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Publication Open Access 3-Amino-thiophene-2-carbohydrazide Derivatives as Anti Colon Cancer Agents: Synthesis, Characterization, In-Silico and In-Vitro Biological Activity Studies(2023-10-01) Şenol H.; Çakır F.; ŞENOL, HALILIn this study, starting from 3-amino-thiophene-2-carboxylic acid methyl ester, eighteen new arylidenehydrazide derivatives (4–21) were synthesized. To determine cytotoxic activity of target compounds they were tested against human colon cancer and human umbilical vein endothelial cell lines. To determine prospective inhibition mechanism, binding affinity and complex stability molecular docking and molecular dynamics studies were carried out on transforming growth factor beta-2 (TGFβ2) and vascular endothelial growth factor receptor 2 (VEGFR2) proteins. According to the biological activity studies compounds (E)-2,4-dichloro-N-(2-(2-(4-fluorobenzylidene)hydrazine-1-carbonyl)thiophen-3-yl)benzamide (11) was found as the highest selective and active compound. Anti-cancer activity results compared to reference drugs doxorubicin and gefitinib. Most active compound was found as 7-fold and 4-fold more selective than doxorubicin and gefitinib, respectively. The detailed in vitro and in silico biological activity studies revealed that related compound demonstrated strong and selective anti-colon cancer effect and also it has promising inhibitory effects on TGFβ2 and VEGFR2. As a result, this compound is a promising candidate for further exploration and development in the field of colon cancer treatment.Publication Metadata only Publication Metadata only A 13-Year-Old Boy Who Has Kawasaki Disease Shock Syndrome Presents with Parotitis(2020-03-01) YOZGAT Y.; UZUNER S.; DOĞAN DEMİR A.; OĞUR M.; YOZGAT C. Y.; TÜREL Ö.; YOZGAT, YILMAZ; UZUNER, SELÇUK; DOĞAN DEMİR, AYŞEGÜL; TÜREL, ÖZDENPublication Metadata only A comprehensive health effects assessment of the use of sanitizers and disinfectants during COVID-19 pandemic: a global survey.(2023-05-11) Hashemi F.; Hoepner L.; Hamidinejad F. S.; Haluza D.; Afrashteh S.; Abbasi A.; Omeragić E.; Imamović B.; Rasheed N. A.; Taher T. M. J.; et al.; BEKTAY, MUHAMMED YUNUSPublication Metadata only A new concept for mandible reconstruction after oncological resection: Multisegment virtual surgical planning(2024-01-01) Ismayilzade M.; YILDIZ K.; Canter H. I.; YILDIZ, KEMALETTİNPurpose: Virtual surgical planning (VSP) is good for three dimensional reconstructions in maxillofacial surgery, but it is not problem-free completely especially when the resection margins cannot be affirmed in preoperative period. We aimed to obtain an ideal reconstruction with elaborating VSP to be prepared for adverse conditions during surgery and to proceed the oncological resections step- by- step with A, B, and C resection planes. Patients and methods: Four patients undergoing multisegment VSP for the primary mandible malignancies were included in the study. The first resection margin was detected as plan A in VSP, and plans of B and C were also prepared considering the tumor- positive result of intraoperative frozen section procedure. Results: Following the tumor resection, margins were extended to the plan B in two patients, and plan C in one patient in accordance with the results of the frozen section procedure.Histogram comparison of the localizations of osteotomies in mandible and fibula, and positions of the implants were calculated at a confidence level of 95 % (p > 0.95) and mean difference was found -0.55 mm, while standard deviation was 1.76 mm. Conclusion: Multisegment virtual surgical planning seems to achieve the optimal reconstruction with the staged resection preventing redundant removal of tumor- free structures like bone and teeth.Publication Metadata only A new maneuver for classical laryngeal mask airway insertion: Prospective randomized study(2022-08-01) Esen A.; Bakan M.; Topuz U.; Ertaş Dursun Z.; Karaaslan K.; ESEN, ASIM; KARAASLAN, KAZıMBackground/Aim: Laryngeal mask airway (LMA) has been frequently used for airway management. But the satisfaction of the insertion and trauma at insertion remain problems. We present