Yayınlar - Eserler
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12645/130
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Browsing Yayınlar - Eserler by Type "Meeting Abstract"
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Publication 16-kDa Prolactin Promotes Cardiac Ischemia/Reperfusion Injury(22.10.2013) Yamac, Aylin HaticeThe recent discovery that anti-angiogenic, pro-apoptotic and pro-inflammatory N-terminal 16-kDa prolactin subform (16-kDa Prl) is generated under enhanced oxidative stress and yielding adverse cardiac effects, prompted us to investigate the potential role of prolactin and its cleaved 16-kDa form in myocardial ischemia/reperfusion (I/R) injury. In the current study we demonstrate that enhanced levels of serum prolactin (Prl) and cathepsin D (CD) activity in patients with acute myocardial infarction (AMI) were associated with the generation of N-terminal 16-kDa subform. In a murine model of myocardial I/R with previous LAD (left anterior descending artery) ligation for 50 minutes, blockage of endogenous Prl release by the dopamine D2 receptor agonist bromocriptine limited infarct size 24 hours post-reperfusion and preserved left ventricular (LV) function after 14 days of reperfusion. Additionally, we demonstrate that after blockage of endogenous Prl release, the subsequent application of a recombinant mutant, prolactin isoform, which is not cleaved into the 16-kDa subform, significantly limited the extent of cardiac injury compared to the well-cleaved corresponding wildtype prolactin isoform 24 hours post-reperfusion. I/R injury-induced up-regulation of pro-inflammatory mediators (e.g. TNF-α, CCL-2, CXCL2) and extravasation of inflammatory infiltrates were significantly reduced in bromocriptine treated mice than untreated controls. The bromocriptine induced cardiac protection was mainly addicted to inhibition of 16-kDa Prl formation, as myocardium treated with the mutant prolactin isoform displayed substantially less inflammatory cell infiltration and cytokine expression than myocardium treated with the wildtype prolactin isoform. In addition, we discovered that recombinant 16-kDa Prl markedly induced the expression of proinflammatory cytokines via activation of NF-κB signalling in neonatal rat cardiomyocytes.Publication A Clinical, Genomic and Proteomic Approach for the Characterization of Fanconi Anemia in Adolescent and Young Adult (AYA) Patients : A Single Center Study of 55 Patients from a National Bone Marrow Failure Referral Center(1.12.2018) Hussain, Taimoor; Alaiya, Ayodele; Dasouki, Majed; Alzahrani, Hazzaa; Al-Sabbagh, Afnan; Al Ammari, Raghad; Ghabashi, Emad; Demirkaya, Abdullah Faruk; Alawwami, Moheeb; Chaudhri, Naeem A.; Alsharif, Fahad Z.; Rasheed, Walid; Hanbali, Amr Suleiman; Shaheen, Marwan; Al Fraih, Feras; Elfakih, Riad; Hashmi, Shahrukh; Alhayli, Saud; Ahmed, Shad; Mannan, Abdul; Saleh, Mostafa; Abdrabou, Ahmed; Alsaadi, Husam; Bin Salman, Ahmed; Alfadhil, Haroon; Hassanein, Mona; Al Sagheir, Ahmed; Morris, Tom; Alhuraiji, Ahmad; Fahad, Almohareb; Aljurf, Mahmoud; Ahmed, Syed OsmanObjective: Bleeding is one of the major complications of surgical procedures. Severe bleeding can be seen after liver injury. Various methods have been described in the literature for stopping liver bleeding such as compression, Pringle maneuver, and other hemostatic agents have been used. In this study, the use of anti-inflammatory, antioxidant, antimicrobial, analgesic, and anticoagulant agents described in the literature were evaluated for hemostatic efficacy following liver injuries. Materials and Methods: In this study 28 Wistar albino female / male rats from out-bred production were used. Animals were divided in 4 groups. After liver damage model creation, various herbal substances were applied to the liver. Hematocrit and platelet counts were measured. In addition, for histopathologic changes in