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DİNCEL, DEMET

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DEMET
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DİNCEL
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    PublicationOpen Access
    Spectrophotometric Determination of Erdosteine at Capsule Dosage Forms
    (2021-03-01T00:00:00Z) Onal, Cem; DİNCEL, DEMET; DİNCEL, DEMET
    Abstract Objective: Two simple, rapid and sensitive methods were developed for determination of Erdosteine (ERD) in pure form as well as in their pharmaceutical formulations. Methods: The methods were based on formation of colored charge transfer complexes with ERD with chloranil (CA) and 7,7,8,8-tetracyanoquinodimethane (TCNQ). The obtained charge-transfer complexes were measured at 454 and 843 nm for CA and TCNQ methods, respectively. Optimization of different experimental conditions were investigated. Results: Beer's plots were obeyed in a general concentration range of 10-500 mu g mL(-1) and 20-600 mu g mL(-1) for CA and TCNQ methods, respectively. The validity of methods in terms of specificity, linearity, accuracy, precision, limit of detection and limit of quantitation were evaluated. Conclusion: The methods were applied successfully in the determination of ERD in capsule dosage forms. Developed new spectrophotometric methods have been found to be very practical and practical. The lack of complex sample preparation increases the applicability of the method.
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    PublicationOpen Access
    Anticholinesterase furocoumarins from Heracleum platytaenium, a species endemic species to Ida Mountains
    (2013-01-01) Dincel, DEMET; Hatipoglu, Seda Damla; GOREN, AHMET CEYHAN; Topcu, Gulacti; DİNCEL, DEMET; GÖREN, AHMET CEYHAN; TOPÇU, GÜLAÇTI
    The petroleum ether extract of Heracleum platytaenium afforded 8 furocoumarins (psoralen, bergapten, xanthotoxin, pimpinellin, isopimpinellin, sphondin, byakangelicin, and heraclenol) and the methanol extract of H. platytaenium gave only 1 glycosylated dihydrofurocoumarin, apterin. In addition, stigmasterol was also obtained from petroleum ether extract. Structure identification of the isolated compounds has been achieved by using spectroscopic methods, namely 1D and 2D NMR experiments and mass spectral analyses. The antioxidant activity of the extracts and pure compounds was investigated by 2 methods, including DPPH free radical scavenging activity and lipid peroxidation inhibitory activity by beta-carotene-linoleic acid assays. The anticholinesterase activity of petroleum ether and methanol extracts of the plant and the isolated furocoumarins was investigated against acetylcholinesterase and butyrylcholinesterase enzymes by the Ellman method in vitro.