Person: GÜNEREN, ETHEM
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Publication Metadata only IS USE OF LIQUID SILICONE INJECTION APPROPRIATE METHOD FOR OPEN ROOF DEFORMITY WHICH OCCURS AFTER RHINOPLASTY?(2012-01-01T00:00:00Z) Yogun, Nilay Fatma; GÜNEREN, Ethem; GÜNEREN, ETHEMPublication Open Access Generation of Bone Tissue Using Adipose Tissue-derived Stem Cells(2021-07-01T00:00:00Z) Baygol, Emre Gonenc; GÜNEREN, Ethem; Karaaltin, Mehmet Veli; Canter, Halil Ibrahim; Ozturk, Kahraman; Ovali, Ercument; Ozpur, Mustafa Aykut; YILDIZ, KEMALETTİN; Eyuboglu, Fatma; GÜNEREN, ETHEM; YILDIZ, KEMALETTİNObjective: Bone grafts and even bone substitutes do not meet all of the requirements of bony reconstructions. The aim of this study was to generate bone tissue from autologous adipose tissue-derived mesenchymal stem cells (ATDMSCs) and decellularised bone allografts. Methods: A 1.5 cm bone defect developed in the middle third of the rabbit's ulna. Reconstructions were carried out using miniplate and screws and interpositional autogenous bone grafts according to the designs of the groups: (1) No touch, (2) cryopreserved, (3) decellularised and (4) ATDMSCs-implanted decellularised bones. Before implantation, ATDMSCs in the last group were labelled with Q-dot and identified microscopically. Results: Graft recovery and irregular callus formation were observed in the first, second and forth groups. In the first group, the organisation of Haversian systems, the structure of the lacunae and the presence of canaliculi ossiums were observed; in the second group, approximately 40% of the Haversian canals contained blood vessels, and canaliculi ossiums in the form of thin filaments were found in 90% of the microscopically examined areas; in the third group, most Haversian canals were empty, most osteocyte canals were devoid of cells, and canaliculi ossiums were absent; in the fourth group, some of the Haversian canals contained blood vessels, and there were partly lacunae containing cells due to decellularisation, whereas in approximately 50% of the examined microscope areas, the presence of canaliculi ossiums with evidence of mesenchymal stem cells differentiated into osteocytes was demonstrated by Q-dot traced cells. Conclusion: In this study, the establishment of a proper niche environment for adipose-derived mesenchymal cells promotes their development into osteogenic cells.Publication Metadata only Problematic Patient(2021-06-01T00:00:00Z) KIRPINAR, İSMET; Ayhan, M. Suhan; GÜNEREN, Ethem; KIRPINAR, İSMET; GÜNEREN, ETHEMThe group of patients defined as -problematic patient- in aesthetic plastic surgical practice has distinctive features. The -problematic patient- is the patient who blocks the establishment of a therapeutic relationship with him/her. In other words, the patient who does not adapt to the patient role that the health-care professional expects, has different values, beliefs, or personal characteristics than he/she expects to see, and sometimes causes the professional to even suspect himself/herself. They are not good candidates for esthetic surgery, and they should definitely not be operated, so to speak, these patients should be removed from the game by removing a red card, and somehow be disqualified from the process.Publication Metadata only Simplifying Free Nipple Graft Mammoplasty in Postmenopausal Obese Patients using Inferior Dermaglandular Flap(2021-06-01T00:00:00Z) Kelahmetoglu, Osman; ÇAMLI, MEHMET FATİH; ÜNAL, Mustafa; Yagmur, Caglayan; Firinciogullari, Remzi; GÜNEREN, Ethem; ÇAMLI, MEHMET FATİH; ÜNAL, MUSTAFA; GÜNEREN, ETHEMBreast hypertrophy causes medical problems ranging from back and neck pain to dermatitis creating a demand for breast reduction surgery along with aesthetic and psychological reasons. Free-nipple-graft breast reduction surgery is a safeguard procedure for patients who are at risk for nipple necrosis with pedicled techniques but has a disadvantage of resultant flat breasts with poor projection. Study included twenty-three