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Now showing 1 - 5 of 5
  • Publication
    Metadata only
    Temperament and Character Traits in Patients With Epilepsy Epileptic Personality
    (2013-05-01) YAZICI, Esra; YAZICI, Ahmet Bulent; Aydin, Nazan; Orhan, Asuman; Kirpinar, Ismet; Acemoglu, Hamit; KIRPINAR, İSMET
    Personality and behavioral changes in epilepsy are well documented. However, neither the quantitative characteristics nor the etiology of these changes is clear yet. Cloninger has developed a psychobiological personality model that provides a way to evaluate personality in a dimensional way. This study examined the relationship between epilepsy and Cloninger-s dimensional psychobiological personality model. A total of 73 epilepsy outpatients and 79 healthy controls were examined using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Axis I Disorders, the Turkish version of the Temperament and Character Inventory, and an epilepsy questionnaire. Epilepsy patients had higher harm avoidance ( HA) and lower persistence, self-directedness (SD), and cooperativeness scores than healthy controls did. In epileptic subjects, there was no correlation between age and duration of epilepsy. Subjects with partial seizures had higher HA scores and lower SD scores than generalized ones. Comorbid depression was represented with lower SD scores. In multiple linear regression models, only major depressive disorder predicted lower scores of SD. This study confirms specific personality changes among epileptics according to Cloninger-s dimensional personality model and indicates a relationship between the characteristics of epilepsy and psychiatric comorbidity.
  • Publication
    Metadata only
    Affective Temperaments in Epilepsy
    (2012-09-01) YAZICI, Esra; YAZICI, Ahmet Bulent; Aydin, Nazan; Varoglu, Asuman Orhan; Kirpinar, Ismet; KIRPINAR, İSMET
    Affective temperaments in epilepsy
  • Publication
    Metadata only
    Neurocognitive functioning in a group of offspring genetically at high-risk for schizophrenia in Eastern Turkey
    (2010-05-31T00:00:00Z) Ozan, Erol; Deveci, ERDEM; ORAL, Meltem; Karahan, Utku; Oral, Elif; Aydin, Nazan; Kirpinar, Ismet; DEVECİ, ERDEM; KIRPINAR, İSMET
    We assessed major cognitive domains in symptom-free children of patients with schizophrenia compared to the healthy children of parents with no psychopathology using neurocognitive tests. We hypothesized that, offspring at high-risk for schizophrenia would have significant impairment in major domains: attention, memory, verbal-linguistic ability and executive functions. Thirty symptom-free children (17-males, 13-females: intelligence quotient = 99.6 +/- 13.6: age = 12.69 +/- 2.32 and education = 5.8 +/- 2.3 years) having a parent diagnosed with schizophrenia and 37 healthy children matched for gender (19-males, 18-females), IQ (106.05 +/- 14.70), age (12.48 +/- 2.58) and years of education (6.0 +/- 2.5) were evaluated. The study group showed significant poor performance in cognitive domains, such as working memory (assessed with Auditory consonant trigram test), focused attention (Stroop test), attention speed (Trail making test), divided attention (Auditory consonant trigram test), executive functions (Wisconsin card sorting test), verbal fluency (Controlled word association test) and declarative memory (Rey verbal learning and Short-term memory test). However, no group differences were detected either on verbal attention (Digit span forward test) or sustained attention (TOVA, a continuous performance task): the latter as consistently reported to be a predictor of schizophrenia. In order to determine the cognitive endophenotype of schizophrenia, it seems more rational to conduct comprehensive evaluation of neurocognitive domains in well-matched groups via using sufficiently challenging tests to detect slight deficits. In addition, longitudinal studies with a larger sample size evaluating neurocognitive functions combined with genetic analysis may provide clues about explaining the genetic background of the disorder within the endophenocognitype concept and serve as new targets for early interventions. (C) 2010 Elsevier Inc. All rights reserved.
  • Publication
    Open Access
    Relationship of Asymmetrical Dimethylarginine, Nitric Oxide, and Sustained Attention during Attack in Patients with Major Depressive Disorder
    (2014-01-01) CANPOLAT, Serpil; Kirpinar, Ismet; Deveci, ERDEM; Aksoy, Hulya; BAYRAKTUTAN, Zafer; EREN, Ibrahim; Demir, Recep; Selek, Salih; Aydin, Nazan; KIRPINAR, İSMET; DEVECİ, ERDEM
    Abstract We investigated the relationship of serum nitric oxide (NO) and asymmetrical dimethylarginine (ADMA) levels with cognitive functioning in patients with major depressive disorder (MDD). 41 MDD patients (Beck depression scale scores>16) and 44 controls were included in the study. Rey verbal learning and memory test, auditory consonant trigram test, digit span test, Wisconsin card sorting test, continuous performance task (TOVA), and Stroop test scores were found to be impaired in patients with major depressive disorder when compared to healthy controls. There was no significant difference between patient and control groups in terms of serum NO and ADMA. Serum NO levels were correlated with TOVA test error scores and Stroop test time scores, whereas serum ADMA levels were negatively correlated with TOVA test error scores. Metabolic detriments especially in relation to NO metabolism in frontal cortex and hypothalamus, psychomotor retardation, or loss of motivation may explain these deficits.
  • Publication
    Metadata only
    Neuro cognitive functioning in young high-risk offspring having a parent with bipolar I disorder
    (2013-01-01) Deveci, ERDEM; Ozan, Erol; Kirpinar, Ismet; ORAL, Meltem; DALOGLU, Ali Gokhan; Aydin, Nazan; Ozturk, AHMET; DEVECİ, ERDEM; KIRPINAR, İSMET; ÖZTÜRK, AHMET
    Aim: To investigate attention, memory, verbal-linguistic ability, and executive functions in symptom-free young offspring having a parent with bipolar I disorder (BD1O) in comparison with healthy controls (CO).