Person: DİNCEL, DEMET
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Publication Metadata only Aromaterapi(2021-08-01T00:00:00Z) Erçin, Esin; Dincel, Demet; DİNCEL, DEMETPublication Metadata only ANALYTICAL METHODS FOR THE DETERMINATION OF POLYBROMINATED DIPHENYL ETHERS IN HUMAN MILK(2020-03-01T00:00:00Z) ASRAM SAĞIROĞLU, ALİ; Onal, Cem; DİNCEL, DEMET; Onal, Armagan; ASRAM SAĞIROĞLU, ALİ; TEKKELİ, ŞERİFE EVRİM; DİNCEL, DEMETPolybrominated diphenyl ethers (PBDEs), which are used as flame retardants, are widely used additives so many different kind of materials that are consumed by public. Current researches reveal a significant increase in the levels of PBDEs in human biological fluids all around the world. According to International Agency for Research on Cancer (IARC), PBDEs are declarated as carcinogenic agents and additionally a considerable risks have been shown in animal studies such as liver damage, alteration of thyroid hormone levels, neurotoxicity and hazardous effects on development of fetus. Due to the simplicity of human exposure routes such as ingestion, inhalation or dermal contact, it gains high importance to quantify PBDEs in biological fluids. The exposure to PBDEs is critic aspecially during pregnancy, fetus development and infancy. Excretion of PBDEs in human milk is the focus area for researchers in recent years.Publication Metadata only Biological Applications of SPME(2023-01-08) Dincel D.; DİNCEL, DEMETPublication Open Access Spectrophotometric Determination of Erdosteine at Capsule Dosage Forms(2021-03-01T00:00:00Z) Onal, Cem; DİNCEL, DEMET; DİNCEL, DEMETAbstract Objective: Two simple, rapid and sensitive methods were developed for determination of Erdosteine (ERD) in pure form as well as in their pharmaceutical formulations. Methods: The methods were based on formation of colored charge transfer complexes with ERD with chloranil (CA) and 7,7,8,8-tetracyanoquinodimethane (TCNQ). The obtained charge-transfer complexes were measured at 454 and 843 nm for CA and TCNQ methods, respectively. Optimization of different experimental conditions were investigated. Results: Beer's plots were obeyed in a general concentration range of 10-500 mu g mL(-1) and 20-600 mu g mL(-1) for CA and TCNQ methods, respectively. The validity of methods in terms of specificity, linearity, accuracy, precision, limit of detection and limit of quantitation were evaluated. Conclusion: The methods were applied successfully in the determination of ERD in capsule dosage forms. Developed new spectrophotometric methods have been found to be very practical and practical. The lack of complex sample preparation increases the applicability of the method.Publication Metadata only Docking Studies of Natural Product Derived Carvacrol Type Aromatic Monoterpenes Against COVID-19 and Comparison with Used Synthetic Drugs: Potential of Carvacryl Acetate Against SARS-CoV-2 (COVID-19)(2023-06-01) Özhan Kocakaya Ş.; Ertaş A.; Yener İ.; Arıca E.; Dincel D.; DİNCEL, DEMETPublication Metadata only A High-Performance Liquid Chromatographic Method for the Determination of Meropenem in Serum(2020-02-01T00:00:00Z) Dincel, Demet; Topçu, Gülaçtı; DİNCEL, DEMET; TOPÇU, GÜLAÇTIPublication Metadata only Preparation of Helichrysum plicatum DC. subsp. plicatum Extracts by Different Extraction Methods and Quantitative Analysis of Phenolic Compounds(2022-11-25) Dincel D.; Kızılarslan Hançer Ç.; DİNCEL, DEMET; KIZILARSLAN HANÇER, ÇAĞLAPublication Metadata only Determination of dihydrocapsaicin adulteration in dietary supplements using LC-MS/MS(2020-01-01T00:00:00Z) DİNCEL, DEMET; Olgan, Hatice; Canbaloglu, Zeynep; Yalcin, Sule; Erkucuk, Aysen; TIRIS, GİZEM; GÖREN, AHMET CEYHAN; DİNCEL, DEMET; TIRIS, GİZEM; GÖREN, AHMET CEYHANAdulterations of dietary supplements are serious threats to public health in all around of world. Nowadays, in order to obtain the intended effect from natural remedies, the adulteration of natural products via artificial or harmful chemicals are increasing. A rapid LC-MS/MS method for determination of capsaicin and dihydrocapsaicin in dietary supplements via Fortis C18 (150 x 3 mm; 3 mu m) column at 25 degrees C was developed and validated in a mixture of mobile phase A (1 % formic acid solution and 0.1 % ammonium formate in water) and B (1 % formic acid solution and 0.1 % ammonium formate in methanol) with gradient program at a flow rate of 0.35 mL/min. The recoveries of developed methods weytre obtained in the range of % 95.4-106.3 for capsaicin and % 96.3-108.9 for dihydrocapsaicin. This study shows that synthetic compound dihydrocapsaicin is widely use in dietary supplements products for adulteration to increase the effects of product without any declaration.Publication Metadata only Biological activities of extracts from Lavandula officinalis and Valeriana officinalis: Immunoregulation and cytotoxicity evaluation(2020-10-07T00:00:00Z) YANIKOĞLU, RABİA SARE; ATASOY, SEZEN; DİNCEL, DEMET; KAPTAN, EYLÜL ZEYNEP; DAĞ, AYDAN; YANIKOĞLU, RABİA SARE; ATASOY, SEZEN; DİNCEL, DEMET; DAĞ, AYDANPublication Metadata only Standard Water Generating Vials for Lipophilic Compounds(2023-01-17) Dincel D.; Rosales-Solano H.; Zeinali S.; Pawliszyn J.; DİNCEL, DEMETAmerican Chemical Society.The study of non-polar compounds in aqueous environments has always been challenging due to their poor solubility in aqueous media. The low affinity of non-polar compounds toward polar solutions facilitates their attachment to glassware, which results in unstable sample concentrations. To address this challenge, and to enable the preparation of a stable mixture of hydrophobic compounds in an aquatic environment, we introduce an in-vial standard water generating system consisting of a vial containing appropriate aqueous solution and a polydimethylsiloxane thin film spiked with target compounds. In this system, a solution with a stable analyte concentration is attained once equilibrium between the thin-film and aqueous solution has been achieved. The developed standard water system was studied using endocannabinoids and phospholipids as model hydrophobic compounds of biological importance, with results indicating that the concentration of hydrophobic compounds in water can remain stable over multiple days. The results also showed that analytes released from the thin film can compensate for analyte loss due to extractions with solid-phase microextraction fibers, thereby re-establishing equilibrium. Thus, the vial is suitable for the repeatable generation of non-polar standards for routine analysis and quality control. The results of this work show that the developed system is stable and reproducible and therefore appropriate for studies requiring the measurement of free concentrations and accurate quantification.