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    A Newly Designed Surgical Instrument to Facilitate Osteotomy: The Lightening Osteotome
    (01.01.2012) Ozalp, Burhan; Karaaltin, Mehmet Veli; Orhan, Kadir Serkan
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    A novel indicator for assessment of mitral regurgitation severity: Pro-adrenomedullin
    (10.10.2013) Turker, Yasin; Aslantas, Yusuf; Turker, Yasemin; Akkaya, Mehmet; Ucgun, Taner; Erkan, Melih Engin
    Trypanosoma cruzi, the causative agent of Chagas disease, encodes for an alpha-carbonic anhydrase (CA, EC 4.2.1.1) possessing high catalytic activity (TcCA) which was recently characterized (Pan et al. J. Med. Chem. 2013, 56, 1761-1771). A new class of sulfonamides possessing low nanomolar/subnanomolar TcCA inhibitory activity is described here. Aromatic/heterocydic sulfonamides incorporating halogeno/methoxyphenacetamido tails inhibited TcCA with K(I)s in the range of 0.5-12.5 nM, being less effective against the human off-target isoforms hCA I and II. A homology model of TcCA helped us to rationalize the excellent inhibition profile of these compounds against the protozoan enzyme, a putative new antitrypanosoma drug target. These compounds were ineffective antitrypanosomal agents in vivo due to penetrability problems of these highly polar molecules that possess sulfonamide moieties.