TR Dizin İndeksli Yayınlar Koleksiyonu

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https://hdl.handle.net/20.500.12645/29770

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Open Access
A CADASIL Case Presenting with Progressive Bulbar Palsy Caused by Acute Simultaneous Multiple Subcortical Infarcts
(2019-04-01T00:00:00Z) GÖKÇAL, ELİF; KOLUKISA, MEHMET; Mustafayev, Nihat; ASİL, Talip; GÖKÇAL, ELİF; KOLUKISA, MEHMET; ASİL, TALIP
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an adult-onset inherited small vessel disease of the brain caused by NOTCH3 mutations. Clinical characteristics of CADASIL include recurrent infarctions, migraine with aura, mood disturbances and cognitive impairment. We report a 35 year-old migraine-free patient with unusual presentation with acute simultaneous multiple subcortical infarctions causing progressive bulbar palsy as the initial manifestation. Hepresented with slurred speech progressing to anarthria and bilateral palsy of lower motor cranial nerves within 24 hour. Initial acute subcortical infarcts enlarged and new infarcts developed in bilateral hemispheres. There was diffuse leukoencephalopathy involving temporal horns and the patient had positive familiy history of migraine and young stroke. CADASIL was diagnosed genetically when NOTCH3 mutationwas shown. The patient improved after treatment with liquid hydration and antiplatelet agent. We experienced with the patient that CADASIL may present with unusual progressive manifestations and bilateral simultaneous infarctions. Irrespective of clinical presentation, patients with leukoencephalopathy and positive familiy history should be tested for NOTCH3 mutation.
Open Access
A Case of Primary Hypoparathyroidism Presenting with Acute Kidney Injury Secondary to Rhabdomyolysis.
(2016-01-01) SUMNU, A; AYDIN, Z; GURSU, MELTEM; UZUN, S; KARADAG, S; CEBECI, E; OZTURK, S; Kazancioglu, RÜMEYZA; GÜRSU, MELTEM; KAZANCIOĞLU, RÜMEYZA
Symmetric calcification of the basal ganglia identified radiographically occurs in a variety of familial and nonfamilial conditions. Primary Familial Brain Calcifications (PFBC), which were known by many names previously, including Fahr disease and striopallidodentate calcinosis, are a genetic disease characterized by various mutations in four separate genes and autosomal dominant inheritance [1–4]. PFBC may present with various psychiatric and neurological symptoms [5]. On the other hand, many secondary causes, either infectious, toxic, or metabolic, have been described to cause symmetrical basal ganglion calcifications and so are in the differential diagnosis of PFBC [6]. Parathyroid diseases such as hypoparathyroidism, pseudohypoparathyroidism, and pseudo-pseudohypoparathyroidism are in the forefront among the metabolic causes. Idiopathic or postsurgical hypoparathyroidism is the most common cause of symmetric calcification of the basal ganglia [7–9]. Herein, a case of primary hypoparathyroidism with severe tetany, rhabdomyolysis, and acute kidney injury (AKI) is presented.
Open Access
A Case Report of Tongue Edema due to Laryngeal Mask with Introducer
(1.10.2018) Daskaya, Hayrettin; Ciftci, Taner; Idin, Kadir; Gul, Kursat; Topuz, Ufuk; Olculu, Hakki
Airway management using a laryngeal mask is an especially preferred noninvasive technique because of its achievement of hemodynamic stability and ease of application in surgeries that have short surgery time and do not require specific positions such as the prone position. Although it is easily performed, serious complications may manifest rarely because of lack of experience and inappropriate choice of instrumentation. In this case report, clinical management and treatment options of tongue edema that developed because of the forgotten introducer in laryngeal mask application are presented.
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A clinical variant in SCN1A inherited from a mosaic father cosegregates with a novel variant to cause Dravet syndrome in a consanguineous family
(2015-07-01) Tuncer, FN; Altıokka uzun , G; Gormez, Z; Calik , M; Yuksel, B; Sagiroglu, MS; Iscan, AKIN; Yuceturk , B; Ugur Iseri, SA; Bebek, N; Baykan, B; Ozbek , U; İŞCAN, AKIN
A consanguineous family from Turkey having two children with intellectual disability exhibiting myoclonic, febrile and other generalized seizures was recruited to identify the genetic origin of these phenotypes. A combined approach of SNP genotyping and exome sequencing was employed both to screen genes associated with Dravet syndrome and to detect homozygous variants. Analysis of exome data was extended further to identify compound heterozygosity. Herein, we report identification of two paternally inherited genetic variants in SCN1A (rs121917918; p.R101Q and p.I1576T), one of which was previously implicated in Dravet syndrome. Interestingly, the previously reported clinical variant (rs121917918; p.R101Q) displayed mosaicisnn in the blood and saliva of the father. The study supported the genetic diagnosis of affected children as Dravet syndrome possibly due to the combined effect of one clinically associated (rs121917918; p.R101Q) and one novel (p.I1576T) variants in SCN1A gene. This finding is important given that heterozygous variants may be overlooked in standard exome scans of consanguineous families. Thus, we are presenting an interesting example, where the inheritance of the condition may be misinterpreted as recessive and identical by descent due to consanguinity and mosaicism in one of the parents. (C) 2015 Elsevier B.V. All rights reserved.
