Tüm Yayınlar

Permanent URI for this communityhttps://hdl.handle.net/20.500.12645/1

Browse

Now showing 1 - 20 of 34

Metadata only
1-Benzhydryl-piperazine: Isolation, structure determination, and in silico studies for a novel potential narcotic agent detected in sports supplements
(2024-11-01) Arslan Z.; Okuroğlu E.; Şenol H.; Türkmen Z.
Metadata only
5-year Clinical Performance of Ceramic Onlay and Overlay Restorations Luted with Light-cured Composite Resin.
(2024-07-25) Yurdagüven G. Y.; Çiftçioğlu E.; Kazokoğlu F. Ş.; Kayahan M. B.
Metadata only
Analyzing Eight Turkish Macroalgae: Fatty Acids, Proteins, and in Silico Biological Activity Profiles
(2024-09-01) Naz M.; Şenol H.; Okudan E. Ş.; Sayın S.; Konuklugil B.; Topçu G.
Metadata only
Association between celiac disease and fibromyalgia and their severity: a cross-sectional study.
(2024-08-30) Kılıçoğlu M. S.; Sayılır S.; Yurdakul O. V.; Aydin T.; Koçhan K.; Basaranoglu M.; Kucukakkas O.
Metadata only
Association between sedentary behavior and wish to die among adults aged ≥50 years: Findings from the Irish Longitudinal Study on Ageing.
(2024-08-06) Smith L.; López Sánchez G. F.; Soysal P.; Veronese N.; Rahmati M.; Tully M. A.; Yon D. K.; Alghamdi B. S.; Butler L.; Ahluwalia S.; et al.
Metadata only
Auditory system and COVID-19
(2024-07-01) Başöz M.; Taş N.
Metadata only
Bioisosteric replacement of the carboxylic acid group in Hepatitis-C virus NS5B thumb site II inhibitors: Phenylalanine derivatives
(2024-12-01) Camcı M.; Şenol H.; Köse A.; Karaman Mayack B.; Alayoubi M. M.; Karalı N. L.; Gezginci M. H.
Metadata only
Current status of simultaneous liver-kidney transplantation
(2024-08-01) Kazancıoğlu R.
Metadata only
Development of phytotherapeutic nanoformulation containing Gypsophila eriocalyx and its evaluation as a candidate formulation for osteoporosis treatment on human bone marrow stem cells
(2024-01-01) Kaymak S.; Kurtur O. B.; Gok B.; KILINÇ Y.; Kecel-Gunduz S.; Nath E. Ö.; KARTAL M.
Introduction: Osteoporosis, one of the common bone diseases, manifests itself as a decrease in bone mass. Recently, the use of medicinal plants in the search for effective and low-toxicity therapeutics for the prevention or treatment of osteoporosis has become a trending topic. Objective: In this study, we aim to prepare a controlled drug carrier system loaded with Gypsophila eriocalyx to determine its potential for anti-osteoporosis applications. Methods: Gypsophila eriocalyx extract (GEE) was prepared, and components were determined. The molecular interactions of the components with Cathepsin K (CatK), which is used as a target in drug development against osteoporosis, were revealed by in silico molecular docking and MD methods. ADMET profiles were also examined. GEE-loaded chitosan nanoparticles (CNPs) were synthesized. The nanoparticles\" morphology, encapsulation efficiency, loading capacity, release profile, average size, polydispersity index, and zeta potentials were determined. The cytotoxic effects of GEE and GEE-loaded CNPs on the L929 and osteogenic proliferation profiles on human bone marrow stem cells (hBMC) were examined. Results: The MD analysis revealed no breaks or atomic changes in the dynamic system, and the docking analysis confirmed the continued interaction of identical residues. It was determined that the GEE-loaded CNP formulation was produced successfully, had no toxic effect on the L929, and had an osteogenic proliferation effect on hBMC. Conclusion: In line with the in vitro and in silico results obtained, it was evaluated that GEE-loaded CNPs can be used as a controlled drug release system as a candidate formulation with phytotherapeutic properties for osteoporosis treatment.q1.
