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Publication Metadata only 1. Cationic Streroid Antibiotics (CSA) Against Pseudomonas aeruginosa biofilms on soft contact lenses(2023-07-09) Yılmaz F. N.; Döşler S.; Hacıoğlu M.; Bozkurt Güzel Ç.; Hacıosmanoğlu E.; HACIOSMANOĞLU, EBRUPublication Metadata only 14 Yıllık Huntington Hastalığı Genetik Tanı Sonuçlarının Değerlendirilmesi(2014-11-24) KÖMÜRCÜ BAYRAK E.; PODA M.; GÜVEN Z. G.; GEYİK F.; ÇOBAN N.; GÜLEÇ Ç.; ABACI N.; AKBAŞ F.; ÖZBEK U.; ÜNALTUNA N.; AKBAŞ, FAHRİPublication Metadata only 2-10 Aylık Bebeği Olan Annelerde Bebek-Taşıyıcısının Annenin Ağrısıyla İlişkisi(2022-09-24) Pehlivan S.; Tanrıverdi M.; Uygur Şahin T.; TANRIVERDİ, MÜBERRA; UYGUR ŞAHİN, TÜRKANPublication Metadata only 2. Effects of Quorum sensing molecules Combinations with Antimicrobial Agents on Candida albicans and Pseudomonas aeruginosa Single and Dual-species Biofilms co-culture on bronchial epithelial cells(2023-09-08) Hacıosmanoğlu E.; Yetke H. İ.; Yılmaz F. N.; Hacıoğlu M.; HACIOSMANOĞLU, EBRU; YETKE, HANDE İPEKPublication Metadata only 22q11.2 duplikasyon sendromu: Hipokalseminin/hipoparatiroidinin nadir bir nedeni mi?(2024-05-04) Cesur Y.Publication Metadata only 65-80 Yaş Arası ve 80 Yaş Üzeri Hasta Gruplarında Akut Böbrek Hasarı Gelişimi İçin Risk Faktörleri ve Böbrek Sağkalımı Üzerine Etki Eden Faktörler(2023-12-06) Guliyeva L.; Hüseyinov N.; Engin Ö. E.; Sağlam Ş. S.; Avşar Ataberk E.; Elçioğlu Ö. C.; Kazancıoğlu R.; Gürsu M.; ELÇİOĞLU, ÖMER CELAL; KAZANCIOĞLU, RÜMEYZA; GÜRSU, MELTEMAmaç: 65 yaş ve üzeri hastalarda akut böbrek hasarı (ABH) risk faktörlerini belirlemek, hastalığın seyrine etki eden faktörleri ve sonlanımın belirleyicilerini tespit etmeyi amaçladık. Gereç-Yöntem: Çalışmamıza 65 yaş ve üzeri olup ABH nedeniyle yatan veya yatış sürecinde ABH gelişen hastalar dahil edilmiştir. ABH neden(ler)i, yatış neden(ler)i, komorbid hastalıklar, kullanılan ilaçlar, takip süresi, sonlanım durumu kaydedilmiş, sonlanıma etki eden faktörler analiz edilmiştir. Bulgular: Hastaların klinik ve laboratuvar verileri Tablo-1’de sunulmuştur. Hastaların 100’ünde evre-2, 53’ünde evre-3 ve 43’ünde evre-1 ABH tespit edilmiştir. Ortalama 13.7±12.0 gün takip sonunda sonlanım durumu tablo 2’de, sağkalım eğrileri şekilde sunulmuştur. 65-80 yaş arası grupta sepsis mevcudiyetinin (p<0.001), ABH evresinin ilerlemesinin (p<0.001) ve malignitenin (p=0.023) ölüm riskini arttırdığı; zeminde KBH olan (p=0.021), beta bloker kullanan ve nonoligürik hastalarda (p<0.001) mortalitenin daha düşük olduğu belirlendi. 80 yaş üzeri grupta mortalitenin dihidropiridin grubu KKB kullanan hastalarda daha düşük (p=0.033); RAAS blokeri (p=0.031) veya beta bloker (p=0.006) kullananlarda daha yüksek olduğu görüldü. Cox regresyon analizinde iyileşme olmaması (diyaliz bağımlı böbrek yetersizliği veya ölüm) için başlıca risk faktörlerinin 65-80 yaş grubunda aminoglikozid kullanımı (p<0.001) ve DM varlığının (p<0.032); 80 yaş üzeri grupta ise kalp yetersizliğinin olması (p=0.004), yatış endikasyonunun kardiyovasküler hastalıklar olması (p<0.001) ve kolistin kullanımı (p=0.026) idi. 65-80 yaş grubunda hastanın nonoligürik olmasının iyileşmeme riskini azalttığı (p=0.003) görülmüştür (p=0.078). ABH evrelerinin 80 yaş üzeri grupta etkisi görülmezken, 65-80 yaş grubunda evre-2 ABH’ nin evre-3 ABH ile kıyaslandığında koruyucu etkisi olduğu görülmüştür (p=0.009). Çok değişkenli analizde ölüm veya diyaliz bağımlı böbrek yetersizliği için zeminde KBH