Person: BOLUKÇU, SİBEL
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Publication Open Access Analysis of infectious spondylodiscitis: 7-years data(2018-11-01) Koc, Meliha Meric; Okay, GÜLAY; Akkoyunlu, YASEMİN; Bolukcu, SİBEL; Durdu, BÜLENT; Hakyemez, Ismail Necati; OKAY, GÜLAY; AKKOYUNLU, YASEMİN; BOLUKÇU, SİBEL; DURDU, BÜLENT; HAKYEMEZ, İSMAİL NECATİ; MERİÇ KOÇ, MELİHAObjective: Infectious spondylodiscitis (SD) is an infectious disease that is rare and difficult to diagnose due to its non-specific clinical features. In this study, we aimed to describe the clinical and diagnostic features of infectious spondylodiscitis. Methods: All patients who were diagnosed with SD at our hospital during a 7-year period from January 1, 2011 through December 31, 2017 were included in the study. Spondylodiscitis is divided into the following three types: pyogenic, tuberculous, and brucellar. Clinical and laboratory data were collected retrospectively from the medical records of the patients. Results: Of the 118 patients, 66 (55.9%) were female, 81 (68.6%) had pyogenic SD (PSD), 21 (17.8%) had tuberculous SD (TSD), and 16 (13.6%) had brucellar SD (BSD). The mean age was 59.3 ± 14.6 years. Leucocytosis was significantly higher in patients with PSD (p=0.01) than in patients with other types of SD. Thoracic involvement (47.6%) was significantly higher in patients with TSD (p=0.005) than in other patients. Sacral involvement (12.5%) was significantly higher in patients with BSD (p=0.01) than in other patients. Paravertebral abscess formation (42.8%) occurred most frequently in patients with TSD. Microbiologic agents were defined in 50% (18/36) of the surgical specimens and in 12.5% of the fine needle aspiration biopsy (FNAB) specimens. Staphylococcus aureus was the most common microbiological agent in patients with PSD. Spinal surgery was defined as a risk factor for PSD (p = 0.0001). Binary logistic regression analysis revealed that female gender, thoracic involvement and night sweats were the predictive markers for TSD (OR 4.5 [95% CI 1.3-15.3] and OR 5 [95% CI 1.7-14.6]). Conclusion: PSD is the most frequent form of SD. Leucocytosis is most common in patients with PSD. Thoracic involvement and paraspinal abscess were prominent in patients with TSD. Sacral involvement was most common in patients with BSD. Thoracic involvement, female gender and night sweats were the predictive markers for TSD. The microbiological culture positivity rate was higher in surgical specimens compared to FNAB specimens. The need for surgical treatment was most common in patients with TSD.Publication Metadata only Red Cell Volume Distribution Width to Platelet Ratio is an Important Predictor of Liver Fibrosis and Cirrhosis in Chronic Hepatitis B(2016-08-01) Hakyemez, Ismail Necati; BOLUKÇU, SİBEL; Durdu, BÜLENT; ASLAN, Turan; HAKYEMEZ, İSMAİL NECATİ; BOLUKÇU, SİBEL; DURDU, BÜLENTObjective: In recent years, a lot of non-invasive tests have been examined for estimating the severity of liver fibrosis in patients with chronic hepatitis B (CHB). We aimed to evaluate the role of simple and valuable platelet-derived indices in estimating the stage of fibrosis and cirrhosis in patients with CHB.Publication Metadata only Solunum Yolu Enfeksiyonu Etkeni Olarak İzole Edilen Haemophilus influenzae ve Moraxella catarrhalis-in Mevsimlere Göre Dağılımı(2017-03-19) GÜLTEPE, BİLGE; DURDU, BÜLENT; CEYLAN, AYŞE NUR; BOLUKÇU, SİBEL; OKAY, GÜLAY; AKKOYUNLU, MUHAMMED