Eczacılık Fakültesi
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- PublicationOpen AccessA Comparative Study on Magnetostructural Properties of Barium Hexaferrite Powders Prepared by Polyethylene Glycol(2014-01-01) Durmus, ZEHRANanocrystalline particles of barium hexaferrite were synthesized by a sol-gel combustion route using nitrate-citrate gels prepared from metal nitrates and citric acid solutions with Fe/Ba molar ratio 12. The present paper aims to study the effect of addition of polyethylene glycol (PEG) solutions with different molecular weights (MW: 400, 2000, and 10.000 g/mol) on magnetostructural properties of barium hexaferrite. The formation of the barium hexaferrite was inspected using X-ray diffraction (XRD) analysis, Fourier transform infrared (FT-IR) analysis, thermogravimetric (TGA) analysis, scanning electron microscopy (SEM) analysis and vibrating sample magnetometer (VSM) analysis for magnetic measurements.
- PublicationMetadata onlyA detailed study on the chemical and biological profiles of essential oil and methanol extract of Thymus nummularius (Anzer tea): Rosmarinic acid(2015-05-01) Ertas, Abdulselam; Boga, Mehmet; Yilmaz, Mustafa Abdullah; Yesil, Yeter; Tel, Gulsen; Temel, Hamdi; Hasimi, Nesrin; Gazioglu, IŞIL; Ozturk, Mehmet; Ugurlu, Pelin; GAZİOĞLU, IŞILThe aim of this study was to determine the chemical profile of Thymus nummularius by LC-MS/MS and GC/MS. Additionally, the methanol extract, essential oil and some individual main compounds of Thymus nummularius were tested for antioxidant, anticholinesterase and antimicrobial activities. Besides, HPLC-FLD was used to determine total aflatoxin in the plant material. Among the twenty-seven compounds studied by LC-MS/MS, rosmarinic acid (131,898.9 +/- 6463.0 mu g/g dry-extract) was found to be the most abundant compound in the methanol extract. On the other hand, thymol (60.38%) and terpinyl-acetate (10.49%) were found to be the major compounds of the essential oil. Both the essential oil and the methanol extract of T. nummularius exhibited strong antioxidant activity in the four tested methods. Furthermore, the essential oil showed high inhibitory activity against acetyl-,butyryl-cholinesterase enzymes and very strong antimicrobial activity against all tested microorganisms. Besides, T. nummularius can be used both as rosmarinic acid source and as food supplement due to its non-aflatoxin content and high antioxidant, anticholinesterase and antimicrobial activities. (C) 2015 Elsevier B.V. All rights reserved.
- PublicationMetadata onlyA Divalent PAMAM-Based Matrix Metalloproteinase/Carbonic Anhydrase Inhibitor for the Treatment of Dry Eye Syndrome.(2016-01-26) RICHICHI, B; BALDONESCHI, V; BURGALASSI, S; FRAGAI, M; VULLO, D; Akdemir, ATİLLA; DRAGONI, E; LOUKA, A; MAMUSA, M; MONTI, D; BERTI, D; NOVELLINO, E; De, Rosa; SUPURAN, CT; NATIVI, C; AKDEMİR, ATİLLA
- PublicationMetadata onlyA multifunctional multimaterial system for on-demand protein release(2018-08-28) Tuncaboylu, DENİZ CEYLAN; FRIESS, Fabian; WISCHKE, Christian; LENDLEIN, Andreas; TUNCABOYLU, DENIZ CEYLANIn order to provide best control of the regeneration process for each individual patient, the release of protein drugs administered during surgery may need to be timely adapted and/or delayed according to the progress of healing/regeneration. This study aims to establish a multifunctional implant system for a local on-demand release, which is applicable for various types of proteins. It was hypothesized that a tubular multimaterial container kit, which hosts the protein of interest as a solution or gel formulation, would enable on-demand release if equipped with the capacity of diameter reduction upon external stimulation. Using devices from poly(epsilon-caprolactone) networks, it could be demonstrated that a shape-memory effect activated by heat or NIR light enabled on-demand tube shrinkage. The decrease of diameter of these shape-memory tubes (SMT) allowed expelling the payload as demonstrated for several proteins including SDF-1 alpha, a therapeutically relevant chemotactic protein, to achieve e.g. continuous release with a triggered add-on dosing (open tube) or an on-demand onset of bolus or sustained release (sealed tube). Considering the clinical relevance of protein factors in (stem) cell attraction to lesions and the progress in monitoring biomarkers in body fluids, such on-demand release systems may be further explored e.g. in heart, nerve, or bone regeneration in the future.