olması (p=0.048) ve hastanın nonoligürik olmasının (p=0.005) koruyucu etkisi olduğu tespit edilmiştir. Sonuç: ABH’ ye karşı daha savunmasız olup diyaliz bağımlı böbrek yetersizliği ve mortalite oranları yüksek olan geriatrik popülasyonunda ilk hedef ABH’den korunmak olmalıdır. Bu amaçla komorbid hastalıkların etkin tedavisi, nefrotoksik ajanlardan kaçınmak, akılcı ilaç kullanımı, dehidratasyonun önlenmesi büyük önem taşımaktadır. Anahtar kelimeler: Akut böbrek hasarı, kronik böbrek hasarı, yaşlılık, mortalitePublication Metadata only A case of diabetes and deafness with heteroplasmic mutations in the mitochondrial DNT1 gene(2022-09-12) Özgen İ. T.; Bahar S.; Uyanık B.; ÖZGEN, İLKER TOLGA; BAHAR, Semra; UYANIK, BÜLENTPublication Metadata only A case report of hyperinsulinemic hypoglycemia caused by a heterozygous novel mutation in the insulin receptor gene(2022-09-15) Özgen İ. T.; Bahar S.; Uyanık B.; ÖZGEN, İLKER TOLGA; BAHAR, Semra; UYANIK, BÜLENTIntroduction: Mutations in the insulin receptor (INSR) gene usually progress with insulin resistance and hyperglycemia. However, rare heterozygous INSR gene mutations that cause hyperinsulinemic hypoglycemia (HH) have also been described. A case with hyperinsulinemic hypoglycemia due to a new variant mutation in the INSR gene, is presented. Case: A 13-month-old male patient was referred to us with complaints of contractions in his entire body and low blood sugar in his history. He was born 3900 grams with spontaneous vaginal delivery as term birth. He had a similar seizure history 1 month ago. In family history; There was no consanguinity between father and mother. His father had a growth hormone treatment history and he had iris coloboma. Anthropometric measurements; Height: 78 cm (SDS: 0.24), weight: 12.1 kg (SDS: 1.08), head circumference: 45 cm (SDS: -0.37) was normal. In the physical examination of the patient, anterior fontanel was 0.5*0,5 cm open, elongated penis length was 3,5 cm, testicles were bilaterally palpable, other system examinations were normal. Laboratory values measured in hypo glycemic state (glucose: 35 mg/dL) are given in the table. In addi tion, the patient’s metabolic tests (tandem, blood amino acid, urine organic acid, ammonia) were normal.Hydrocortisone and diazoxide treatment were started simulta neously because the cortisol levels measured at the time of hypo glycemic attack were 3.9 ug/dL (low) and insulin was 7.6 uU/mL. Abdominal ultrasound was requested for the examination of pan creatic anomaly and it was found to be normal. Genetic result showed in INSR NM_000208.2 Exon 20 c.3634G>A p mutation. Anew mutation was detected in Val1212lle. During the follow-up the basal cortisol value measured was 16.2 ug/dL. After this result and genetical diagnosis, hydrocortisone treatment was discontin ued and diazoxide treatment was continued. The patient’s blood sugar is followed closely, and the follow-up continues in terms of conversion to diabetes. Conclusion: In conclusion, heterozygous INSR gene mutation causing hyper insulinemic hypoglycemia was detected in our case. This case is presented because INSR mutations are rare in the eti ology of hyperinsulinism in hypoglycemic patients and also the detected mutation is new.Publication Metadata only A case report of Pituitary Stalk Interruption Syndrome caused by novel compound heterozygous mutations in the KATNIP gene(2022-09-15) Bahar S.; Özgen İ. T.; Uyanık B.; BAHAR, Semra; ÖZGEN, İLKER TOLGA; UYANIK, BÜLENTPublication