Person: İŞCAN, AKIN
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Publication Metadata only Yeni mutasyon tespit edilen Sandhof Hastalığı vakası(2017-04-30) CESUR, YAŞAR; TAŞ, İBRAHİM; YEŞİL, GÖZDE; İŞCAN, AKIN; CESUR, YAŞAR; TAŞ, İBRAHİM; YEŞİL, GÖZDE; İŞCAN, AKINPublication Metadata only Evaluation of carotid intima-media thickness, a marker of subclinical atherosclerosis, in children with cerebral palsy(2012-06-01) Cece, Hasan; Yetisgin, Abdulkadir; Abuhandan, Mahmut; Yildiz, Sema; Calik, Mustafa; Karakas, Omer; Karakas, Ekrem; Iscan, AKIN; İŞCAN, AKINRespiratory and cardiovascular diseases are the most common causes of death in children with cerebral palsy.Publication Metadata only A CASE OF L-2 HYDROXYGLUTARIC ACIDURIA PRESENTING AS FEBRILE SEIZURE(2014-01-01) Calik, M.; Tuncer, F. N.; Sarikaya, S.; Karakas, O.; Cece, H.; Iscan, AKIN; İŞCAN, AKINA case of L-2 hydroxyglutaric aciduria presenting as febrile seizure: L-2 hydroxyglutaric aciduria (L2HGA) is a rare, infantile-onset, autosomal recessive organic aciduria affecting exclusively the central nervous system. A case is reported here of L2HGA presenting with macrocephaly and febrile seizure. Although there have been reports of epilepsy associated with L2HGA, to the best of our knowledge this is the second case in literature of febrile seizure in a patient with L2HGA. This report suggests that detailed neurological evaluation of macrocephalic children with febrile convulsion is important. Moreover, metabolic and genetic investigations may be necessary for these kinds of patients.Publication Metadata only Akut Poststreptokoksik Glomerulonefrite Bağlı Gelişen Posterior reverzibl Ensefalopati Olgusu(2014-10-26T00:00:00Z) DOĞAN DEMİR, AYŞEGÜL; GÖKSU, AHMET ZAHİD; VEHAPOĞLU TÜRKMEN, AYSEL; UZUNER, SELÇUK; ERENBERK, UFUK; İŞCAN, AKIN; ÖKTEM, FARUK; DOĞAN DEMİR, AYŞEGÜL; GÖKSU, AHMET ZAHİD; VEHAPOĞLU TÜRKMEN, AYSEL; UZUNER, SELÇUK; ERENBERK, UFUK; İŞCAN, AKINPublication Open Access Correlation of Brain Neuropeptide (Nesfatin-1 and Orexin-A) Concentrations with Anthropometric and Biochemical Parameters in Malnourished Children(2015-09-01) Kahraman, Feyza Ustabas; Vehapoglu, Aysel; Ozgen, Ilker Tolga; Terzioglu, Sule; Cesur, YAŞAR; Dundaroz, Rusen; VEHAPOĞLU TÜRKMEN, AYSEL; USTABAŞ KAHRAMAN, FEYZA; ÖZGEN, İLKER TOLGA; TERZİOĞLU, ŞULE; CESUR, YAŞAR; İŞCAN, AKINObjective: Malnutrition continues to be a leading cause of stunted growth in many countries. This study aimed to investigate serum nesfatin-1 and orexin-A levels in underweight children and the potential correlations of these levels with anthropometric and nutritional parameters. Methods: The study enrolled 44 prepubertal children (between 2 and 12 years of age) with thinness grades of 1-3 and 41 healthy age- and gender-matched children. The demographic, clinical and laboratory parameters including nesfatin-1 and orexin-A concentrations were compared between the two groups. The correlations of nesfatin-1 and orexin-A with biochemical and anthropometric parameters were investigated. The receiver operating characteristic (ROC) analysis were also performed for evaluating nesfatin-1 and orexin-A in distinguishing children with malnutrition from healthy controls. Results: Thyroid-stimulating hormone, vitamin B12 and insulin levels were significantly lower in the study group than controls (p=0.001, p=0.049 and p=0.033, respectively). Mean nesfatin-1 levels in the malnourished group was also significantly lower compared to the healthy controls (3871.2 ± 1608.8 vs. 5515.0 ± 3816.4 pg/mL, p=0.012). No significant difference was observed in the orexin-A levels between the two groups (malnourished vs. control groups: 1135.7 ± 306.0 vs. 1025.7 ± 361.6 pg/mL, p=0.141). Correlation