a new insertion maneuver for classical LMA (cLMA) with a partially inflated cuff and examine its success and complication rate.Methods: In 4 months, 158 patients who were classified as ASA I–III and older than 18 years old and were planned for LMA were included in this study consecutively (according to the study design, one patient was excluded during the study). Emergency cases, patients with any contraindications with LMA, patients who were expected to undergo surgery for more than 2 h, patients with preoperative respiratory tract infection or sore throat, patients undergoing oral or nasal surgery, and patients with aspirated oropharyngeal secretions after removal of LMA was excluded from the study. Age, gender, height, weight, ASA scores, comorbidities, and the duration of anesthesia and surgery of the patients were recorded. One-hundred-fifty-seven consecutive patients were randomized into two groups by a coin toss [control group (group C) and study group (group S)]. The groups were compared in terms of LMA insertion success, the number of insertion attempts, the presence of blood on the LMA or in secretions, and postoperative sore throat. Classical Laryngeal Mask Airway was inserted with Brain’s standard technique in group C and with the new technique in group S. In the new technique, the head and neck of the patient were supported in a straight position, the mouth was opened, cLMA was held with a dominant hand from the tube part and inserted until the tip touches to the oropharynx. The index finger of the non-dominant hand was inserted into the mouth to pass by the cLMA and reach the tip of the cLMA. The tip of cLMA was directed to the caudal by the index finger. Then, cLMA was inserted by the guidance of the index finger until it reached the triangular base of the oropharynx.Results: There was no statistically significant difference in terms of demographic data and placement success; placement success was better in the study group (100% versus 98.6% and P = 0.45). Similarly, the count of attempts was better in the study group. The mean attempt number was 1.11 in group S and 1.28 in group C (P = 0.02). Also, blood on LMA was seen to be more common in group C (P = 0.04). There were no statistical differences in sore throat, but it was less seen in group S.Conclusion: The new maneuver was better than the standard technique and easy to use in daily practice.Keywords: Airway management, Laryngeal mask airway, ComplicationsPublication Metadata only A new method of pulse control in cardiopulmonary resuscitation; Continuous femoral pulse check.(2024-03-31) Sonmez E.; Taslidere B.; Ozkan A.; TAŞLIDERE, BAHADIRPublication Metadata only A novel EGFR Inhibitor, HNPMI regulates apoptosis and oncogenesis by modulating BCL-2/BAX and p53 in colon cancer.(2023-05-15) Kandhavelu J.; Subramanian K.; Naidoo V.; Sebastianelli G.; Doan P.; Mani S. K.; Yapislar H.; Haciosmanoglu E.; Arslan L.; Ozer S.; et al.; HACIOSMANOĞLU, EBRUPublication Metadata only A perspective at the daily routines of esports players: life balance(2023-12-01) Akel S.; Yiğit A. B.; Çorakçı Z.; Özkan Ş.; Uğurlu Ü.; ÇORAKÇI, ZEYNEPPublication Metadata only A Rare Cause of Acute Pancreatitis - Annular Pancreas: A Case Report(2015-12-01) KAYAR Y.; YİĞİT M.; EKİNCİ İ.; ATAY M.; ŞENTÜRK H.; EKİNCİ, İSKENDER; ŞENTÜRK, HAKANPublication Metadata only A Rare Cause of Renal Infarct: Paradoxical Embolism Through the Patent Foramen Ovale(2014-11-01) EKİNCİ İ.; DAE S. A.; ASOĞLU E.; ATAY M.; RAKHYMZHAN G.; KAZANCIOĞLU R.; ERKOÇ R.; EKİNCİ, İSKENDER; KAZANCIOĞLU, RÜMEYZAPublication Metadata only A Rare Complication of Umbilical Vein Catheterization: TPNoma: US, X-ray, and MRI Findings(2023-01-01) Sari L.; ORAN Z.; Ali Gültekin M.; Sharifov R.; TOPRAK H.; SARI, LÜTFULLAH; ORAN, ZEYNEP; SHARIFOV, RASUL; TOPRAK, HÜSEYİNBACKGROUND: Umbilical vein catheterization (UVC) is an early venous access route in newborns and is frequently used for delivering total parenteral nutrition (TPN) and medications. Vascular, hepatic parenchymal, and infectious complications of UVC can be seen rarely. OBJECTIVE: We present preterm neonates\" X-ray, US, and MRI findings with parenchymal TPN