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MALYA, FATMA ÜMİT

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FATMA ÜMİT
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MALYA
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Unusual Histopathological Findings in Appendectomy Specimens: A Retrospective Analysis of 2047 Cases.

2019-04-01, UNVER, NURCAN, COBAN, GANİME, ARıCı, DİLEK SEMA, BUYUKPıNARBASıLı, NUR, Gucin, ZÜHAL, MALYA, FATMA ÜMİT, ONARAN, OI, TOPALAN, K, ÜNVER, NURCAN, ÇOBAN, GANİME, ARICI, DILEK SEMA, BÜYÜKPINARBAŞILI, NUR, GÜCİN, ZÜHAL, MALYA, FATMA ÜMİT

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PublicationOpen Access

The Role of C-Reactive Protein in the Early Prediction of Serious Pancreatic Fistula Development after Pancreaticoduodenectomy

2018-01-01T00:00:00Z, MALYA, Fatma Ümit, Hasbahceci, Mustafa, Tasci, Yunus, KADIOĞLU, HÜSEYİN, GÜZEL, Mehmet, Karatepe, Oguzhan, DOLAY, Kemal, MALYA, FATMA ÜMİT, KADIOĞLU, HÜSEYİN, GÜZEL, MEHMET, DOLAY, KEMAL

Introduction. Despite recent advances in surgical techniques, pancreatic fistulas are common. We aimed to determine the role of C-reactive protein in the prediction of clinically relevant fistula development. Materials and Methods. Data from patients who underwent pancreaticoduodenectomy between 2012 and 2015 is collected. Postoperative 1st, 3rd, and 5th day (POD1, POD3, and POD5) C-reactive protein (CRP) levels, postoperative pancreatic fistula (POPF) development, other complications, length of hospital stay, and mortality were recorded. Results. Of 117 patients, 43 patients (36.8%) developed complications (including fistulas). Of the patients developing fistulas, 21 (17.9%) had POPF A, 2 (1.7%) had POPF B, and 7 (6.0%) had POPF C. POD5 CRP and POD3 CRP were shown to be significantly correlated with mortality and development of clinically relevant POPF (p = 0 001 and p = 0 0001, resp.) and with mortality (p = 0 017), respectively. The development of clinically relevant POPFs (B and C) could be predicted with 90% sensitivity and 82.2% specificity by POD5 CRP cut-off level of 19 mg/dL and with 100% sensitivity and 63.6% specificity by the difference between POD5 and POD1 CRP cut-off level of > 2.5 mg/dL. Conclusion. CRP levels can effectively predict the development of clinically relevant pancreatic fistulas.

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The role of miRNAs as a predictor of multicentricity in breast cancer.

2019-02-01, AKBULUT, H, ERSOY, YELİZ EMİNE, COŞKUNPINAR, E, GÜCİN, ZÜHAL, YILDIZ, S, MALYA, FATMA ÜMİT, HASTÜRK, B, MUSLUMANOGLU, MAHMUT, ERSOY, YELIZ EMINE, GÜCİN, ZÜHAL, YILDIZ, ŞEYMA, MALYA, FATMA ÜMİT

Expression profiles of miRNAs are shown to be different in various cancers to regulate expression of mRNA or to have a role in inhibition of translation, thus it shows the possible effect in progression, invasion and metastasis of breast cancer cells. The effect of breast conserving treatment in local recurrence and survival rates for the patients who have multicentric breast cancer is still controversial. In our study, we intended to evaluate the foresight of 84 miRNAs which are identified in breast cancer for having differentiated expressions. Thirty-one patients with unifocal and 26 patients with multicentric breast cancer were included in this study. These tissue samples of both malignant and normal breast tissues were kept in RNA later solution at -80 degrees C. Eighty-four miRNAs were studied with miScript miRNA PCR Array Human Breast Cancer kit. Fold change, cut off value was accepted as four. In unifocal group, there were 13 upregulated and five downregulated miRNAs and in multicentric group, there were three upregulated and seven downregulated miRNAs. To reach better results for breast cancer diagnosis and treatment, it is important to enlighten tumor biology, and pay attention to target and individual therapy. Thus, miRNAs have potential role in identifying tumor characteristics in supporting diagnosis and resulting with better evaluated disease for better treatment results with individual strategies.