Unknown
A clinically unsuspected nasopharyngeal sarcoidosis.
(2016-05-01) TUGRUL, SELHATTİN; GOKTAS, SS; OZUCER, B; SÖNMEZ, FATMA CAVİDE; Özturan, ORHAN; TUĞRUL, SELAHATTİN; SÖNMEZ, FATMA CAVİDE; ÖZTURAN, ORHAN
Unknown
A Clinico-Pathological Study of Transvaginal Endometrial ThicknessMeasurement in Asymptomatic Postmenopausal Patients and Patientswith Postmenopausal Bleeding
(2019-05-01T00:00:00Z) GÖKMEN KARASU, AYŞE FİLİZ; ATEŞ, SEDA; gürbüz, tuğba; ŞAHİN, NURHAN; takmaz, taha; GÖKMEN KARASU, AYŞE FİLİZ; ATEŞ, SEDA; ŞAHİN, NURHAN
Unknown
A comparison of extracorporeal shock wave therapy, physiotherapy, and local steroid injection in treatment of lateral epicondylitis
(2016-03-01T00:00:00Z) AKKURT, SONER; Yilmaz, Ahmet; SAKA, TOLGA; SAKA, TOLGA
Objectives: This study aims to compare the efficacy of extracorporeal shock wave therapy (ESWT), physiotherapy, and local steroid injection in the treatment of lateral epicondylitis.
Open Access
A Comparison of Pregabalin and Ketamine in Acute Pain Management After Laparoscopic Cholecystectomy
(2017-10-01T00:00:00Z) Haliloglu, Murat; BİLGİLİ, BELİZ; ÜLGEN ZENGİN, SENİYYE; Ozdemir, Mehtap; Yildirim, Ahmet; Bakan, Nurten; ÜLGEN ZENGİN, SENİYYE
Objective: Pregabalin and ketamine are popular analgesic adjuvants for improving perioperative pain management. We designated this double-blind, placebo controlled study to test and compare the preventive effects of pregabalin and ketamine on postoperative pain management after elective laparoscopic cholecystectomy.
Open Access
A comparison of the prevalence of orthostatic hypotension between older patients with Alzheimer-s Disease, Lewy body dementia, and without dementia.
(2019-09-01) Soysal, PINAR; Aydin, AE; Isik, AT; Smith, L; Kocyigit, SE; SOYSAL, PINAR
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A High-Performance Liquid Chromatographic Method for the Determination of Meropenem in Serum.
(2019-11-18T00:00:00Z) Dincel, D; Sagirli, O; Topcu, GÜLAÇTI
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Open Access
A minimally invasive transfer method of mesenchymal stem cells to the intact periodontal ligament of rat teeth: a preliminary study
(2018-01-01) GÜL AMUK, NİSA; KURT, GÖKMEN; YANDIM KARTAL, MELIS; ADAN, AYSUN; BARAN, YUSUF; KURT, GÖKMEN
The aim of this study was to introduce a minimally invasive procedure for mesenchymal stem cell (MSC) transfer into the intact periodontal ligament (PDL) of the molar teeth in rats. Ten 12-week-old Wistar albino rats were used for this preliminary study. MSCs were obtained from bones of two animals and were labeled with green fluorescent protein (GFP). Four animals were randomly selected for MSC injection, while 4 animals served as a control group. Samples were prepared for histological analysis, Cox-2 mRNA expression polymerase chain reaction analysis, and fluorescent microscopy evaluation. The number of total cells, number of osteoclastic cells, and Cox-2 mRNA expression levels of the periodontal tissue of teeth were calculated. The number of total cells was increased with MSC injections in PDL significantly (P < 0.001). The number of osteoclastic cells and Cox-2 mRNA expression were found to be similar for the two groups. GFP-labeled MSCs were observed with an expected luminescence on the smear samples of the PDL with transferred MSCs. The results of this preliminary study demonstrate successful evidence of transferring MSCs to intact PDL in a nonsurgical way and offer a minimally invasive procedure for transfer of MSCs to periodontal tissues.
