2020-10-15T00:00:00Z, Dirim, Ahmet Burak, Mirioğlu, Şafak, Yazıcı, Halil, Oto, Özgür Akın, Şafak, Seda, Güller, Nurane, Demir, Erol, Türkmen, Aydın, Çalışkan, Yaşar Kerem, Sever, Mehmet Şükrü, MİRİOĞLU, ŞAFAK

2021-11-16T00:00:00Z, Çalışkan, Yaşar, Demir, Erol, Karatay, Ecem, Özlük, Mesude Yasemin, Mirioğlu, Şafak, Dirim, Ahmet Burak, Artan, Ayşe Serra, Usta Akgül, Sebahat, Oto, Özgür Akın, Savran Oğuz, Fatma, Türkmen, Aydın, Lentıne, Krista L., Yazıcı, Halil, MİRİOĞLU, ŞAFAK

2020-10-15T00:00:00Z, Mirioğlu, Şafak, Çalışkan, Yaşar Kerem, Özlük, Mesude Yasemin, Dirim, Ahmet Burak, Aksoy, Elif, Demir, Erol, Oto, Özgür Akın, Kazancıoğlu, Rümeyza, Kılıçaslan, Işın, Oğuz, Fatma, Yazıcı, Halil, Türkmen, Aydın, MİRİOĞLU, ŞAFAK, KAZANCIOĞLU, RÜMEYZA

2021-01-01T00:00:00Z, Oto, Özgür Akın, Demir, Erol, Mirioğlu, Şafak, Dirim, Ahmet Burak, Özlük, Mesude Yasemin, Cebeci, Egemen, Baştürk, Taner, Uçar, Ali Rıza, Soltanova, Lala, Nuriyev, Kanan, Kılıçaslan, Işın, Yazıcı, Halil, Çalışkan, Yaşar Kerem, MİRİOĞLU, ŞAFAK

Background We aimed to investigate the effects of glomerular C3 deposition on clinical, histopathological features, and outcomes of patients with primary membranous nephropathy (MN). Methods A total of 261 patients with biopsy-proven primary MN, who were on follow up for at least 6 months, were included in the study. The patients were grouped according to their C3 immunostaining in kidney biopsy samples at the time of diagnosis: Low intensity [LI; (C3 1 +)] and high intensity [HI; (C3 2 + or C3 3 +)]. The primary outcome was the development of kidney failure. Complete (CR) or partial remission (PR) was defined as secondary outcome. Results Sixteen patients reached the primary outcome after a median follow-up of 33.8 months. Patients in the high intensity group (119 cases) had lower eGFR and higher proteinuria at admission and last follow-up compared to patients in the low intensity group (142 cases). Also, more patients in the high intensity group reached the primary outcome compared to patients in the low intensity group: twelve patients (10.1%) in the high intensity group and four patients (2.8%) in the low intensity group reached the primary outcome (p = 0.015). Kaplan-Meier analysis demonstrated that patients in the high intensity group had a higher risk for kidney failure (p = 0.02). In multivariate logistic regression analysis, high intensity C3 deposition and initial estimated glomerular filtration rate (eGFR) indepenently predicted primary outcome. Conclusion Extensive glomerular C3 deposition is a predictor of kidney failure in patients with MN.

2021-10-13T00:00:00Z, Oto, Özgür Akın, Mirioğlu, Şafak, Yazıcı, Halil, Dirim, Ahmet Burak, Güller, Nurane, Şafak, Seda, Demir, Erol, Artan, Ayşe Serra, Özlük, Mesude Yasemin, Çalışkan, Yaşar, Türkmen, Aydın, MİRİOĞLU, ŞAFAK

2021-08-01T00:00:00Z, Artan, Ayşe Serra, Mirioğlu, Şafak, Demir, Erol, Dirim, Ahmet Burak, Şafak, Seda, Garayeva, Nurana, Özlük, Mesude Yasemin, Oto, Özgür Akın, Yazıcı, Halil, Çalışkan, Yaşar, MİRİOĞLU, ŞAFAK

2022-05-01T00:00:00Z, Oto, Özgür Akın, Mirioğlu, Şafak, Dirim, Ahmet Burak, Şafak, Seda, Güller, Nurana, Demir, Erol, Artan, Ayşe Serra, Özlük, Mesude Yasemin, Uçar, Ali Rıza, Soltanova, Lala, Nuriyev, Kanan, Yazıcı, Halil, Çalışkan, Yaşar Kerem, MİRİOĞLU, ŞAFAK

2021-06-04T00:00:00Z, Çalışkan, Yaşar, Güller, Nurane, Dirim, Ahmet Burak, Şafak, Seda, Mirioğlu, Şafak, Yazıcı, Halil, Yıldız, Abdulmecit, Oto, Özgür Akın, Demir, Erol, Özlük, Mesude Yasemin, Türkmen, Aydın, Lentıne, Krista, MİRİOĞLU, ŞAFAK

2020-10-15T00:00:00Z, Mirioğlu, Şafak, Çalışkan, Yaşar Kerem, Özlük, Mesude Yasemin, Dirim, Ahmet Burak, Gürel, Erdem, Demir, Erol, Oto, Özgür Akın, Kazancıoğlu, Rümeyza, Kılıçaslan, Işın, Oğuz, Fatma, Yazıcı, Halil, Türkmen, Aydın, MİRİOĞLU, ŞAFAK, KAZANCIOĞLU, RÜMEYZA

2021-04-28T00:00:00Z, Çalışkan, Yaşar, Karahan, Gonca, Usta Akgül, Sebahat, Mirioğlu, Şafak, Özlük, Mesude Yasemin, Yazıcı, Halil, Demir, Erol, Dirim, Ahmet Burak, Türkmen, Aydın, Edwards, John, Oğuz Savran, Fatma, Sever, Mehmet Şükrü, Kiryluk, Krzysztof, Gharavi, Ali, Lentine, Krista L, MİRİOĞLU, ŞAFAK

Background:This study aims to examine the association of LIM Zinc Finger Domain Containing 1 (LIMS1) genotype with allograft rejection in an independent kidney transplant cohort.Methods:We genotyped 841 kidney transplant recipients for LIMS1 rs893403 variant by Sanger sequencing followed by PCR confirmation of the deletion. Recipients who were homozygous for LIMS1 rs893403 genotype GG were compared to AA/AG genotypes. The primary outcome was T-cell mediated (TCMR) or antibody mediated rejection (ABMR) and secondary outcome was allograft loss.Results:After a median follow-up of 11.4 years, the rate of TCMR was higher in recipients with the GG (n = 200) compared to AA/AG (n = 641) genotypes [25 (12.5%) vs 35 (5.5%); p = 0.001] while ABMR did not differ by genotype [18 (9.0%) vs 62 (9.7%)]. Recipients with GG genotype had 2.4-times higher risk of TCMR than those who did not have this genotype (adjusted hazard ratio (aHR), 1.442.434.12, p = 0.001). A total of 189 (22.5%) recipients lost their allografts during follow up. Kaplan-Meier estimates of 5-year (94.3% vs. 94.4%, p = 0.99) and 10-year graft survival rates (86.9% vs. 83.4%, p = 0.31) did not differ significantly in those with GG compared to AA/AG groups.Conclusions:Our study demonstrates that recipient LIMS1 risk genotype is associated with increased risk of TCMR after kidney transplantation, confirming the role of LIMS1 locus in allograft rejection. These findings may have clinical implications for the prediction and clinical management of kidney transplant rejection by pretransplant genetic testing of recipients and donors for LIMS1 risk genotype.