TR Dizin İndeksli Yayınlar Koleksiyonu
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Publication A Case of Primary Hypoparathyroidism Presenting with Acute Kidney Injury Secondary to Rhabdomyolysis.(2016-01-01) SUMNU, A; AYDIN, Z; GURSU, MELTEM; UZUN, S; KARADAG, S; CEBECI, E; OZTURK, S; Kazancioglu, RÜMEYZA; GÜRSU, MELTEM; KAZANCIOĞLU, RÜMEYZASymmetric calcification of the basal ganglia identified radiographically occurs in a variety of familial and nonfamilial conditions. Primary Familial Brain Calcifications (PFBC), which were known by many names previously, including Fahr disease and striopallidodentate calcinosis, are a genetic disease characterized by various mutations in four separate genes and autosomal dominant inheritance [1–4]. PFBC may present with various psychiatric and neurological symptoms [5]. On the other hand, many secondary causes, either infectious, toxic, or metabolic, have been described to cause symmetrical basal ganglion calcifications and so are in the differential diagnosis of PFBC [6]. Parathyroid diseases such as hypoparathyroidism, pseudohypoparathyroidism, and pseudo-pseudohypoparathyroidism are in the forefront among the metabolic causes. Idiopathic or postsurgical hypoparathyroidism is the most common cause of symmetric calcification of the basal ganglia [7–9]. Herein, a case of primary hypoparathyroidism with severe tetany, rhabdomyolysis, and acute kidney injury (AKI) is presented.Publication A Case Report of Tongue Edema due to Laryngeal Mask with Introducer(1.10.2018) Daskaya, Hayrettin; Ciftci, Taner; Idin, Kadir; Gul, Kursat; Topuz, Ufuk; Olculu, HakkiAirway management using a laryngeal mask is an especially preferred noninvasive technique because of its achievement of hemodynamic stability and ease of application in surgeries that have short surgery time and do not require specific positions such as the prone position. Although it is easily performed, serious complications may manifest rarely because of lack of experience and inappropriate choice of instrumentation. In this case report, clinical management and treatment options of tongue edema that developed because of the forgotten introducer in laryngeal mask application are presented.Publication A clinical variant in SCN1A inherited from a mosaic father cosegregates with a novel variant to cause Dravet syndrome in a consanguineous family(2015-07-01) Tuncer, FN; Altıokka uzun , G; Gormez, Z; Calik , M; Yuksel, B; Sagiroglu, MS; Iscan, AKIN; Yuceturk , B; Ugur Iseri, SA; Bebek, N; Baykan, B; Ozbek , U; İŞCAN, AKINA consanguineous family from Turkey having two children with intellectual disability exhibiting myoclonic, febrile and other generalized seizures was recruited to identify the genetic origin of these phenotypes. A combined approach of SNP genotyping and exome sequencing was employed both to screen genes associated with Dravet syndrome and to detect homozygous variants. Analysis of exome data was extended further to identify compound heterozygosity. Herein, we report identification of two paternally inherited genetic variants in SCN1A (rs121917918; p.R101Q and p.I1576T), one of which was previously implicated in Dravet syndrome. Interestingly, the previously reported clinical variant (rs121917918; p.R101Q) displayed mosaicisnn in the blood and saliva of the father. The study supported the genetic diagnosis of affected children as Dravet syndrome possibly due to the combined effect of one clinically associated (rs121917918; p.R101Q) and one novel (p.I1576T) variants in SCN1A gene. This finding is important given that heterozygous variants may be overlooked in standard exome scans of consanguineous families. Thus, we are presenting an interesting example, where the inheritance of the condition may be misinterpreted as recessive and identical by descent due to consanguinity and mosaicism in one of the parents. (C) 2015 Elsevier B.V. All rights reserved.Publication A clinically unsuspected nasopharyngeal sarcoidosis.