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1,25-Dihydroxyvitamin D-3 stimulates odontoblastic differentiation of human dental pulp-stem cells in vitro
(2017-01-01T00:00:00Z) MUCUK, GÖKŞEN; SEPET, ELİF; ERGÜVEN, MİNE; EKMEKÇİ, ÖZLEM; BİLİR, AYHAN; MUCUK, GÖKŞEN
Background: 1,25-Dihydroxyvitamin D-3 (1,25-OH D-3) plays an important role in mineralized tissue metabolism, including teeth. However, few studies have addressed its role in odontoblastic differentiation of human dental pulp-stem cells (hDPSCs). Aim: This study aimed to understand the influence of various concentrations of 1,25-OH D-3 on the proliferation capacity and early dentinogenesis responses of hDPSCs. Materials and Methods: hDPSCs were obtained from the impacted third molar teeth. Monolayer cultured cells were incubated with a differentiation medium containing different concentrations of 1,25-OH D-3 (0.001, 0.01, and 0.1 mu M). All groups were evaluated by S-phase rate [immunohistochemical (IHC) bromodeoxyuridine (BrdU) staining], STRO-1 and dentin sialoprotein (DSP)+ levels (IHC), and alkaline phosphatase (ALP, enzyme-linked immunosorbent assay (ELISA)) levels. Results: The number of cells that entered the S-phase was determined to be the highest and lowest in the control and 0.001 mu M 1,25-OH D-3 groups, respectively. The 0.1 mu M vitamin D-3 group had the highest increase in DSP+ levels. The highest Stro-1 levels were detected in the control and 0.1 mu M 1,25-OH D-3 groups, respectively. The 0.1 mu M 1,25-OH D-3 induced a mild increase in ALP activity. Conclusions: This study demonstrated that 1,25-OH D-3 stimulated odontoblastic differentiation of hDPSCs in vitro in a dose-dependent manner. The high DSP + cell number and a mild increase in ALP activity suggest that DPSCs treated with 0.1 M 1,25-OH D-3 are in the later stage of odontoblastic differentiation. The results confirm that 1,25-OH D-3-added cocktail medium provides a sufficient microenvironment for the odontoblastic differentiation of hDPSCs in vitro.
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120-W GreenLight Laser Photoselective Vaporization of Prostate for Benign Prostatic Hyperplasia: Midterm Outcomes
(01.07.2011) Tasci, Ali Ihsan; Ilbey, Yusuf Ozlem; Luleci, Huseyin; Cicekler, Olcay; Sahin, Selcuk; Cevik, Cem; Tugcu, Volkan
OBJECTIVES To evaluate the safety and efficacy of 120-W high-performance system (HPS) laser photoselective vaporization of the prostate (PVP) in the treatment of patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia. METHODS Two experienced surgeons performed 120-W HPS laser PVP. The baseline characteristics, perioperative data, complications, and postoperative outcomes were evaluated at 3, 6, 12, 24, and 36 months postoperatively. RESULTS A total of 550 consecutive patients, with a mean age of 67.6 years, underwent PVP with a 120-W HPS laser. The mean prostate volume was 72.93 cm(3), with a mean prostate-specific antigen level of 3.57 ng/mL. The mean operative duration and the mean applied energy was 61.3 minutes and 164.06 kJ, respectively. No major complication occurred intraoperatively or postoperatively. The mean follow-up was 17.80 months. Significant improvements were observed postoperatively in the mean International Prostate Symptom Score, quality of life score, maximal urinary flow rate, and postvoid residual urine volume. The mean catheterization time was 18.5 hours. The complications included delayed hematuria in 26 (4.8%), recatheterization in 24 (4.4%), reoperation owing to residual prostatic adenoma in 46 (8.5%), urethral stricture in 19 (3.5%), and bladder neck contracture in 6 (1.1%) patients. CONCLUSIONS PVP with a 120-W HPS laser for benign prostatic hyperplasia has been proved to be a safe and effective procedure for our patients, including those treated with oral anticoagulants. The functional outcome in larger prostates was similar to that in smaller glands. UROLOGY 78: 134-141, 2011. (C) 2011 Elsevier Inc.
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120-W GreenLight Laser Photoselective Vaporization of Prostate for Benign Prostatic Hyperplasia: Midterm Outcomes
(2011-07-01T00:00:00Z) Tasci, Ali Ihsan; İLBEY, YUSUF ÖZLEM; Luleci, Huseyin; Cicekler, Olcay; Sahin, Selcuk; ÇEVİK, CEM; Tugcu, Volkan; İLBEY, YUSUF ÖZLEM
OBJECTIVES To evaluate the safety and efficacy of 120-W high-performance system (HPS) laser photoselective vaporization of the prostate (PVP) in the treatment of patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia.
