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Now showing 1 - 9 of 9
  • PublicationMetadata only
    Kurkuminin meme kanserinde TGF-β temelli Smad4 sinyal yolağında etkisinin gen ekspresyon düzeyinde araştırılması
  • PublicationOpen Access
    Circulating furin, IL-6, and presepsin levels and disease severity in SARS-CoV-2-infected patients
    (2021-06-01T00:00:00Z) Kocyigit, Abdurrahim; Sogut, Ozgur; Kanimdan, Ebru; Guler, Eray Metin; Kaplan, Onur; Eren, Canan; Ozman, Zeynep; Yasar, Oznur; KOÇYİĞİT, ABDÜRRAHİM; BALKAN, EZGİ; KANIMDAN, EBRU; YENİGÜN, VILDAN BETÜL; ÖZMAN, ZEYNEP
    Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a vast number of infections and deaths that deeply affect the world. When the virus encounters the host cell, it binds to angiotensin-converting enzyme 2, then the S protein of the virus is broken down by the transmembrane protease serine 2 with the help of furin, allowing the virus to enter the cell. The elevated inflammatory cytokines suggest that a cytokine storm, also known as cytokine release syndrome, may play a major role in the pathology of COVID-19. Therefore, the aim of this study is to investigate the relationship between circulating furin levels, disease severity, and inflammation in patients with SARS-CoV-2. A total of 52 SARS-CoV-2 patients and 36 healthy control participants were included in this study. SARS- CoV-2 patients were scored by the disease activity score. Serum furin, presepsin, and interleukin-6 (IL-6) levels were assessed using an enzyme-linked immunosorbent assay. The mean furin, presepsin, and IL-6 levels were significantly higher in the peripheral blood of SARS-CoV-2 compared to the controls (p < 0.001). There were close positive relationship between serum furin and IL-6, furin and presepsin, and furin and disease severity (r = 0.793, p < 0001; r = 0.521, p < 0.001; and r = 0,533, p < 0.001, respectively) in patients with SARS-CoV-2. These results suggest that furin may contribute to the exacerbation of SARS-CoV-2 infection and increased inflammation, and could be used as a predictor of disease severity in COVID-19 patients.
  • PublicationOpen Access
    Evaluation of Some Physico-chemical and Antioxidant Characteristics of Commercial Honey Samples Originated from Different Regions of Turkey
    (2022-01-01T00:00:00Z) Bilgin, Mehmet Gültekin; Güneş Bayır, Ayşe; Özman, Zeynep; Babalı Balıbey, Fatmanur; Turgay, Feyzanur; Karakaş, İrem; Köse, Nesrin; Sevinç, Tülay; Selçuk, Tuğbanur; Öztürk, Nezire; BİLGİN, MEHMET GÜLTEKİN; GÜNEŞ BAYIR, AYŞE; ÖZMAN, ZEYNEP; BABALI BALIBEY, FATMANUR
  • PublicationOpen Access
    Comparison of the effects of rutaecarpine on molecular subtypes of breast cancer
    (2021-06-01T00:00:00Z) Çokluk, Erdem; Özman, Zeynep; Güney, Gamze; Deveci, Asuman; Şekeroğlu, Mehmet Ramazan; ÖZMAN, ZEYNEP
    Objective: Natural compounds have gained considerable attention in recent years due to disadvantages and properties of current chemotherapy drugs in cancer therapy. In addition, the impact of these compounds is specific for each type and/or subtypes of cancer due to different treatment response. Rutaecarpine, an alkaloid obtained from Evodia Rutaecarpa Chinese herb, has anticancer activity by inhibiting topoisomerase and/or cyclo-oxygenase-2 levels. However, the effectiveness of rutaecarpine has not been well known in breast cancer in terms of subtype. Therefore, we investigated the potential therapeutic effects of rutaecarpine on two different subtypes of breast cancer cells. Materials and methods: The cytotoxic and apoptotic effects of rutaecarpine on MCF-7 and MDA-MB-231 cells were analyzed by WST-1, Annexin V, cell cycle, and acridine orange staining. Results: WST-1 results indicated that rutaecarpine significantly inhibited the growth of both cancer cells for 48 h (P < 0.05). In addition, rutaecarpine treatment caused apoptotic cell death through chromatin condensation and nuclear blebbing and G0/G1 arrest in both breast cancer cells. However, the efficacy of rutaecarpine was more profound in MCF-7 cells than MDA-MB-231 cells. Conclusions: Consequently, rutaecarpine has a potential therapeutic effect on breast cancer. However, the effectiveness of rutaecarpine is dependent on the subtype of breast cancer.
  • PublicationMetadata only
    Regulation of valproic acid induced EMT by AKT/GSK3β/β-catenin signaling pathway in triple negative breast cancer
    (2021-01-30T00:00:00Z) Ozman, Zeynep; Ozbek Iptec, Betul; Sahin, Elvan; Guney Eskiler, Gamze; Deveci Ozkan, Asuman; Kaleli, Suleyman; ÖZMAN, ZEYNEP
  • PublicationMetadata only
    The Effects of Rutaecarpine on Metastatic Prostate Cancer Cells
    (2022-04-01T00:00:00Z) Şekeroğlu, Mehmet Abdülkadir; Çokluk, Erdem; Özman, Zeynep; Deveci Özkan, Asuman; Güney, Gamze; Şekeroğlu, Mehmet Ramazan; Tuncer, Fatıma Betül; ÖZMAN, ZEYNEP
  • PublicationMetadata only
    In vitro therapeutic effects of abemaciclib on triple-negative breast cancer cells.
    (2021-07-26T00:00:00Z) Ozman, Zeynep; Guney Eskiler, Gamze; Sekeroglu, Mehmet R; ÖZMAN, ZEYNEP
  • PublicationMetadata only
    IL-6 mediated JAK/STAT3 signaling pathway in cancer patients with cachexia
    (2019-01-01T00:00:00Z) Eskiler, Guney G.; Bezdegumeli, E.; Ozman, Zeynep; Ozkan, Deveci A.; Bilir, C.; Kucukakca, B. N.; Ince, M. N.; Men, A. Y.; Aktas, O.; Horoz, Y. E.; Akpinar, D.; Genc, I; Kaleli, S.; ÖZMAN, ZEYNEP
    OBJECTIVES: We investigated the changes in the IL-6 and STAT3 expression levels in cachectic and non-cachectic patients with gastric, lung and breast cancer and evaluated the association between IL-6 and STAT3 levels and cancer types in terms of cachexia condition. BACKGROUND: Cancer-associated cachexia, observed in nearly 50.80 % of cancer patients, has drawn attention in advanced patients. IL-6/JAK/STAT pathway plays an essential role in the progression of cancer cachexia through the regulation of the inflammatory response.
  • PublicationMetadata only
    Sakarya İlinde Yapılan Toplum Sağlığı Taramalarında Beslenme Alışkanlığının İncelenmesi
    (2018-06-01T00:00:00Z) CİNEMRE, FATMA BEHİCE; ÖZMAN, ZEYNEP; Dilaveroğlu, Nilgün; CİNEMRE, HAKAN; Kaçal, Zübeyde; AYDEMİR, BİRSEN; ÖZMAN, ZEYNEP