(2016-05-01) TUGRUL, SELHATTİN; GOKTAS, SS; OZUCER, B; SÖNMEZ, FATMA CAVİDE; Özturan, ORHAN; TUĞRUL, SELAHATTİN; SÖNMEZ, FATMA CAVİDE; ÖZTURAN, ORHANPublication A comparison of the prevalence of orthostatic hypotension between older patients with Alzheimer-s Disease, Lewy body dementia, and without dementia.(2019-09-01) Soysal, PINAR; Aydin, AE; Isik, AT; Smith, L; Kocyigit, SE; SOYSAL, PINARPublication A High-Performance Liquid Chromatographic Method for the Determination of Meropenem in Serum.(2019-11-18T00:00:00Z) Dincel, D; Sagirli, O; Topcu, GÜLAÇTI{{abstract}}Publication A minimally invasive transfer method of mesenchymal stem cells to the intact periodontal ligament of rat teeth: a preliminary study(2018-01-01) GÜL AMUK, NİSA; KURT, GÖKMEN; YANDIM KARTAL, MELIS; ADAN, AYSUN; BARAN, YUSUF; KURT, GÖKMENThe aim of this study was to introduce a minimally invasive procedure for mesenchymal stem cell (MSC) transfer into the intact periodontal ligament (PDL) of the molar teeth in rats. Ten 12-week-old Wistar albino rats were used for this preliminary study. MSCs were obtained from bones of two animals and were labeled with green fluorescent protein (GFP). Four animals were randomly selected for MSC injection, while 4 animals served as a control group. Samples were prepared for histological analysis, Cox-2 mRNA expression polymerase chain reaction analysis, and fluorescent microscopy evaluation. The number of total cells, number of osteoclastic cells, and Cox-2 mRNA expression levels of the periodontal tissue of teeth were calculated. The number of total cells was increased with MSC injections in PDL significantly (P < 0.001). The number of osteoclastic cells and Cox-2 mRNA expression were found to be similar for the two groups. GFP-labeled MSCs were observed with an expected luminescence on the smear samples of the PDL with transferred MSCs. The results of this preliminary study demonstrate successful evidence of transferring MSCs to intact PDL in a nonsurgical way and offer a minimally invasive procedure for transfer of MSCs to periodontal tissues.Publication A multicenter experience of thrombotic microangiopathies in Turkey: The Turkish Hematology Research and Education Group (ThREG)-TMA01 study(1.02.2018) Tekgunduz, Emre; Yilmaz, Mehmet; Erkurt, Mehmet Ali; Kiki, Ilhami; Kaya, Ali Hakan; Kaynar, Leylagul; Alacacioglu, Inci; Cetin, Guven; Ozarslan, Ibrahim; Kuku, Irfan; Sincan, Gulden; Salim, Ozan; Namdaroglu, Sinem; Karakus, Abdullah; Karakus, Volkan; Altuntas, Fevzi; Sari, Ismail; Ozet, Gulsum; Aydogdu, Ismet; Okan, Vahap; Kaya, Emin; Yildirim, Rahsan; Yildizhan, Esra; Ozgur, Gokhan; Ozcebe, Osman Ilhami; Payzin, Bahriye; Akpinar, Seval; Demirkan, FatihThrombotic microangiopathies (TMAs) are rare, but life-threatening disorders characterized by microangiopathic hemolytic anemia and thrombocytopenia (MAHAT) associated with multiorgan dysfunction as a result of microvascular thrombosis and tissue ischemia. The differentiation of the etiology is of utmost importance as the pathophysiological basis will dictate the choice of appropriate treatment. We retrospectively evaluated 154 (99 females and 55 males) patients who received therapeutic plasma exchange (TPE) due to a presumptive diagnosis of TMA, who had serum ADAMTSI3 activity/antiADAMTS13 antibody analysis at the time of hospital admission. The median age of the study cohort was 36 (14-84). 67 (43.5%), 32 (20.8%), 27 (17.5%) and 28 (18.2%) patients were diagnosed as thrombotic thrombocytopenic purpura (TTP), infection/complement-associated hemolytic uremic syndrome (IA/CAHUS), secondary TMA and TMA-not otherwise specified (TMA-NOS), respectively. Patients received a median of 18 (1-75) plasma volume exchanges for 14 (153) days. 81 (52.6%) patients received concomitant steroid therapy with TPE. Treatment responses could be evaluated in 137 patients. 