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14 Mart: Kurtuluş Mücadelesinin İlk Kıvılcımı
(2018-03-01) YILDIRIM, NURAN; YILDIRIM, NURAN
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15 Haftalık Fetusun İntrauterin Fetal Ölümü ile Sonuçlanan Boynuna ve Sol Koluna Dolanmış Umblikal Kord
(2016-01-01) YILMAZ, BÜLENT; ŞEVKET, OSMAN; ATEŞ, SEDA; şekerci, zehra; ÖZKAL, FULYA; KELEKÇİ, SEFA; ŞEVKET, OSMAN; ATEŞ, SEDA
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1893-1895 İstanbul Kolera Salgınında Avrupalı Uzmanlar ve Osmanlı Devleti’nde Sağlık Modernizasyonuna Katkıları
(2020-03-01T00:00:00Z) Yıldırım, Nuran; Ertin, Hakan; YILDIRIM, NURAN
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2-D and 3-D ultrasonographic characteristics of the ovary in women with PCOS and multifollicular ovaries
(2020-10-01T00:00:00Z) Bozkurt, Murat; Kara Bozkurt, Duygu; Kurban, Didem; TAKMAZ, TAHA; ŞEVKET, Osman; ÖZCAN, Pınar; TAKMAZ, TAHA; ŞEVKET, OSMAN; ÖZCAN, PINAR
In this prospective study, seventy-six patients (PCOS group; n = 36, multifollicular ovary group; n = 40) were evaluated by 2-D and 3-D ultrasonography. VOCAL programme, echogenicity, number of follicles and blood flow parameters were evaluated. The patients with PCOS had a higher total ovarian volume, mean stromal volume and stromal echogenicity (18.6 +/- 4.75 to 10.2 +/- 3.4p .05). 3 D power Doppler parameters included VI, FI, and VFI values of the patients with PCOS were higher when compared to those of the patients with multifollicular ovary (3.82 +/- 2.65 to 1.78 +/- 1.2,p < .01; 50.76 +/- 4.45 to 40.6 +/- 3.64,p = .03; and 2.34 +/- 1.02 to 1.12 +/- 0.65,p = .02, respectively). Our results revealed that total ovarian volume, stromal volume and echogenicity; VFI, VI, and FI could be useful for differential diagnosis in women with PCOS and multifollicular ovaries.Impact statement What is already known on this subject?Ultrasonography is considered the new diagnostic tool for PCOS. Enlarged ovaries with multiple small follicles peripherally located around increased ovarian stroma with increased stromal echogenicity are the sonographic features of polycystic ovaries. What do the results of this study add?3-D Doppler ultrasonography may be more specific in the determination of multifollicular and polycystic ovaries when compared to RI and PI in 2-D Doppler ultrasonography. Moreover, 3-D power Doppler ultrasonography could be useful for differential diagnosis in women with PCOS and multifollicular ovaries. What are the implications of these findings for clinical practice and/or further research?In clinical practice, the differentiation of multifollicular ovaries and polycystic ovaries (PCO) is difficult with the use of 2-D sonography alone. Therefore, 3-D ultrasound and power Doppler may also be used in addition to 2-D ultrasound for the differentiation of multifollicular ovaries and PCO.
Open Access
3-Amino-thiophene-2-carbohydrazide Derivatives as Anti Colon Cancer Agents: Synthesis, Characterization, In-Silico and In-Vitro Biological Activity Studies
(2023-10-01) Şenol H.; Çakır F.; ŞENOL, HALIL
In this study, starting from 3-amino-thiophene-2-carboxylic acid methyl ester, eighteen new arylidenehydrazide derivatives (4–21) were synthesized. To determine cytotoxic activity of target compounds they were tested against human colon cancer and human umbilical vein endothelial cell lines. To determine prospective inhibition mechanism, binding affinity and complex stability molecular docking and molecular dynamics studies were carried out on transforming growth factor beta-2 (TGFβ2) and vascular endothelial growth factor receptor 2 (VEGFR2) proteins. According to the biological activity studies compounds (E)-2,4-dichloro-N-(2-(2-(4-fluorobenzylidene)hydrazine-1-carbonyl)thiophen-3-yl)benzamide (11) was found as the highest selective and active compound. Anti-cancer activity results compared to reference drugs doxorubicin and gefitinib. Most active compound was found as 7-fold and 4-fold more selective than doxorubicin and gefitinib, respectively. The detailed in vitro and in silico biological activity studies revealed that related compound demonstrated strong and selective anti-colon cancer effect and also it has promising inhibitory effects on TGFβ2 and VEGFR2. As a result, this compound is a promising candidate for further exploration and development in the field of colon cancer treatment.