Metadata only A Mobile Application For Early Prediction of Skeletal Class III Malocclusion from Profile Photos Integrating Deep Learning and Machine Learning Models(2022-09-10) AKSOY S.; KILIÇ B.; SÜZEK T.; KILIÇ, BANUPublication Metadata only A New Method for Therapeutic Drug Monitoring of Anxiolytic Drugs in Plasma by LC-MS/MS(2023-07-02) Kul A.; Al S.; Özdemir M.; Dincel D.; Sağırlı A. O.; DİNCEL, DEMETPublication Metadata only A new technique at insertion of laryngeal mask airway(2013-06-04) Esen A.; Bakan M.; Topuz U.; Ertaş Dursun Z.; Karaaslan K.; ESEN, ASIM; KARAASLAN, KAZIMA new technique at insertion of laryngeal mask airway Esen A., Bakan M., Topuz U., Ertas Z., Karaaslan K. (Bezmialem Vakif University, Dept of Anaesthesiology & Intensive Care, Istanbul, Turkey) Background and Goal of Study: Laryngeal mask airway (LMA) have been frequently used for airway management. The satisfaction of the insertion and trauma at insertion are problems. We present a new in insertion technique for LMA with partially inflated cuff. Materials and Methods: Consecutive 157 patients undergoing general anesthesia with LMA were randomized to two groups by coin toss. Induction and maintenance of anesthesia were standart in two groups. There were 85 patients in study group (group S) and 72 patients in control group (group C). LMA insertions were made by same physician. LMA was inserted with standart technique -which was described by Brain- at group C. Laryngeal mask airway was inserted with new techinque at group S. In new technique the head was positioned with extension by nondominant hand, mouth was opened with dominant hand, LMA was held with dominant hand from the tube part and inserted until the tip touches to the oropharynx. The index finger of nondominant hand was inserted to mouth to pass by the LMA and reach the tip of it and the tip of LMA was directed to caudal by index finger. Then LMA was inserted by the guidance of the index finger towards it reaches to the trianguler base of the orophariynx. Results and Discussion: There were no difference between the groups for the demographic details, ASA scores, insertion success and duration of anesthesia. The mean age was 47 ,4 for group S and 51,7 for group C. Count of attempt was better in study group. Mean count number was 1,11 at group S and 1,28 at group C (p=0.02). Also blood on LMA were seen more common at group C (p=0.04). There were no statistical difference at sore throat but it was less seen at group S. Also airway satisfaction was not statistical different between groups but while all airways were succesfull in group S we can not inserted LMA by standart method at 1 patient and inserted it at first attempt by new technique. Conclusion: New technique is less traumatic and easy to use at daily practice. References: 1. Brain AIJ : The laryngeal mask. A new consept in airway management. Br J Anaesth 55:801,1983. 2. Asai T, Morris S : The laryngeal mask airway: its’ features, effects and role. Can J Anaesth 41:930-60, 1994. 