90 patients (65.7%) achieved clinical remission following TPE, while 47 (34.3%) patients had non-responsive disease. 25 (18.2%) non-responsive patients died during follow-up. Our study present real-life data on the distribution and follow-up of patients with TMAs who were referred to therapeutic apheresis centers for the application of TPE. (C) 2018 Elsevier Ltd. All rights reserved.Publication A new alien species record for the flora of Turkey: Proboscidea louisianica (Miller) Thell.(2017-10-01) SEVGİ, ECE; KIZILARSLAN HANÇER, ÇAĞLA; Yılmaz, Hatice; Akkaya, Muhammed; SEVGİ, ECE; KIZILARSLAN HANÇER, ÇAĞLAPublication A NOVEL HERBAL EXTRACT MEDICINE FOR LIVER HEMOSTASIS: AN EXPERIMENTAL ANIMAL STUDY(1.07.2019) Kunduz, Enver; Dincel, Zeyneb Afra; Seker, Busra; Saylak, Hatice Kubra; Demir, Okan; Akbulut, Huseyin; Aysan, ErhanObjective: Bleeding is one of the major complications of surgical procedures. Severe bleeding can be seen after liver injury. Various methods have been described in the literature for stopping liver bleeding such as compression, Pringle maneuver, and other hemostatic agents have been used. In this study, the use of anti-inflammatory, antioxidant, antimicrobial, analgesic, and anticoagulant agents described in the literature were evaluated for hemostatic efficacy following liver injuries. Materials and Methods: In this study 28 Wistar albino female / male rats from out-bred production were used. Animals were divided in 4 groups. After liver damage model creation, various herbal substances were applied to the liver. Hematocrit and platelet counts were measured. In addition, for histopathologic changes in the liver parenchyma, the rats were sacrificed, and the liver was resected. Results: The amount of bleeding (p: 0.001) and the preoperative and postoperative hematocrit changes (p: 0.009) were statistically significant between the groups. There was no significant difference in connective tissue growth (p: 0.065) and necrosis (p: 0.062). There were significant differences in inflammation and without karyorrhexis (p: 0.003). Discussion: Histopathological examinations showed that the groups using active agents had more connective tissue and karyorrhexis. Therefore these tissues could help to stop bleeding.Publication A NOVEL HERBAL EXTRACT MEDICINE FOR LIVER HEMOSTASIS:AN EXPERIMENTAL ANIMAL STUDY(2019-03-01) KUNDUZ, ENVER; DİNCEL, Zeyneb Afra; ŞEKER, Büşra; SAYLAK, HATİCE KÜBRA; DEMİR, Okan; Akbulut, HÜSEYİN; Ayşan, MUSTAFA ERHAN; KUNDUZ, ENVER; AKBULUT, HÜSEYİN; AYŞAN, MUSTAFA ERHANPublication A Pathological Process Should be Carefully Conducted in the Breast: Mucocele-Like Lesion(2018-04-01) Gucin, ZÜHAL; GÜCİN, ZÜHALMucoccic-like lesion (MLL) of the breast has been firstly described as a benign lesion resembling mucinous carcinoma of the breast. Subsequently, it has also been reported to be associated with ductal hyperplasia or breast carcinoma. The risk of cancer development in the long term is unknown. Therefore, the approach to pure MLL of the breast detected during percutaneous biopsy is controversial. In this report, a mucocele-like breast lesion in a 47-year-old woman was first noticed during a core biopsy and later detected to be associated with ductal carcinoma in-situ focuses in excisional biopsy material is presented. The aim of this paper was to provide an overview of this rare and controversial lesion and its variabilities with regard of the presented case.Publication A Preliminary Result from Ecological Wood Anatomy of Quercus ilex L. in Different Regions of Turkey.