Metadata only
Effect of Hospital Employees’ Psychological Capital on Counterproductive Work Behavior: Role of Work Alienation and Procrastination
(2024-08-01) Ayşe Göksu Özüdoğru G.; Görener A.; Toker K.
Counterproductive work behavior (CWB) causes financial losses and psychologically affects other employees exposed to verbal or physical attacks from their colleagues. This issue creates a stressful workplace and has a negative impact on organizational outputs. The objective of this study is to develop a coherent logic and a thorough comprehension of the CWB’s predecessors and their relationships to the CWB. Our research applied partial least squares structural equation modeling (PLS-SEM) to test hypotheses on a sample of 390 healthcare personnel in a hospital. We propose an approach in which administrators can reduce counterproductive work behaviors by strengthening psychological capital. Also, eliminating work alienation and workplace procrastination is an original and critical argument for preventing counterproductive work behavior. The findings reveal that high psychological capital negatively affected counterproductive work behaviors and reduced these behaviors in the workplace. However, the partial mediation role of work alienation and the mediation role of workplace procrastination were determined in the relationship between psychological capital and counterproductive work behavior
Metadata only
Exploring Balance Impairment and Determinants in Chronic Obstructive Pulmonary Disease: A Comparative Study with Healthy Subjects
(2024-07-01) Ucgun H.; Kaya M.; OGUN H.; Kulli H. D.
Background: Many pulmonary and extrapulmonary factors may impair balance in patients with chronic obstructive pulmonary disease (COPD), but the determinants of this impairment are still debated. The primary aim was to compare both balance-related and independent variables that may affect balance with healthy subjects. The secondary aim was to investigate the potential determinants of balance in patients with COPD. Methods: This comparative study recruited 23 patients with COPD and 23 age- and comorbidity-matched healthy subjects. Participants were assessed regarding demographic and clinical data, \"Postural Stability Test\" (PST), \"Limits of Stability Test\" (LOST), \"Clinical Test of Sensory Integration of Balance\" (CTSIB), pulmonary function, respiratory and peripheral muscle strength, functional capacity, and cognitive function. Results: There were significant differences in all outcome measures assessing balance, pulmonary function, respiratory muscle strength, peripheral muscle strength, and functional capacity, but not cognitive function, in the COPD group compared to the healthy group (p < 0.05). The PST had a significant and strong correlation with maximal inspiratory pressure (MIP) (r = -0.630, p = 0.001) and a significant and moderate correlation with m. quadriceps strength and 6 min walk test (6MWT) distance (r = -0.472, p = 0.023; r = -0.496, p = 0.016; respectively). MIP, m. quadriceps strength, and 6MWT distance were independent predictors to explain the PST with an R-2 = 0.336 (p = 0.004). Conclusions: The present study revealed that balance is impaired in adults with COPD, even if compared with age- and comorbidity-matched healthy subjects. Assessing and improving balance and its determinants, inspiratory and peripheral muscle strength, and functional capacity may be important for fall prevention and disease management in patients with COPD.
Open Access
Exploring highly selective polymethoxy fenamate isosteres as novel anti-prostate cancer agents: Synthesis, biological activity, molecular docking, molecular dynamics, and ADME studies
(2025-01-05) Tokalı F. S.; Şenol H.; Ateşoğlu Ş.; Tokalı P.; Akbaş F.; AKBAŞ, FAHRİ; ATEŞOĞLU, ŞEYMA; ŞENOL, HALIL
In this study, we synthesized and characterized sixteen new polymethoxy-substituted hydrazone derivatives. These compounds were evaluated for their in vitro cytotoxic activity against human prostate cancer (PC3) and human umbilical vein endothelial (HUVEC) cell lines. Compounds 5, 6, 7, and 11 exhibited significant cytotoxic effects with high selectivity index. Molecular docking studies and MM-GBSA binding free energy calculations were performed against tubulin protein. Compound 7 emerged as a particularly promising candidate, displaying an IC50 value of 1.49 µM against PC3 cells and a selectivity index of 264. Compound 7 achieved impressive docking score -13.655 kcal/mol against tubulin and formed stable hydrogen bonds and π-π stacking interactions with key residues in this protein. MD simulations confirmed the stability of the 7-tubulin complex. ADME analysis indicated that compound 7 has favorable absorption, solubility, and permeability properties, with minimal rule violations. The SAR analysis highlighted the significance of specific functional groups in enhancing the compound\"s cytotoxic and binding properties. Overall, compound 7 is identified as a leading candidate due to its exceptional cytotoxicity, high selectivity index, strong binding affinities, and favorable pharmacokinetic profile, making it a top candidate for further investigation and development as a novel anticancer agent.
Metadata only
Factors affecting global adherence for the uptake of diabetic retinopathy screening: A systematic review and meta-analysis.
(2024-07-31) Rahmati M.; Smith L.; Boyer L.; Fond G.; Yon D. K.; Lee H.; Soysal P.; Piyasena M. P.; Pardhan S.
Metadata only
Food insecurity and body mass index among older people: A systematic review and meta-analysis.
(2024-08-27) Gianfredi V.; Nucci D.; Lattanzio R.; Piccinelli S.; Cicconi G.; Farfan S. J. S.; Berti A.; D'Amico M.; Sabatelli N.; Guzzardi F.; et al.
Metadata only
Global burden of vaccine-associated rheumatic diseases and their related vaccines, 1967–2023: A comprehensive analysis of the international pharmacovigilance database
(2024-08-01) Oh J.; Jo H.; Park J.; Lee H.; Kim H. J.; Lee H.; Kang J.; Hwang J.; Woo S.; Son Y.; et al.
Vaccine-associated rheumatic diseases are rare but one of the most feared adverse drug reactions (ADRs). However, this topic has been investigated less with large-scale data in the literature. With the rapid progress in the development and approval of vaccines during the pandemic, public concerns regarding their safety have been raised. To assess the global and regional burden, long-term trends, and potential risk factors of vaccines-associated six types of rheumatic diseases (ankylosing spondylitis [AS], polymyalgia rheumatica [PMR], rheumatoid arthritis [RA], Sjögren\"s syndrome, Systemic lupus erythematosus [SLE], Systemic scleroderma), this study conducted disproportionality analysis based on the reports from the World Health Organization International Pharmacovigilance Database documented between 1967 and 2023 (n for total reports = 131 255 418) across 156 countries and territories. We estimated the reporting odds ratio (ROR) and information component (IC) to determine the disproportionality signal for rheumatic diseases. Of 198 046 reports of all-cause rheumatic diseases, 14 703 reports of vaccine-associated rheumatic diseases were identified. While the reporting counts have gradually increased over time globally, we observed a dramatic increase in reporting counts after 2020, potentially due to a large portion of reports of COVID-19 mRNA vaccine-associated rheumatic diseases. The disproportionality signal for rheumatic diseases was most pronounced in HBV vaccines (ROR, 4.11; IC025, 1.90), followed by COVID-19 mRNA (ROR, 2.79; IC025, 1.25), anthrax (ROR, 2.52; IC025, 0.76), papillomavirus (ROR, 2.16; IC025, 0.95), encephalitis (ROR, 2.01; IC025, 0.58), typhoid (ROR, 1.91; IC025, 0.44), influenza (ROR, 1.49; IC025, 0.46), and HAV vaccines (ROR, 1.41; IC025, 0.20). From age- and sex-specific perspective, young females and old males are likely to have vaccine-associated rheumatic disease reports. Furthermore, overall vaccines showed a disproportionality signal for PMR (IC025, 3.13) and Sjögren\"s syndrome (IC025, 0.70), systemic scleroderma (IC025, 0.64), specifically while the COVID-19 mRNA vaccines are associated with all six types of diseases. Although multiple vaccines are associated with rheumatic disease reports, healthcare providers should be aware of the potential of autoimmune manifestations following vaccination, particularly the COVID-19 mRNA and HBV vaccines, and take into account for risk factors associated with these ADRs. Most ADRs exhibited an average time to onset of 11 days, underscoring the significance of monitoring and timely management by clinicians.