EMİN; DOYMAZ, MEHMET ZİYA; SÜMBÜL, BİLGE; DURDU, BÜLENT; CEYLAN, AYŞE NUR; BOLUKÇU, SİBEL; AKKOYUNLU, MUHAMMED EMİN; DOYMAZ, MEHMET ZIYAPublication Metadata only Infective endocarditis case due to streptococcus parasanguinis presented with spondylodiscitis(2016-01-01) Hakyemez, Ismail Necati; Durdu, BÜLENT; Okay, GÜLAY; GULTEPE, Bilge; Bolukcu, SİBEL; ASLAN, Turan; HAKYEMEZ, İSMAİL NECATİ; DURDU, BÜLENT; OKAY, GÜLAY; BOLUKÇU, SİBEL; SÜMBÜL, BİLGEStreptococcus parasanguinis is a natural member of oral flora. It is an opportunistic pathogen, and rarely cause systemic infections due to it-s low virulence. Subacute infective endocarditis may present with various clinical manifestations (eg., spondylodiscitis). A sixty-five years old male patient from Northern Iraq has referred to our emergency service with high fever, weight loss, back pain and inability to walk. The patient was a veterinarian. He was operated three years ago for colonic carcinoma and irradiated. In magnetic resonance imaging, spondylodiscitis was detected localized in lumbar 1-2 region. Transthorasic echocardiography demonstrated aortic valve vegetation. S. parasanguinis was identified in the blood cultures. In conclusion; all in all, it-s remarkable to isolate S. parasanguinis as a causal agent of infective endocarditis in a patient who is a veterinarian with history of colonic carcinoma presented with clinical manifestation of spondylodiscitis.Publication Metadata only Evaluation of the Relationship Between ABO/Rh Blood Groups and Severity of Liver Fibrosis in Patients with Chronic Hepatitis B(2016-04-01) Hakyemez, Ismail Necati; Durdu, BÜLENT; BOLUKÇU, SİBEL; ASLAN, Turan; HAKYEMEZ, İSMAİL NECATİ; DURDU, BÜLENT; BOLUKÇU, SİBELObjective: Studies on the severity of fibrosis in chronic viral hepatitis are scarce and limited with only hepatitis C infection. The aim of this study was to determine the role of ABO-Rh blood groups in the severity of fibrosis and progression to cirrhosis in patients with chronic hepatitis B (CHB).Publication Metadata only Protez Eklem Enfeksiyonlarının Risk Faktörleri ve Etkenlerin Dağılımı Açısından İrdelenmesi: Bir Üniversite Hastanesi Verileri(2017-04-08) BOLUKÇU, SİBEL; Okay, GÜLAY; Durdu, BÜLENT; HAKYEMEZ, İSMAİL NECATİ; AKKOYUNLU, YASEMİN; ASLAN, TURAN; OKAY, GÜLAY; BOLUKÇU, SİBEL; DURDU, BÜLENT; HAKYEMEZ, İSMAİL NECATİ; AKKOYUNLU, YASEMİNPublication Metadata only Changes in HIV demographic patterns in a low prevalence population: no evidence of a shift towards men who have sex with men(2016-07-01) SARGIN, Fatma; YILDIZ, Dilek; AYDIN, Ozlem Altuntas; Mete, Bilgul; GUNDUZ, Alper; KARAOSMANOGLU, Hayat Kumbasar; Yemisen, Mucahit; YAZICI, Saadet; BOLUKÇU, SİBEL; Durdu, BÜLENT; SENATES, Ebubekir; Ozaras, Resat; DOKMETAS, Ilyas; Tabak, Fehmi; BOLUKÇU, SİBEL; DURDU, BÜLENTObjectives: This study aimed to examine the changes in HIV demographics over time in an exceptionally low prevalence population, with particular emphasis on men who have sex with men (MSM).Publication Open Access Investigation the Relationship Between Body Mass Index and Mortality in COVID-19 Patients(2021-02-01T00:00:00Z) BOLUKÇU, SİBEL; ÖZMEN, MEHMET EMİN; EKŞİ, ÇAĞLA; OKAY, GÜLAY; SÜMBÜL, BİLGE; KAÇMAZ, ASİYE BAHAR; DURDU, BÜLENT; AKKOYUNLU, YASEMİN; MERİÇ KOÇ, MELİHA; BOLUKÇU, SİBEL; ÖZMEN, MEHMET EMİN; EKŞİ, ÇAĞLA; OKAY, GÜLAY; SÜMBÜL, BİLGE; KAÇMAZ, ASİYE BAHAR; DURDU, BÜLENT; AKKOYUNLU, YASEMİN; MERİÇ KOÇ, MELİHAObjective: Obesity might be a risk factor for patients with Coronavirus disease-19 (COVID-19). We aimed to investigate the association of the obesity with intensive care need and mortality caused by severe acute respiratory syndrome-CoV-2 (SARS-CoV-2) infection in this retrospective cohort. Methods: Between March 11th and May 1st, 135 patients, who were treated in our clinic, were enrolled in the study. Body mass index (BMIs) of the patients were grouped according as WHO criteria (<25 kg/m(2): normal, 25 30 kg/m(2): overweight, >30 kg/m(2): obese). Results: Of our patients, 34.1% (n=46) were obese. Mean BM! of the mortality group was 31.2 kg/m(2) and was not different from that of the survivors (p=0.09), However, mean BMI of the patients, in whom intensive care was needed, teas 31.2 kg/m(2) and higher than that of those intensive care was nut needed (p=0.04). In subgroup analyses, obesity (BMI >31) kg/m(2)) was more common among mortality group versus survivors in males older than 60 years old (p=0.03). Conclusion: Obesity with associated disorders are negative prognostic factors for COVID-19 and should be tackled as the end of the pandemic is obscure.Publication Open Access Assessment of the 24th Week Success of Anti-Retroviral Therapy in the Action against HIV in Istanbul Database: Results from a Region with Increasing Incidence(2019-05-01) Bolukçu, Sibel; METE, BİLGÜL; Gündüz, Alper; Karaosmanoglu, Hayat Kumbasar; Sargın, Fatma; DURDU, BÜLENT; Aydin, Ozlem Altuntas; Yildiz, Dilek; DÖKMETAŞ, İLYAS; Asian, Turan; TABAK, ÖMER FEHMİ; BOLUKÇU, SİBEL; DURDU, BÜLENTWe aimed to assess the 24-week virological and immunological success of the treatment of treatment-naive and treatment-experienced patients included in the Action against HIV in Istanbul (ACTHIV-IST) database. The ACTHIV-IST database was screened retrospectively from January 2012 to January 2014. The data for these patients such as age, sex, treatment-naive or treatment-experienced status, date of diagnosis, date of commencing antiretroviral therapy, antiretroviral therapy regimen, CD4+ cell count, and viral load before and after therapy were analyzed. In the 24th week of antiretroviral therapy, there were 40 (17.9%) and 29 (14.1%) virological and immunological failures, respectively. Virological failure (VF) was associated with a baseline viral load > 100,000 copies (p = 0.004). A CD4+ cell count lower than 200 cells/µl was not found to be associated with VF (p = 0.843). Immunological failure was substantially rare in patients with a baseline CD4+ cell count > 200 cells/µl (p = 0.005). Although an HIV-RNA 侑 100,000 copies/ml was protective against VF in the 24th week, in individuals with an HIV-RNA > 100,000 copies/ml, VF was 3.2 times more likely to occur. Baseline VF was the most predictive parameter to estimate 24th week virological success and VF. VF is an important prognostic parameter resulting in CD4+ cell depletion, AIDS-related events, and increased mortality.Publication Metadata only A rare cause of liver abscess secondary to hydatid cyst: pseudomonas stutzeri(2016-01-01) Durdu, BÜLENT; Hakyemez, Ismail Necati; Bolukcu, SİBEL; Okay, GÜLAY; ASLAN, Turan; DURDU, BÜLENT; HAKYEMEZ, İSMAİL NECATİ; BOLUKÇU, SİBEL; OKAY, GÜLAYPseudomonas stutzeri is non-fermentative gram negative bacteria which rarely leads to infections. In this report, we presented for the first time a liver abscess which was caused by P.stutzeri.