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BELCE, AHMET

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Kurumdan Ayrılmıştır
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AHMET
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BELCE
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2017 - 20193
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Author: ÇAKATAY, Ufuk ×

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Now showing 1 - 3 of 3
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    Galactose-induced Aging Model in Rat Testicular Tissue
    (2018-07-01T00:00:00Z) AYDIN, Seval; YANAR, Karolin; Simsek, Bahadir; Cebe, Tamer; Sitar, Mustafa Erinc; BELCE, Ahmet; ÇAKATAY, Ufuk; BELCE, AHMET
    Objective: To examine whether the D-galactose induced aging model is an appropriate model for further aging research.
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    The effects of lipoic acid on redox status in brain regions and systemic circulation in streptozotocin-induced sporadic Alzheimer-s disease model
    (2017-08-01T00:00:00Z) Erdogan, Mehmet Evren; AYDIN, Seval; YANAR, Karolin; Mengi, Murat; Kansu, Ahmet Dogukan; Cebe, Tamer; BELCE, Ahmet; Celikten, Mert; ÇAKATAY, Ufuk; BELCE, AHMET
    While the deterioration of insulin-glucose metabolism (IGM), impaired redox homeostasis (IRH), beta-amyloid accumulation was reported in Sporadic Alzheimer-s Disease (SAD) model, aforementioned factors related to lipoic acid administration and anthropometric indexes (AIs) are not yet studied with integrative approach. beta-amyloid accumulation, redox homeostasis biomarkers and AIs are investigated in SAD model. Streptozotocin-induced inhibition of insulin-signaling cascade but not GLUT-2 and GLUT-3 transporters takes a role in beta-amyloid accumulation. Inhibition types are related to IRH in cortex, hippocampus and systemic circulation. Lipoic acid (LA) shows both antioxidant and prooxidant effect according to the anatomical location. LA administration also leads to improved AIs during GLUT-2 inhibition and cortical redox status in GLUT-3 inhibited group. Optimal LA action could be possible if its redox behavior is balanced to antioxidant effect. Diagnostic usage of systemic IRH parameters as biomarkers and their possible correlations with deteriorated IGM should be investigated.
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    Caloric restriction and redox homeostasis in various regions of aging male rat brain: Is caloric restriction still worth trying even after early-adulthood? Redox homeostasis and caloric restriction in brain
    (2019-03-01T00:00:00Z) YANAR, Karolin; Simsek, Bahadir; Cayli, Nisanur; Bozkir, Haktan Ovul; MENGİ, MURAT; BELCE, Ahmet; AYDIN, Seval; ÇAKATAY, Ufuk; BELCE, AHMET
    Despite recent studies have shown that caloric restriction (CR) could improve some functional loss associated with brain aging, the biochemical effects of CR on brain aging are still not well understood on a quantifiable biochemical basis, including whether CR could be protective when started around middle adulthood, when age-related neurodegenerative diseases are thought to set in. Therefore, in the light of more than ever aging societies and increasing neurodegenerative diseases, we aimed to test the biochemical effects of CR on redox homeostasis in different parts of male Sprague-Dawley rat brain by using the biomarkers we consistently validated in our previous work (TOS, PCO, AOPP, AGEs, sRAGE, P-SH, LHPs, 4-HNE, TAS, Cu, Zn-SOD). Our results indicate that oxidative stress biomarkers are lower in CR group, implying a more favorable redox status that has been previously shown to be correlated with better neural function.