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TOK, OLGU ENİS

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OLGU ENİS
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Now showing 1 - 9 of 9
  • PublicationMetadata only
    Dose Dependent Effects of Dimethyl Sulfoxide on the Mitochondria of Hepatocellular Carcinoma Cells
    (2016-01-01) Aktas, R. G.; Isan, H.; Caliskan, E. B.; Tok, OLGU ENİS; AYDIN, M. S.; KAYA, ÖZLEM TUĞÇE; TOK, OLGU ENİS
  • PublicationMetadata only
    Correlation between the mechanical and histological properties of liver tissue
    (2014-01-01) Yarpuzlu, Berkay; Ayyildiz, Mehmet; Tok, OLGU ENİS; Aktas, Ranan Gulhan; Basdogan, Cagatay; TOK, OLGU ENİS
    In order to gain further insight into the mechanisms of tissue damage during the progression of liver diseases as well as the liver preservation for transplantation, an improved understanding of the relation between the mechanical and histological properties of liver is necessary. We suggest that this relation can only be established truly if the changes in the states of those properties are investigated dynamically as a function of post mortem time. In this regard, we first perform mechanical characterization experiments on three bovine livers to investigate the changes in gross mechanical properties (stiffness, viscosity, and fracture toughness) for the preservation periods of 5, 11, 17, 29, 41 and 53 h after harvesting. Then, the histological examination is performed on the samples taken from the same livers to investigate the changes in apoptotic cell count, collagen accumulation, sinusoidal dilatation, and glycogen deposition as a function of the same preservation periods. Finally, the correlation between the mechanical and histological properties is investigated via the Spearman-s Rank-Order Correlation method. The results of our study show that stiffness, viscosity, and fracture toughness of bovine liver increase as the preservation period is increased. These macroscopic changes are very strongly correlated with the increase in collagen accumulation and decrease in deposited glycogen level at the microscopic level. Also, we observe that the largest changes in mechanical and histological properties occur after the first 11-17 h of preservation. (C) 2013 Elsevier Ltd. All rights reserved.
  • PublicationMetadata only
    The Impact of Unilateral Experimental Rat Varicocele Model on Testicular Histopathology, Leydig Cell Counts, and Intratesticular Testosterone Levels of Both Testes
    (2013-06-01T00:00:00Z) OZTURK, Metin Ishak; KOCA, Orhan; KELES, Muzaffer Oguz; Haklar, Gonca; Baykan, Ozgur; ERCAN, FERİHA; Tok, OLGU ENİS; KARAMAN, Muhammet Ihsan; TOK, OLGU ENİS
    Purpose: Varicocele, most treatable pathologic condition in male infertility, exerts unfavorable effects on testicular ultrastructure via various mechanisms. In this study we aimed to demonstrate adverse effects of varicocele on both testes.
  • PublicationMetadata only
    Effects of beta-glucan on protection of young and aged rats from renal ischemia and reperfusion injury
    (2016-01-01) ESREFOGLU, MUKADDES; Tok, OLGU ENİS; AYDIN, M. S.; OZER, O. F.; SELEK, S.; Iraz, M.; EŞREFOĞLU, MUKADDES; TOK, OLGU ENİS; ÖZER, ÖMER FARUK; SELEK, ŞAHABETTİN
    BACKGROUND: Ischemia reperfusion injury is one of the leading causes of acute renal failure which is a common clinical event leading to development of chronic kidney disease and a high mortality; especially in elderly people. beta-glucans are glucose polymer groups with free-radical scavenger, macrophage activator, and immune defense inducer functions. We designed this study to determine the possible protective effects of beta-glucan against renal ischemia reperfusion injury comparatively in young and aged rats.
  • PublicationMetadata only
    High cholesterol diet-mediated unfolded protein response activation enhances autophagic cell death in heart tissue
    (2017-07-01) Sozen, Erdi; Yazgan, Burak; Tok, OLGU ENİS; Ercan, Feriha; KARADEMİR, BETÜL; Ozer, Nesrin Kartal; TOK, OLGU ENİS
  • PublicationOpen Access
    Can Coenzyme Q10 supplementation protect the ovarian reserve against oxidative damage?
