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- PublicationOpen AccessA Case of Neglected Patella Dislocation Related to Tibial Plateau Fracture(2013-12-01T00:00:00Z) Elmadag, Mehmet; Ceylan, Hasan Huseyin; BIlsel, Kerem; Acar, Mehmet Ali; ELMADAĞ, NUH MEHMET; BİLSEL, İSMAIL KEREMAcute dislocation of the patella is a common orthopaedic emergency. The dislocated patella commonly reduces spontaneously or is reduced by a physician as an emergency. Rarely, open reduction is needed. Osteochondral fragments that detach from the patella or medial femoral condyle might interfere with patellar reduction, and sometimes osteophytes can interfere with reduction. Therefore, arthroscopic or, rarely, open reduction can be necessary. We present an unusual case of a locked knee related to a tibial plateau fracture. An osteochondral fragment that originated from the tibial plateau inhibited reduction of the patella. Such a fracture related to permanent patella dislocation has not previously been reported.
- PublicationOpen AccessA Preliminary Investigation on the Chromosome Aberrations in Acute Lymphoblastic Leukaemia Using Multiprobe Fluorescence In Situ Hybridization Panel(2022-06-01T00:00:00Z) Gokkaya, Bengisu; Atasoy, Sezen; ÇIRAKOĞLU, AYŞE; ARGÜDEN, YELDA; KURU, RAHİYE DİLHAN; YILMAZ, ŞÜKRİYE; ÖNGÖREN, ŞENİZ; DEVİREN, AYHAN; ATASOY, SEZENObjective: Acute lymphoblastic leukemia (ALL) is a disease related to the overproduction of immature lymphocytes. For diagnosis and classification of ALL, recognizing chromosome aberrations using conventional cytogenetic analysis (CCA) is essential. However, limited ability of CCA to capture cryptical chromosomal aberrations is a major drawback. The aim of this study was to investigate recurrent aberrations in patients with ALL with normal karyotype or unsuccessful karyotyping using the fluorescence in situ hybridization (FISH) method. Methods: Ten patients with ALL were included in this study. CCA was done according to the standart protocols, and then, multiprobe FISH panel was used for analyzing different chromosomal regions located on 12p13.2/21q22.12, 9q34.11-q34.12/22q11.22-q11.23, 9p21.3, 19p13.3, 11q23.3, 8q24.21, 14q32.33, 10p11.1-q11.1, 17p11.1-q11.1 and 4q12. Results: Analyses of the specific chromosomal regions with FISH assay revealed undetected chromosome rearrangements. Among all the cases, four of them harbored chromosomal abnormalities. MYC, TCF3, IGH rearrangements, CDKN2A deletion and hyperdiploidy were detected in the study Conclusion: Diagnostic sensitivity of FISH probes in comparison with CCA is effective in the detection of multiple chromosomal rearrangements with prognostic significance. For the improvement of the cytogenetic examination and achieving optimum results for patients with ALL , FISH panels are needed to be used combining with conventional cytogenetics routinely.
- PublicationOpen AccessA Rare Case: Mucous Membrane Plasmacytosis in the Larynx(2014-07-01) BÜYÜKPINARBAŞILI, NUR; ÇOBAN, GANİME; GÜCİN, ZÜHAL; Meriç, Ayşenur; BÜYÜKPINARBAŞILI, NUR; ÇOBAN, GANİME; GÜCİN, ZÜHALMucous membrane plasmacytosis is a rare reactive process characterized by plasma cell infiltration of mucous membranes for unknown reasons. It may be confused with malignancy because of its exophytic structure and pavement appereances. A laryngeal polypoid lesion was sent to the pathology department, clinically called fibroma, and presented to emphasize the diagnostic and differential diagnostic criteria.
