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YURTSEVER, İSMAİL

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İSMAİL
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YURTSEVER
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    Relationship between KRAS mutation and diffusion weighted imaging in colorectal liver metastases; Preliminary study.
    (2020-02-25T00:00:00Z) Türk, HM; Gültekin, MEHMET ALİ; Uysal, Ö; Beşiroğlu, M; Yilmaz, TF; Yurtsever, I; GÜLTEKİN, MEHMET ALİ; TÜRK, HACI MEHMET; TOPRAK, HÜSEYİN; YURTSEVER, İSMAİL; YILMAZ, TEMEL FATİH; SHARIFOV, RASUL; UYSAL, ÖMER
    Purpose: We aimed to investigate whether there are any differences in apparent diffusion coefficient (ADC) values obtained from colorectal liver metastases (CRLM) according to Kirsten rat sarcoma (KRAS) gene mutation status.
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    Radiosurgery, Gamma Knife Radiosurgery, Vestibular schwannomas, tumor volume, Diffusion Tensor Imaging, Apparent diffusion coefficient.
    (2021-11-01T00:00:00Z) Kaya, Ahmet; Çeşme, Dilek Hacer; Yurtsever, İsmail; Sarı, Lütfullah; Alkan, Gökberk; Seyithanoglu, Mehmet Hakan; KAYA, AHMET; YURTSEVER, İSMAİL
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    PublicationOpen Access
    Diffusion Tensor Imaging Can Discriminate the Primary Cell Type of Intracranial Metastases for Patients with Lung Cancer.
    (2021-03-04T00:00:00Z) Bilgin, Sabriye Sennur; Gultekin, Mehmet Ali; Yurtsever, Ismail; Yilmaz, Temel Fatih; Cesme, Dilek Hacer; Bilgin, Melike; Topcu, Atakan; Besiroglu, Mehmet; Turk, Haci Mehmet; Alkan, ALPAY; Bilgin, Mehmet; GÜLTEKİN, MEHMET ALİ; YURTSEVER, İSMAİL; YILMAZ, TEMEL FATİH; ÇEŞME, DİLEK HACER; TÜRK, HACI MEHMET; ALKAN, ALPAY; BİLGİN, MEHMET
    Purpose: Histopathological differentiation of primary lung cancer is clinically important. We aimed to investigate whether diffusion tensor imaging (DTI) parameters of metastatic brain lesions could predict the histopathological types of the primary lung cancer. Methods: In total, 53 patients with 98 solid metastatic brain lesions of lung cancer were included. Lung tumors were subgrouped as non-small cell carcinoma (NSCLC) (n = 34) and small cell carcinoma (SCLC) (n = 19). Apparent diffusion coefficient (ADC) and Fractional anisotropy (FA) values were calculated from solid enhanced part of the brain metastases. The association between FA and ADC values and histopathological subtype of the primary tumor was investigated. Results: The mean ADC and FA values obtained from the solid part of the brain metastases of SCLC were significantly lower than the NSCLC metastases (P < 0.001 and P = 0.003, respectively). ROC curve analysis showed diagnostic performance for mean ADC values (AUC=0.889, P = < 0.001) and FA values (AUC = 0.677, P = 0.002). Cut-off value of > 0.909 × 10-3 mm2/s for mean ADC (Sensitivity = 80.3, Specificity = 83.8, PPV = 89.1, NPV = 72.1) and > 0.139 for FA values (Sensitivity = 80.3, Specificity = 54.1, PPV = 74.2, NPV= 62.5) revealed in differentiating NSCLC from NSCLC. Conclusion: DTI parameters of brain metastasis can discriminate SCLC and NSCLC. ADC and FA values of metastatic brain lesions due to the lung cancer may be an important tool to differentiate histopathological subgroups. DTI may guide clinicians for the management of intracranial metastatic lesions of lung cancer.
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    Anevrizmatik subaraknoid kanama sonrası prognostik faktör olarak platelet volüm indeksinin değerlendirilmesi
    (2019-09-01) Dündar, Tolga Turan; DÜNDAR, TOLGA TURAN; KİTİŞ, SERKAN; YURTSEVER, İSMAİL
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    PublicationOpen Access
    The effect of sarcopenia on erlotinib therapy in patients with metastatic lung adenocarcinoma.
