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MİRİOĞLU, ŞAFAK

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Type: Article × Author: Oto, Özgür Akın ×

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Now showing 1 - 5 of 5
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    Oxidative stress and macrophage infiltration in IgA nephropathy.
    (2021-11-16T00:00:00Z) Çalışkan, Yaşar; Demir, Erol; Karatay, Ecem; Özlük, Mesude Yasemin; Mirioğlu, Şafak; Dirim, Ahmet Burak; Artan, Ayşe Serra; Usta Akgül, Sebahat; Oto, Özgür Akın; Savran Oğuz, Fatma; Türkmen, Aydın; Lentıne, Krista L.; Yazıcı, Halil; MİRİOĞLU, ŞAFAK
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    Lower baseline eGFR levels and IgA nephropathy prediction tool.
    (2021-08-01T00:00:00Z) Artan, Ayşe Serra; Mirioğlu, Şafak; Demir, Erol; Dirim, Ahmet Burak; Şafak, Seda; Garayeva, Nurana; Özlük, Mesude Yasemin; Oto, Özgür Akın; Yazıcı, Halil; Çalışkan, Yaşar; MİRİOĞLU, ŞAFAK
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    The importance of glomerular C3 accumulation in elderly patients with primary membranous nephropathy
    (2022-05-01T00:00:00Z) Oto, Özgür Akın; Mirioğlu, Şafak; Dirim, Ahmet Burak; Şafak, Seda; Güller, Nurana; Demir, Erol; Artan, Ayşe Serra; Özlük, Mesude Yasemin; Uçar, Ali Rıza; Soltanova, Lala; Nuriyev, Kanan; Yazıcı, Halil; Çalışkan, Yaşar Kerem; MİRİOĞLU, ŞAFAK
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    Middle-term outcomes in renal transplant recipients with COVID-19: a national, multicenter, controlled study
    (2022-02-01T00:00:00Z) Oto, Özgür Akın; Öztürk, Savaş; Arıcı, Mustafa; Velioğlu, Arzu; Dursun, Belda; Guller, Nurana; Şahin, İdris; Eser, Zeynep Ebru; Paydaş, Saime; Trabulus, Sinan; Koyuncu, Sumeyra; Uyar, Murathan; Ural, Zeynep; Sadioglu, Rezzan Eren; Dheir, Hamad; Koc, Neriman Sila; Ozer, Hakan; Durak, Beyza Algul; Gul, Cuma Bulent; Kasapoglu, Umut; Oguz, Ebru Gok; Tanrisev, Mehmet; Kuzgun, Gulsah Sasak; Mirioğlu, Şafak; Dervisoglu, Erkan; Erken, Ertugrul; Gorgulu, Numan; Ozkurt, Sultan; Aydin, Zeki; Kurultak, Ilhan; Ogutmen, Melike Betul; Bakirdogen, Serkan; Kaya, Burcu; Karadag, Serhat; Ulu, Memnune Sena; Gungor, Ozkan; Bakir, Elif Ari; Odabas, Ali Riza; Seyahi, Nurhan; Yildiz, Alaattin; Ates, Kenan; MİRİOĞLU, ŞAFAK
    Background In this study, we evaluated 3-month clinical outcomes of kidney transplant recipients (KTR) recovering from COVID-19 and compared them with a control group. Method The primary endpoint was death in the third month. Secondary endpoints were ongoing respiratory symptoms, need for home oxygen therapy, rehospitalization for any reason, lower respiratory tract infection, urinary tract infection, biopsy-proven acute rejection, venous/arterial thromboembolic event, cytomegalovirus (CMV) infection/disease and BK viruria/viremia at 3 months. Results A total of 944 KTR from 29 different centers were included in this study (523 patients in the COVID-19 group; 421 patients in the control group). The mean age was 46 +/- 12 years (interquartile range 37-55) and 532 (56.4%) of them were male. Total number of deaths was 8 [7 (1.3%) in COVID-19 group, 1 (0.2%) in control group; P = 0.082]. The proportion of patients with ongoing respiratory symptoms [43 (8.2%) versus 4 (1.0%); P Conclusion The prevalence of ongoing respiratory symptoms increased in the first 3 months post-COVID in KTRs who have recovered from COVID-19, but mortality was not significantly different.
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    Clinical significance of glomerular C3 deposition in primary membranous nephropathy
    (2021-01-01T00:00:00Z) Oto, Özgür Akın; Demir, Erol; Mirioğlu, Şafak; Dirim, Ahmet Burak; Özlük, Mesude Yasemin; Cebeci, Egemen; Baştürk, Taner; Uçar, Ali Rıza; Soltanova, Lala; Nuriyev, Kanan; Kılıçaslan, Işın; Yazıcı, Halil; Çalışkan, Yaşar Kerem; MİRİOĞLU, ŞAFAK
    Background We aimed to investigate the effects of glomerular C3 deposition on clinical, histopathological features, and outcomes of patients with primary membranous nephropathy (MN). Methods A total of 261 patients with biopsy-proven primary MN, who were on follow up for at least 6 months, were included in the study. The patients were grouped according to their C3 immunostaining in kidney biopsy samples at the time of diagnosis: Low intensity [LI; (C3 1 +)] and high intensity [HI; (C3 2 + or C3 3 +)]. The primary outcome was the development of kidney failure. Complete (CR) or partial remission (PR) was defined as secondary outcome. Results Sixteen patients reached the primary outcome after a median follow-up of 33.8 months. Patients in the high intensity group (119 cases) had lower eGFR and higher proteinuria at admission and last follow-up compared to patients in the low intensity group (142 cases). Also, more patients in the high intensity group reached the primary outcome compared to patients in the low intensity group: twelve patients (10.1%) in the high intensity group and four patients (2.8%) in the low intensity group reached the primary outcome (p = 0.015). Kaplan-Meier analysis demonstrated that patients in the high intensity group had a higher risk for kidney failure (p = 0.02). In multivariate logistic regression analysis, high intensity C3 deposition and initial estimated glomerular filtration rate (eGFR) indepenently predicted primary outcome. Conclusion Extensive glomerular C3 deposition is a predictor of kidney failure in patients with MN.