Browsing by Author "SONMEZ, Fatih"

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Synthesis, anticholinesterase activity and molecular modeling studies of novel carvacrol-substituted amide derivatives

Kurt, BELMA; Durdagi, Serdar; Celebi, Gulsen; Salmas, Ramin Ekhteiari; SONMEZ, Fatih (2019-04-19)

In the present study, 23 novel carvacrol derivatives involving the amide moiety as a linker between the alkyl chains and/or the heterocycle nucleus were synthesized and tested in vitro as acetylcholinesterase (AChE) and ...
Synthesis, biological activity and multiscale molecular modeling studies of bis-coumarins as selective carbonic anhydrase IX and XII inhibitors with effective cytotoxicity against hepatocellular carcinoma

Kurt, BELMA; Dag, AYDAN; Dogan, Berna; Angeli, Andrea; Durdagi, Serdar; Nocentini, Alessio; Supuran, Claudiu T.; SONMEZ, Fatih (2019-06-01)

A series of novel bis-coumarin derivatives containing triazole moiety as a linker between the alkyl chains was synthesized and their inhibitory activity against the human carbonic anhydrase (hCA) isoforms I, II, IX and XII ...