the liver parenchyma, the rats were sacrificed, and the liver was resected. Results: The amount of bleeding (p: 0.001) and the preoperative and postoperative hematocrit changes (p: 0.009) were statistically significant between the groups. There was no significant difference in connective tissue growth (p: 0.065) and necrosis (p: 0.062). There were significant differences in inflammation and without karyorrhexis (p: 0.003). Discussion: Histopathological examinations showed that the groups using active agents had more connective tissue and karyorrhexis. Therefore these tissues could help to stop bleeding.Publication A Multicenter Experience of Thrombotic Microangiopathies in Turkey: The Turkish Hematology Research and Education Group (ThREG)-TMA01 Study(1.12.2016) Tekgunduz, Emre; Yilmaz, Mehmet; Erkurt, Mehmet Ali; Kiki, Ilhami; Kaya, Ali Hakan; Kaynar, Leylagul; Alacacioglu, Inci; Cetin, Guven; Ozarslan, Ibrahim; Kuku, Irfan; Sincan, Gulden; Salim, Ozan; Namdaroglu, Sinem; Karakus, Abdullah; Karakus, Volkan; Pamuk, Gulsum Emel; Altuntas, Fevzi; Sari, Hakan Ismail; Ozet, Gulsum; Aydogdu, Ismet; Okan, Vahap; Kaya, Emin; Yildirim, Rahsan; Yildizhan, Esra; Ozgur, Gokhan; Ozcebe, Osman Ilhami; Payzin, Bahriye; Akpinar, Seval; Demirkan, FatihIn this study, we propose a novel cooling dehumidifying strategy, in which a condensing panel can be hydronically connected in series with the radiant cooling system to overcome condensation risk and improve indoor thermal comfort level. Based on the concept, the sensible heat-load is primarily covered by radiant cooling panels and some amount of latent heat and sensible heat can be treated by the condensing panel, while improving indoor thermal comfort level. Since, the surface temperature of the condensing panel is lower than the dew point temperature, while the radiant surface is higher for same supply water temperatures - condensation occurs only over the condensing plate. This paper evaluates the thermal comfort performance of the proposed novel condensing panel. For these aim, a new experimental chamber was developed. General thermal comfort level and the temperature, relative humidity ratio distribution in the tested room were evaluated for 10 different experimental cases. Multiple tests were conducted by varying surface temperature of the condensing panel and initial relative humidity ratios of air in the room. The results show that proposed simple solution can improve thermal comfort level, for the places where the latent heat loads are not considerable high, and reduce the condensation risk over the radiant cooling panels.Publication A New Echocardiographic Parameter of Arterial Stiffness in End-Stage Renal Disease(01.10.2013) Sahin, Musa; Simsek, Hakki; Akyol, Aytac; Akdag, Serkan; Yaman, Mehmet; Inan, Bekir; Aydin, Cemalettin; Kul, Seref; Soyoral, Yasemin; Gumrukcuoglu, Hasan AliPublication A novel candidate therapeutic target for diabetic nephropathy: Gas6(01.06.2011) Erek, A.; Ozakpinar, O.; Karaca, Z.; Uras, F.; Uras, A. R.Gastrointestinal stromal tumors (GISTs) are rare in the childhood period. The authors reported a case who was admitted to the neonatal intensive care unit (NICU) on a suspicion of intestinal obstruction. She was operated and a mass in a size of 6 xx 4.5 xx 4 cm was resected from the ileum. Histologic and immunohistochemical studies showed a GIST. CD34, small muscle actin (SMA), and desmin were positive. The baby was discharged on the 13th day after operation.Publication A Novel Indicator for Assessment of Mitral Regurgitation Severity: Pro-Adrenomedullin(21.10.2013) Turker, Yasin; Aslantas, Yusuf; Turker, Yasemin; Ucgun, Taner; Akkaya, Mehmet; Erkan, Melih EnginPublication A Possible Relation Between Survivin Gene Polymorphism and Acromegaly(2.06.2014) Ilhan, Muzaffer; Turan, Saime; Turgut, Seda; Korkmaz, Gurbet; Ozkan, Nazli Ezgi; Karaman, Ozcan; Yaylim, Ilhan; Tasan, Ertugrul