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3-miktoarm star terpolymers using triple click reactions: Diels-Alder, copper-catalyzed azide-alkyne cycloaddition, and nitroxide radical coupling reactions
(2012-02-15T00:00:00Z) Günay, Ufuk Saim; Durmaz, Hakan; Gungor, Eda; Dag, Aydan; Hızal, Gürkan; Tunca, Ümit; DAĞ, AYDAN
Well-defined linear furan-protected maleimide-terminated poly(ethylene glycol) (PEG-MI), tetramethylpiperidine-1-oxyl-terminated poly(epsilon-caprolactone) (PCL-TEMPO), and azide-terminated polystyrene (PS-N-3) or -poly(N-butyl oxanorbornene imide) (PONB-N-3) were ligated to an orthogonally functionalized core (1) in a two-step reaction mode through triple click reactions. In a first step, DielsAlder click reaction of PEG-MI with 1 was performed in toluene at 110 degrees C for 24 h to afford alpha-alkyne-alpha-bromide-terminated PEG (PEG-alkyne/Br). As a second step, this precursor was subsequently ligated with the PCL-TEMPO and PS-N-3 or PONB-N-3 in N,N-dimethylformamide at room temperature for 12 h catalyzed by Cu(0)/Cu(I) through copper-catalyzed azide-alkyne cycloaddition and nitroxide radical coupling click reactions, yield resulting ABC miktoarm star polymers in a one-pot mode. (c) 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 50: 729-735, 2012
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3240 mg long acting methylphenidate intake for suicide attempt
(2014-03-01T00:00:00Z) Kilicoglu, Ali Güven; Ipek, Hamiyet; Mutlu, Caner; Dogan, Halil; Avci, Akkan; Erdogan, Ayten; KILIÇOĞLU, ALİ GÜVEN
Pharmacotherapy is frequently used to treat symptoms of attention-deficit/hyperactivity disorder (ADHD), the most common neurobehavioral disorder of childhood. There are a few reported cases of overdose for suicide attempts or abuse with methylphenidate in current literature. Majority of these cases fully recovered after supportive therapy. We present a patient who ingested 3240 mg long acting methylphenidate for suicide attempt. He experienced increase in heart beat rate and blood pressure but he did not have additional symptoms. Although no serious neurological or cardiovascular event happened in this case, the supervised stimulant use is needed in child and adolescent population. Further studies are needed to evaluate the effect of methylphenidate overdose.
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4-Furfuryloxymethyl-1,2,3-triazol-1-yl-acetohydrazide Hybrids as Cholinesterase and Carbonic Anhydrase Inhibitors: Synthesis, Characterization and Comprehensive Biological Activity Studies
(2024-02-01) Şenol H.; ŞENOL, HALIL
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57PD NEOADJUVANT CHEMORADIOTHERAPY FOR LOCALLY ADVANCED NON SMALL CELL LUNG CANCER
(2013-04-01) ZİYADE, SEDAT; ZİYADE, SEDAT
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A clinical and microbiological comparison of Er: YAG laser and mechanical debridement for the nonsurgical periodontal therapy: a randomized controlled clinical study
(2018-06-01) ZENGİN ÇELİK, TUĞBA; ERCAN, ÇİLEM; AKBAŞ, FAHRİ; SAĞLAM, EBRU; Nazaroğlu, KENAN; TUNALI, MUSTAFA; ZENGİN ÇELİK, TUĞBA; ERCAN, ÇİLEM; AKBAŞ, FAHRİ; TUNALI, MUSTAFA
Open Access
A 13-Year-Old Boy Who Has Kawasaki Disease Shock Syndrome Presents with Parotitis
(2020-03-01T00:00:00Z) YOZGAT, Yılmaz; UZUNER, SELÇUK; Demir, Aysegul Dogan; OĞUR, MUSTAFA; Yozgat, Can Yilmaz; TÜREL, Özden; YOZGAT, YILMAZ; UZUNER, SELÇUK; OĞUR, MUSTAFA; TÜREL, ÖZDEN
We report a 13-year-old boy who (initially) had symptoms of toxic shock-like syndrome and mumps. Then, the patient was hospitalized in the pediatric intensive care unit (PICU) because of his ongoing hemodynamic instability (low blood pressure of 70/30 mm Hg and capillary refill time of > 4 seconds). During his stay in the PICU, the patient was treated with fluid resuscitation and vasoactive infusion and at the same time was diagnosed with Kawasaki disease shock syndrome (KDSS), when giant right coronary artery aneurysms were detected on echocardiographic examination. This case illustrates the risk of KDSS in patient who carries both parotitis and toxic shock-like syndrome. The clinicians should be cautious about detecting any types of coronary artery aneurysms in such patients. This is the first case of KDSS associated with parotitis reported in the literature.