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A multicenter experience of thrombotic microangiopathies in Turkey: The Turkish Hematology Research and Education Group (ThREG)-TMA01 study
(1.02.2018) Tekgunduz, Emre; Yilmaz, Mehmet; Erkurt, Mehmet Ali; Kiki, Ilhami; Kaya, Ali Hakan; Kaynar, Leylagul; Alacacioglu, Inci; Cetin, Guven; Ozarslan, Ibrahim; Kuku, Irfan; Sincan, Gulden; Salim, Ozan; Namdaroglu, Sinem; Karakus, Abdullah; Karakus, Volkan; Altuntas, Fevzi; Sari, Ismail; Ozet, Gulsum; Aydogdu, Ismet; Okan, Vahap; Kaya, Emin; Yildirim, Rahsan; Yildizhan, Esra; Ozgur, Gokhan; Ozcebe, Osman Ilhami; Payzin, Bahriye; Akpinar, Seval; Demirkan, Fatih
Thrombotic microangiopathies (TMAs) are rare, but life-threatening disorders characterized by microangiopathic hemolytic anemia and thrombocytopenia (MAHAT) associated with multiorgan dysfunction as a result of microvascular thrombosis and tissue ischemia. The differentiation of the etiology is of utmost importance as the pathophysiological basis will dictate the choice of appropriate treatment. We retrospectively evaluated 154 (99 females and 55 males) patients who received therapeutic plasma exchange (TPE) due to a presumptive diagnosis of TMA, who had serum ADAMTSI3 activity/antiADAMTS13 antibody analysis at the time of hospital admission. The median age of the study cohort was 36 (14-84). 67 (43.5%), 32 (20.8%), 27 (17.5%) and 28 (18.2%) patients were diagnosed as thrombotic thrombocytopenic purpura (TTP), infection/complement-associated hemolytic uremic syndrome (IA/CAHUS), secondary TMA and TMA-not otherwise specified (TMA-NOS), respectively. Patients received a median of 18 (1-75) plasma volume exchanges for 14 (153) days. 81 (52.6%) patients received concomitant steroid therapy with TPE. Treatment responses could be evaluated in 137 patients. 90 patients (65.7%) achieved clinical remission following TPE, while 47 (34.3%) patients had non-responsive disease. 25 (18.2%) non-responsive patients died during follow-up. Our study present real-life data on the distribution and follow-up of patients with TMAs who were referred to therapeutic apheresis centers for the application of TPE. (C) 2018 Elsevier Ltd. All rights reserved.
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A new alien species record for the flora of Turkey: Proboscidea louisianica (Miller) Thell.
(2017-10-01) SEVGİ, ECE; KIZILARSLAN HANÇER, ÇAĞLA; Yılmaz, Hatice; Akkaya, Muhammed; SEVGİ, ECE; KIZILARSLAN HANÇER, ÇAĞLA
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A NOVEL HERBAL EXTRACT MEDICINE FOR LIVER HEMOSTASIS: AN EXPERIMENTAL ANIMAL STUDY
(1.07.2019) Kunduz, Enver; Dincel, Zeyneb Afra; Seker, Busra; Saylak, Hatice Kubra; Demir, Okan; Akbulut, Huseyin; Aysan, Erhan
Objective: Bleeding is one of the major complications of surgical procedures. Severe bleeding can be seen after liver injury. Various methods have been described in the literature for stopping liver bleeding such as compression, Pringle maneuver, and other hemostatic agents have been used. In this study, the use of anti-inflammatory, antioxidant, antimicrobial, analgesic, and anticoagulant agents described in the literature were evaluated for hemostatic efficacy following liver injuries. Materials and Methods: In this study 28 Wistar albino female / male rats from out-bred production were used. Animals were divided in 4 groups. After liver damage model creation, various herbal substances were applied to the liver. Hematocrit and platelet counts were measured. In addition, for histopathologic changes in the liver parenchyma, the rats were sacrificed, and the liver was resected. Results: The amount of bleeding (p: 0.001) and the preoperative and postoperative hematocrit changes (p: 0.009) were statistically significant between the groups. There was no significant difference in connective tissue growth (p: 0.065) and necrosis (p: 0.062). There were significant differences in inflammation and without karyorrhexis (p: 0.003). Discussion: Histopathological examinations showed that the groups using active agents had more connective tissue and karyorrhexis. Therefore these tissues could help to stop bleeding.