    (2022-05-14T00:00:00Z) Topcu, Atakan; Ozturk, Akin; Yurtsever, İSMAİL; Besiroglu, Mehmet; Yasin, Ayse Irem; Turk, Haci Mehmet; Seker, Mesut; YURTSEVER, İSMAİL; TÜRK, HACI MEHMET
    Erlotinib, a tyrosine kinase inhibitor, has been shown to improve the survival of patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer. Sarcopenia is a status with increasing importance in lung cancer, and it may predict a poor prognosis. We aimed to evaluate the impact of sarcopenia on erlotinib therapy and prognosis in patients with EGFR-mutated (exon 19 or 21 L858R) metastatic lung adenocarcinoma. Sarcopenia was defined as skeletal muscle index ≤39 cm2/m2 for women and ≤55 cm2/m2 for men. The patient characteristics, inflammation parameters, clinical and survival outcomes of the erlotinib therapy were examined according to sarcopenia status. We also analyzed the erlotinib treatment-related toxicity. Seventy-two patients were included in our retrospective study, and the mean age of the patients was 63.7 years. A total of 39 (54.2%) patients were diagnosed with sarcopenia. Patients with sarcopenia had a poor prognosis and had a shorter median progression-free survival (PFS) than patients without sarcopenia (10.5 months vs. 21.8 months, p=0.002). Sarcopenia (HR 2.08) and C-reactive protein > 6.5 mg/L (HR 2.57) were determined as independent poor prognostic factors for PFS of erlotinib therapy. Treatment-related toxicity occurred in 34.7% of patients treated with erlotinib, and sarcopenia did not significantly affect treatment-related toxicity. We also found that sarcopenia significantly affected the response to erlotinib. The expected survival outcomes may be low when erlotinib therapy is used in patients with sarcopenia and metastatic lung adenocarcinoma. This study showed that survival and clinical outcomes could be better predicted by detecting sarcopenia in patients with lung cancer using erlotinib.
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    PublicationOpen Access
    Relationship of white matter hyperintensities with clinical features of seizures in patients with epilepsy
    (2021-11-19T00:00:00Z) Uslu, Ferda Ilgen; Çetintaş, Elif; Alkan, ALPAY; Kolukisa, Mehmet; USLU, FERDA; YURTSEVER, İSMAİL; ALKAN, ALPAY
    Background: Although epilepsy is primarily known as a cortical disorder, there is growing body of research demonstrating white matter alterations in patients with epilepsy. Objective: To investigate the prevalence of white matter hyperintensities (WMH) and its association with seizure characteristics in patients with epilepsy. Methods: The prevalence of WMH in 94 patients with epilepsy and 41 healthy controls were compared. Within the patient sample, the relationship between the presence of WMH and type of epilepsy, frequency of seizures, duration of disease and the number of antiepileptic medications were investigated. Results: The mean age and sex were not different between patients and healthy controls (p>0.2). WMH was present in 27.7% of patients and in 14.6% of healthy controls. Diagnosis of epilepsy was independently associated with the presence of WMH (ß=3.09, 95%CI 1.06-9.0, p=0.039). Patients with focal epilepsy had higher prevalence of WMH (35.5%) than patients with generalized epilepsy (14.7%). The presence of WMH was associated with older age but not with seizure characteristics. Conclusions: WMH is more common in patients with focal epilepsy than healthy controls. The presence of WMH is associated with older age, but not with seizure characteristics.
