Browsing by Author "Nocentini, Alessio"

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Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment

Nocentini, Alessio; Supuran, Claudiu T.; Carta, Fabrizio; Winum, Jean-Yves; Dedhar, Shoukat; Donald, William A.; Carradori, Simone; Monti, Simona Maria; De Simone, Giuseppina; Capasso, Clemente; Eldehna, Wagdy M.; Onnis, Valentina; AKDEMİR, ATİLLA; Zalubovskis, Raivis; Angeli, Andrea (2020-10-01)

The tumor microenvironment is crucial for the growth of cancer cells, triggering particular biochemical and physiological changes, which frequently influence the outcome of anticancer therapies. The biochemical rationale ...
Synthesis, biological activity and multiscale molecular modeling studies of bis-coumarins as selective carbonic anhydrase IX and XII inhibitors with effective cytotoxicity against hepatocellular carcinoma

Durdagi, Serdar; Supuran, Claudiu T.; Nocentini, Alessio; Dogan, Berna; Angeli, Andrea; Kurt, BELMA; Dag, AYDAN; SONMEZ, Fatih (2019-06-01)

A series of novel bis-coumarin derivatives containing triazole moiety as a linker between the alkyl chains was synthesized and their inhibitory activity against the human carbonic anhydrase (hCA) isoforms I, II, IX and XII ...