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Effect of pre-operative red blood cell distribution on cancer stage and morbidity rate in patients with pancreatic cancer.

2014-09-15T00:00:00Z, ŞENTÜRK, H, YILMAZ, A, Malya, FATMA ÜMİT, OZTURK, G, CITGEZ, B, OZDENKAYA, Y, ERSAVAS, C, AGAN, A, KARATEPE, O, MALYA, FATMA ÜMİT, ŞENTÜRK, HAKAN

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PublicationOpen Access

A rare tumor in a patient with hepatic hydatic cyst: adrenal hepatoid adenocarcinoma.

2014-01-01T00:00:00Z, Malya, FATMA ÜMİT, BOZKURT, SÜLEYMAN, HASBAHCECI, M, CIPE, G, AHMAD, IC, GÜCIN, ZÜHAL, KARATEPE, O, MUSLUMANOGLU, M, MALYA, FATMA ÜMİT, BOZKURT, SÜLEYMAN, GÜCİN, ZÜHAL

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PublicationOpen Access

Jejunogastric intussusception: a rare complication of gastric surgery.

2013-01-01, CIPE, G, Malya, FATMA ÜMİT, HASBAHCECI, M, ERSOY, YELİZ EMİNE, KARATEPE, O, MUSLUMANOGLU, M, MALYA, FATMA ÜMİT, ERSOY, YELIZ EMINE

Jejunogastric intussusception is a rare complication of gastric surgery. It usually presents with severe epigastric pain, vomiting, and hematemesis. A history of gastric surgery can help in making an accurate and early diagnosis which calls forth an urgent surgical intervention. Only reduction or resection with revision of the previously performed anastomosis is the choice which is decided according to the operative findings. We present a case of JGI in a patient with a history of Billroth II operation diagnosed by computed tomography. At emergent laparotomy, an efferent loop type JGI was found. Due to necrosis, resection of the intussuscepted bowel with Roux-en-Y anastomosis was performed. Postoperative recovery was uneventful.

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PublicationOpen Access

The role of PET and MRI in evaluating the feasibility of skin-sparing mastectomy following neoadjuvant therapy.

2018-02-01, MALYA, FATMA ÜMİT, KADIOGLU, HÜSEYİN, BEKTASOGLU, HÜSEYİN KAZIM, Gucin, ZÜHAL, YILDIZ, S, GUZEL, MEHMET, ERDOGAN, EZGİ BAŞAK, YUCEL, S, ERSOY, YELİZ EMİNE, MALYA, FATMA ÜMİT, KADIOĞLU, HÜSEYİN, BEKTAŞOĞLU, HÜSEYİN KAZIM, GÜCİN, ZÜHAL, YILDIZ, ŞEYMA, GÜZEL, MEHMET, ERDOĞAN, EZGİ BAŞAK, ERSOY, YELIZ EMINE

Abstract Objective: To investigate the role of positron emission tomography (PET) and magnetic resonance imaging (MRI) in evaluating the feasibility of skin-sparing mastectomy in patients with locally-advanced breast cancer (LABC) who will undergo neoadjuvant chemotherapy (NAC) by evaluating the sensitivity and specificity of PET and MRI compared with skin biopsy results before and after NAC treatment. Methods: Patients with LABC who were treated with NAC between November 2013 and November 2015 were included in this study. Demographic, clinical, radiological and histopathological features of the patients were recorded. Results: A total of 30 patients were included in the study with a mean age of 52.6 years (range, 35– 70 years). Sensitivity and specificity for detecting skin involvement in LABC was 100%/10% (62%/ 85%) with MRI and 60%/80% (12%/92%) with PET before (after) NAC, respectively. When radiological skin involvement was assessed in relation to the final histopathological results, the preNAC PET results and histopathological skin involvement were not significantly different; and there was no difference between postNAC MRI and histopathological skin involvement. Conclusions: As preNAC PET and postNAC MRI more accurately determined skin involvement, it might be possible to use these two radiological evaluation methods together to assess patient suitability for skin-sparing mastectomy in selected patients.

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Clinical Significance of Intraoperative Frozen Section Analysis of Pancreatic Cancer Surgical Margin at the Time of Pancreaticoduodenectomy.

