Person: İŞCAN, AKIN
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Publication Metadata only Evaluation of carotid intima-media thickness, a marker of subclinical atherosclerosis, in children with cerebral palsy(2012-06-01) Cece, Hasan; Yetisgin, Abdulkadir; Abuhandan, Mahmut; Yildiz, Sema; Calik, Mustafa; Karakas, Omer; Karakas, Ekrem; Iscan, AKIN; İŞCAN, AKINRespiratory and cardiovascular diseases are the most common causes of death in children with cerebral palsy.Publication Metadata only Assessment of the Clinical and Radiological Findings of Cases with Subacute Sclerosing Panencephalitis(2014-05-01T00:00:00Z) ÇALIK, MUSTAFA; Abuhandan, Mahmut; PİŞKİN, İBRAHİM ETEM; Karakas, Ekrem; Boyaci, Nurefsan; İŞCAN, AKIN; İŞCAN, AKINAim: Subacute sclerosing panencephalitis (SSPE) is a slow virus infection, arising in the central nervous system in the form of late complication of measles virus. In this study we aimed to research the clinical and radiological features of our patients with SSPE. Material and Method: The study was attended by 19 patients with SSPE being followed-up in the Child Neurology Clinic of the Medical Faculty of Harran University. Patients were assessed as per the following aspects, including age, gender, measles case, complaints resulting in the application, findings from clinical phase and magnetic resonance imaging (MRI) of brain. Results: While 68.4% (n = 13) of the patients were male, remaining 31.6% (n = 6) thereof were female. At the time of application, atonic and myoclonus seizures were seen among 31.5% (n = 6) of the patients, and mental and behavioral changes were seen among 20% (n = 4) thereof. In MRI of brain, involvement was seen the most in cortical, sub-cortical, and periventricular white matter fields. Among the findings from MRI of brain, those detected as normal were 36.8% (n = 7) of the total. Discussion: At places where SSPE is seen as endemic, presence of such psychological findings among children, including atonic and myoclonic seizures, personality changes, aggressive behaviors, or autism, should be considered as a warning. Meanwhile, it should further be considered that, MRI of the brain at the earlier stages of the disease may bring forth normal findings in high ratios.Publication Metadata only PD-1 Gene Polymorphism in Children with Subacute Sclerosing Panencephalitis(2013-08-01) Piskin, Ibrahim Etem; Calik, Mustafa; Abuhandan, Mahmut; KOLSAL, Ebru; Celik, Sevim Karakas; Iscan, AKIN; İŞCAN, AKINSubacute sclerosing panencephalitis (SSPE) is a progressive inflammatory and degenerative disorder of the central nervous system. Several factors influence the risk of chronic brain infection with the mutant measles virus. However, to date, no pathogenic mechanism that may predispose to SSPE has been determined. Studies have indicated that specific polymorphisms in certain host genes are probably involved in impairing the ability of host immune cells to eradicate the measles virus in SSPE patients. Programmed cell death protein 1 (PD-1), a member of the CD28 family, is a negative regulator of the immune system. The purpose of our study was to investigate whether PD-1 gene polymorphisms affect susceptibility to the development of SSPE in Turkish children. In total, 109 subjects (54 SSPE patients and 55 healthy controls) were genotyped for the PD-1.9 C/T (rs2227982) single-nucleotide polymorphism (SNP). The distributions of T alleles in the PD-1.9 polymorphism in SSPE patients and healthy controls were 2.8 and 10.9%, respectively. There was a statistically significant difference between the groups; the 95% confidence interval (CI) was 0.06 to 0.85 and the odds ratio (OR) was 0.23 (chi(2) test). Thus, we identified an association between SSPE and the PD-1 rs2227982 gene polymorphism; the frequency of T alleles was higher in controls than in SSPE patients.Publication Metadata only Visual and brainstem auditory evoked potentials in infants with severe vitamin B-12 deficiency(2015-01-01T00:00:00Z) Demir, Nihat; Koç, Ahmet; Abuhandan, Mahmut; Çalık, Mustafa; İşcan, AKIN; İŞCAN, AKINBackground/aim: Vitamin B-12 plays an important role in the development of mental, motor, cognitive, and social functions via its role in DNA synthesis and nerve myelination. Its deficiency in infants might cause neuromotor retardation as well as megaloblastic anemia. The objective of this study was to investigate the effects of infantile vitamin B-12 deficiency on evoked brain potentials and determine whether improvement could be obtained with vitamin B-12 replacement at appropriate dosages.Publication Metadata only The oxidative and antioxidative status of simple febrile seizure patients(2013-05-01) Abuhandan, Mahmut; Calik, Mustafa; Taskin, Abdullah; Yetkin, Ilhan; Selek, ŞAHBETTİN; Iscan, AKIN; SELEK, ŞAHABETTİN; İŞCAN, AKINObjective: To evaluate the oxidative status following a seizure in children experiencing a simple febrile seizure.Publication Metadata only Interictal serum S-100B protein levels in intractable epilepsy: A case-control study(2014-01-13) Calik, Mustafa; Abuhandan, Mahmut; Kandemir, Hasan; Guzel, Bulent; Solmaz, Abdullah; Celik, Hakim; Taskin, Abdullah; Iscan, AKIN; İŞCAN, AKINEpilepsy is the most common neurologic disorder of childhood. In approximately 6-14% of all patients with epilepsy, complete seizure control is difficult to achieve with current antiepileptic treatments. Several current studies have shown in both animals and people that the lengthening of epileptic seizures and frequent recurrence increases the likelihood of