Eczacılık Fakültesi
Permanent URI for this collection
Browse
Browsing Eczacılık Fakültesi by Title
Now showing 1 - 20 of 407
Results Per Page
Sort Options
- PublicationOpen AccessA Comparative Study on Magnetostructural Properties of Barium Hexaferrite Powders Prepared by Polyethylene Glycol(2014-01-01) Durmus, ZEHRANanocrystalline particles of barium hexaferrite were synthesized by a sol-gel combustion route using nitrate-citrate gels prepared from metal nitrates and citric acid solutions with Fe/Ba molar ratio 12. The present paper aims to study the effect of addition of polyethylene glycol (PEG) solutions with different molecular weights (MW: 400, 2000, and 10.000 g/mol) on magnetostructural properties of barium hexaferrite. The formation of the barium hexaferrite was inspected using X-ray diffraction (XRD) analysis, Fourier transform infrared (FT-IR) analysis, thermogravimetric (TGA) analysis, scanning electron microscopy (SEM) analysis and vibrating sample magnetometer (VSM) analysis for magnetic measurements.
- PublicationMetadata onlyA Comporative Study on the Morphology, Anatomy and Ecology of Dactylorhiza romana (Seb.) Soo subsp. romana and Dactylorhiza romana (Seb.) Soo subsp. georgica (Klinge) Soo ex Renz & Taub. (Orchidaceae) in Turkey(2011-02-24) ALTUNDAG, ERNAZ; SEVGİ, ECE; KARA, OMER; SEVGI, ORHAN; TECIMEN, HUSEYIN BARIS; BOLAT, ILYAS; SEVGİ, ECE
- PublicationMetadata onlyA Coumarin Bearing Amphiphilic Block Copolymer: Synthesis, Characterization and Micellization(2016-07-21) TEMEL, BİNNUR; TEMEL, BİNNUR
- PublicationMetadata onlyA detailed study on the chemical and biological profiles of essential oil and methanol extract of Thymus nummularius (Anzer tea): Rosmarinic acid(2015-05-01) Ertas, Abdulselam; Boga, Mehmet; Yilmaz, Mustafa Abdullah; Yesil, Yeter; Tel, Gulsen; Temel, Hamdi; Hasimi, Nesrin; Gazioglu, IŞIL; Ozturk, Mehmet; Ugurlu, Pelin; GAZİOĞLU, IŞILThe aim of this study was to determine the chemical profile of Thymus nummularius by LC-MS/MS and GC/MS. Additionally, the methanol extract, essential oil and some individual main compounds of Thymus nummularius were tested for antioxidant, anticholinesterase and antimicrobial activities. Besides, HPLC-FLD was used to determine total aflatoxin in the plant material. Among the twenty-seven compounds studied by LC-MS/MS, rosmarinic acid (131,898.9 +/- 6463.0 mu g/g dry-extract) was found to be the most abundant compound in the methanol extract. On the other hand, thymol (60.38%) and terpinyl-acetate (10.49%) were found to be the major compounds of the essential oil. Both the essential oil and the methanol extract of T. nummularius exhibited strong antioxidant activity in the four tested methods. Furthermore, the essential oil showed high inhibitory activity against acetyl-,butyryl-cholinesterase enzymes and very strong antimicrobial activity against all tested microorganisms. Besides, T. nummularius can be used both as rosmarinic acid source and as food supplement due to its non-aflatoxin content and high antioxidant, anticholinesterase and antimicrobial activities. (C) 2015 Elsevier B.V. All rights reserved.