- PublicationOpen AccessA Rare Presentation of Systemic Lupus Erythematosus during Childhood: Chorea(2017-04-01T00:00:00Z) DOĞAN DEMİR, AYŞEGÜL; Kucukkoc, Mehmet; Goknar, Nilufer; UYGUR ŞAHİN, TÜRKAN; ERENBERK, UFUK; DOĞAN DEMİR, AYŞEGÜL; UYGUR ŞAHİN, TÜRKAN; ERENBERK, UFUKSystemic lupus erythematosus (SLE) is a systemic, chronic, inflammatory, autoimmune disease characterized by multi-organ and - system involvement such as the kidneys and hematologic and central nervous systems. The clinical presentation of the disease is extremely variable. Systemic findings, nephritis, neuropsychiatric disease, and cytopenia are more common in children than in adults at presentation. Chorea typically manifests with jerky, involuntary, and purposeless movements, involving the face, four limbs, and neck. In addition, patients suffer from dysarthria, gait disturbance, and neuropsychiatric symptoms. Chorea can be the first finding of SLE during childhood. Herein we reported a 13-year female patient who presented with movement and speech disorders and who was diagnosed chorea-related SLE.
- PublicationOpen AccessACE-2, TMPRSS2 and Beyond; Promising Targets and Tools for COVID-19 Prophylaxis and Treatment(2020-12-01T00:00:00Z) Gepdiremen, Ali Akçahan; Kumaş, Meltem; GEPDİREMEN, ALİ AKÇAHANSeveral repurposing drugs and ongoing vaccine researches tocombat Coronavirus Disease-19 (COVID-19) are testing clinically,worldwide. COVID-19 caused by severe acute respiratory failuresyndrome-CoV-2, uses angiotensin-converting enzyme 2 (ACE-2) as a functional receptor for entry into the cells, followed by itspriming by transmembrane protease serine 2 (TMPRSS2). Most ofthe ACE-2 expressing cells are alveolar type II pneumocytes. ViralS-glycoprotein, TMPRSS2 and ACE-2 inhibition, as extracellularmedia components, are potential targets of future therapy. ACE-2 and/or TMPRSS2 blockade is thought to be beneficial in theprevention or treating of this infection which will be the mostconvenient for pharmacoeconomics and effectiveness, regardingsimilar future pandemics. Despite substrate-based design andsynthesis of ACE-2 inhibitor compounds were presented almosttwo decades ago, data on renin angiotensin system activation orits blockers, especially ACE-2, are limited by now. Priority mustbe given to design a convenient vaccine soon, but due to the highmutation ability of such viruses mean that new vaccines may needto be developed for each outbreak. So, de novo drugs such as ACE-2or TMPRSS2 blockers need to be developed which can specificallyblock spike binding sites of the target cells and prevent virusintrusion, especially at the extracellular media, for future pandemics.
- PublicationOpen AccessActinomyces neuii subsp. neuii Isolated from Perineal Abscess; Case Report(2019-04-01T00:00:00Z) AKBAŞ, EMEL; Sumbul Gultepe, Bilge; ERSÖZ, CEVPER; CEYLAN, AYŞE NUR; DOYMAZ, Mehmet Ziya; AKBAŞ, EMEL; SÜMBÜL, BİLGE; ERSÖZ, CEVPER; CEYLAN, AYŞE NUR; DOYMAZ, MEHMET ZIYAActinomyces are gram positive bacilli which generally colonize in mouth, colon and vagina. The members of genus Actinomyces are facultative anaerobic or microaerophilic organisms and have a branching flamentous structure. They cause classical actinomycosis. Among the Actinomyces species; A. israelii, A. viscosus, A. naeslundii, A. odontolyticus, A. bovis and A. neuii are the mostly isolated organisms from clinical cases. A rarely encountered member of this group, Actinomyces neuii does not show branching and is catalase and CAMP positive and is a coryneform shaped bacillus. Although Actinomyces is mostly found as contaminating organism, in some cases it is reported as a pathogen. Actinomyces neuii has been reported in chorioamnionitis, neonatal sepsis, vertebral osteomyelitis, cervical lymphadenitis, breast abscess, fatal bacteremia and postoperative endophthalmitis. In our case, A. neuii was isolated from a perineal abcess and it was not previously reported. In our case, Actinomyces neuii was identified by commercial identification systems. For this purpose; VITEK MS and VITEK (R) 2 Compact (both by bioMerieux, France) were used in the clinical microbiology laboratory and then this identification was confirmed as the Actinomyces neuii subsp. neuii by the 16S rRNA sequencing. Also, the positivity of CAMP was demonstrated in the laboratory. As in the cases of other actinomycosis, the treatment of the abcess caused by the Actinomyces neuii is through the surgical debridement. The antimicrobial susceptibility testing is not performed since the organism is reported to be susceptibile to common antibiotics. Beta lactam antibiotics are acknowledged as the proper selection for antibiotic treatment.