(2019-09-09T00:00:00Z) AKKEMİK, ÜNAL; YILMAZ, OSMAN YALÇIN; Selvi, Erşan; YILMAZ, HATİCE; SEVGİ, ECE; SEVGİ, ORHAN; SEVGİ, ECEPublication A Radiographic Comparison of the Root Length and Area After Class II Treatment with Two Different Functional Appliances(1.10.2020) Seker, Elif Dilara; Yagci, Ahmet; Kurt Demirsoy, Kevser; Yuzuak, Ela NurObjective: The purpose of this study was to compare the changes in root lengths and root surface areas that occur after treatment with two functional appliances the Twin Block (TWB) and Crown Herbst appliances. Methods: Forty patients (12 boys, 28 girls) were included in this study. Half of them were treated with the stainless steel Crown Herbst appliance (with crowns placed on the first molars and the first and second premolars), and the other half were treated with the TWB appliance. Panoramic and cephalometric films were obtained before treatment (T1) and after the functional treatment (T2). All upper and lower teeth except second and third molars were analysed with the ImageJ software (version 1.37, National Institutes of Health, Bethesda) on panoramic films. Root length and area values were compared using t-tests. Results: The intragroup comparison showed that root length values were significantly decreased in right and left mandibular incisors and canines in the Crown Herbst group (12 years 7 months +/- 9 months). However, significantly increased root length was observed in right and left maxillary second premolars and right maxillary first premolar in the TWB group (11 years 1 month +/- 4 months). The intergroup comparison indicated that root length values were significantly decreased in right maxillary premolars, right and left mandibular laterals and left mandibular canine in the Crown Herbst group when compared with those in the TWB group. Conclusion: It was concluded that the Crown Herbst group showed a greater tendency for decreased root length than the TWB group. In orthopaedic correction of Class II malocclusions, in the absence of any contraindications, TWB appliance may be preferred for the promotion of root development.Publication A randomized controlled study of vitamin D in the treatment of primary dysmenorrhea Primer dismenore tedavisinde vitamin D ile randomize kontrollü bir çalisma(2019-01-01) Özel, Ayşegül; ATEŞ, SEDA; ŞEVKET, OSMAN; Özdemır, Mucize; Ilhan, Gülsah; Davutoğlu, Ebru; ATEŞ, SEDA; ŞEVKET, OSMANPublication A rare co-existence of helicobacter pylori, candida albicans and candida keyfr in a giant gastric ulcer(2014-08-01) Ince, ALİ TÜZÜN; KOCAMAN, Orhan; ISMAILOVA, Medina; TOZLU, Mukaddes; Gucin, ZÜHAL; IRAZ, Meryem; İNCE, ALİ TÜZÜN; GÜCİN, ZÜHALPublication A rare complication of tuberculous meningitis pediatric anterior glenohumeral instability.(2012-01-01) BILSEL, K; ERDIL, M; Elmadag, M; CEYLAN, HH; CELIK, D; TUNCAY, İBRAHİM; ELMADAĞ, NUH MEHMET; TUNCAY, İBRAHİMDislocation and instability of the shoulder joint are rare occurrences in childhood. Traumatic, infectious, congenital, and neuromuscular causes of pediatric recurrent shoulder dislocations are reported before. Central nervous system infection in infancy may be a reason for shoulder instability during childhood. This situation, which causes a disability for children, can be treated successfully with arthroscopic stabilization of the shoulder and postoperative effective rehabilitation protocols. Tuberculous meningitis may be a reason for neuromuscular shoulder instability. We describe a 12-year-old child with a recurrent anterior instability of the shoulder, which developed after tuberculous meningitis at 18 months of age. We applied arthroscopic treatment and stabilized the joint.Publication A Spontaneous Thoracic Spinal Epidural Hematoma Causing Hemiplegia and Back Pain(2016-12-01) Gulen, BEDİA; Dundar, TOLGA TURAN; Sonmez, ERTAN; AKPINAR, Guleser; GÜLEN, BEDİA; DÜNDAR, TOLGA TURAN; SÖNMEZ, ERTANSpontaneous spinal epidural hematoma (SEH) is an uncommon and emergency condition leading to spinal cord compression. Early diagnosis can be achieved by magnetic resonance imaging (MRI) or computed