3. Wakeling HG, Butler PJ, Baxter PJ : The laryngeal mask airway: a comparison between two insertion techniques. Anesth Analg 85:687-90,1997.Publication Metadata only A novel heterozygous STAT5B variant in a patient with resistant atopic dermatitis and short stature(2022-09-15) Bahar S.; Özgen İ. T.; Uyanık B.; BAHAR, Semra; ÖZGEN, İLKER TOLGA; UYANIK, BÜLENTIntroduction: Growth hormone (GH) exerts its effect through insulin-like growth factor 1 (IGF-I), an intracellular signalling molecule whose production is stimulated by STAT-5b after bind ing to the growth hormone receptor. STAT-5b deficiency, is char acterized by short stature, immune dysregulation and chronic lung disease. And these occur as a result of disruption of the growth hormone axis. Our case is an example of STAT-5b gene mutation, which is a rare disease and it has been defined for the last 10 years. Case: A 12-year-old male patient was admitted to our outpa tient clinic with complaints of short stature and skin rash. He was born 900 gr by cesarean section at 26th gestational week and had a 3-month neonatal intensive care hospitalization history. He was hospitalized with severe acute bronchiolitis attack twice, 1 year and 2.5 years old. He was followed up with diagnosis of atopic derma titis and hyperimmunoglobulin E for the last 3 years. In the family history; his mother’s and father’s height were 150 cm and 175 cm respectively, there was no consanguinity between mother andfather, and he had 2 healthy siblings. Anthropometric measure ments; his height, weight and body mass index were 134 cm (SDS: -1.9), 25.7 kg (SDS: -2.54), and 14.2 kg/m2 (SDS: -2.15) respec tively. The mid parental height SDS of the patient was -1.17. In his physical examination; he had erythematous eczematous lesions around the eyes, cheeks and chin, and xerosis on the hands, promi nent forehead and saddle nose. His testicular volumes were 4/4 ml and pubic hair was tanner stage 1. Laboratory examinations revealed low IGF level (98.7 ng/ml SDS: -1.67) and IGF binding protein 3 (IGFBP3) level (3.75 ng/L SDS: -3.56). Bone age was 8 years-old. GH stimulation tests with L-dopa revealed low basal GH levels and reduced GH response (peak GH of 2.24 ng/ml). Prolactin level was found to be 12.3ug/l. Height velocity was 6 cm per year. A new heterozygous STAT5b mutation (C.1906+1G>A) was detected.Publication Metadata only A Rare Entity: Bone Marrow Metastasis in a Patient with Wilms Tumour(2016-10-19) Kaygusuz S. B.; Çoban G.; Güler B.; Çakır F. B.; Gücin Z.; ÇOBAN, GANİME; GÜLER, BERIL; ÇAKIR, FATMA BETÜLPublication Metadata only A Study of The Association Between Medication Adherence and Self-Care Activities In Patients With Type 2 Diabetes Mellitus.(2023-04-28) Demirhan Ş.; Bektay M. Y.; Şekerci A.; Güler E. M.; İzzettin F. V.; BEKTAY, MUHAMMED YUNUS; ŞEKERCİ, ABDÜSSELAM; İZZETTİN, FIKRET VEHBIPublication Metadata only Publication Metadata only Affection through works of art and its contribution to ESP(2022-03-18) Sarı A.; SARI, AKıNThis presentation starts with the narrative of Adam and Eve portrayed in multiple forms of art form, such as paintings or novels. After the video session, the participants will be invited to make comments on the paintings and question the fundamental concepts of Nutrition and Dietetics profession. The latter half of the presentation will discuss \"The Anatomy Lesson of Dr. Nicolaes Tulp\" (by Rembrandt), and put forward how and why art matters in language learning.Publication Metadata only Akademik kütüphaneler Sürdürülebilir Kalkınma Amaçlarının geliştirilmesine nasıl katkıda bulunabilir: Türkiye durum analizi(2023-01-30) Zayim Gedik K.; ZAYİM GEDİK, KÜBRAPublication Metadata only Akademik Tıp Kütüphanelerinin Sürdürülebilir Kalkınma Amaçlarındaki Rolü(2023-10-27) Yalçınkaya Ö.; YALÇINKAYA, ÖZLEMPublication Metadata only Akciğerlerde fibrozis gelişimi hangi lobda daha fazla? posmortem çalışma(2023-10-20) Soysal Ö.; SOYSAL, ÖMER