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    PublicationOpen Access
    Persistent pleural effusion in an infant with an unusual diagnosis: congenital alveolar rhabdomyosarcoma
    (2020-01-01T00:00:00Z) Yozgat, Can Yilmaz; YEŞİLBAŞ, Osman; YOZGAT, Yılmaz; AKDEMİR, OSMAN CEMİL; YURTSEVER, İsmail; TEKİN, NUR; BAGHISHOV, DAMAT; BAYRAMOVA, NİGAR; ELAGÖZ, Şahande; ÇAKIR, FATMA BETÜL; YEŞİLBAŞ, OSMAN; YOZGAT, YILMAZ; AKDEMİR, OSMAN CEMİL; YURTSEVER, İSMAİL; TEKİN, NUR; BAGHISHOV, DAMAT; BAYRAMOVA, NİGAR; ELAGÖZ, ŞAHANDE; ÇAKIR, FATMA BETÜL
    Rhabdomyosarcoma (RMS) is a malignant form of neoplasm that originates from skeletal muscle. RMSs can exist anywhere in the human body but are more commonly detected in the neck region and extremities. The alveolar type is one of the subtypes of RMS that has a poor prognosis. Because the clinical manifestation of a tumour can be a painless mass, symptoms might be non-contributary to the diagnosis. Herein, a four-month-old girl was admitted to the emergency department with complaints of respiratory distress without a runny nose, cough, and fever. Recurrent effusions subsided with subsequent tube thoracostomy. Video-assisted thoracoscopic surgery (VATS) was performed to determine the aetiology of the recurrent effusion. The Tru-Cut biopsy obtained during VATS resulted in the diagnosis of alveolar rhabdomyosarcoma. Pleural effusion decreased, and the tube drainage was stopped rapidly after first vincristine, actinomycin-D, and cyclophosphamide chemotherapy cycle. Persistent and recurrent pleural effusions should alert physicians to rule out unusual diagnoses like that of our case.
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    Meme kanseri beyin metastazlarının moleküler subgruplarının difüzyon tensor görüntüleme ile değerlendirilmesi
    (2019-04-27T00:00:00Z) Yurtsever, İsmail; Gültekin, Mehmet Ali; Yılmaz, Temel Fatih; Türk, Hacı Mehmet; Alkan, Alpay; YURTSEVER, İSMAİL; GÜLTEKİN, MEHMET ALİ; YILMAZ, TEMEL FATİH; TÜRK, HACI MEHMET; ALKAN, ALPAY
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    PublicationOpen Access
    COVİD-19 PANDEMİSİNDE Hastalık/Hastane Yönetimi-COVID-19 PANDEMİSİNDE RADYOLOJİK TANI YÖNTEMLERİ
    (2021-10-01T00:00:00Z) Yurtsever, İsmail; YURTSEVER, İSMAİL
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    PublicationOpen Access
    Analysis of the involvement of the thyroid gland using computed tomography in patients with suspected SARS-CoV-2 infection: a retrospective study
    (2021-01-01T00:00:00Z) Akkoyunlu, Y.; Kalaycioglu, B.; Yurtsever, I; Eren, A.; Bayram, M.; Mert, A.; Akkoyunlu, M. E.; AKKOYUNLU, YASEMİN; YURTSEVER, İSMAİL
    Objective: SARS-CoV-2 primarily infects the respiratory tract and leads to severe pneumonia by binding to the ACE-2 receptor. The virus can also interact with ACE-2 receptors expressed in other tissues as in thyroid. This study predicted the complications involving the thyroid in patients with suspected SARS-CoV-2. Patients and methods: Patients with suspected SARS-CoV-2 infection between March 11, 2020-May 31, 2020 were retrospectively evaluated. Sixty-nine patients who were radiologically diagnosed as COVID-19 according to thoracic CT and had previously performed thoracic CT before November 2019 were included in the study according to the exclusion and inclusion criteria. Age and gender-matched controls (No. 69) were selected with normal thoracic CT whose PCR tests were also negative. Thyroid densities of participants were calculated and compared from the previous and current thoracic CTs. Results were also compared with the control group. Results: Participants were composed of 69 patients (39 male, mean age 64.35 years). Thyroid densities were significantly decreased from 89HU to 76HU for whole gland, from 88HU to 76HU for right lobes and from 87.5HU to 75.5HU for left lobes at current thoracic CTs performed during COVID-19 (p<0.001, p<0.001, p<0.001 respectively). The decrease in densities of the whole thyroid gland, both left and right lobes, was correlated with mortality (p<0.001). The changes in thyroid densities were not correlated with age nor gender. The decreases in HU values of thyroid densities for whole gland, left and right lobes, were correlated with mortality (p<0.001, p<0.001, and p<0.001 respectively). Conclusions: COVID-19 is a multi-systemic disease that threatens vital organs, including the thyroid. Future studies are needed to investigate the association between SARS-CoV-2 and other complications.