extravasation and portal vein thrombosis. Our case was the first case about MRI findings of TPNoma. CASE PRESENTATION: A 30 week female with a birth weight of 1340 g was born via Cesarean section. Due to the diagnosis of transient tachypnea of the newborn and prematurity, the infant was hospitalized in the neonatal intensive care unit. On the first day of hospitalization, UVC was inserted and TPN with 20% lipid content was started. After 10 days, UVC was removed and TPN treatment was continued with a piccline catheter. Abdominal US and portal venous Doppler examination was applied to the patient whose general condition deteriorated on the 12th day. US and Doppler revealed a lesion of 17x17x18mm in size with lobulated contour, hyperechoic heterogeneous internal structure, and no central or peripheral blood supply was observed in the left lobe of the liver. Moreover, a filling defect compatible with a thrombus was observed in the proximal part of the left portal vein. An abdominal MRI was performed to characterize this liver lesion. Axial T1 weighted and T2- weighted images showed a heterogeneous hyperintense lesion without contrast enhancement. Axial fat saturation T1-weighted and out of phase T1-weighted images showed a reduction in signal intensity. US and MRI examinations showed that the thrombosed umbilical vein ended superior to the lesion. In the differential diagnoses, fat-containing lesions such as lipoma-teratoma and fat-containing collection secondary to extravasation of TPN treatment via UVC were thought. CONCLUSION: In the differential diagnosis of liver localized lesions in newborns, UVC-related liver injury should be considered and the localization of the catheter tip should be checked. In case of the doubt based on US and X-ray findings, presence of fat on MRI could be diagnosed. Serious complications should be avoided with catheter revision or removal.Publication Metadata only A rare presentation of congenital isolated bilateral agenesis of a lateral rectus muscle in a child.(2023-01-01) Sijahovic S.; Donmez Z.; Yozgat C. Y.; Atasoy B.; Alkan A.; ALKAN, ALPAYPublication Metadata only A Review of Medicinal Properties of Ginkgo biloba L.(2023-05-01) Dincel D.; Aydemir G. G.; Altınbaşak O.; Büyükkılıç Altınbaşak B.; Yüksel Mayda P.; DİNCEL, DEMETThe history of the Ginkgo biloba L. species’ history dates back to very ancient times. It can live for approximately a thousand years and it is quite resistant to adverse conditions. Its leaves contain important components that make them useful for medicinal purposes. In addition, its seeds have also been used as a therapeutic agent in traditional Chinese medicine. G. biloba extracts are usually used in standardized dosage forms in medicinal preparations. Today, the preffered form is a standardized extract of G. biloba called Tebonin Egb761. Studies have shown that G. biloba leaf extract is effective in treating symptomatic relief of mild to moderate cerebral insufficiency in humans. It provides effective treatment in both Alzheimer's and vascular dementia patients. The herbal extract can also have positive effects on the quality of life in healthy individuals. G. biloba is effective against inner ear disorders and provides protection against endothelial damage. Besides, scientific studies have demonstrated that it has antioxidant, anti-inflammatory, antiviral, antibacterial, antidiabetic, anticancer, neuroprotective, cardioprotective, and many other effects. G. biloba is considered an important nutraceutical due to its scientifically proven effects. There is a growing interest in the scientific community regarding this plant. In this study, a review was made by compiling the data obtained from the literature on the "botanical characteristics", "history", "bioactive components", and "biological activities" of the G. biloba species.Publication Metadata only A single dose of genetically-attenuated malaria blood-stage parasites protects against two Plasmodium species infections.