess the risk factors of secondary cancers in MF patients from our center.Publication Metadata only Hafif ve Orta Şiddetli Akne Hastalarında A ve E Vitamini Düzeyleri(2017-04-01T00:00:00Z) CENGİZ, FATMA PELİN; EMİROĞLU, NAZAN; BAHALI, ANIL GÜLSEL; SU KÜÇÜK, ÖZLEM SU; ONSUN, NAHİDE; CENGİZ, FATMA PELIN; EMİROĞLU, NAZAN; BAHALI, ANIL GÜLSEL; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDEPublication Metadata only Alopesi areatanın patogenezinde dehidroepiandrosteron sülfatın yeri(2017-04-15T00:00:00Z) EMİROĞLU, NAZAN; CENGİZ, FATMA PELİN; SU KÜÇÜK, ÖZLEM SU; ONSUN, NAHİDE; EMİROĞLU, NAZAN; CENGİZ, FATMA PELIN; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDE