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MİRİOĞLU, ŞAFAK

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ŞAFAK
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MİRİOĞLU
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  • PublicationMetadata only
    Co-Deposition of IgM and C3 May Indicate Unfavorable Renal Outcomes in Adult Patients with Primary Focal Segmental Glomerulosclerosis
    (2019-10-01T00:00:00Z) Mirioglu, ŞAFAK; Caliskan, Yasar; Ozluk, Yasemin; DİRİM, Ahmet Burak; Istemihan, Zulal; Akyildiz, Arif; YAZICI, Halil; TÜRKMEN, Aydın; KILIÇASLAN, Işın; SEVER, Mehmet Şükrü; MİRİOĞLU, ŞAFAK
    Background/Aims: We aimed to investigate the effects of glomerular IgM and C3 deposition on outcomes of adult patients with primary focal segmental glomerulosclerosis (FSGS). Methods: In this retrospective analysis, 86 consecutive adult patients with biopsy-proven primary FSGS were stratified into 3 groups according to their histopathological features: IgM- C3-, IgM+ C3-, and IgM+ C3+. Primary outcome was defined as at least a 50% reduction in baseline estimated glomerular filtration rate (eGFR) or development of kidney failure, while complete or partial remission rates were secondary outcomes. Results: Glomerular IgM deposits were found in 44 (51.1%) patients, 22 (25.5%) of which presented with accompanying C3 deposition. Patients in IgM+ C3+ group had higher level of proteinuria (5.6 g/24 h [3.77-8.5], p = 0.073), higher percentage of segmental glomerulosclerosis (20% [12.3-27.2], p = 0.001), and lower levels of eGFR (69 +/- 37.2 mL/min/1.73 m(2), p = 0.029) and serum albumin (2.71 +/- 0.85 g/dL, p = 0.045) at the time of diagnosis. Despite 86.3% of patients in IgM+ C3+ group (19/22) received immunosuppressive treatment, the primary outcome was more common in patients in the IgM+ C3+ group compared with patients in IgM+ C3- and IgM- C3- groups (11 [50%] vs. 2 [9%] and 11 [26.1%] respectively [p = 0.010]). Complete or partial remission rates were lower in patients in the IgM+ C3+ group (5/22, 22.7%), as well (p = 0.043). Multivariate Cox regression analysis revealed that IgM and C3 co-deposition was an independent risk factor associated with primary outcome (hazard ratio 3.355, 95% CI 1.349-8.344, p = 0.009). Conclusions: Glomerular IgM and C3 co-deposition is a predictor of unfavorable renal outcomes in adult patients with primary FSGS.
  • PublicationMetadata only
    Recurrent and de novo glomerulonephritis following renal transplantation: higher rates of rejection and lower graft survival
    (2017-12-01T00:00:00Z) Mirioglu, ŞAFAK; Caliskan, Yasar; Goksoy, Yagmur; Gulcicek, Sibel; Ozluk, Yasemin; Sarihan, Irem; Seyahi, Nurhan; KILIÇASLAN, Işın; TÜRKMEN, Aydın; SEVER, Mehmet Şükrü; MİRİOĞLU, ŞAFAK
    In this retrospective study with case-control design, we aimed to determine the clinical and pathological characteristics of post-transplant glomerulonephritis (GN), and their effects on transplant recipients.