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Now showing 1 - 9 of 9
  • Publication
    Open Access
    Development of Hyperprolactinemia Induced by the Addition of Bupropion to Venlafaxine XR Treatment
    (2018-04-01) KILIÇ, Alperen; Ozturk, AHMET; Deveci, ERDEM; Kirpinar, Ismet; ÖZTÜRK, AHMET; DEVECİ, ERDEM; KIRPINAR, İSMET
    Hyperprolactinemia is characterized by abnormally increased serum prolactin levels. Menstrual irregularities and hyperprolactinemia can be caused by a variety of medical conditions as well as due to the use of some psychopharmacological drugs, namely antipsychotics; it can also develop during antidepressant treatment. Bupropion is an antidepressant functioning via the inhibition of noradrenaline and dopamine reuptake. The endocrine and sexual adverse events of this agent are rare. In the literature, only one case reporting hyperprolactinemia or galactorrhea caused by bupropion use is available. Here, we present the case of a patient diagnosed with depressive disorder and receiving venlafaxine, who developed hyperprolactinemia and oligomenorrhea after the addition of bupropion the ongoing treatment and showed serum prolactin levels decreased to normal ranges shortly after the discontinuation of bupropion.
  • Publication
    Open Access
    Clozapine Treatment and Thrombocytopenia: a Case Report
    (2014-09-01) Ozturk, AHMET; Deveci, ERDEM; DURSUN, Ali Emre; Soyucok, Etem; Kirpinar, Ismet; DEVECİ, ERDEM; KIRPINAR, İSMET
  • Publication
    Metadata only
    Depression at the early phase of first myocardial infarction
    (2012-09-01) Deveci, ERDEM; Ozan, Erol; Gulec, Mustafa; Kirpinar, Ismet; DEVECİ, ERDEM; KIRPINAR, İSMET
    Objective: To assess clinical depression and severity of depression symptoms early after a first acute myocardial infarction (MI). Methods: Data was collected with a structured questionnaire including sociodemographic characteristics and Beck Depression Inventory (BDI). The questionnaire was applied to the 100 patients, who had suffered from first MI, after they were transferred to the ward from the coronary intensive care unit. Results: The mean age of the patients was 58.4 +/- 9.9 years, of whom 86.0% were male and 95.0% were married. The mean education duration was 4.6 +/- 4.1 years; the rate of illiterate and literate patients was 34.0% and the rate of patients graduated from primary school was 42.0%. Forty-seven percent of patients had a previous concomitant physical disease. Forty-three percent patients obtained a BDI score lower than 10, while 31.0% had a score of >= 17. A positive significant, but weak correlation was observed between BDI scores and age. The rate of patients with clinical depression (BDI score >= 17) was significantly higher in females as compared to males (64.3% and 25.6%, respectively, p<0.05). Conclusions: The diagnosis of post-MI depression may be difficult because of the non-specific complaints. Female gender was found to be a significant independent variable predicting the presence of depression symptoms and severity during the post-MI period. It would be beneficial to routinely investigate the presence and intensity of depression symptoms after MI. (Anatolian Journal of Psychiatry 2012; 13:179-183)
  • Publication
    Metadata only
    Frontal lobe syndrome due to olfactory groove meningioma: a literature review
    (2010-09-01T00:00:00Z) Ozan, Erol; Deveci, ERDEM; Kirpinar, Ismet; TEHLI, Ozkan; DEVECİ, ERDEM; KIRPINAR, İSMET
    Behavioral syndromes observed with frontal lobe injury involve lesions of the circuits, connecting the frontal lobe to subcortical structures. Dorsolateral prefrontal circuit lesions result in executive function deficits, orbitofrontal circuit lesions result in disinhibition and impulsivity, and abulia (apathy and amotivation) occur with injury to the anterior cingulate circuit. Thirty-nine years-old female patient was evaluated in our outpaient clinic due to experiencing anosmia for the past two years and headache which appeared a few months after this complaint. In addition to these complaints, the patient reported apathy, anhedonia, lack of energy, inability to perform household chores and increased sleep need for the past 1.5 years. Lately, the patient also reported having blurred vision and had an incidence of urinary incontinence during sleep. The clinical presentation was compatible with anterior cingulate syndrome due to a large olfactory groove meningioma. Depending on the data, we were motivated to review the frontal lobe syndrome and meningiomas, especially the ones originating from the olfactory groove. (Anatolian Journal of Psychiatry 2010; 11:279-284)
  • Publication
    Metadata only
    The relationship between nine types temperament model with psychobiological personality model and affective temperament model
    (2015-04-01) YILMAZ, Enver Demirel; GENCER, Gorkem; UNAL, Ozge; OREK, Alp; Aydemir, Omer; Deveci, ERDEM; Kirpinar, Ismet; DEVECİ, ERDEM; KIRPINAR, İSMET
    Objective: This study aims to determine Nine Types Temperament Model (NTTM), which is a new temperament model, with Psychobiological Personality Model (PPM) and Affective Temperament Model (ATM) and define the possible relations between categories and dimensions and their degrees of predicting each other. Methods: The sample group consists of 206 healthy volunteers who did not receive any psychiatric treatment in their life and do not have any chronic disease. Structured Clinical Interview for DSM-IV (SCID-I), Structured Clinical Interview for DSM-III-R personality disorders (SCID-II), Temperament and Character Inventory (TCI), Temperament Evaluation of Memphis, Pisa, Paris and San Diego Autoquestionnaire Version (TEMPS-A) and Nine Type Temperament Scale (NTTS) were used to collect data. Results: Except for NTM3, NTM8 and NTM9 temperament categories, all NTTS categories have significant correlation with various TCI dimensions at a level r=0.40 and above. Except for NTM1, NTM5 and NTM9 temperament categories, all NTTS categories have significant correlation with various TEMPS-A categories at a level r=0.40 and above. According to the results of regression analyses, it is found that TCI dimensions and TEMPS-A categories can explain 29-63% of variance of NTTS temperament categories. Conclusion: This study indicates that although there are consistent and significant correlations between dimensions and categories of NTTS and the two scales widely used in psychiatry, there are conceptual differences between NTTM, PPM and ATM and temperament categories of NTTM have unique features.