analyses revealed a positive correlation of nesfatin-1 and a negative correlation of orexin-A with body mass index (BMI) z-score. ROC analysis demonstrated that nesfatin-1 and orexin-A cannot be used to distinguish children with malnutrition from healthy controls (AUC: 0.620, p=0.061 for nesfatin-1 and AUC: 0.584, p=0.190 for orexin-A). Conclusion: The positive correlation of nesfatin-1 and the negative correlation of orexin-A with BMI suggest that these neuropeptides may be a part of a protective mechanism in the maintenance of nutritional status and that they may have a role in regulating food intake in undernourished children.Publication Metadata only Oxidative Stress in Children with Noninfectious Acute Urticaria(2016-03-01T00:00:00Z) ÖZKAYA, EMİN; YAZICI, MEBRURE; ERENBERK, UFUK; Dilek, Fatih; Dundaroz, Rusen; ÖZKAYA, EMİN; YAZICI, MEBRURE; ERENBERK, UFUK; İŞCAN, AKINPlasma oxidative stress parameters such as as total oxidant status (TOS) and total antioxidant status (TAS) were well studied in some chronic allergies, but their role is not well known in acute allergic disease such as acute urticaria (AU). The aim of this study is to investigate the oxidative and antioxidative status in children with AU. Eighty-seven children with noninfectious AU and 70 healthy controls were enrolled in the study. Blood samples were taken for complete blood count, serum immunoglobulin E (IgE), and C-reactive protein (CRP) levels routinely and for TOS and TAS. The skin prick test was performed and/or specific IgE assays were performed as indicated. Blood samples were also taken for TAS and TOS in the control group. Forty-eight (55%) of the children with AU were male, 39 (45%) of them were female. Mean ages were 6 +/- 2.02 and 7 +/- 1.38 years in the study and control groups, respectively. TOS levels were significantly high and TAS levels were significantly lower in the acute urticarial group (P < 0.001) than controls. There was no significant correlation between age, total IgE levels, or eosinophil count and TAS and TOS levels in children with AU. Plasma TOS levels are elevated in children with AU. The high level of TOS indicates that children with AU were exposed to severe oxidative stress.Publication Metadata only The Relationship Between Normal Motor Development and Disease Impact-Disability Level In Children With Epilepsy.(2015-09-09) Güler , Serhat; TANRIVERDİ, MÜBERRA; Karantay Mutluay , Fatma; İŞCAN, AKIN; TANRIVERDİ, MÜBERRA; İŞCAN, AKINPublication Metadata only The Relationship Between Demographic Characteristics of Preterm Infants and a Detailed Assessment of Fidgety Movements.(2016-06-04) Alemdaroğlu, İpek; TANRIVERDİ, MÜBERRA; İŞCAN, AKIN; KEPENEK VAROL, BÜŞRA; TANRIVERDİ, MÜBERRA; İŞCAN, AKINPublication Open Access PATIENT WITH INTERMITTENT POSTURE ABNORMALITY: AN ALEXANDER DISEASE CASE REPORT(2019-06-01T00:00:00Z) İÇAĞASIOĞLU, Dilara Füsun; İŞCAN, AKIN; ARALAŞMAK, Ayşe; NURSOY, HATİCE; YEŞİL, Gözde; AYDIN, NİHAL; Sahin, Seyma Sonmez; İÇAĞASIOĞLU, DİLARA FÜSUN; İŞCAN, AKIN; ARALAŞMAK, AYŞE; NURSOY, HATİCE; YEŞİL, GÖZDE; AYDIN, NİHALPublication Open Access Enuresis Nocturna in children with asthma: prevalence and associated risk factors(2016-06-01T00:00:00Z) ÖZKAYA, EMİN; Aydin, Seren Calis; YAZICI, MEBRURE; Dundaroz, Rusen; ÖZKAYA, EMİN; YAZICI, MEBRURE; İŞCAN, AKINBackground: Enuresis Nocturna (EN) is a common disorders in childhood. Although many different underlying pathophysiological mechanisms have been proposed to explain EN, its etiology is multifactorial. Some reports demonstrate that there is an association between EN and allergic diseases. To study (1) the prevalence of EN in children with asthma, (2) to determine the possible risk factors for EN in asthmatic children.