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DİNCEL, DEMET

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DEMET
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DİNCEL
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Biological Activities and Chemical Composition of Ferulago idaea

2015-06-12, Aslan, Esin, DİNCEL, DEMET, Çakar, Begüm, TOPÇU, GÜLAÇTI, DİNCEL, DEMET, TOPÇU, GÜLAÇTI

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Ent-kaurane diterpenoids isolated from Sideritis congesta

2011-12-01, Topcu, GÜLAÇTI, Ertas, Abdulselam, Ozturk, Mehmet, Dincel, Demet, Kilic, Turgut, Halfon, Belkis, TOPÇU, GÜLAÇTI, DİNCEL, DEMET

A new ent-kaurane diterpenoid, together with eight known ent-kauranes, were isolated from the petroleum ether and acetone extracts of the whole plant of Sideritis congesta P. H. Davis & Hub.-Mor. and their structures were elucidated as the new compound ent-7 alpha-acetoxy-16 beta, 18-dihydroxy-kaurane (7-acetyldistanol) (1) and the known compounds ent-3 beta,7 alpha-dihydroxy, 18-acetoxy-15 beta,16 beta-epoxykaurane (epoxyisolinearol) (2), sideroxol (3), sideridiol (4), siderol (5), 7-epicandicandiol (6), foliol (7), linearol (8) and sidol (9). Characterization of compounds 1-9 was based on spectral analyses and comparison with reported data, particularly the new compound 1 was identified by 1D- and 2D-NMR and mass spectroscopic analyses. The antioxidant potential of the extracts, and also of the ent-kauranes except for 7, was investigated by three methods including beta-carotene bleaching method, free radical scavenging activity and superoxide anion scavenging activity. The anticholinesterase activity was also evaluated for the ent-kauranes except for 7, and most of the diterpenes exhibited weak acetylcholinesterase inhibitory activity. However, almost all diterpenes exhibited some inhibitory activity against butyrylcholinesterase; particularly, compounds 3 and 6 exhibited better BChE inhibitory activity than the standard compound galanthamine. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.

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Prangos ilanae Bitkisinden Elde Edilen Kumarinlerin Antikoagülan Etkisinin İncelenmesi

2019-03-17, DİNCEL, DEMET, UÇKAYA, FATİH, Özer, Ö.F., TOPÇU, GÜLAÇTI, DİNCEL, DEMET, UÇKAYA, FATİH, ÖZER, ÖMER FARUK, TOPÇU, GÜLAÇTI

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LIQUID CHROMATOGRAPHIC ANALYSIS OF CAROTENOIDS IN FOODS

2019-06-01, Tekkeli, Serife Evrim Kepekci, DİNCEL, DEMET, Onal, Cem, Onal, Armagan, Sagirli, Olcay, DİNCEL, DEMET, TEKKELİ, ŞERİFE EVRİM

Current scientific studies indicate that carotenoids (CRTDs) are beneficial for maintaining health and lowering the risk of different pathologies. Considering the increasing role of carotenoids in healthcare, determination of carotenoid content of foods become important. Mostly, the analytical procedures that are used for this aim, are based on extraction techniques followed by different analytical procedures, especially high performance liquid chromatography. In this publication, a review of various analytical techniques developed for the determination of carotenoids in different food commodities starting from 2006 up to now, has been presented.

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Stachys thirkei C. Koch Bitkisinin Antikolinesteraz Potansiyelinin Araştırılması

2017-04-29, Babalı, Fatmanur, DİNCEL, DEMET, TOPÇU, GÜLAÇTI, DİNCEL, DEMET, TOPÇU, GÜLAÇTI

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An HPLC Method for the Determination of Saxagliptin in Human Plasma with Fluorescence Detection

2013-12-01, Tekkeli, Şerife Evrim, Kızıltas, M. V., Dincel, Demet, TEKKELİ, ŞERİFE EVRİM, DİNCEL, DEMET

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A HPLC Method for Simultaneous Determination of Phenol and p-Cresol in Human UrineA HPLC Method for Simultaneous Determination of Phenol and p-Cresol in Human Urine

2013-08-16T00:00:00Z, Tekkeli, Şerife Evrim, Dincel, Demet, Önal, Armağan, Erkoç, Reha, Topçu, Gülaçtı, TEKKELİ, ŞERİFE EVRİM, DİNCEL, DEMET, TOPÇU, GÜLAÇTI

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Fatty acid content of Reseda lutea var. lutea with antioxidant potential.

2015-06-12, Ertaş, Abdülselam, Boğa, Mehmet, DİNCEL, DEMET, BÜTÜN, BURCU, Yeşil, Yeter, Soruhan, H.F., TOPÇU, GÜLAÇTI, KUŞMAN, TUBA, DİNCEL, DEMET, BÜTÜN, BURCU, TOPÇU, GÜLAÇTI

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A High Performance Liquid Chromatography Method for the Determination of Meropenem in Serum

2019-10-01T00:00:00Z, Dincel, Demet, Sağırlı, Ahmet Olcay, Topçu, Gülaçtı, DİNCEL, DEMET, TOPÇU, GÜLAÇTI

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Simultaneous Determination of Phenol and p-Cresol in Human Urine by an HPLC Method

2016-06-01, Tekkeli, S. E. Kepekci, Kiziltas, M. V., Dincel, DEMET, ERKOC, R., Topcu, GÜLAÇTI, TEKKELİ, ŞERİFE EVRİM, DİNCEL, DEMET, TOPÇU, GÜLAÇTI

Introduction: In patients with chronic kidney disease (CKD), uremic toxins accumulate in blood and cannot be excreted with urine. Accumulation of these toxins has negative effects on many body functions. Because of the importance of these toxins, we developed and validated a simple, sensitive, accurate, and precise method for the determination of two main uremic toxins:phenol and p-cresol in human urine. Materials and methods:Separation of these analytes in urine samples was achieved by reverse-phase high-performance liquid chromatography (RP-HPLC) with a C18 column at 35 degrees C using the mobile phase of methanol-water (65:35) at a flow rate of 1.4 mL min(-1). Fluorimetric detection was used at 284 nm for excitation and 310 nm for emission. Results:The method is linear over the range of 1.5-35 ng mL(-1) and 1-45 ng mL(-1) for phenol and p-cresol, respectively. The method was applied to urine samples from 10 healthy subjects and 10 chronic kidney disease patients. Conclusions:This assay appears to be useful in routine analysis of clinical samples for simultaneous determination of phenol and p-cresol levels in urine.