- PublicationMetadata onlyA new alien species record for the flora of Turkey: Proboscidea louisianica (Miller) Thell.(2017-10-01) SEVGİ, ECE; KIZILARSLAN HANÇER, ÇAĞLA; Yılmaz, Hatice; Akkaya, Muhammed; SEVGİ, ECE; KIZILARSLAN HANÇER, ÇAĞLA
- PublicationMetadata onlyA new dinuclear copper (II) complex of 2,5– Furandicarboxyclic acid with 4(5)-Methylimidazole as a high potential ?-glucosidase inhibitor: Synthesis, Crystal structure, Cytotoxicity study, and TD/DFT calculations(2019-01-01) Sönmez, Fatih; Basoglu, Adil; Altürk, Sümeyye; Avcı, Davut; Tamer, Ömer; Öztürk, Dilek; Dege, Necmi; Zengin Kurt, Belma; Atalay, Yusuf; ZENGİN KURT, BELMA; ÖZTÜRK CİVELEK, DİLEK
- PublicationMetadata onlyA novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms.(2016-03-01) CERUSO, M; SECCI, D; De, Monte; MOLLICA, A; SOBOLEV, AP; Akdemir, ATİLLA; SUPURAN, CT; GUGLIELMI, P; De, Cosmi; CODISPOTI, R; CARRADORI, S; AKDEMİR, ATİLLA
- PublicationMetadata onlyA novel series of M(II) complexes of 6-methylpyridine-2-carboxylic acid with 4(5)methylimidazole: Synthesis, crystal structures, α-glucosidase activity, density functional theory calculations and molecular docking(2019-07-01) Avcı, Davut; Altürk, Sümeyye; Sönmez, Fatih; Tamer, Ömer; Başoğlu, Adil; Atalay, Yusuf; Zengin Kurt, Belma; Dege, Necmi; ZENGİN KURT, BELMA
- PublicationMetadata onlyA novel series of mixed-ligand M(II) complexes containing 2,2′-bipyridyl as potent α-glucosidase inhibitor: synthesis, crystal structure, DFT calculations, and molecular docking(2019-08-01) Avcı, Davut; Altürk, Sümeyye; Sönmez, Fatih; Tamer, Ömer; Başoğlu, Adil; Atalay, Yusuf; Zengin Kurt, Belma; Dege, Necmi; ZENGİN KURT, BELMA
- PublicationMetadata onlyA potential therapeutic role in multiple sclerosis for stigmast-5,22-dien-3β-ol myristate isolated from Capparis ovata(2017-07-01) ACAR, Özden Özgür; GAZİOĞLU, IŞIL; KOLAK, UFUK; ŞEN, ALAATTİN; TOPÇU, GÜLAÇTI; GAZİOĞLU, IŞIL; TOPÇU, GÜLAÇTI
- PublicationOpen AccessA Realistic View on -The Essential Medicinal Chemistry of Curcumin-(2017-09-01) Bahadori, FATEMEH; DEMIRAY, Mutlu; BAHADORİ, FATEMEHThe review paper entitled “The Essential Medicinal Chemistry of Curcumin”, published in the Journal of Medicinal Chemistry, by Nelson et al.1 is a well-designed paper, presenting a new (and negative) approach to the well-known biologically active compound; curcumin. Although some arguments throughout this paper are completely true, the approach of the authors is unfortunately far from impartial, and many of the conclusions the authors draw from some of their referred papers are especially hard to accept. On page 1621, line 11, the authors mention that the in vivo stability of curcumin is T1/2 < 5 min and F < 1% by referring to the research papers of Wang et al.2 and Yang et al.3 (refs 27 and 28 of the original paper). Interestingly, neither Wang nor Yang et al. directly report these values as the half-life of curcumin, which makes this a very biased supposition of the authors. The paper, published by Wang et al., reports the stability of curcumin in buffer solvents at laboratory conditions and in rat blood circulation. Since it is impossible to directly dissolve curcumin in water, curcumin was dissolved in methanol and then diluted with a buffer, and the amount of curcumin was measured in HPLC at different intervals. It is obvious that curcumin will start precipitating upon dilution with a buffer. Thus, it is doubtful that the sample injected in HPLC or administered to rats includes the supposed amount of curcumin. Yang et al. also do not report the half-life of curcumin below 5 min. This paper reports the elimination period as 28.1 ± 5.6 and 44.5 ± 7.5 min for 500 mg/kg, p.o. and 10 mg/kg, i.v. of curcumin, respectively. It is noteworthy that the half-life results are reported by the studies made in rats, not human studies. A rat weighing 400 g has a total blood volume of approximately 25.6 mL,4 and the human blood volume is approximately 5.5 L. The half-life measurements of the compound during blood circulation were made without considering the insolubility of curcumin in buffer solutions or the stability measurements in rat blood circulation and therefore do not accurately illustrate the fate of curcumin upon circulation within human blood. More interestingly, the authors acknowledge that the half-life of curcumin with pH 7.4 and 37 °C in human blood is 360−480 min in Supplemental Table 2 of ref 1. However, they report its stability as T1/2 < 5 min on page 1621, left column line 11.