    (2016-09-01) OZCAN, PINAR; Ficicioglu, Cem; Kizilkale, Ozge; Yesiladali, Mert; Tok, OLGU ENİS; Ozkan, Ferda; Esrefoglu, MUKADDES; ÖZCAN, PINAR; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDES
    Purpose: We investigated antioxidant effects of CoQ10 supplementation on the prevention of OS-induced ovarian damage and to evaluate the protective effect of such supplementation against OS-related DNA damage. Methods: Twenty-four adult female Sprague-Dawley rats were randomly divided into three groups (8 rats per group): group 1 (control): saline, ip, and orally; group 2 (cisplatin group): cisplatin, 4.5 mg/kg ip, two times with an interval of 7 days; and group 3 (cisplatin + CoQ10 group): cisplatin, 4.5 mg/kg ip, two times with an interval of 7 days, and 24 h before cisplatin, 150 mg/kg/day orally in 1 mL of saline daily for 14 days. Serum concentrations of anti-Mullerian hormone (AMH), number of AMH-positive follicles, the assessment of the intensity of 8'OHdG immunoreactivity, the primordial, antral and atretic follicle counts in the ovary were assessed. Result(s): The mean serum AMH concentrations were 1.3 ± 0.19, 0.16 ± 0.03, and 0.27 ± 0.20 ng/mL in groups 1, 2, and 3, respectively (p < 0.01). Serum AMH levels were significantly higher in group 1 compared to groups 2 and 3 (p < 0.01 and p = 0.01, respectively). There was a statistically significant difference in AMH-positive follicle count between the groups (p < 0.01). Group 1 showed higher numbers of AMH-positive granulosa cells compared to group 2 (p = 0.01). A significant difference was found in the primordial, the atretic, and antral follicle counts between the three groups (p < 0.01, p < 0.01, and p < 0.01, respectively). The atretic follicle count was significantly lower in the cisplatin plus CoQ10 group compared to the cisplatin group (p < 0.01). The antral follicle counts were significantly higher in the cisplatin plus CoQ10 group compared with the cisplatin group (p < 0.01). There was a statistically significant difference in the intensity of staining of the follicles that were positive for anti-8'OHdG between the groups (p = 0.02). Group 1 showed a significant lower intensity of staining of the follicles positive for anti-8'OHdG compared with group 2 (p = 0.03). Conclusion(s): CoQ10 supplementation may protect ovarian reserve by counteracting both mitochondrial ovarian ageing and physiological programmed ovarian ageing although the certain effect of OS in female infertility is not clearly known.
  • PublicationUnknown
    Protection with thymoquinone against formaldehyde-induced neurotoxicity in the rats.
    (2018-01-01) SAYGIN, Bilal; Esrefoglu, MUKADDES; Bayindir, NİHAN; Tok, OLGU ENİS; Selek, S; Bulut, HURİ; Ozer, OF; Ozturk, AHMET; Yilmaz, ONUR; Meydan, SEDAT; EŞREFOĞLU, MUKADDES; BAYINDIR, NİHAN; TOK, OLGU ENİS; SELEK, ŞAHABETTİN; BULUT, HURI; ÖZER, ÖMER FARUK; ÖZTÜRK, AHMET; YILMAZ, ONUR; MEYDAN, SEDAT
  • PublicationUnknown
    Therapeutic effects of melatonin and quercetin in improvement of hepatic steatosis in rats through supression of oxidative damage
    (2017-01-01) ESREFOGLU, MUKADDES; ÇETİN, AYMELEK; TASLIDERE, ELİF; Elbe, H.; ATEŞ, BURHAN; Tok, OLGU ENİS; AYDIN, M. S.; EŞREFOĞLU, MUKADDES; TAŞLIDERE, ELİF; TOK, OLGU ENİS
    BACKGROUND: Non-alcoholic steatohepatitis, a cause of cirrhosis, is characterized by fatty infiltration of the liver, inflammation, hepatocellular damage and fibrosis. The aim of the present study was to investigate the effects of melatonin and quercetin on CCl4-induced steatosis characterized by fatty infiltration of the liver, inflammation, hepatocellular damage and fibrosis.