Person:
ELİBOL, BİRSEN

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BİRSEN
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ELİBOL
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Now showing 1 - 10 of 22
  • PublicationMetadata only
    Behavioral and molecular effects of perinatal music on rat pups
    (2016-11-16) Yanık, Hilal; CAN, BİRSEN; KIRPINAR, İSMET; BEKER, MERVE; ELİBOL, BİRSEN; KIRPINAR, İSMET; BEKER, MERVE
  • PublicationMetadata only
    Association of reelin silencing and topo isomerase IIβ expression in human SH-SY5Y neuroblastoma cell line
    (2019-09-07) TERZİOĞLU UŞAK, ŞULE; BEKER, MERVE; ELİBOL, BİRSEN; TERZİOĞLU, ŞULE; ELİBOL, BİRSEN; BEKER, MERVE
  • PublicationMetadata only
    Melatonin promotes neurological recovery, peri-lesional tissue remodeling, and contralesional pyramidal tract plasticity after focal cerebral ischemia
    (2015-10-21) kılıç, ülkan; Beker, mustafa çağlar; çağlayan, ahmet burak; ELİBOL, BİRSEN; BEKER, MERVE; altuğ, burcugül; gök, özlem; keleştemur, taha; kılıç, ertuğrul; ELİBOL, BİRSEN; BEKER, MERVE
  • PublicationMetadata only
    Effects of fetal alcohol and maternal intubation stress on the expression of proteins controlling postnatal development of male rat hippocampus
    (2020-09-01T00:00:00Z) ELİBOL, BİRSEN; BEKER, MERVE; KILIÇ, ÜLKAN; Jakubowska-Dogru, Ewa; ELİBOL, BİRSEN; BEKER, MERVE
    Background Developing brains can partially get over prenatal alcohol exposure-related detrimental conditions by activating some mechanisms involved in survival. Objectives This study aimed to shed light on the molecular correlates of compensatory mechanisms by examining temporal profiles in the expression of proteins controlling postnatal development in the rat hippocampus prenatally exposed to intubation stress/ethanol. Methods Male pups were randomly assigned to age subgroups (n = 21/age) which were sacrificed on postnatal day (PD)1, PD10, PD30, and PD60. Ethanol (6 g/kg/day) were intragastrically intubated to the dams throughout 7-21 gestation days. The expression of neurogenesis and angiogenesis markers, extracellular matrix proteins, and growth-promoting ligands were examined by western blot. Results The most rapid increase in the index of neuronal maturation was noted between PD10-PD30 (p< .05). Prenatal stress caused a decrease of neurogenesis markers at birth and an increase of their expressions at PD10 and PD30 to reach control levels (p< .001). The impact of fetal-alcohol was observed as a decrease in the expression of synaptic plasticity protein versican at birth (p< .001), an increase in the synaptic repulsion protein ephrin-B2 at PD10 (p< .001), and a decrease in the maturation of BDNF at PD30 (p< .001) with a decrease in the mature neuron markers at PD30 (p< .001) and PD60 (p= .005) which were compensated with upregulation of angiogenesis and increasing brevican expression, a neuronal maturation protein (p< .001). Conclusion These data providein vivoevidence for the potential therapeutic factors related to neurogenesis, angiogenesis, and neurite remodeling which may tolerate the alcohol/stress dependent teratogenicity in the developing hippocampus.
  • PublicationMetadata only
    Thymoquinone administration ameliorates Alzheimer-s disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta(1-42) infused rat model
    (2020-12-01T00:00:00Z) ELİBOL, BİRSEN; Beker, Merve; Terzioglu-Usak, Sule; Dalli, Tugce; Kilic, Ulkan; ELİBOL, BİRSEN; BEKER, MERVE; TERZİOĞLU, ŞULE
    Background: Thymoquinone (TQ), a biologically active ingredient of Nigella sativa, has anti-inflammatory, antioxidative and neuroprotective properties. Therefore, it could be a good candidate in the recovery of Alzheimer-s disease (AD) pathology rather than current symptomatic reliefs.
  • PublicationMetadata only
    Thymoquinone activates MAPK pathway in hippocampus of streptozotocin-treated rat model
    (2018-03-01) Elibol, BİRSEN; Akbas, FAHRİ; dallı, Tugce; Terzioglu-Usak, ŞULE; Beker, MERVE; BEKER, MERVE; TERZİOĞLU, ŞULE; AKBAŞ, FAHRİ; ELİBOL, BİRSEN
    Streptozotocin (STZ), a glucosamine-nitrosourea compound, produces deficiencies in learning, memory, and cognitive functions when it was administered intracerebroventricularly (i.c.v). In molecular level, increase in neuroinflammation and oxidative stress in brain, and decrease in the number of surviving neurons are the outcomes of STZ administration. Herein, we aimed to investigate the effect of thymoquinone (TQ), an anti-inflammatory, immunomodulatory and neuroprotective agent, on STZ-induced neurodegeneration in rats. For this purpose, bilateral i.c.v. injection of STZ (3 mg/kg) was given to adult female rats on days 1 and 3. TQ (20 mg/kg/day in cornoil) was administered intragastrically to rats for 15 days starting from the 15th day of STZ injection. The Morris water maze test and passive avoidance test were applied to measure the learning and memory performance of animals. Following the behavioral tests, all of the rats were sacrificed for evaluation of molecular alterations. Rats in the STZ-TQ group showed higher performance in passive avoidance test than rats in the STZ group whose memory performance declined compared to control group. The worse memory performance in STZ group was correlated with low number of surviving neurons and high number of degenerating neurons. In addition, an increase in APOE expression and a decrease in NGF expression were observed with STZ injection. Administration of TQ reversed these STZ-triggered cognitive and molecular alterations. In the present study, we observed the neuroregenerative effects of TQ by activation of JNK protein, upregulation of mir-124, and downregulation of ERK1/2 and NOS enzymes. The same ameliorative effect of TQ was also observed in the pTau protein expression. To sum up, we can say that the healing effect of TQ on STZ induced neurodegeneration opens a new door for the development of Alzheimer-s disease treatment using natural products as an adjuvant when their action mechanism was explained in detail.
  • PublicationMetadata only
    Understanding the regeneration mechanisms in the hippocampus of control and fetal alcohol rats during the first two postnatal months
    (2016-11-16) ELİBOL, BİRSEN; Beker, MERVE; Kılıç, Ülkan; Jakubowska-Doğru, Ewa; ELİBOL, BİRSEN; BEKER, MERVE
  • PublicationMetadata only
    Plasticity-Promoting Effect of Melatonin After Experimental Cerebral Ischemia
    (2016-09-01) Kilic, Ulkan; Elibol, Birsen; Beker, Mustafa Caglar; Caglayan, Ahmet Burak; Tasa, Burcugul Altug; Beker, Merve; Ozen, Mustafa; Yilmaz, Bayram; Kilic, Ertugrul; ELİBOL, BİRSEN; BEKER, MERVE
  • PublicationMetadata only
    Perinatal dönemde farklı müzik türlerine maruz kalmanın genç yaştaki sıçanların motor aktiviteleri üzerine etkileri
    (2020-08-01T00:00:00Z) Elibol, Birsen; Beker, Merve; Kırpınar, İsmet; ELİBOL, BİRSEN; BEKER, MERVE; KIRPINAR, İSMET
  • PublicationMetadata only
    Could thymoquinone be used as a rescuer in the amyloid beta-induced neurotoxicity
    (2017-05-10) dallı, tuğçe; kılıç, ülkan; BEKER, MERVE; AKBAŞ, FAHRİ; ELİBOL, BİRSEN