Person: TOK, OLGU ENİS
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Publication Metadata only Shea Yağının Yara İyileşmesi Üzerine Etkisi.(2016-05-03) BAYINDIR, NİHAN; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDES; Kılıç, Elif; BULUT, HURİ; BAYINDIR, NİHAN; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDES; BULUT, HURIPublication Metadata only Genç Ve Yaşlı Sprague-Dawley Sıçanlarda Parsiyel Hepatektomi Sonrası Melatoninin Karaciğer Rejenerasyonuna Etkisi.(2016-05-03) TOK, OLGU ENİS; AYDIN, M. S.; ESREFOGLU, MUKADDES; IRAZ, M.; KESKİN, Sıdıka; KOÇYİĞİT, ABDÜRRAHİM; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDES; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Uzun Süreli ve Düşük Doz Siklosporin Kullanımının Böbrek Dokusu Üzerine Apopitotik Etkileri(2014-03-09) Garip, Aylin; Uzak, Emirhan; TOK, OLGU ENİS; ESREFOGLU, MUKADDES; AKTAS, R. G.; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDESPublication Metadata only Effects of beta-glucan on protection of young and aged rats from renal ischemia and reperfusion injury(2016-01-01) ESREFOGLU, MUKADDES; Tok, OLGU ENİS; AYDIN, M. S.; OZER, O. F.; SELEK, S.; Iraz, M.; EŞREFOĞLU, MUKADDES; TOK, OLGU ENİS; ÖZER, ÖMER FARUK; SELEK, ŞAHABETTİNBACKGROUND: Ischemia reperfusion injury is one of the leading causes of acute renal failure which is a common clinical event leading to development of chronic kidney disease and a high mortality; especially in elderly people. beta-glucans are glucose polymer groups with free-radical scavenger, macrophage activator, and immune defense inducer functions. We designed this study to determine the possible protective effects of beta-glucan against renal ischemia reperfusion injury comparatively in young and aged rats.Publication Metadata only Fluoxetine prevents ischemia perfusion induced acute cardiac inflammation and injury.(2016-08-25) Sahin, G.; Yaman, OM; Guner, I.; TOK, OLGU ENİS; Pala, M.; EŞREFOĞLU, MUKADDES; Yelmen, N.; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDESPublication Metadata only Protective effect of beta-glucan on renal ischemia and reperfusion injury in young and aged rats.(2014-09-12) EŞREFOĞLU, MUKADDES; TOK, OLGU ENİS; AYDIN, M. S.; IRAZ, M.; SELEK, ŞAHBETTİN; ÖZER, ÖMER FARUK; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDES; TOK, OLGU ENİS; SELEK, ŞAHABETTİN; ÖZER, ÖMER FARUK; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Remote Myocardial Injury: The Protective Role of Fluoxetine(2017-09-01) Yaman, Onur; Erman, Hayriye; Güner, İbrahim; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDES; Pala, Mukaddes; Gelisgen, Remise; Uzun, Hafize; Uğur, Aksu; Yelmen, Nermin; Şahin, Gülderen; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDESPublication Metadata only Effects of Cichorium intybus on seizure development in pentyleneterazole kindling model of epilepsy(2015-05-03) ERKEC, OZLEM ERGUL; MERAL, İSMAİL; KARA, MEHMET; ESREFOGLU, MUKADDES; TOK, OLGU ENİS; MERAL, İSMAİL; EŞREFOĞLU, MUKADDES; TOK, OLGU ENİSPublication Open Access Can Coenzyme Q10 supplementation protect the ovarian reserve against oxidative damage?(2016-09-01) OZCAN, PINAR; Ficicioglu, Cem; Kizilkale, Ozge; Yesiladali, Mert; Tok, OLGU ENİS; Ozkan, Ferda; Esrefoglu, MUKADDES; ÖZCAN, PINAR; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDESPurpose: We investigated antioxidant effects of CoQ10 supplementation on the prevention of OS-induced ovarian damage and to evaluate the protective effect of such supplementation against OS-related DNA damage. Methods: Twenty-four adult female Sprague-Dawley rats were randomly divided into three groups (8 rats per group): group 1 (control): saline, ip, and orally; group 2 (cisplatin group): cisplatin, 4.5 mg/kg ip, two times with an interval of 7 days; and group 3 (cisplatin + CoQ10 group): cisplatin, 4.5 mg/kg ip, two times with an interval of 7 days, and 24 h before cisplatin, 150 mg/kg/day orally in 1 mL of saline daily for 14 days. Serum concentrations of anti-Mullerian hormone (AMH), number of AMH-positive follicles, the assessment of the intensity of 8'OHdG immunoreactivity, the primordial, antral and atretic follicle counts in the ovary were assessed. Result(s): The mean serum AMH concentrations were 1.3 ± 0.19, 0.16 ± 0.03, and 0.27 ± 0.20 ng/mL in groups 1, 2, and 3, respectively (p < 0.01). Serum AMH levels were significantly higher in group 1 compared to groups 2 and 3 (p < 0.01 and p = 0.01, respectively). There was a statistically significant difference in AMH-positive follicle count between the groups (p < 0.01). Group 1 showed higher numbers of AMH-positive granulosa cells compared to group 2 (p = 0.01). A significant difference was found in the primordial, the atretic, and antral follicle counts between the three groups (p < 0.01, p < 0.01, and p < 0.01, respectively). The atretic follicle count was significantly lower in the cisplatin plus CoQ10 group compared to the cisplatin group (p < 0.01). The antral follicle counts were significantly higher in the cisplatin plus CoQ10 group compared with the cisplatin group (p < 0.01). There was a statistically significant difference in the intensity of staining of the follicles that were positive for anti-8'OHdG between the groups (p = 0.02). Group 1 showed a significant lower intensity of staining of the follicles positive for anti-8'OHdG compared with group 2 (p = 0.03). Conclusion(s): CoQ10 supplementation may protect ovarian reserve by counteracting both mitochondrial ovarian ageing and physiological programmed ovarian ageing although the certain effect of OS in female infertility is not clearly known.Publication Metadata only The effects of melatonin on hepatic regeneration after partial hepatectomy in young and aged Sprague–dawley rats.(2015-08-28) EŞREFOĞLU, MUKADDES; AYDIN, M. S.; TOK, OLGU ENİS; IRAZ, M.; KESKİN, Sıdıka; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDES; TOK, OLGU ENİS; KOÇYİĞİT, ABDÜRRAHİM