tomography, but preferably MRI. Surgical decompression is urgent and can relieve neurologic deficits. A 27-year-old man presented to the emergency department with back pain, which began approximately 10 days before. While waiting for the results of biological markers for differential diagnosis, right hemiplegia became evident. Epidural hematoma was revealed with thoracic and lumbar MRI at level T1-T2. Hematoma evacuation and decompression laminectomy was immediately performed.Publication ABO and Rh Blood Group Distribution in Istanbul Province (Turkey)(2015-09-01) SALDUZ, Zeyneb Irem Yuksel; Cetin, GÜVEN; KARATOPRAK, CUMALİ; Ozder, ACLAN; BILGINC, Mesut; GULTEPE, Ilhami; GUL, Omer; YÜKSEL SALDUZ, ZEYNEB İREM; ÇETİN, GÜVEN; KARATOPRAK, CUMALİ; ÖZDER, ACLANObjective: An understanding of the distribution of blood groups in a city is useful for individuals in need. In this study, we aimed to determine the distribution rates of ABO and Rh blood groups in Istanbul Province.Publication Acute renal infarction in Turkey: a review of 121 cases(2018-11-01) EREN, NECMİ; Gungor, Ozkan; KOÇYİĞİT, Ismail; Guzel, Fatma Betul; Erken, Ertugrul; Altunoren, Orcun; TATAR, Erhan; EROĞLU, Eray; Senel, Egemen; KAYA, BÜLENT; Paydas, Saime; Onan, Bilen; Sahin, Safak; Yilmaz, Mumtaz; Ulu, Sena; Gursu, MELTEM; Ozkok, Abdullah; Yildiz, Abdulmecit; Kurultak, Ilhan; Ucar, Ali Riza; TANRISEV, Mehmet; Turgutalp, Kenan; Turan, Mehmet Nuri; HÜZMELİ, Can; SOYPAÇACI, Zeki; Akdam, Hakan; Huddam, Bulent; Adibelli, Zelal; KARA, Ekrem; Inci, Ayca; TÜRKMEN, Ercan; Tekce, Hikmet; Dogukan, Ayhan; Turkmen, Aydin; GÜRSU, MELTEMPurposeRenal infarction is a clinical condition which is caused by renal artery occlusion and leads to permanent renal parenchymal damage. In the literature, there are generally case reports on this subject, and few studies that include a large group of patients. Therefore, we aimed to present the data of a large group of patients who were diagnosed with acute renal infarction in our country in this retrospective study.MethodsThe data of patients who were diagnosed with acute renal infarction according to clinical and radiological findings in Turkey in the last 3years were examined. For this purpose, we contacted with more than 40 centers in 7 regions and obtained support from clinically responsible persons. Demographic data of patients, laboratory data at the time of diagnosis, tests performed for etiologic evaluation, given medications, and patients- clinical status during follow-up were obtained from databases and statistical analysis was performed.ResultsOne-hundred and twenty-one patients were included in the study. The mean age was 531.4 (19-91) years. Seventy-one (58.7%) patients were male, 18 (14.9%) had diabetes, 53 (43.8%) had hypertension, 36 (30%) had atrial fibrillation (AF), and 6 had a history of lupus+antiphospholipid syndrome (APS). Forty-five patients had right renal infarction, 50 patients had left renal infarction, and 26 (21.5%) patients had bilateral renal infarction. The examinations for the ethiologies revealed that, 36 patients had thromboemboli due to atrial fibrillation, 10 patients had genetic anomalies leading to thrombosis, 9 patients had trauma, 6 patients had lupus+APS, 2 patients had hematologic diseases, and 1 patient had a substance abuse problem. Fifty-seven (57%) patients had unknown. The mean follow-up period was 14 +/- 2months. The mean creatinine and glomerular filtration rate (GFR) values at 3months were found to be 1.65 +/- 0.16mg/dl and 62 +/- 3ml/min, respectively. The final mean creatinine and GFR values were found to be 1.69 +/- 0.16mg/dl and 62 +/- 3ml/min, respectively.Conclusions Our study is the second largest series published on renal infarction in the literature. More detailed studies are needed to determine the etiological causes of acute renal infarction occurring in patients.