- PublicationMetadata onlyA Review of Current Methods for the Determination of Acrylamide in Food Products(2012-02-01) Tekkeli, Serife Evrim Kepekci; Onal, Cem; Onal, Armagan; TEKKELİ, ŞERİFE EVRİMAcrylamide (AA) is a potentially carcinogenic substance which is formed during heating of food products containing carbohydrates and asparagine. It was first detected in food products in 2002. Since that time, several analytical methods have been made available for the quantification of AA in various foods. Starting from the announcement in 2002, occurrence, formation, chemistry, toxicology, and potential health risk in the human diet have been investigated and methods of analysis have been reviewed in many articles. In this paper, current information and analytical methods for the determination of AA have been reviewed.
- PublicationMetadata onlyA Study On Synthesis, Biological Activities and Molecular Modelling of Some Novel Trisubstituted 1,2,4-Triazole Derivatives(2018-08-23) Gultekin, Ergun; KOLCUOĞLU, YAKUP; Akdemir, ATİLLA; Sirin, Yakup; Bektas, Hakan; BEKİRCAN, OLCAY; AKDEMİR, ATİLLAIn this study, 1-(4-substitued benzyl)-3,5-diphenyl-1H-1,2,4-triazoles (2 a-e) and ethyl(3,5-diphenyl-/H-1,2,4-triazole-1-yl) acetate (3) were synthesized starting from 3,5-diphenyl-/H1,2,4-triazole (1). The ethyl acetate derivative (3) was converted to 2-(3,5-diphenyl-1H-1,2,4-triazole-1-yl)acetohydrazide (4) in ethanolic medium with hydrazine hydrate. The reaction of the acetohydrazide (4) with suitable isothiocyanates generate 2-[(3, 5-diphenyl-1H-1,2,4-triazole-1-yl)acetyl]-4-methyl/phenyh-Ithiosemicarbazide (5a,b). The cyclization of the thiosemicarbazide (5a,b) in the presence of NaOH (2 M) resulted in the formation of 5-[(3,5-diphenyl-1H-1,2,4-triazole-1-yl)methyl]-4methyl/phenyl-2,4-dihidro-3H-1,2,4-triazole-3-thiol (6a,b). Finally, the synthesized 1,2,4-triazole-3-thiols (6a,b) were converted to their 5-substituebenzyl derivatives (7 a-j). All of the synthesized compounds (1-7) were also examined for antioxidant capacities, and antiurease and anti-acetylcholinesterase (anti-AChE) activities. It has been found that antioxidant capacity and anti-urease activity of the compound 7f is very good in biochemically active compounds.
