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BÜYÜKPINARBAŞILI, NUR

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Now showing 1 - 10 of 25
  • PublicationMetadata only
    Unusual Histopathological Findings in Appendectomy Specimens: A Retrospective Analysis of 2047 Cases.
    (2019-04-01) UNVER, NURCAN; COBAN, GANİME; ARıCı, DİLEK SEMA; BUYUKPıNARBASıLı, NUR; Gucin, ZÜHAL; MALYA, FATMA ÜMİT; ONARAN, OI; TOPALAN, K; ÜNVER, NURCAN; ÇOBAN, GANİME; ARICI, DILEK SEMA; BÜYÜKPINARBAŞILI, NUR; GÜCİN, ZÜHAL; MALYA, FATMA ÜMİT
  • PublicationMetadata only
    p53 expression and relationship with MDM2 amplification in breast carcinomas
    (2016-04-01) Buyukpinarbasili, NUR; Gucin, ZÜHAL; Ersoy, YELİZ EMİNE; ILBAK, Ayca; Kadioglu, HÜSEYİN; Muslumanoglu, Mahmut; BÜYÜKPINARBAŞILI, NUR; GÜCİN, ZÜHAL; ERSOY, YELIZ EMINE; KADIOĞLU, HÜSEYİN
    Carcinoma of the breast, like other malignancies, is a genetic disease with multiple genetic events leading to the malignant phenotype. p53 mutations are the most common genetic events in human cancer. Inactivation of p53 can be a result of mutation in gene sequence. One of the main structures that regulate p53 stabilization is MDM2. It suppresses p53 transcriptional activation by recognizing transactivation domain of p53. The loss of MDM2 function on p53 regulation results in deprivation of p53 tumor suppressor ability. Single nucleotide polymorphisms (SNP309 T->G exchange) or MDM2 amplification has been proposed to play a role in this issue. In the present study, our aim is to analyze p53 and MDM2 status and investigate their interactions in human sporadic breast carcinoma. The study groups were separated according to their molecular classifications. In each group, histologic type of the tumor, conventional prognostic parameters, p53, and MDM2 interactions were compared statistically. Tumors are divided into 4 subtypes due to estrogen and progesterone receptor status, HER-2, and Ki-67 proliferation index results. According to this classification, 23 cases are in the luminal A, 32 cases are in the luminal B, 15 cases are in the HER-2 positive, and 22 cases are in the triple-negative group, with a total of 92 cases. p53 expression is low in luminal breast carcinomas than HER-2 and triple-negative subtypes. MDM2 amplification frequency was found to be 5.4% in total. MDM2 gene amplification does not have a significant role in breast carcinogenesis, but other possible mechanisms may play a role in its inactivation. (C) 2016 Elsevier Inc. All rights reserved.
  • PublicationMetadata only
    Does Every Necrotizing Granulomatous Inflammation Identified by NSCLC Resection Material Require Treatment?
    (2016-04-01T00:00:00Z) Yakar, Fatih; Yakar, Aysun; BÜYÜKPINARBAŞILI, NUR; Erelel, Mustafa; BÜYÜKPINARBAŞILI, NUR
    Background: Lung cancer and tuberculosis (TB) are two major public health problems. They can coexist or appear sequentially. In patients with TB, lung cancer risk is increased. However, vice versa is not crystal clear. In this study, we aimed to determine the development of TB in patients with resectabled non-small cell lung cancer (NSCLC) in a 2-year postoperative follow-up period.
  • PublicationMetadata only
    Clinical Significance of Intraoperative Frozen Section Analysis of Pancreatic Cancer Surgical Margin at the Time of Pancreaticoduodenectomy.
    (2015-09-01) BENDER, O; BOZKURT, SÜLEYMAN; BUYUKPINARBASILI, NUR; Malya, FATMA ÜMİT; BATTAL, M; KARATEPE, O; BOZKURT, SÜLEYMAN; BÜYÜKPINARBAŞILI, NUR; MALYA, FATMA ÜMİT
  • PublicationMetadata only
    Pneumatized septal turbinate
    (2014-06-01) Yenigun, ALPER; Ozturan, ORHAN; Buyukpinarbasili, NUR; YENİGÜN, ALPER; ÖZTURAN, ORHAN; BÜYÜKPINARBAŞILI, NUR
    Intumenscentia septi nasi anterior is an anatomical variation in the nasal cavity, first described by Morgagni in 1662; septal turbinate and tuberculum septi nasi anterior are among the various other names attributed to this anatomical structure. It is an expandable vascular network which develops from the septal mucosa. Computed tomography, following history-taking and physical examination, is a valuable tool in diagnosing turbinate pneumatisation. This paper reports the case of a 23-year-old female with nasal stuffiness as her primary complaint, who was found to have pneumatization of the septum mimicking the septal concha. Pneumatization of the septal turbinate may also be a cause of septal enlargement. The symptomatology, diagnosis and treatment options for cases of septal turbinate are discussed. The surgical interventions performed in the presented case are briefly described. The presented patient had a pneumatization of the septal turbinate, like those of the conchae. It is reported for the first time in medical literature, and the histological and functional similarities of the septal turbinate and of the nasal conchae are pointed out. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
  • PublicationMetadata only
    Crucial Roles of Systemic and Tissue Lipid Peroxidation Levels and Anti-Oxidant Defences Following Contrast Agent Application
    (2016-06-01T00:00:00Z) Sitar, Gungor; Kucuk, Mehmet; Sitar, Mustafa Erinc; Yasar, Ozgur; AYDIN, Seval; YANAR, Karolin; ÇAKATAY, Ufuk; BÜYÜKPINARBAŞILI, NUR; BÜYÜKPINARBAŞILI, NUR
    Background: One of the most important side effects of contrast pharmaceutical agents, which are used very common in routine radiology practice, is contrast induced nephropathy. Even ischemia, oxidative stress and osmolality related cytotoxic effects are considered, the molecular mechanisms underlying this pathology have not been identified completely yet.
