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BELCE, AHMET

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Kurumdan Ayrılmıştır
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AHMET
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BELCE
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    PublicationOpen Access
    The Role of Beta-3-Adrenoceptors in Autonomic Nervous System
    (2013-12-01T00:00:00Z) Aksu, Ugur; BELCE, Ahmet; DEMİRCİ TANSEL, Cihan; BELCE, AHMET
    Catecholamines play a regulatory role in the cardiovascular system, primarily via beta (1-2)-adrenoreceptors (AR). However, in the late 1980s, the cloning of a third beta-AR subtype (beta 3-AR) in the heart has altered the conventional view on the regulation of heart function via the betaadrenergic receptors. Additionally, in blood vessels, beta 3-AR was shown to produce relaxation. Currently, the physiological role of beta 3-AR is not clearly known. Hence, the purpose of this review is to summarize the physiological evidences supporting the functional roles of beta 3-AR in various tissues, particularly cardiac and vascular. In addition, this review discusses the potential role of beta 3-AR in obesity and insulin resistance and emphasizes their putative involvement as new therapeutic targets.
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    PublicationOpen Access
    Effect of Dexamethasone in Mediating Oxidative Stress Induced by Sodium Nitroprusside on Frog Sciatic Nerve Action Potentials
    (2013-12-01T00:00:00Z) Aksu, Ugur; Atukeren, Pinar; Terzioglu, Duygu; BELCE, Ahmet; DEMİRCİ TANSEL, Cihan; BELCE, AHMET
    Objective: High concentrations of nitric oxide cause a neurotoxic effect on nerve action potentials. Although glucocorticoids can decrease that effect, the degree of mediation is not known. This study determined the effect of dexamethasone on frog sciatic nerve axon fibers subjected to in vitro oxidative stress. Methods: Frog sciatic nerves were isolated into Groups: -Control Group-incubation in Ringer's solution; SNP Group-incubation in 10-M-2 sodium nitroprusside solution; SNP+ DEX Group-incubation in 10-M-3 sodium nitroprusside solution followed by incubation in 10-3 M dexamethasone solution; DEX group-incubation in 10-M-3 dexamethasone solution. Results: In the SNP group, significant changes were observed in the action potential velocity of propagation (p< 0.01), the action potential maximum amplitude (p< 0.01), the slope of the emerging phase (p< 0.01), and the area under the signal curve (p< 0.05). Considering electrophysiological parameters, conduction velocity; maximum amplitude; and signal area values increased above normal by dexamethasone incubation after sodium nitroprusside exposure. In biochemical parameters, the group that received sodium nitroprusside increased the thiobarbituric acid reactive substances (TBARS) concentration (p< 0.001) and decreased superoxide dismutase (SOD) activity (p< 0.01). Conclusion: Findings supported our hypothesis that dexamethasone reverses damage and decreases oxidative damage to nerve action potential caused by exposure to sodium nitroprusside.