postmenopausal women who underwent breast reduction with inferior pedicled dermaglandular flap and free-nipple-grafting, between September 2015 and January 2020. A rectangular 8 x 10 cm inferior-pedicled dermaglandular flap was dissected and anchored to the thoracic wall for better projection and upper pole fullness. All patients had at least one comorbidity. Visual analog scale was evaluated at 1-3 months. Mean age of the patients was 54.08 SD 4.65 years, and mean body mass index (BMI) was 33.56 SD 2.53. Mean follow-up period was 10.56 SD 5.6 months. Mean SN-N distance was 37.45 SD 3.77 and 38.86 SD 3.91 cm for right and left breasts, respectively. Mean resection weight was 1373 SD 440 g. Wound dehiscence was seen in 3 patients (13.0%) and treated medically. No other complications, including total nipple areolar complex (NAC) loss, were seen. Mean visual analog scale score for patient satisfaction was 7.7. All patients were satisfied with their final breast shapes. Utilizing inferior dermaglandular pedicled flap technique with free-nipple-graft breast reduction mammaplasty provides better nipple projection and a more aesthetically pleasing breast shape and contour. It helps achieve an effortless preoperative planning and a straightforward procedure with high patient satisfaction in postmenopausal obese women.Publication Metadata only A novel autologous dermal filler based on cultured fibroblasts and plasma gel for facial wrinkles: Long term results(2022-01-01T00:00:00Z) Oram, Yasemin; Akkaya, A. Deniz; GÜNEREN, Ethem; Turgut, Gursel; GÜNEREN, ETHEMAutologous cultured fibroblasts combined with plasma gel (Fibrogel(TM)) can be used as an injectable autologous soft tissue filler. Herein, we report the assessment of the long-term clinical efficacy and safety of Fibrogel for facial wrinkles. Ten healthy adults were treated for facial wrinkles with Fibrogel, an innovative autologous filler. Patients underwent three treatment sessions at 1-month intervals for the correction of infraorbital, nasolabial, and marionette folds. In each session, 6-8 mL of Fibrogel filler containing 4 million fibroblasts/mL, was injected into the deep dermis or subdermal plane. Three evaluators independently assessed the efficacy at 3, 6 and 12 months after the last treatment, using the validated Global Esthetic Improvement Scale at two different times in a blinded manner. Infraorbital area and lower face were evaluated separately. All patients showed immediate improvement after the first injection at the infraorbital area and lower face. Follow-ups at 3, 6 and 12 months revealed that the improvement was persistent. Adverse reactions were mild and the treatment was well tolerated. Delivering autologous cultured fibroblasts embedded in an autologous plasma gel (Fibrogel) to the skin can provide immediate volume effect and long-term improvement. Therefore, Fibrogel can be considered as a promising novel autologous filler.Publication Metadata only LOWER EXTREMITY RECONSTRUCTION WITH BIPEDICULATED FREE DEEP INFERIOR EPIGASTRIC ARTERY PERFORATOR (DIEP) FLAP: A CASE REPORT(2011-09-01T00:00:00Z) Yogun, Nilay Fatma; Karaaltin, Mehmet Veli; GÜNEREN, Ethem; GÜNEREN, ETHEMHigher quality, fast, safe and permanent repair results can be observed with lower extremity reconstruction with free tissue transfer. Nevertheless the partial or total loss of flap is a serious problem due to the vascular problems of free tissue transfer.Publication Metadata only Free ALT Perforator Flap in Nonobese Patients: The Recontouring of Soft Tissue Defects Around Foot(2021-09-01T00:00:00Z) Kelahmetoglu, Osman; MEHDIZADE, TURAN; ÜNAL, Mustafa; Keles, Musa Kemal; GÜNEREN, Ethem; MEHDIZADE, TURAN; ÜNAL, MUSTAFA; GÜNEREN, ETHEMBackground The anterolateral thigh (ALT) perforator flap is well-described and versatile option for reconstruction of soft tissue defects around foot and ankle. This retrospective review was performed for reconstruction of soft tissue defects around foot with ALT perforator flaps in patients