- PublicationOpen AccessAn Iron Deficiency Anemia Case That Came with Raw Rice Consumption(2015-02-01) ÇAMLI, AHMET ADİL; KARATOPRAK, CUMALİ; ÇETİN, GÜVEN; ZORLU, MEHMET; ALAY, MURAT; ÇAMLI, AHMET ADİL; KARATOPRAK, CUMALİ; ÇETİN, GÜVEN; ZORLU, MEHMETPica is the chronic consumption of edible or nonedible materials that is thought to be caused by mental problems, pregnancy, or anemia. We wanted to report this case, which we have not seen in the literature before, of a pica patient who consumed raw rice due to iron deficiency anemia. A 26-year-old female patient was brought to the internal medicine polyclinic by her mother with complaints of consuming a bowl of raw rice (200 gr) every evening. The patient was treated with parenteral ferik hydroxide + sucrose complex (2700 mg) for 5 days. After 15 days, when she came to control her will to eat raw rice had been lost completely. As a result, the attention of doctors and family members for pica due to treatable causes, such as anemia, will prevent many probable complications.
- PublicationOpen AccessAn Overview of COVID-19 Medicines in Current Guidelines(2020-12-01T00:00:00Z) GÖKÇE, MUSTAFA; GÜLER, ERAY METİN; GÖKÇE, MUSTAFAAn acute respiratory disease caused by a new coronavirus (Severe acute respirotary syndrome-coronavirus-2, previously known as 2019-nCoV), coronavirus disease 2019 (COVID-19), appeared in December 2019 and then has spread rapidly throughout the world starting from China, Japan and South Korea. As of January 30, 2020, the World Health Organization has officially declared the COVID-19 outbreak. Considering the clinical symptoms of COVID-19, it has many symptoms such as high fever, cough, and fatigue. It is reported that this disease is very severe and causes serious consequences such as cytokine storm and acute respiratory distress syndrome in the elderly and those with chronic diseases. Currently, scientists are trying to find a specific antiviral treatment strategy. Various medications such as hydroxychloroquine, lopinavir/ritonavir, ribavirin, remdesivir and favipiravir are currently being applied in clinical trials to test their efficacy and safety worldwide in COVID-19 treatment, and some promising results have been achieved so far. In this review, agents with potential efficacy against COVID-19 are presented in summary.
- PublicationOpen AccessAn Overwiev of the Neural Crest Cells and Tumor Metastasis(2016-08-01) Bayindir, NİHAN; Esrefoglu, MUKADDES; BAYINDIR, NİHAN; EŞREFOĞLU, MUKADDESNeural crest cells (NCCs) derived from neuroectoderm are multipotential cells. NCCs leave the neuroepithelium and migrate to various tissues by epithelial-mesenchymal transition. In this areas NCCs differentiate to variety of cells including melanocytes, glia cells, chromaffin cells. Cancer is a complex process which involves a dinamic interaction between tumor cells and surrounding micrenvironment. Cancer cells similar to neural crest cells leave their own environments and metastasize into a different tissue. The development of the neural crest and that of cancer progression share paralel morphological and molecular characteristics. Many signalling pathway and transcription factors are mutual for both processes. To investigate neural crest developmental mechanisms will provide a better understanding for cancer development, progression and metastasis.
- PublicationOpen AccessAnesthesia Management of a Parturient with Generalized Psoriasis Who Underwent Planned Cesarean Section(2014-09-01T00:00:00Z) Basaranoglu, Gokeen; Umutoglu, Tarik; Bakan, Mefkur; Topuz, Ufuk; Idin, Kadir; SALİHOĞLU, ZiyaPsoriasis is the most common chronic and inflammatory skin disease. The anesthetic approach may be regional or general. In this case, we described the anesthetic management of a parturient with generalized psoriasis who underwent a planned cesarean section.