neuronal damage. S-100B protein is the most analyzed brain derived peripheral biochemical marker in brain damage. This study aimed to evaluate interictal serum S-100B protein levels in children diagnosed with intractable epilepsy. A group of 32 patients with intractable epilepsy and 25 healthy controls were recruited. Serum S-100B protein levels were measured using a commercially available electrochemiluminescence immunoassay (ECLIA kit, as supplied and according to the manufacturer-s standards. The serum S-100B protein levels of the patient group in the study were found to be 0.094 +/- 0.011 mu m/L, and 0.083 +/- 0.014 mu m/L in the age-matched control group. The difference between the groups was determined to be statistically significant (P = 0.004). In conclusions, it can be said that as the serum S-100B protein levels of the patients with focal epilepsy were high compared to those of the control group, this can be reliable peripheral biomarker for neuronal damage in patients with focal intractable epilepsy. (C) 2013 Elsevier Ireland Ltd. All rights reserved.Publication Metadata only Masked subdural empyema secondary to frontal sinusitis(2012-10-01) Calik, Mustafa; Iscan, AKIN; Abuhandan, Mahmut; Yetkin, Ilhan; Bozkus, Ferhat; Torun, M. Fuat; İŞCAN, AKINIntracranial complications of pediatric sinusitis are rare but potentially life threatening. These complications include cavernous sinus thrombosis, orbital infection, meningitis, and subdural empyema. Children with these complications may experience significant morbidity from their infection. In such cases, delay in diagnosis and treatment may lead to severe brain damage or death. Emergency physicians, pediatricians, and otolaryngologists should maintain a high index of suspicion for this complication of disease when treating patients with sinusitis in the emergency department or outpatient clinic. Early and accurate diagnosis of subdural empyema will lead to prompt treatment and a favorable outcome for the patient. We report a case of subdural empyema secondary to frontal sinusitis in an otherwise healthy immunocompetent adolescent boy.Publication Open Access Elevated serum S-100B levels in children with temporal lobe epilepsy(2013-03-01) Calik, Mustafa; Abuhandan, Mahmut; Sonmezler, Abdurrahman; Kandemir, Hasan; OZ, Ibrahim; Taskin, Abdullah; Selek, ŞAHBETTİN; Iscan, AKIN; SELEK, ŞAHABETTİN; İŞCAN, AKINPurpose: An elevated level of S-100B in serum is generally considered to be a biochemical marker of nervous tissue damage. According to our knowledge, no studies have evaluated the serum S-100B protein concentration in children with temporal lobe epilepsy. The objective of this study was to measure the serum levels of S-100B protein in pediatric cases with temporal epilepsy.Publication Metadata only Increased oxidant status in children with breath-holding spells(2013-06-01T00:00:00Z) Calik, Mustafa; Abuhandan, Mahmut; Aycicek, Ali; Taskin, Abdullah; Selek, Sahabettin; Iscan, AKIN; SELEK, ŞAHABETTİN; İŞCAN, AKINBreath-holding spells (BHS) are the most common form of non-epileptic paroxysmal events in infancy. The pathophysiology of BHS is not fully understood. Iron-deficiency anemia (IDA) may be a factor contributing to breath-holding spells. Although numerous reports have shown that elevated oxidative stress is implicated in the pathophysiology of neurodegenerative diseases and neurological conditions, such as epileptic seizures, brain damage, and neurotrauma, there are no data regarding the role of oxidative stress in the development of BHS. This study aimed to investigate oxidative stress in children with BHS.Publication Metadata only Association of Interleukin 18, Interleukin 2, and Tumor Necrosis Factor Polymorphisms with Subacute Sclerosing Panencephalitis(2013-06-01) Piskin, Ibrahim Etem; Karakas-Celik, Sevim; Calik, Mustafa; Abuhandan, Mahmut; KOLSAL, Ebru; Genc, Gunes Cakmak; Iscan, AKIN; İŞCAN, AKINSubacute sclerosing panencephalitis (SSPE) is a progressive inflammatory and degenerative disorder of the central nervous system. The measles virus (MV) and host and environmental factors are involved in the development of SSPE, but the precise mechanism by which the MV causes SSPE is still unknown. Studies have indicated that in SSPE patients, specific polymorphisms of certain genes are most likely involved in impairing the host-s ability to eradicate the MV. The purpose of our study was to elucidate the role of polymorphisms in the genes encoding interleukin (IL)-2, IL-18, and tumor necrosis factor alpha (TNF-alpha) in the development of SSPE. Using the polymerase chain reaction with sequence-specific primers, the single-nucleotide polymorphisms (SNPs) of the promoter regions of IL-2 (-330), TNF-alpha (-308), and IL-18 (-137 and -607) were studied in 54 patients with SSPE and 72 healthy controls. The frequency of SSPE patients with the AA genotype of IL-18 at position -607 was significantly higher than the frequency of those with the CC genotype (p < 0.001, odds ratio [OR]: 5.76), and a significantly higher proportion of patients had the C allele at -137 compared with the controls (p = 0.002, OR: 2.72). In a haplotype analysis of two SNPs in the IL-18 gene, the frequency of the CA haplotype was significantly higher in SSPE patients (p < 0.001, OR: 3.99) than in the controls. The IL-2 (-330) and TNF-alpha (-308) polymorphisms revealed no significant differences. In conclusion, these data suggest that the IL-18 gene polymorphisms at position -607 and -137 might be genetic risk factors for the SSPE disease.