Person: KILIÇOĞLU DANE, PAKİZER BANU
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Publication Open Access Vitamin D status in the first-trimester: effects of Vitamin D deficiency on pregnancy outcomes(2016-01-01) Ates, SEDA; Sevket, OSMAN; ÖZCAN, PINAR; ÖZKAL, Fulya; Kaya, MEHMET ONUR; Dane, Banu; ATEŞ, SEDA; ŞEVKET, OSMAN; ÖZCAN, PINAR; KAYA, MEHMET ONUR; KILIÇOĞLU DANE, PAKİZER BANUObjective: To assess serum levels of 25-hydroxyvitamin D [25(OH)D] in the first trimester and to determine the factors affecting deficiency levels and its association with pregnancy outcomes. Methods: Serum 25(OH)D concentrations were measured at 11-14 weeks' gestation in 229 singleton pregnancies using liquid chromatography-tandem mass spectrometry. Results: The median serum 25(OH)D concentration was 10.8 ng/mL and 45.9% of women had severe vitamin D deficiency with concentrations of <10 ng/mL. Logistic regression analysis revealed that covered dressing style, lack of multivitamin intake, season of blood sampling (November-April) were factors associated with 25(OH)D deficiency. There was a negative correlation between 25(OH)D levels and gestational age at sampling. Low 25(OH)D levels were not associated with adverse pregnancy outcomes. Higher rate of cesarean section (CS) was noted in women with 25(OH)D ≥10 ng/mL compared to those with 25(OH)D < 10mg/ml (p= 0.01). Conclusion: A high prevalence of vitamin D deficiency was observed in early pregnancy which was related to dress code, use of multi-vitamins and season at sampling. Low 25(OH)D levels were not related with adverse pregnancy outcomes. Women with severe vitamin D deficiency were more likely to deliver vaginally.Publication Open Access Retrospective analysis of patients with placenta previa Plasenta previa olgularının retrospektif incelemesi(2015-12-01) BATMAZ, Gonca; MOLLA, Fulya; MOLLA, Taner; ÖZCAN, PINAR; Dansuk, RAMAZAN; Dane, Banu; ÖZCAN, PINAR; DANSUK, RAMAZAN; KILIÇOĞLU DANE, PAKİZER BANUAim: To evaluate risk factors of patients with placenta previa and investigate management strategies. Methods: A retrospective review of medical records of 41 cases with placenta previa who were followed up in our center. The cases were evaluated according to demographic features, presence of placental invasion of the uterus, and necessity of blood transfusion. Requirement for a peripartum hysterectomy, relaparotomy rates and neonatal outcomes were also addressed. All patients with placenta previa were considered for elective surgery. Results: Eighteen patients, who did not have any sign of uterine invasion in their antenatal sonographic evaluations, were observed alike during cesarean section. In 23 patients, uterine invasion was detected by antenatal sonographic evaluations, 15 patients underwent hysterectomy due to invasion. Subsequent laparotomy was needed in four patients in whom hysterectomy was performed. Out of 15 patients, who underwent hysterectomy, 9 had placenta accreata, 2 had placenta percreata, and 2 had placenta increata. Organ-preserving treatment was performed in 8 patients who had a suspicious uterine invasion owing to their antenatal sonographic evaluations. Conclusion: In our study, abnormal placental invasion was predicted by antenatal sonographic findings. Multidisciplinary approach is required for patients with placenta previa to determine appropriate mode and timing of delivery.Publication Open Access Pregnancy Outcome of Multiparous Women Aged over 40 Years.(2013-01-01) ATES, SEDA; BATMAZ, G; SEVKET, OSMAN; MOLLA, T; DANE, C; Dane, B; ATEŞ, SEDA; ŞEVKET, OSMAN; KILIÇOĞLU DANE, PAKİZER BANUwomen multiparaous in outcome obstetric and prenatal on age maternal of effect the evaluate to was study this of aim e.Objective ,group study (over and years 40 aged women including, conducted was study control case retrospective A. Methods and Materials age mean e. Results, 𝑛𝑛 𝑛 𝑛𝑛). group control (years 29–20 aged women and beyond or gestation s’week 20 at delivered who𝑛𝑛 𝑛 𝑛𝑛) associated was age maternal Advanced. group control the in years 3.2±4.25 versus years 7.1±2.41 was group study the in women of .