- PublicationOpen AccessAnxiety, Depression and Health Profile in Mothers with Children in the Pediatric Intensive Care Unit(2020-04-01T00:00:00Z) Cabuk, Burcu; KOSTANOĞLU, Alis; KOSTANOĞLU, ALİSObjective: The aim of this study was to investigate, anxiety, depression and health profile among mothers of patients at pediatric intensive care unit (PICU) and pediatric inpatient service (PIS). Methods: The sample consisted of a total of 40 mothers, including mothers with children in a PICU (group I) and PIS (group II). The mothers’ quality of life was measured with the Nottingham Health Profile (NHP), anxiety was measured with the State- Trait Anxiety Inventory (STAI), and depression levels were measured with the Beck Depression Inventory (Beck-D) for the all mothers. Results: The mean age of the mothers was 31.5 years for group I and 31.25 years for group II. The mean total NHP score of the mothers was 279.0 for group I and 113.33 for group II. The mean total STAI-S score of mothers was 37.1 for group I and 36.65 for group II. The mean total of STAI-T score of mothers was 46.9 for group I and 47.75 for group II. The mean total Beck-D score was 39.7 for group I and 18.5 for group II. There was a statistically significant differences in the levels of anxiety, depression and health profile between the mothers with children in the PICU and those with children in the PIS (p<0.001). Conclusion: This study showed that having a critically ill child at a PICU unit has negative 17 effect on mothers' depression levels, state anxiety levels and health profile.
- PublicationOpen AccessApproach to Trichobezoar Cases in Children: Literature Review(2014-03-01T00:00:00Z) Kilincaslan, Huseyin; AYDOĞDU, İbrahim; Kucukkoc, Mehmet; Osmanoglu, Nurcan Keskin; Karacanoglu, Dilek; AYDOĞDU, İBRAHİMTrichobezoar is a mass found trapped in the gastrointestinal system formed from the ingestion of hair. They are mostly localized inside the stomach, and they can occasionally extend from the pylorus into the duodenum and small intestines. At the same time, they are almost always associated with trichotillomania, trichophagia, and other psychiatric diseases. Trichobezoar can be easily confused with other diseases characterized by abdominal pain and vomiting. Removal of the mass with laparotomic, laparoscopic, and endoscopic interventions is an available treatment approach. Among them, the laparotomic approach is the most effective treatment modality. Herein, we present a case and reviewed the literature from a general outlook in order to emphasize current, updated approaches to the pediatric cases with trichobezoar.
- PublicationOpen AccessBilateral Complete-type Medial Discoid Meniscus(2015-12-01T00:00:00Z) Uzer, GÖKÇER; Yildiz, FATİH; PULATKAN, MEHMET ANIL; Elmadag, NUH MEHMET; UZER, GÖKÇER; YILDIZ, FATİH; PULATKAN, MEHMET ANIL; ELMADAĞ, NUH MEHMETDiscoid meniscus is an uncommon congenital anomaly, and it is rarely seen in the medial compartment of the knee. Literature about bilateral medial discoid meniscus pathology is also limited because one of the knees is usually asymptomatic, although the pathology bilaterally exists. The incidence of bilateral cases should be more than that in current literature because of a number of non-diagnosed cases. In this study, we discuss the approach for a patient with one-sided symptomatic bilateral medial discoid meniscus and present partial meniscectomy as a treatment method.