(2023-01-16) Deveci G.; Kamil M.; Aly A. S. I.; DEVECİ, GÖZDEPublication Metadata only A Study on Thymoquinone: Antioxidant Capacity and Anticancer Activities in LoVo Colorectal Cancer Cells(2024-02-02) Bozali K.; Metin Guler E.; KOÇYİĞİT A.; KOÇYİĞİT, ABDÜRRAHİMThymoquinone has antioxidant and anticancer effects. This study investigates the cytotoxic, genotoxic, and apoptotic effects of black seed and its active ingredient, thymoquinone on colorectal cancer cells. The antioxidant content of Black seed methanolic extracts (BSME) with different concentrations (50, 500 and 1000 mu g/mL) were determined by the photometric methods. The reactive oxygen production (iROS) of BSME and thymoquinone on colorectal cancer cells (LoVo) and normal epithelial cells (CCD18Co) were analyzed by the fluorometric methods. A luminometric glutathione kit was employed to observe the changes in intracellular glutathione (GSH) levels. Cytotoxicity was determined by the ATP method, genotoxicity was determined by Comet Assay, and the apoptosis was identified by the Acridine Orange/Ethidium Bromide (AO/EB) double dye method. The cytotoxicity was increased by BSME and thymoquinone in LoVo cells in a dose-dependent manner (p<0.001). BSME and thymoquinone also increased iROS, and induced apoptosis and DNA damage (p<0.001). High doses of BSME and thymoquinone on cancer and healthy cells have cytotoxic, genotoxic and apoptotic effects with pro-oxidant effects. Colorectal cancer cells are more sensitive than healthy cells.Publication Metadata only A view on pediatric airway management : a cross sectional survey study(2022-12-01) Saracoglu A.; Saracoglu K. T.; Sorbello M.; Kurdi R.; Greif R.; European Airway Management Soc E. A. M. S.; SÜMER, İSMAİLBACKGROUND: This survey aimed to investigate routine practices and approaches of clinicians on pediatric airway in anesthesia and intensive care medicine. METHODS: A 20-question multiple-choice questionnaire with the possibility to provide open text answers was devel-oped and sent. The survey was sent to the members of European Airway Management Society via a web-based platform. Responses were analyzed thematically. Only the answers from one representative of the pediatric service of each hospital was included into the analysis. RESULTS: Among the members, 143 physicians responded the survey, being anesthesiologists (83.2%), intensivists (11.9%), emergency medicine physicians (2.1%), and (2.8%) pain medicine practitioners. A straight blade was preferred by 115 participants (80.4%) in newborns, whereas in infants 86 (60.1%) indicated a curved blade and 55 (38.5%) a straight blade. Uncuffed tracheal tube were preferred by 115 participants (80.4%) in newborns, whereas 24 (16.8%) used cuffed tubes. Approximately 2/3 of the participants (89, 62.2%) reported not to use routinely a cuff manometer in their clinical practice, whereas 54 participants (37.8%) use it routinely in pediatric patients. Direct laryngoscopy for routine pediatric tracheal intubation was reported by 127 participants (88.8%), while 16 (11.2%) reported using videolaryngo-scopes routinely. Interestingly, 39 (27.3%) had never performed neither videolaryngoscopy nor flexible bronchoscopy in children. These results were significantly less in hospitals with a dedicated pediatric anesthesiologist. CONCLUSIONS: This survey on airway management in pediatric anesthesia revealed that the use of cuffed tubes and the routine monitoring of cuff pressure are rare. In addition, the rate of videolaryngoscopy or flexible optical intubation was low for expected difficult intubation. Our survey highlights the need for properly trained pediatric anesthesiologists working in-line with updated scientific evidence.Publication Metadata only Acil Serviste Piyüri Saptanan Çocuklarda İdrar Kültüründe Üreme Oranları ve Akut Faz Belirteçleri ile İlişkisinin Araştırılması(2020-01-01) USTABAŞ KAHRAMAN F.; UZUNER S.; USTABAŞ KAHRAMAN, FEYZA; UZUNER, SELÇUKPublication Metadata only Acute Effect of Unilateral Muscle Training Supported with Visual Feedback on Contralateral Muscle Strength and Joint Position Sense(2022-12-01) Denizoğlu Külli H.; Alpay K.; Durgut E.; Temizel A.; ALPAY, KÜBRA; DURGUT, ELİFPublication Metadata only Acute Effects of Kinesio Taping on Women with Diastasis Recti Abdominis(2023-01-01) DENİZOĞLU KÜLLİ H.; ALPAY K.; ALPAY, KÜBRA