(�𝑃𝑃𝑃� �� �𝑃�) 7Publication Open Access Soluble TNF-Like Weak Inducer of Apoptosis as a New Marker in Preeclampsia: A Pilot Clinical Study.(2016-01-01) YILDIRIM, ZEYNEP BEYZA; SUMNU, A; BADEMLER, N; KILIC, ERDEM; SUMNU, G; KARADAG, S; GURSU, MELTEM; OZEL, A; BATMAZ, G; ATES, SEDA; Dane, B; OZTURK, S; YILDIRIM, ZEYNEP BEYZA; KILIÇ, ERDEM; GÜRSU, MELTEM; ATEŞ, SEDA; KILIÇOĞLU DANE, PAKİZER BANUntroduction: All findings of preeclampsia appear as the clinical consequences of diffuse endothelial dysfunction. Soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) was recently introduced as a TNF related cytokine in various inflammatory and noninflammatory disorders. sTWEAK was found to be related to endothelial dysfunction in patients with chronic kidney disease. In our study we aimed to compare sTWEAK levels in women with preeclampsia to corresponding levels in a healthy pregnant control group. Materials and methods: The study was undertaken with 33 patients with preeclampsia and 33 normal pregnant women. The concentration of sTWEAK in serum was calculated with an enzyme linked immunosorbent assay (ELISA) kit. Results: Serum creatinine, uric acid, LDH levels, and uPCR were significantly higher in the patient group compared to the control group. sTWEAK levels were significantly lower in preeclamptic patients (332 ± 144 pg/mL) than in control subjects (412 ± 166 pg/mL) (p = 0.04). Discussion: Our study demonstrates that sTWEAK is decreased in patients with preeclampsia compared to healthy pregnant women. There is a need for further studies to identify the role of sTWEAK in the pathogenesis of preeclampsia and to determine whether it can be regarded as a predictor of the development of preeclampsia.Publication Open Access Effects of altitude changes on Doppler flow parameters for uterine, umbilical, and mid-cerebral arteries in term pregnancy: A pilot study(2015-12-01T00:00:00Z) Aksoy, Ayse Nur; Batmaz, Gonca; Dane, Banu; Kucur, Suna Kabil; Gozukara, Ilay; KILIÇOĞLU DANE, PAKİZER BANUObjective: We hypothesized that maternal and fetal circulations may be affected by moderately high altitudes. Therefore, we compared the differences in maternal and fetal Doppler flow parameters in women with term pregnancy living at a moderately high altitude (1890 m in Erzurum) with those of women living at the sea level (31 m in Istanbul).Publication Open Access Follicular variant of papillary thyroid carcinoma arising from a dermoid cyst: a rare malignancy in young women and review of the literature(2012-09-01) DANE, C; EKMEZ, M; KARACA, A; AK, A; Dane, B; KILIÇOĞLU DANE, PAKİZER BANUObjective Benign or mature cystic teratomas, also known as dermoid cysts, are composed of mature tissues, which can contain elements of all three germ cell layers. Malignant transformation of a mature cystic teratoma is more common in postmenopausal women, however, it can also, rarely, be identified in younger women. We present a case of a 19-year-old woman with malignant transformation of an ovarian mature cystic teratoma. Case Report Our case was a 19-year-old woman, who was diagnosed postoperatively with follicular variant of papillary thyroid carcinoma in a mature cystic teratoma. She underwent right cystectomy for adnexal mass. Postoperative metastatic workup revealed a non-metastatic disease and the patient did not undergo any further treatment. After 2 months, a near-total thyroidectomy was performed. Serum thyroglobulin levels were monitored on follow-up and the patient is asymptomatic. Conclusion Malignant transformation of a dermoid cyst is a rare ovarian neoplasm. We believe that unilateral oophorectomy or cystectomy is a reasonable treatment option for cases in which there is no evidence of capsular invasion, vascular invasion or gross metastasis, and preservation of fertility is desired. Total thyroidectomy was diagnosed in selected cases. Serial serum thyroglobulin should be used as a tumor marker for follow-up.