- PublicationOpen AccessComparison of Small-diameter-hole and Traditional Microfracture in Cartilage Repair and the Effect of Adding a Hyaluronic Acid-based Acellular Matrix Scaffold: An Animal Study(2021-03-01T00:00:00Z) UÇAN, VAHDET; YILDIZ, FATİH; ELMADAĞ, Nuh Mehmet; UZER, GÖKÇER; GÜZEL, YUNUS; TOK, OLGU ENİS; Mukaddes, E.; UÇAN, VAHDET; YILDIZ, FATİH; ELMADAĞ, NUH MEHMET; UZER, GÖKÇER; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDESAbstract Objective: Since, there is no standardized technique for the treatment of focal cartilage defects that can recreate original cartilage tissue; researchers continue to explore and evaluate various treatment modalities. This study compared post-operatke healing of cartilage defects after treatment with small-diameter-hole microfracture (SDHM) technique with that of traditional microfracture technique. The effects of the hole density and augmentation with hyaluronic acid-based acellular matrix (HA-based AM) on cartilage healing were also investigated. Methods: Articular cartilage defects measuring 5 mm in diameter and 3 mm in depth were created in each femoral trochlear groove of 21 New Zealand rabbits. Rabbits were assigned to seven groups comprising six knees each. The rabbits were sacrificed 12 weeks later, and the regenerated cartilage was harvested for histological evaluation using the Wakitani scoring system. Results: All defects were filled with regenerated tissue macroscopically. Group I (14; range 10-14 points) had significantly higher Wakitani score than in groups VI (6; range 1-11 points) and VII (5; range 3-10 points) (p=0.043 and p=0.016, respectively). No significant differences were observed among the other groups. Augmentation with HA-based AM did not contribute to cartilage healing. Conclusion: Improved cartilage healing was observed with increasing SDHM density than with traditional microfracture technique. SDHM combined with HA-based AM implantation did not improve the quality of the regenerated cartilage.
- PublicationOpen AccessCoronavirus (COVID-19) and its Relationship with Ocular Surface(2021-02-01T00:00:00Z) EKİNCİ, CANSU; ÖZDEMİR, MEHMET HAKAN; EKİNCİ, CANSU; ÖZDEMİR, MEHMET HAKANAn outbreak in China-s Wuhan city in December 2019, characterized by unidentified pneumonia, leading to severe acute respiratory distress syndrome has begun. The cause of the outbreak has been detected as Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2), which is a new coronavirus and due to its rapid spread in a short time, it has been announced as a pandemic in terms of public health by the World Health Organization. The virus is transmitted mainly by direct contact with the secretions of patients and inhalation of virus-containing micro-droplets. The transmission of the virus via the ocular route is a controversial issue and there arc limited number of studies in the literature. Follicular conjunctivitis may he one of the ocular manifestations of the disease and even if there is no concomitant conjunctivitis, it is very important for the ophthalmologists and healthcare professionals to take preventive measures. In this review, the relationship of SARS-CoV-2 with ocular surface findings was evaluated in the light of the literature.
- PublicationOpen AccessCorrelation of Body Composition Analysis with Anthropometric Measurements in Peritoneal Dialysis Patients(2022-01-01T00:00:00Z) ARTAN, AYŞE SERRA; GÜRSU, Meltem; ELÇİOĞLU, Ömer Celal; YABACI TAK, AYŞEGÜL; KAZANCIOĞLU, Rümeyza; ARTAN, AYŞE SERRA; GÜRSU, MELTEM; ELÇİOĞLU, ÖMER CELAL; YABACI TAK, AYŞEGÜL; KAZANCIOĞLU, RÜMEYZAObjective: This study investigates correlations between different methods for diagnosis of protein energy malnutrition (PEM) in peritoneal dialysis patients. Methods: Twenty four patients were included. Patients with amputations, infections, peritonitis, malignancies and PD duration less than three months were excluded. Physical examination findings, laboratory results and anthropometric measurements were recorded. Body composition analysis was performed with multi-frequency bioimpedance analyzer. Dialysis malnutrition score (DMS) was calculated. The correlations of different parameters were searched. Results: Eleven patients were female and 13 patients were male. Mean age was 58.9±12.6 years. Median dialysis duration was 25 (interquartile range: 14) months. Protein percentage was negatively correlated with fat percentage (r=-0.785; p<0.001), triceps skinfold thickness (SFT) (r=-0.641; p<0.001), biceps SFT (r=-0.685; p<0.001), body mass index (BMI) (r=-0.867; p<0.001), mid-arm circumference (r=-0.680; p=0.001). Fat percentage was positively correlated with BMI (r=0.780; p<0.001), biceps SFT (r=0.817; p<0.001), triceps SFT (r=0.901; p<0.001) and mid-arm circumference (r=0.558; p=0.005) Albumin was negatively correlated with DMS (r= -0.439; p=0.032). DMS and albumin were not correlated with bioimpedance and anthropometry Conclusion: Albumin is a marker of PEM in PD patients. Malnutrition scores may be used as adjunct methods. Increase in fat mass and percentage may influence the interpretation of anthropometric measurements.