with normal and overweight body mass index (BMI). Methods Between January 2016 and November 2020, ALT flaps were used in 30 patients for foot defects. Results Etiologic factors were trauma (18 patients), diabetic foot ulcer (6 patients), tumor (3 patients), infection (2 patients) and burn contracture (1 patient). Mean body mass index (BMI) value was 24.9 +/- 4.1 (17-30). Mean flap dimension was 145 +/- 86 (40-420) cm(2). Recipient vessels were anterior tibial artery in 17 patients (56%), posterior tibial artery in 12 patients (40%), reversed flow dorsalis pedis artery in 1 patient (3.3%). In 24 patients (80%), 2 vein anastomoses were done. Debulking were applied in two patients (6.6%). Donor area was grafted in four patients (13.3%). Mean flap score was 1.25 +/- 0.5. Mean flap thickness was 10 +/- 2 (7-14) mm. Visual Analogue Scale (VAS) score was 7.75 +/- 1.04 (6-10). The patients were followed up for a mean of 14 +/- 11 (1-30) months. Conclusion We think that ALT flap is still reliable and precious option because it provides ideal soft tissue reconstruction by means of recontouring of foot in nonobese patients.Publication Open Access Menopause Does Not Reduce Hematoma Risk After Reduction Mammoplasty Surgery: A Retrospective Analysis(2020-10-01T00:00:00Z) Kelahmetoglu, Osman; Yagmur, Caglayan; Firinciogullari, Remzi; Akman, Onur; GÜNEREN, Ethem; KELAHMETOĞLU, OSMAN; AKMAN, ONUR; GÜNEREN, ETHEMObjective: Hematoma is one of the early complications of breast reduction surgery. According to our literature review, this concomitance was not discussed in detail. The aim of this study is to show the relationship of postoperative hematoma with menopausal status in reduction mammoplasty patients. Methods: This study included 153 patients who underwent breast reduction surgery from 2014 to 2018, and had no comorbid disease and were questioned for menopause retrospectively. The patients were divided into two groups: Group 1 comprised premenopausal women, and Group 2 comprised postmenopausal women. Results: The mean age of the patients in Group 1 and Group 2 was 33.26 +/- 7.58 years and 52.96 +/- 4.34 years, respectively (p=0.00). The mean of total resected tissue weights in Groups 1 and 2 were 2.104 +/- 1.201 grammes and 2.492 +/- 1.098 grammes, respectively (p=0.119). Hematomas were seen in six (4.8%) patients in Group 1, and no hematoma was seen in Group 2 (p=0.593). Conclusion: Our findings showed that menopause does not reduce the risk for hematoma, but we recommend further clinical studies.Publication Metadata only Contribution of the Use of a Pen-Type Endoscope to Evaluate and Treat Ears Simultaneously During Cleft Palate Surgery in Late Presented Cases(2019-06-01T00:00:00Z) GÜNEREN, Ethem; Ture, Nurullah; Karabekmez, Furkan Erol; Zahir, Khalique; GÜNEREN, ETHEMBackground: The prevalence of secretory otitis media is very high among the nonoperated cleft palate patients.Publication Open Access The use of segmental bone resection to assist in a tension-free cleft palate repair(2022-04-01T00:00:00Z) GÜNEREN, Ethem; GÜNEREN, ETHEMThe traditional two-flap palatoplasty technique described by Veau-Wardill-Kilner is a two-flap palatoplasty suggests a posterior pushback movement of flaps should require an intact pedicle. Even a proper dissection of greater palatine vessels is done, some sort of tension burdens on the flaps due to the traction of the pedicle is inevitable. In addition to that, the right-angled flexion of the pedicle at the posteromedial bony corner of foramina palatinum majus diminishes blood flow. Particularly, in wide clefts, tight approximation of flap compromises the wound healing and resulting fistulas. A segmental bone resection from posteromedial wall of foramen palatinum majus as an outfracturing fashion is performed to assist a tension-free cleft palate repair. The more release of the pedicle from its hole loosens the flaps. It provides an easy posteromedial transposition of tissues. This maintains also most push-back movement of flaps.