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A NOVEL HERBAL EXTRACT MEDICINE FOR LIVER HEMOSTASIS:AN EXPERIMENTAL ANIMAL STUDY
(2019-03-01) KUNDUZ, ENVER; DİNCEL, Zeyneb Afra; ŞEKER, Büşra; SAYLAK, HATİCE KÜBRA; DEMİR, Okan; Akbulut, HÜSEYİN; Ayşan, MUSTAFA ERHAN; KUNDUZ, ENVER; AKBULUT, HÜSEYİN; AYŞAN, MUSTAFA ERHAN
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A novel platelet concentrate for guided bone regeneration: Titanium prepared platelet-rich fibrin (T-PRF)
(2015-01-01T00:00:00Z) Tunali, MUSTAFA; Özdemir, Hakan; Küçükodaci, Zafer; EZİRGANLI, Şeref; Bariş, Emre; Akman, Serhan; ATAY, Arzu; Firatli, Erhan; TUNALI, MUSTAFA
Open Access
A Pathological Process Should be Carefully Conducted in the Breast: Mucocele-Like Lesion
(2018-04-01) Gucin, ZÜHAL; GÜCİN, ZÜHAL
Mucoccic-like lesion (MLL) of the breast has been firstly described as a benign lesion resembling mucinous carcinoma of the breast. Subsequently, it has also been reported to be associated with ductal hyperplasia or breast carcinoma. The risk of cancer development in the long term is unknown. Therefore, the approach to pure MLL of the breast detected during percutaneous biopsy is controversial. In this report, a mucocele-like breast lesion in a 47-year-old woman was first noticed during a core biopsy and later detected to be associated with ductal carcinoma in-situ focuses in excisional biopsy material is presented. The aim of this paper was to provide an overview of this rare and controversial lesion and its variabilities with regard of the presented case.
Open Access
A Possible Correlation Among Different Disease Activity Parameters and Functional Status in Patients with Ankylosing Spondylitis
(2013-01-01T00:00:00Z) Demir, Saliha Eroglu; Aytekin, Ebru; Ozgonenel, Levent; REZVANİ, AYLİN; Dogan, Yasemin Pekin; Caglar, Nil Sayiner; Ozaras, Nihal; Okur, Sibel Caglar; AYDIN, Teoman; Tutun, Sule; Guler, Mustafa; REZVANİ, AYLİN; AYDIN, TEOMAN
Objectives: The primary aim of this study was to assess the possible relationship among the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Bath Ankylosing Spondylitis Functional Index (BASFI), and two Ankylosing Spondylitis Disease Activity Score (ASDAS) including the C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) scores in patients with ankylosing spondylitis (AS). The secondary aim was to investigate gender differences in terms of disease activity scores and functional status.
Open Access
A Radiographic Comparison of the Root Length and Area After Class II Treatment with Two Different Functional Appliances
(1.10.2020) Seker, Elif Dilara; Yagci, Ahmet; Kurt Demirsoy, Kevser; Yuzuak, Ela Nur
Objective: The purpose of this study was to compare the changes in root lengths and root surface areas that occur after treatment with two functional appliances the Twin Block (TWB) and Crown Herbst appliances. Methods: Forty patients (12 boys, 28 girls) were included in this study. Half of them were treated with the stainless steel Crown Herbst appliance (with crowns placed on the first molars and the first and second premolars), and the other half were treated with the TWB appliance. Panoramic and cephalometric films were obtained before treatment (T1) and after the functional treatment (T2). All upper and lower teeth except second and third molars were analysed with the ImageJ software (version 1.37, National Institutes of Health, Bethesda) on panoramic films. Root length and area values were compared using t-tests. Results: The intragroup comparison showed that root length values were significantly decreased in right and left mandibular incisors and canines in the Crown Herbst group (12 years 7 months +/- 9 months). However, significantly increased root length was observed in right and left maxillary second premolars and right maxillary first premolar in the TWB group (11 years 1 month +/- 4 months). The intergroup comparison indicated that root length values were significantly decreased in right maxillary premolars, right and left mandibular laterals and left mandibular canine in the Crown Herbst group when compared with those in the TWB group. Conclusion: It was concluded that the Crown Herbst group showed a greater tendency for decreased root length than the TWB group. In orthopaedic correction of Class II malocclusions, in the absence of any contraindications, TWB appliance may be preferred for the promotion of root development.
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A randomized controlled study of vitamin D in the treatment of primary dysmenorrhea Primer dismenore tedavisinde vitamin D ile randomize kontrollü bir çalisma
(2019-01-01) Özel, Ayşegül; ATEŞ, SEDA; ŞEVKET, OSMAN; Özdemır, Mucize; Ilhan, Gülsah; Davutoğlu, Ebru; ATEŞ, SEDA; ŞEVKET, OSMAN

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