  • PublicationMetadata only
    Bir Üniversitenin Girişimsel Olmayan Araştırmalar Etik Kuruluna Yapılan Başvurularda Eksiklikler ve Sıklıkla Yapılan Hatalar
    (2019-08-01) Meral, İsmail; Aştı, Türkinaz; Soysal, Ömer; Yıldırım, Nuran; Özçelik, Semra; Aydın, Teoman; Akbaş, Fahri; Temel, Binnur; Özder, Aclan; Büyükpınarbaşılı, Nur; Dönmez, Nazmiye; Alkaya, Mustafa Fırat; MERAL, İSMAİL; AŞTI, TÜRKINAZ; SOYSAL, ÖMER; YILDIRIM, NURAN; ÖZÇELİK, SEMRA; AYDIN, TEOMAN; AKBAŞ, FAHRİ; TEMEL, BİNNUR; ÖZDER, ACLAN; BÜYÜKPINARBAŞILI, NUR; DÖNMEZ, NAZMİYE
    Girişimsel olmayan araştırmalarda, ilgili etik kurulun onayını almadan çalışmalara başlamak mümkün değildir. Dünya Sağlık Örgütü-nün kurallarına göre, gerekli tüm belgeleri içeren başvuru dosyası ilgili Etik Kurula eksiksiz sunulmalıdır. Araştırmacıların başvuru dosyasındaki belgeleri eksiksiz tamamlamadaki isteksizliği, Etik Kurulların çalışma sürecini yavaşlatmakta ve hatta Etik Kurul ile araştırmacılar arasında tartışmaya bile neden olabilmektedir. Bu nedenle bu çalışma, bir üniversitenin Girişimsel Olmayan Araştırmalar Etik Kuruluna gönderilen proje başvuru dosyalarındaki eksiklikleri ve en çok yapılan hataları göstermek ve araştırmacılar için bir rehber oluşturmak amacıyla yapıldı. 24 Mart 2016 ve 30 Haziran 2018 tarihleri arasında Girişimsel Olmayan Araştırmalar Etik Kurula gönderilen başvuru dosyaları ve kararları ilgili etik kurulun veri tabanından analiz edildi. Başvuru dosyalarının revizyonuna neden olan en önemli gerekçeler, projenin amacının ilgili referanslar eşliğinde yeterince açıklanamaması ve özellikle iyi yazılamamış yöntem kısmı gibi başvuru formundaki eksikliklerdi. Araştırmacıları proje başvuru dosyası hazırlarken en çok yapılan hatalar hakkında eğitmek, Üniversite Etik Kurullarının gözden geçirme sürecinin verimliliğini ve hızını artıracaktır.
  • PublicationMetadata only
    Triple-negative breast cancer presented with metastasis to the heart as first sign of recurrence
    (2020-10-01T00:00:00Z) Bayramgil, Ayberk; Bilici, Ahmet; Hamdard, Jamshid; Acikgoz, Ozgur; Seker, Mehmet; Kilicaslan, Fethi; KÖKSAL, CENGİZ; BÜYÜKPINARBAŞILI, NUR; Mammadov, Elkhan; Goktas Aydin, Sabin; Olmez, Omer Fatih; Yildiz, Ozcan; KÖKSAL, CENGİZ; BÜYÜKPINARBAŞILI, NUR
  • PublicationMetadata only
    Schwannoma of the Servical Vagus with Intrathoracic Extension
    (2015-06-01) TUGRUL, Selahattin; SENTURK, EROL; Ozturan, ORHAN; KOK, ABDÜLAZİZ; Buyukpinarbasili, NUR; ŞENTÜRK, EROL; ÖZTURAN, ORHAN; KÖK, ABDÜLAZİZ; BÜYÜKPINARBAŞILI, NUR
    Schwannomas are the rare benign tumors of the neck. Patients developing from the brachial plexus and cervical truncus and extending to the posterior mediastinum have been reported, but for the first time the following case report describes the extension of a vagal origin schwannoma from the anterior and middle mediastinum and its extraction with thoracotomy without sternotomy.
  • PublicationMetadata only
    The Association Between Paranasal Mucous Retention Cysts and Allergic Sensitization
    (2021-01-01T00:00:00Z) USTABAŞ KAHRAMAN, Feyza; YAZICI, MEBRURE; BÜYÜKPINARBAŞILI, NUR; Soylu, Nihal; İŞCAN, AKIN; ÖZKAYA, EMİN; USTABAŞ KAHRAMAN, FEYZA; YAZICI, MEBRURE; BÜYÜKPINARBAŞILI, NUR; İŞCAN, AKIN; ÖZKAYA, EMİN
    Objective: Although there is no consensus regarding the etiology of paranasal mucous retention cysts (MRCs) in the literature, several studies suggest an allergic etiology. This study aimed to investigate a potential association between paranasal MRCs diagnosed with MRI scans and allergic sensitization in the pediatric population.