- PublicationOpen AccessCOVID-19 and Influenza Coexistence(2021-02-01T00:00:00Z) Uslu Ersoz, Ayse Betul; KAÇMAZ, ASİYE BAHAR; OKAY, GÜLAY; Andic, Nurgul; Karakus, Dilara; BOLUKÇU, SİBEL; SÜMBÜL, BİLGE; MERİÇ KOÇ, MELİHA; AKKOYUNLU, YASEMİN; DURDU, BÜLENT; USLU, AYŞE BETÜL; BOLUKÇU, SİBEL; ANDIÇ, NURGÜL; OKAY, GÜLAY; SÜMBÜL, BİLGE; KAÇMAZ, ASİYE BAHAR; DURDU, BÜLENT; AKKOYUNLU, YASEMİN; MERİÇ KOÇ, MELİHAObjective: Viral pneumonia cases occur quite frequently in the community. The rate of viral infections in community-acquired pneumonia is about 25%. severe acute respiratory syndrome coronas i rus-2 (SARS-CoV-2) and influenza are also viruses that can cause pneumonia. In this study. we aimed to determine the rate of influenza co-infection in Coronavirus disease-19 (COVID-19) Cases.
- PublicationOpen AccessCOVID-19 Pandemic: Stress and Psychiatric Disorders(2021-02-01T00:00:00Z) KIRPINAR, İSMET; KIRPINAR, İSMETThe epidemic, which first started as viral pneumonia in Wuhan, China at the end of 2019 and is now known as Coronavirus disease-19 (COVID-19). rapidly spread to almost every part of the world and named a pandemic in March 2020. It is well known that psychiatric symptoms and syndromes, especially posttraumatic stress disorder, major depression, anxiety, and sleep disorders reach high prevalence values in natural or man-made disasters, Especially in infectious disease epidemics where mortality rates are high, patients, those who arc quarantined, and the whole society experience very intense mental stress and trauma. It is not easy to avoid psychological distress after facing highly fatal illnesses such as Ebola, severe acute respiratory syndrome (SARS), or COVID-19. When pandemics turn into a rapid and global disaster, the prevalence values of mental problems reach even higher levels. Combating mental disorders not only provides psychological well-being but also affects the course of the epidemic, as these disorders can delay efforts to fight epidemics.
- PublicationOpen AccessCurrent Minimal Invasive Surgery Treatment For Kidney Stones: Bezmialem Experience(2016-08-01T00:00:00Z) AKÇAY, MUZAFFER; Tepeler, Abdulkadir; TOSUN, MUHAMMED; Basibuyuk, Ismail; Elbir, Fatih; KARDAŞ, SİNA; Akman, Tolga; Armagan, Abdullah; Tasci, Ali Ihsan; AKÇAY, MUZAFFER; TOSUN, MUHAMMED; KARDAŞ, SİNAObjective: We aimed to present the outcomes of patients with symptomatic kidney stones treated with percutaneous nephrolithotomy (PNL) or retrograde intrarenal surgery (RIRS).
- PublicationOpen AccessDental Treatment of Two Children with Niemann Pick Disease Type B Under General Anesthesia: Case Reports(2019-03-01) KAYA, MUSTAFA SARP; BAKKAL, MELTEM; YEŞİLTAŞ, SERDAR; KAYA, MUSTAFA SARP; BAKKAL, MELTEM; YEŞİLTAŞ, SERDARNiemann-Pick disease (NPD) is an autosomal recessive lysosomal lipid storage disorder with accompanying symptoms including hepatosplenomegaly and thrombocytopenia. Delayed or extensive dental treatment may need to be delivered under general anesthesia and the management of such treatments in these children may require advanced medical support including intensive care (IC). Two children with NPD type B who underwent dental treatment with general anesthesia and their post-operative follow-ups requiring in IC are were presented. Patients with NPD may present with fragile blood clots in extracted tooth socket and should be subjected to strict bleeding control standards; especially the ones that may require further respiratory assistance since oral intubation is an invasive application to the oral surgical site.