Person:
KIRPINAR, İSMET

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İSMET
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KIRPINAR
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  • PublicationMetadata only
    Neuro cognitive functioning in young high-risk offspring having a parent with bipolar I disorder
    (2013-01-01) Deveci, ERDEM; Ozan, Erol; Kirpinar, Ismet; ORAL, Meltem; DALOGLU, Ali Gokhan; Aydin, Nazan; Ozturk, AHMET; DEVECİ, ERDEM; KIRPINAR, İSMET; ÖZTÜRK, AHMET
    Aim: To investigate attention, memory, verbal-linguistic ability, and executive functions in symptom-free young offspring having a parent with bipolar I disorder (BD1O) in comparison with healthy controls (CO).
  • PublicationMetadata only
    Neurocognitive functioning in a group of offspring genetically at high-risk for schizophrenia in Eastern Turkey
    (2010-05-31T00:00:00Z) Ozan, Erol; Deveci, ERDEM; ORAL, Meltem; Karahan, Utku; Oral, Elif; Aydin, Nazan; Kirpinar, Ismet; DEVECİ, ERDEM; KIRPINAR, İSMET
    We assessed major cognitive domains in symptom-free children of patients with schizophrenia compared to the healthy children of parents with no psychopathology using neurocognitive tests. We hypothesized that, offspring at high-risk for schizophrenia would have significant impairment in major domains: attention, memory, verbal-linguistic ability and executive functions. Thirty symptom-free children (17-males, 13-females: intelligence quotient = 99.6 +/- 13.6: age = 12.69 +/- 2.32 and education = 5.8 +/- 2.3 years) having a parent diagnosed with schizophrenia and 37 healthy children matched for gender (19-males, 18-females), IQ (106.05 +/- 14.70), age (12.48 +/- 2.58) and years of education (6.0 +/- 2.5) were evaluated. The study group showed significant poor performance in cognitive domains, such as working memory (assessed with Auditory consonant trigram test), focused attention (Stroop test), attention speed (Trail making test), divided attention (Auditory consonant trigram test), executive functions (Wisconsin card sorting test), verbal fluency (Controlled word association test) and declarative memory (Rey verbal learning and Short-term memory test). However, no group differences were detected either on verbal attention (Digit span forward test) or sustained attention (TOVA, a continuous performance task): the latter as consistently reported to be a predictor of schizophrenia. In order to determine the cognitive endophenotype of schizophrenia, it seems more rational to conduct comprehensive evaluation of neurocognitive domains in well-matched groups via using sufficiently challenging tests to detect slight deficits. In addition, longitudinal studies with a larger sample size evaluating neurocognitive functions combined with genetic analysis may provide clues about explaining the genetic background of the disorder within the endophenocognitype concept and serve as new targets for early interventions. (C) 2010 Elsevier Inc. All rights reserved.
  • PublicationOpen Access
    Relationship of Asymmetrical Dimethylarginine, Nitric Oxide, and Sustained Attention during Attack in Patients with Major Depressive Disorder
    (2014-01-01) CANPOLAT, Serpil; Kirpinar, Ismet; Deveci, ERDEM; Aksoy, Hulya; BAYRAKTUTAN, Zafer; EREN, Ibrahim; Demir, Recep; Selek, Salih; Aydin, Nazan; KIRPINAR, İSMET; DEVECİ, ERDEM
    Abstract We investigated the relationship of serum nitric oxide (NO) and asymmetrical dimethylarginine (ADMA) levels with cognitive functioning in patients with major depressive disorder (MDD). 41 MDD patients (Beck depression scale scores>16) and 44 controls were included in the study. Rey verbal learning and memory test, auditory consonant trigram test, digit span test, Wisconsin card sorting test, continuous performance task (TOVA), and Stroop test scores were found to be impaired in patients with major depressive disorder when compared to healthy controls. There was no significant difference between patient and control groups in terms of serum NO and ADMA. Serum NO levels were correlated with TOVA test error scores and Stroop test time scores, whereas serum ADMA levels were negatively correlated with TOVA test error scores. Metabolic detriments especially in relation to NO metabolism in frontal cortex and hypothalamus, psychomotor retardation, or loss of motivation may explain these deficits.