- PublicationMetadata onlyA Divalent PAMAM-Based Matrix Metalloproteinase/Carbonic Anhydrase Inhibitor for the Treatment of Dry Eye Syndrome.(2016-01-26) RICHICHI, B; BALDONESCHI, V; BURGALASSI, S; FRAGAI, M; VULLO, D; Akdemir, ATİLLA; DRAGONI, E; LOUKA, A; MAMUSA, M; MONTI, D; BERTI, D; NOVELLINO, E; De, Rosa; SUPURAN, CT; NATIVI, C; AKDEMİR, ATİLLA
- PublicationMetadata onlyA multifunctional multimaterial system for on-demand protein release(2018-08-28) Tuncaboylu, DENİZ CEYLAN; FRIESS, Fabian; WISCHKE, Christian; LENDLEIN, Andreas; TUNCABOYLU, DENIZ CEYLANIn order to provide best control of the regeneration process for each individual patient, the release of protein drugs administered during surgery may need to be timely adapted and/or delayed according to the progress of healing/regeneration. This study aims to establish a multifunctional implant system for a local on-demand release, which is applicable for various types of proteins. It was hypothesized that a tubular multimaterial container kit, which hosts the protein of interest as a solution or gel formulation, would enable on-demand release if equipped with the capacity of diameter reduction upon external stimulation. Using devices from poly(epsilon-caprolactone) networks, it could be demonstrated that a shape-memory effect activated by heat or NIR light enabled on-demand tube shrinkage. The decrease of diameter of these shape-memory tubes (SMT) allowed expelling the payload as demonstrated for several proteins including SDF-1 alpha, a therapeutically relevant chemotactic protein, to achieve e.g. continuous release with a triggered add-on dosing (open tube) or an on-demand onset of bolus or sustained release (sealed tube). Considering the clinical relevance of protein factors in (stem) cell attraction to lesions and the progress in monitoring biomarkers in body fluids, such on-demand release systems may be further explored e.g. in heart, nerve, or bone regeneration in the future.
- PublicationMetadata onlyA new alien species record for the flora of Turkey: Proboscidea louisianica (Miller) Thell.(2017-10-01) SEVGİ, ECE; KIZILARSLAN HANÇER, ÇAĞLA; Yılmaz, Hatice; Akkaya, Muhammed; SEVGİ, ECE; KIZILARSLAN HANÇER, ÇAĞLA
- PublicationMetadata onlyA new dinuclear copper (II) complex of 2,5– Furandicarboxyclic acid with 4(5)-Methylimidazole as a high potential ?-glucosidase inhibitor: Synthesis, Crystal structure, Cytotoxicity study, and TD/DFT calculations(2019-01-01) Sönmez, Fatih; Basoglu, Adil; Altürk, Sümeyye; Avcı, Davut; Tamer, Ömer; Öztürk, Dilek; Dege, Necmi; Zengin Kurt, Belma; Atalay, Yusuf; ZENGİN KURT, BELMA; ÖZTÜRK CİVELEK, DİLEK
- PublicationMetadata onlyA New Validated HPLC/UV Method for the Simultaneous Determination of Vildagliptin and Metformin in Pharmaceutical Preparations(2013-08-16) KIZILTAS, M. V.; DİNCEL, DEMET; TEKKELİ, ŞERİFE EVRİM; TEKKELİ, ŞERİFE EVRİM; DİNCEL, DEMET
- PublicationMetadata onlyA novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms.(2016-03-01) CERUSO, M; SECCI, D; De, Monte; MOLLICA, A; SOBOLEV, AP; Akdemir, ATİLLA; SUPURAN, CT; GUGLIELMI, P; De, Cosmi; CODISPOTI, R; CARRADORI, S; AKDEMİR, ATİLLA
- PublicationMetadata onlyA Novel Nano Formulation For Synthetic And Plant Based Metal Chelators With Blood-Brain Barrier Targeting Property For Treatment Of Alzheimer’s Disease(2015-06-12) BAHADORİ, FATEMEH; Kazdal, Fatma; ÇELİK, BURAK; BAHADORİ, FATEMEH; ÇELİK, BURAK
- PublicationMetadata onlyA Novel Nano Formulation for Targeting Breast Cancer(2018-11-28) BAHADORİ, FATEMEH; Eskandari, Zahra; YENİGÜN, VİLDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİM; Onyuksel, Hayat; BAHADORİ, FATEMEH; YENİGÜN, VILDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİM
- PublicationMetadata onlyA novel series of M(II) complexes of 6-methylpyridine-2-carboxylic acid with 4(5)methylimidazole: Synthesis, crystal structures, α-glucosidase activity, density functional theory calculations and molecular docking(2019-07-01) Avcı, Davut; Altürk, Sümeyye; Sönmez, Fatih; Tamer, Ömer; Başoğlu, Adil; Atalay, Yusuf; Zengin Kurt, Belma; Dege, Necmi; ZENGİN KURT, BELMA
- PublicationMetadata onlyA novel series of mixed-ligand M(II) complexes containing 2,2′-bipyridyl as potent α-glucosidase inhibitor: synthesis, crystal structure, DFT calculations, and molecular docking(2019-08-01) Avcı, Davut; Altürk, Sümeyye; Sönmez, Fatih; Tamer, Ömer; Başoğlu, Adil; Atalay, Yusuf; Zengin Kurt, Belma; Dege, Necmi; ZENGİN KURT, BELMA