- PublicationMetadata onlyAchieving the balance: Biphasic effects of genistein on PC-3 cells(2019-06-01) TERZİOĞLU, ŞULE; Goncu, Beyza; Ozten Kandas, NUR; TERZİOĞLU, ŞULE; ÖZTEN KANDAŞ, NUR
- PublicationMetadata onlyAdaçayı Yaprağı, Çok Gövdeli(2018-10-01) TOPÇU, GÜLAÇTI; TAN, NUR; GÜRDAL, BAHAR; TUFAN, SELİN; ERUÇAR, FATMA MEMNUNE; ALAN, ZINAR; AKALIN, EMİNE; TOPÇU, GÜLAÇTI
- PublicationMetadata onlyAdaçayı Yaprağı, Kara Şalba(2018-10-01) Tan, Nur; Yazıcı Tütüniş, Seçil; Yeşil, Yeter; Ekinci, Miraç; Topçu, Gülaçtı; ALİM TORAMAN, GÜLBAHAR ÖZGE; TOPÇU, GÜLAÇTI
- PublicationMetadata onlyAflatoxins in various food from Istanbul, Turkey(2013-12-01) Hacibekiroglu, IŞIL; Kolak, U.; GAZİOĞLU, IŞILThe present work reports the total aflatoxin and aflatoxin B1 levels in 62 food samples from Istanbul, Turkey. The total aflatoxin content in dried American cucumber, squash, tomato, okra and saffron samples was found to be 1.7g/kg. AFB1 levels in five dried vegetables (red bell pepper, American cucumber, squash, tomato and okra), two tea (linden and jasmine flower) and three spice samples (cardamom, galangal and saffron) were 1g/kg. Of the tested samples, 76% exceeded legal limits of total aflatoxin. The highest levels were determined in chestnut (232.9g/kg), nutmeg (206.1g/kg) and sumac (182.5g/kg). These findings confirm the existing knowledge that food should be regularly and effectively controlled.
- PublicationMetadata onlyAlaçam Dağları Karaçam Ormanlarının Epifit Likenleri (Balıkesir - Kütahya)(2011-10-01) COBANOGLU, GULSAH; SEVGİ, ECE; SEVGI, ORHAN; TECIMEN, HUSEYIN BARIS; YILMAZ, OSMAN YALÇIN; Açıkgöz, Birkan; SEVGİ, ECE
- PublicationMetadata onlyAlaçam Dağları Karaçam Ormanlarının Liken ölü örtü pH-sının İrdelenmesi(2011-09-01) SEVGI, ORHAN; TECIMEN, HUSEYIN BARIS; COBANOGLU, GULSAH; SEVGİ, ECE; YILMAZ, OSMAN YALÇIN; SEVGİ, ECE
- PublicationMetadata onlyAlbumin-polymer conjugate nanoparticles and their interactions with prostate cancer cells in 2D and 3D culture: comparison between PMMA and PCL(2016-01-01) JIANG, Yanyan; Lu, Hongxu; Dag, AYDAN; HART-SMITH, Gene; STENZEL, Martina H.; DAĞ, AYDANUsing proteins as the hydrophilic moiety can dramatically improve the biodegradability and biocompatibility of self-assembled amphiphilic nanoparticles in the field of nanomedicine. In this study, we fabricated and evaluated curcumin loaded albumin-polycaprolactone nanoparticles as a novel drug delivery system for prostate carcinoma therapeutics and compared their performance to poly(methyl methacrylate) (PMMA), a non-degradable and amorphous polymer. The maleimide functionalized poly(epsilon-caprolactone) (PCL) was obtain using ring opening polymerization (ROP) of epsilon-caprolactone where N-(2-hydroxyethyl) maleimide was used as an initiator. The resorbable albumin-polymer conjugate was prepared by conjugating the hydrophobic maleimide-terminated PCL to the hydrophilic bovine serum albumin (BSA) via a simple Michael addition reaction. PMMA was conjugated in a similar manner. The amphiphilic BSA-polymer conjugates can self-assemble into nanoparticles, displaying well-defined structure, prolonged storage stability, and excellent biocompatibility. The BSA nanoparticles, with encapsulated curcumin, exhibited highly enhanced antitumor activity compared to free curcumin. Furthermore, the high efficacy of the curcumin loaded nanoparticles was verified by effectively inhibiting the growth of three-dimensional LNCaP multicellular tumour spheroids. The cytotoxicity was attributed to the efficient cellular uptake of the nanoparticles through caveolic endocytosis. The direct comparison between PCL and the PMMA revealed that drug loading and release as well as cytotoxicity is not significantly affected by the nature of the polymer. However, it seems that nanoparticles based on PMMA penetrate quicker into LNCaP multicellular tumour spheroids thanks to the increased stability. The faster penetration was found to reduce the toxicity of the nanoparticles as evidenced by the lower number of dead cells. In contrast, the fully degradable PCL-based nanoparticles were more efficient in delivering the drug, thus limiting the growth of LNCaP multicellular tumour spheroids.