TR Dizin İndeksli Yayınlar Koleksiyonu
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Browsing TR Dizin İndeksli Yayınlar Koleksiyonu by Subject "Alzheimer"
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Publication Open Access Physical activity and exercise in dementia: an umbrella review of intervention and observational studies(2020-12-26T00:00:00Z) Demurtas, Jacopo; Schoene, Daniel; Torbahn, Gabriel; Petrovic, Mirko; Maggi, Stefania; Marengoni, Alessandra; Cesari, Matteo; Lamb, Sarah; Soysal, Pınar; Sieber, Cornel; Shenkin, Susan; Grande, Giulia; Schwingshack, Lukas; Smith, Lee; Veronese, Nicola; SOYSAL, PINARObjectives The aim of this umbrella review was to determine the effect of physical activity/exercise on improving cognitive and noncognitive outcomes in people with MCI (mild cognitive impairment) and dementia. Design Umbrella review of systematic reviews (SR), with or without meta-analyses (MAs), of randomized controlled trials (RCTs) and observational studies. Settings and Participants People with MCI or dementia, confirmed through validated assessment measures. Any form of physical activity/exercise was included. As controls, we included participants not following any prespecified physical activity/exercise intervention or following the same standard protocol with the intervention group. Methods The protocol was registered in PROSPERO (CDR 164197). Major databases were searched until December 31, 2019. The certainty of evidence of statistically significant outcomes was evaluated using the Grading of Recommendations Assessment, Development and Evaluation approach. SRs' findings, without a formal MA, were reported descriptively. Results Among 1160 articles initially evaluated, 27 SRs (all of RCTs, 9 without MA) for a total of 28,205 participants with MCI/dementia were included. In patients with MCI, mind-body intervention (standardized mean difference [SMD] = 0.36; 95% confidence intervals [CI] 0.20–0.52; low certainty) and mixed physical activity interventions (SMD = 0.30; 95% CI 0.11–0.49; moderate certainty) had a small effect on global cognition, whereas resistance training (SMD = 0.80; 95% CI 0.29–1.31; very low certainty) had a large effect on global cognition. In people affected by dementia, physical activity/exercise was effective in improving global cognition in Alzheimer disease (SMD = 1.10; 95% CI 0.65–1.64; very low certainty) and in all types of dementia (SMD = 0.48; 95% CI 0.22–0.74; low certainty). Finally, physical activity/exercise improved noncognitive outcomes in people with dementia including falls, and neuropsychiatric symptoms. Conclusions and Implications Supported by very low-to-moderate certainty of evidence, physical activity/exercise has a positive effect on several cognitive and noncognitive outcomes in people with MCI and dementia, but RCTs, with low risk of bias/confounding, are still needed to confirm these relationships.Publication Open Access Reliability and Validity of the Abbreviated Turkish Version of the Zarit Caregiver Burden Interview(2016-08-01T00:00:00Z) Yildiz, Gilsen Babacan; Yaci, Omer; Akca, Zeynep; Kulaksizoglu, Isin BaralObjective: Our aim was to validate the Turkish version of the 12 item form of the Zarit Caregiver Burden Interview (T-ZBI-12) as an instrument to measure the caregiver burden in caregivers of patients with dementia in Turkey and to evaluate its reliability. Methods: A total of 90 caregivers of Alzheimer's patients with dementia from two outpatient clinics were included in the study. MMSE was used to determine dementia severity, and validity was examined using the correlation between the T-ZBI-12 and MMSE score. We used item-total correlations to check whether there was an item inconsistent with the rest of the interview. Results: The abbreviated scale (T-ZBI-12) is valid and reliable, with a Cronbach's alpha value of 0.92. All item-total correlations were significant (p<0.01). The results demonstrated good validity, with significant correlations between caregiver burden and dementia severity. Conclusion: T-ZBI-12 is reliable and valid for the assessment of dementia caregiver burden in Turkey.