Metadata only
HEDONİK AÇLIK VE OBEZİTE
(2024-08-01) Teymur Z.; Öney B.
Metadata only
Impact of peptic ulcer bleeding on the in-hospital outcomes of cirrhotic patients with acute gastrointestinal bleeding: an international multicenter study
(2024-08-12) Yin Y.; Ji F.; Romeiro F. G.; Sun M.; Zhu Q.; Ma D.; Yuan S.; He Y.; Liu X.; Philips C. A.; et al.
Objectives: Peptic ulcer is the most common source of non-variceal bleeding. However, it remains controversial whether the outcomes of cirrhotic patients with peptic ulcer bleeding differ from those with variceal bleeding. Methods: Cirrhotic patients with acute gastrointestinal bleeding (AGIB) who underwent endoscopy and had an identifiable source of bleeding were retrospectively screened from an international multicenter cohort. Logistic regression analyses were performed to explore the impact of peptic ulcer bleeding on in-hospital death and 5-day failure to control bleeding. Propensity score matching (PSM) analysis was performed by matching age, gender, Child-Pugh score, and model for end-stage liver disease score between the peptic ulcer bleeding and variceal bleeding groups. Results: Overall, 1535 patients were included, of whom 73 (4.7%) had peptic ulcer bleeding. Multivariate logistic regression analyses showed that peptic ulcer bleeding was not independently associated with in-hospital death (OR = 2.169, p = 0.126) or 5-day failure to control bleeding (OR = 1.230, p = 0.680). PSM analyses demonstrated that both in-hospital mortality (9.7% vs. 6.3%, p = 0.376) and rate of 5-day failure to control bleeding (6.9% vs. 5.4%, p = 0.787) were not significantly different between the two groups. Conclusions: The impact of peptic ulcer bleeding on the in-hospital outcomes of cirrhotic patients is similar to that of variceal bleeding.
Metadata only
Investigation of the effect of boric acid in different concentrations on dentin microhardness
(2023-06-01) Nalcı Çalık G.; Alim Uysal B. A.; Kotan G.; Özbek M.
Purpose: This study compared the effects of different irrigation solutions on the microhardness of root dentin. Methods: Fifty single-rooted human teeth were chosen, and the roots were randomly divided into five groups (n = 10) according to the irrigant used for 5 min: 17% ethylenediaminetetraacetic acid (EDTA), 2% boric acid (BA), 5% BA, 10% BA, and distilled water (DW). After the irrigation procedure, dentin surface microhardness was calculated using a Vickers indenter 100 μm from the root canal lumen. Comparisons between the groups were performed with a two-way ANOVA test and and Tukey’s multiple comparison test (p = 0.05). Results: All irrigation solutions decreased the microhardness of root canal dentin. The DW and 2% BA had a minimum effect on the microhardness of root canal dentin, whereas a significant decrease in surface microhardness was found in 10% BA group (p < 0.05). The coronal third of the 10% BA group showed the lowest percentage decrease, with a significant difference between the apical and middle thirds (p < 0.05). Conclusion: In this study, 5% BA and 17% EDTA showed similar effects on the microhardness of root canal dentin. Further clinical research is required to evaluate the biocompatibility and safety of BA solutions.
Metadata only
Mechanical versus manual cardiopulmonary resuscitation (CPR): an umbrella review of contemporary systematic reviews and more
(2024-12-01) El-Menyar A.; Naduvilekandy M.; Rizoli S.; Di Somma S.; CANDER B.; Galwankar S.; Lateef F.; Abdul Rahman M. A.; Nanayakkara P.; Al-Thani H.