- PublicationMetadata onlyA novel type radar absorbing materials: hard ferrite- graphene nanocomposites(2014-08-13) DURMUŞ, ZEHRA; KAVAS, H.; DURMUS, ALI
- PublicationMetadata onlyA potential therapeutic role in multiple sclerosis for stigmast-5,22-dien-3β-ol myristate isolated from Capparis ovata(2017-07-01) ACAR, Özden Özgür; GAZİOĞLU, IŞIL; KOLAK, UFUK; ŞEN, ALAATTİN; TOPÇU, GÜLAÇTI; GAZİOĞLU, IŞIL; TOPÇU, GÜLAÇTI
- PublicationMetadata onlyA promising Neuroprotective Agent for the Treatment of Multiple Sclerosis: 3-beta-Hydroxyolean-12-en-28-oate İsolated from Capparis ovata(2017-07-05) ŞEN, ALAATTİN; ÖZGÜN ACAR, Özden; GAZİOĞLU, IŞIL; TOPÇU, GÜLAÇTI; GAZİOĞLU, IŞIL; TOPÇU, GÜLAÇTI
- PublicationMetadata onlyA promising novel antidiabetic compound: Alysine-A(2016-09-01) Sen, A.; Ayar, B.; Topcu, GÜLAÇTI; Yilmaz, ANIL; TOPÇU, GÜLAÇTI; YILMAZ, ANIL
- PublicationOpen AccessA Realistic View on -The Essential Medicinal Chemistry of Curcumin-(2017-09-01) Bahadori, FATEMEH; DEMIRAY, Mutlu; BAHADORİ, FATEMEHThe review paper entitled “The Essential Medicinal Chemistry of Curcumin”, published in the Journal of Medicinal Chemistry, by Nelson et al.1 is a well-designed paper, presenting a new (and negative) approach to the well-known biologically active compound; curcumin. Although some arguments throughout this paper are completely true, the approach of the authors is unfortunately far from impartial, and many of the conclusions the authors draw from some of their referred papers are especially hard to accept. On page 1621, line 11, the authors mention that the in vivo stability of curcumin is T1/2 < 5 min and F < 1% by referring to the research papers of Wang et al.2 and Yang et al.3 (refs 27 and 28 of the original paper). Interestingly, neither Wang nor Yang et al. directly report these values as the half-life of curcumin, which makes this a very biased supposition of the authors. The paper, published by Wang et al., reports the stability of curcumin in buffer solvents at laboratory conditions and in rat blood circulation. Since it is impossible to directly dissolve curcumin in water, curcumin was dissolved in methanol and then diluted with a buffer, and the amount of curcumin was measured in HPLC at different intervals. It is obvious that curcumin will start precipitating upon dilution with a buffer. Thus, it is doubtful that the sample injected in HPLC or administered to rats includes the supposed amount of curcumin. Yang et al. also do not report the half-life of curcumin below 5 min. This paper reports the elimination period as 28.1 ± 5.6 and 44.5 ± 7.5 min for 500 mg/kg, p.o. and 10 mg/kg, i.v. of curcumin, respectively. It is noteworthy that the half-life results are reported by the studies made in rats, not human studies. A rat weighing 400 g has a total blood volume of approximately 25.6 mL,4 and the human blood volume is approximately 5.5 L. The half-life measurements of the compound during blood circulation were made without considering the insolubility of curcumin in buffer solutions or the stability measurements in rat blood circulation and therefore do not accurately illustrate the fate of curcumin upon circulation within human blood. More interestingly, the authors acknowledge that the half-life of curcumin with pH 7.4 and 37 °C in human blood is 360−480 min in Supplemental Table 2 of ref 1. However, they report its stability as T1/2 < 5 min on page 1621, left column line 11.
- PublicationMetadata onlyA Review of Current Methods for the Determination of Acrylamide in Food Products(2012-02-01) Tekkeli, Serife Evrim Kepekci; Onal, Cem; Onal, Armagan; TEKKELİ, ŞERİFE EVRİMAcrylamide (AA) is a potentially carcinogenic substance which is formed during heating of food products containing carbohydrates and asparagine. It was first detected in food products in 2002. Since that time, several analytical methods have been made available for the quantification of AA in various foods. Starting from the announcement in 2002, occurrence, formation, chemistry, toxicology, and potential health risk in the human diet have been investigated and methods of analysis have been reviewed in many articles. In this paper, current information and analytical methods for the determination of AA have been reviewed.