  • Publication
    Neurocognitive functioning in a group of offspring genetically at high-risk for schizophrenia in Eastern Turkey
    (2010-05-31T00:00:00Z) Ozan, Erol; Deveci, ERDEM; ORAL, Meltem; Karahan, Utku; Oral, Elif; Aydin, Nazan; Kirpinar, Ismet; DEVECİ, ERDEM; KIRPINAR, İSMET
    We assessed major cognitive domains in symptom-free children of patients with schizophrenia compared to the healthy children of parents with no psychopathology using neurocognitive tests. We hypothesized that, offspring at high-risk for schizophrenia would have significant impairment in major domains: attention, memory, verbal-linguistic ability and executive functions. Thirty symptom-free children (17-males, 13-females: intelligence quotient = 99.6 +/- 13.6: age = 12.69 +/- 2.32 and education = 5.8 +/- 2.3 years) having a parent diagnosed with schizophrenia and 37 healthy children matched for gender (19-males, 18-females), IQ (106.05 +/- 14.70), age (12.48 +/- 2.58) and years of education (6.0 +/- 2.5) were evaluated. The study group showed significant poor performance in cognitive domains, such as working memory (assessed with Auditory consonant trigram test), focused attention (Stroop test), attention speed (Trail making test), divided attention (Auditory consonant trigram test), executive functions (Wisconsin card sorting test), verbal fluency (Controlled word association test) and declarative memory (Rey verbal learning and Short-term memory test). However, no group differences were detected either on verbal attention (Digit span forward test) or sustained attention (TOVA, a continuous performance task): the latter as consistently reported to be a predictor of schizophrenia. In order to determine the cognitive endophenotype of schizophrenia, it seems more rational to conduct comprehensive evaluation of neurocognitive domains in well-matched groups via using sufficiently challenging tests to detect slight deficits. In addition, longitudinal studies with a larger sample size evaluating neurocognitive functions combined with genetic analysis may provide clues about explaining the genetic background of the disorder within the endophenocognitype concept and serve as new targets for early interventions. (C) 2010 Elsevier Inc. All rights reserved.
  • Publication
    Open Access
    Relationship of Asymmetrical Dimethylarginine, Nitric Oxide, and Sustained Attention during Attack in Patients with Major Depressive Disorder
    (2014-01-01) CANPOLAT, Serpil; Kirpinar, Ismet; Deveci, ERDEM; Aksoy, Hulya; BAYRAKTUTAN, Zafer; EREN, Ibrahim; Demir, Recep; Selek, Salih; Aydin, Nazan; KIRPINAR, İSMET; DEVECİ, ERDEM
    Abstract We investigated the relationship of serum nitric oxide (NO) and asymmetrical dimethylarginine (ADMA) levels with cognitive functioning in patients with major depressive disorder (MDD). 41 MDD patients (Beck depression scale scores>16) and 44 controls were included in the study. Rey verbal learning and memory test, auditory consonant trigram test, digit span test, Wisconsin card sorting test, continuous performance task (TOVA), and Stroop test scores were found to be impaired in patients with major depressive disorder when compared to healthy controls. There was no significant difference between patient and control groups in terms of serum NO and ADMA. Serum NO levels were correlated with TOVA test error scores and Stroop test time scores, whereas serum ADMA levels were negatively correlated with TOVA test error scores. Metabolic detriments especially in relation to NO metabolism in frontal cortex and hypothalamus, psychomotor retardation, or loss of motivation may explain these deficits.
  • Publication
    Open Access
    Improvement in attention and executive functions during isotretinoin treatment in patients with acne
    (2013-06-01) Deveci, ERDEM; Ozturk, AHMET; Kirpinar, Ismet; ENGIN, Ragip Ismail; MELIKOGLU, Mehmet; SAKAT, Selcen Caferoglu; DEMIR, Muhammet; CANPOLAT, Serpil; DEVECİ, ERDEM; ÖZTÜRK, AHMET; KIRPINAR, İSMET
    Background and Design: We assessed attention, memory, verbal-linguistic ability, and executive functions in acne vulgaris patients before and during isotretinoin treatment.
  • Publication
    Metadata only
    Neuro cognitive functioning in young high-risk offspring having a parent with bipolar I disorder
    (2013-01-01) Deveci, ERDEM; Ozan, Erol; Kirpinar, Ismet; ORAL, Meltem; DALOGLU, Ali Gokhan; Aydin, Nazan; Ozturk, AHMET; DEVECİ, ERDEM; KIRPINAR, İSMET; ÖZTÜRK, AHMET
    Aim: To investigate attention, memory, verbal-linguistic ability, and executive functions in symptom-free young offspring having a parent with bipolar I disorder (BD1O) in comparison with healthy controls (CO).