Background: High-quality cardiopulmonary resuscitation (CPR) can restore spontaneous circulation (ROSC) and neurological function and save lives. We conducted an umbrella review, including previously published systematic reviews (SRs), that compared mechanical and manual CPR; after that, we performed a new SR of the original studies that were not included after the last published SR to provide a panoramic view of the existing evidence on the effectiveness of CPR methods. Methods: PubMed, EMBASE, and Medline were searched, including English in-hospital (IHCA) and out-of-hospital cardiac arrest (OHCA) SRs, and comparing mechanical versus manual CPR. A Measurement Tool to Assess Systematic Reviews (AMSTAR-2) and GRADE were used to assess the quality of included SRs/studies. We included both IHCA and OHCA, which compared mechanical and manual CPR. We analyzed at least one of the outcomes of interest, including ROSC, survival to hospital admission, survival to hospital discharge, 30-day survival, and survival to hospital discharge with good neurological function. Furthermore, subgroup analyses were performed for age, gender, initial rhythm, arrest location, and type of CPR devices. Results: We identified 249 potentially relevant records, of which 238 were excluded. Eleven SRs were analyzed in the Umbrella review (January 2014–March 2022). Furthermore, for a new, additional SR, we identified eight eligible studies (not included in any prior SR) for an in-depth analysis between April 1, 2021, and February 15, 2024. The higher chances of using mechanical CPR for male patients were significantly observed in three studies. Two studies showed that younger patients received more mechanical treatment than older patients. However, studies did not comment on the outcomes based on the patient\"s gender or age. Most SRs and studies were of low to moderate quality. The pooled findings did not show the superiority of mechanical compared to manual CPR except in a few selected subgroups. Conclusions: Given the significant heterogeneity and methodological limitations of the included studies and SRs, our findings do not provide definitive evidence to support the superiority of mechanical CPR over manual CPR. However, mechanical CPR can serve better where high-quality manual CPR cannot be performed in selected situations.
Metadata only
Non-invasive estimation of cerebrospinal fluid pressure in idiopathic intracranial hypertension: magnetic resonance imaging analysis of optic nerve and eyeball
(2024-08-16) Kula A. Y.; Polat Y. B.; Atasoy B.; Yiğit M.; Kırık F.; Pasin Ö.; Alkan A.
Purpose Invasive methods such as lumbar puncture and intraventricular catheters are commonly used to measure intracranial pressure (ICP). This study aims to develop quantitative and non-invasive techniques to measure ICP in patients with Idiopathic Intracranial Hypertension (IIH) using magnetic resonance imaging (MRI) findings. MethodsMRI data obtained from 50 patients with IIH and 30 age- and sex- matched controls were analyzed and optic nerve sheath diameter (ONSD), eyeball transverse diameter (ETD) and optic nerve diameter (OND) were measured. ONSD, ONSD/ETD and OND/ONSD indexes were calculated according to different ONSD measurement distances. Correlations of MRI findings with ICP were calculated. Sensitivity and specificity of all methods were analyzed. Results ONSD and ONSD/ETD index at 3 mm and 10 mm behind the eyeball were significantly higher (p < 0.001) and OND/ONSD index at 3 mm behind the eyeball was significantly lower (p < 0.001) in the IIH group. The ONSD/ETD index at 3 mm had the highest area under the curve (AUC) value (0.898) with a cut-off of 0.27 mm (82% sensitivity and 91.67% specificity) for predicting high cerebrospinal fluid (CSF) pressure, followed by ONSD measurements at 3 mm (AUC = 0.886) with a cut-off of 6.17 mm (83% sensitivity and 86.67% specificity). The OND/ONSD index at 3 mm posterior to the eyeball decreased significantly as ICP increased, and the strength of the relationship was moderate (p < 0.001; r = -0.358). Conclusions ONSD and ONSD/ETD index measured on MRI sequences are potentially useful in detecting elevated ICP. The OND/ONSD index correlates with CSF pressure and these techniques may be helpful in diagnosing IIH.

Browse

Browsing by Type "article"