Browsing by Author "Angeli, A"

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Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold.

De, Filippis; Rotondi, G; Guglielmi, P; De, Monte; Carradori, S; Secci, D; Supuran, CT; Maccallini, C; Akdemir, ATİLLA; Amoroso, R; Cirilli, R; Angeli, A (2019-12-01)

A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, ...
Development of Thiazolidinones as Fungal Carbonic Anhydrase Inhibitors.

Güzel-Akdemir, Ö; Carradori, S; Grande, R; Demir-Yazıcı, K; Akdemir, ATİLLA; Angeli, A; Supuran, CT (2020-04-22)

In our efforts to find new and selective thiazolidinone-based anti-Candida agents, we synthesized and tested 26 thiazolidinones against several Candida spp. and Gram-positive and Gram-negative bacteria. The compounds ...
Novel Indole-Based Hydrazones as Potent Inhibitors of the α-class Carbonic Anhydrase from Pathogenic Bacterium <i>Vibrio cholerae</i>.

Demir-Yazıcı, K; Güzel-Akdemir, Ö; Angeli, A; Supuran, Ct; Akdemir, Atilla (2020-04-29)

Due to the increasing resistance of currently used antimicrobial drugs, there is an urgent problem for the treatment of cholera disease, selective inhibition of the α-class carbonic anhydrases (CA, EC 4.2.1.1) from the ...