2015-09-01, BENDER, O, BOZKURT, SÜLEYMAN, BUYUKPINARBASILI, NUR, Malya, FATMA ÜMİT, BATTAL, M, KARATEPE, O, BOZKURT, SÜLEYMAN, BÜYÜKPINARBAŞILI, NUR, MALYA, FATMA ÜMİT

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PublicationOpen Access

Comparison of Laparoscopic and Conventional Cystotomy/Partial Cystectomy in Treatment of Liver Hydatidosis

2019-01-01, Bektasoglu, HÜSEYİN KAZIM, HASBAHCECI, Mustafa, Taşçı, Yunus, Aydogdu, Ibrahim, MALYA, FATMA ÜMİT, Kunduz, ENVER, Dolay, KEMAL, BEKTAŞOĞLU, HÜSEYİN KAZIM, AYDOĞDU, İBRAHİM, MALYA, FATMA ÜMİT, KUNDUZ, ENVER, DOLAY, KEMAL

Introduction. Hydatidosis is a zoonotic infection and treatment is mandatory to avoid complications. Surgery remains the frst choice in the treatment especially for CE2-CE3b cysts. Open or laparoscopic approaches are available. However, comparative studies are limited. Materials and Methods. Data of patients who underwent cystotomy/partial cystectomy for liver hydatidosis between January 2012 and September 2016 (n=77) were evaluated retrospectively. Recurrent cases and the patients with previous hepatobiliary surgery were excluded. 23 patients were operated upon laparoscopically and named as Group 1. 48 patients operated conventionally named as Group 2. Demographics, cyst characteristics, operative time, length of hospital stay, recurrences, and surgery related complications were evaluated. Results. Groups were similar in terms of demographics, cyst characteristics, and operative time. Te length of hospital stay was 3.4 days in Group 1 and 4.7 days in Group 2 (p=0,007). Te mean follow-up period was 17.8 months and 21.7 months, respectively (p=0.170). Overall complication rates were similar in two groups (p=0.764). Tree conversion cases occurred (13%). One mortality was seen in Group 2. Four recurrences occurred in each group (17% versus 8.3%, respectively) (p=0.258). Conclusions. Laparoscopy is a safe and feasible approach for surgical treatment of liver hydatidosis. Recurrence may be prevented by selection of appropriate cases in which exposure of cysts does not pose an intraoperative difculty

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Co-existence of acute appendicitis and inflammatory myofibroblastic tumor of the small intestine: A case report

2015-09-01, Unver, NURCAN, Coban, GANİME, ONARAN, Oyku Izel, ARSLAN, ADNAN, Malya, FATMA ÜMİT, HASBAHCECI, Mustafa, ÜNVER, NURCAN, ÇOBAN, GANİME, KUNDUZ, ENVER, ARSLAN, ADNAN, MALYA, FATMA ÜMİT

Introduction: Inflammatory myofibroblastic tumor as a rare neoplastic lesion is seen most commonly in the pulmonary system. Beside the presence of limited number of inflammatory myofibroblastic tumors of the gastrointestinal tract in the literature, co-existence with acute appendicitis has not been reported before. Presentation of case: A 27-year-old woman admitted to emergency department with acute abdominal pain at the right lower quadrant. The initial diagnosis was as acute appendicitis. Intraoperatively, a mass with a diameter of almost 5 cm originated from the distal ileal segments neighboring the appendix was seen. The patient was managed by segmental resection of the small intestine including the mass with appendectomy. Histologically, there were bundles of spindle cells accompanied by lymphoplasmocytic infiltration. The immunohistochemical studies showed that tumor cells were positive for smooth muscle actin, vimentin, perinuclear activity for anaplastic lymphoma kinase and CD 68. The final pathologic diagnosis was inflammatory myofibroblastic tumor. Discussion: Concomitant resection of tumoral lesions detected in the neighbor intestinal segments during appendectomy should be considered to diagnose and treat. For the diagnosis of inflammatory myofibroblastic tumor, immunohistochemistry pattern including positivity for actin, vimentin, CD 68 and anaplastic lymphoma kinase plays a crucial role. Therefore, detailed immunohistochemistry analysis should be performed in suspicious cases. Conclusion: Coexistence of inflammatory myofibroblastic tumor located in the gastrointestinal system with acute appendicitis is a rare event. Complete surgical excision should be regarded as the mainstay of the treatment. Long-term follow up with serial imaging techniques is recommended.