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A 13-Year-Old Boy Who Has Kawasaki Disease Shock Syndrome Presents with Parotitis
(2020-03-01) YOZGAT Y.; UZUNER S.; DOĞAN DEMİR A.; OĞUR M.; YOZGAT C. Y.; TÜREL Ö.; YOZGAT, YILMAZ; UZUNER, SELÇUK; DOĞAN DEMİR, AYŞEGÜL; TÜREL, ÖZDEN
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A 17-Year-Old Female with Systemic Lupus Presents with Complex Movement Disorder: Possible Relationship with Antiribosomal P Antibodies
(2013-01-01T00:00:00Z) Ozcan, Muhammed Emin; Altinoz, Meric Adil; Karadeli, Hasan Huseyin; ASİL, Talip; Kocer, Abdulkadir; ASİL, TALIP
Complex movement disorder is a relatively rare presentation of neurolupus. Antiphospholipid antibodies are associated with movement disorders likely via aberrant neuronal stimulation. Antiribosomal P antibodies have been previously associated with neuropsychiatric disorders but their correlation with movement disorder was not previously established. Our case report involves a 17-year-old Caucasian female patient positive for only antiribosomal P antibody and lupus anticoagulant who presented with a sudden onset of complex movement disorder. After complete cessation of physical signs with olanzapine, anticardiolipin and anti-beta 2 glycoprotein I antibodies became positive which indicates a likely discordance between movement disorder and antiphospholipid antibodies. This also indicates a potential causal role of antiribosomal P antibodies in inducing movement disorder.
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A 4-year clinical evaluation of direct composite build-ups for space closure after orthodontic treatment
(2015-12-01) Demirci, Mustafa; Tuncer, Safa; Oztas, Evren; TEKÇE, NESLİHAN; Uysal, Omer; UYSAL, ÖMER
To evaluate the medium-term clinical performance of direct composite build-ups for diastema closures and teeth recontouring using a nano and a nanohybrid composite in combination with three- or two-step etch-and-rinse adhesives following treatment with fixed orthodontic appliances.
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A 9-year follow-up of a girl with pyridoxine (vitamin B6)-dependent seizures: magnetic resonance spectroscopy findings
(2012-05-01T00:00:00Z) DOĞAN, MÜBEYNA; DOĞAN, DERYA; KAHRAMAN, A. S.; ÖZCAN, ÖZLEM; Yakinci, C.; Alkan, ALPAY; ALKAN, ALPAY
Being an extremely rare condition makes the diagnosis of pyridoxine-dependent seizures (PDS) difficult. Early diagnosis of PDS is very important to prevent unwanted clinical outcomes. Elevated levels of glutamate and decreased levels of gamma-aminobutyric acid (GABA) in the frontal and parietal cortices are detected in this disorder. Here we present an 18 year old girl with PDS, who was reported 9 years ago with Magnetic Resonance Spectroscopy (MRS) findings. Present and past MRS findings showed a decrease in N-acetyl-aspartate-to creatine ratio on MRS. In this case it is surprising that neuronal damage has been preceded despite the administration of accurate treatment. That can be because of delay in treatment and/or under treatment.
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A Basic Algorithmic Surgical Approach for Nicolau Syndrome
(2020-04-01T00:00:00Z) Yeniocak, Ali; Güneren, Ethem; Özkan, Mustafa; Temel, Metin; Kelahmetoğlu, Osman; YENİOCAK, ALİ; GÜNEREN, ETHEM; KELAHMETOĞLU, OSMAN
Background: Nicolau syndrome (NS) is a rare complication that develops after the administration of intramuscular diclofenac sodium. The etiology and surgical treatments of 11 patients with NS were evaluated and studies in the literature were examined. The aim of this study was to compose a basic algorithm for surgical approaches to treat NS. Materials and methods: Eleven patients were evaluated for NS between December 2013 and January 2018. Two patients did not accept treatment, and nine patients underwent surgical debridement of necrotic tissues. The tissue defects of five patients were closed with a fasciocutaneous flap and, in four patients, the defects were repaired primarily. Results: No complications, such as wound infection, wound dehiscence, seroma, or flap necrosis, were encountered. Of the seven patients who received concurrent antibiotic therapy, no patient had any problems at their follow-up (2-30 months). The results were satisfactory from an aesthetic and functional point of view. Conclusion: NS was more frequent in women with a high body mass index and high fat in gluteal regions. We considered that any kind of medication could lead to NS. Different methods are discussed for treatment.
Open Access
A bibliometric analysis of rheumatology and COVID-19 researches
(2021-07-01T00:00:00Z) PASİN, ÖZGE; Pasin, Tugce; PASİN, ÖZGE
Objective COVID-19 has had a substantial impact on rheumatology. There were many studies about rheumatology and COVID-19. But there is no study about bibliometric analysis of these studies. This study provides a general overview of studies on rheumatology and COVID-19.

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