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1. Esthetic Management of Midline Diestama Closure with Lithium disilicate glass ceramic laminate veneers by using CAD-CAM system: A case report- 13 - 15 October 2017
(2017-10-15T00:00:00Z) DÖNMEZ KIRAN, GÖKÇE; DÖNMEZ, NAZMİYE; DÖNMEZ, NAZMİYE
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120-W GreenLight Laser Photoselective Vaporization of Prostate for Benign Prostatic Hyperplasia: Midterm Outcomes
(01.07.2011) Tasci, Ali Ihsan; Ilbey, Yusuf Ozlem; Luleci, Huseyin; Cicekler, Olcay; Sahin, Selcuk; Cevik, Cem; Tugcu, Volkan
OBJECTIVES To evaluate the safety and efficacy of 120-W high-performance system (HPS) laser photoselective vaporization of the prostate (PVP) in the treatment of patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia. METHODS Two experienced surgeons performed 120-W HPS laser PVP. The baseline characteristics, perioperative data, complications, and postoperative outcomes were evaluated at 3, 6, 12, 24, and 36 months postoperatively. RESULTS A total of 550 consecutive patients, with a mean age of 67.6 years, underwent PVP with a 120-W HPS laser. The mean prostate volume was 72.93 cm(3), with a mean prostate-specific antigen level of 3.57 ng/mL. The mean operative duration and the mean applied energy was 61.3 minutes and 164.06 kJ, respectively. No major complication occurred intraoperatively or postoperatively. The mean follow-up was 17.80 months. Significant improvements were observed postoperatively in the mean International Prostate Symptom Score, quality of life score, maximal urinary flow rate, and postvoid residual urine volume. The mean catheterization time was 18.5 hours. The complications included delayed hematuria in 26 (4.8%), recatheterization in 24 (4.4%), reoperation owing to residual prostatic adenoma in 46 (8.5%), urethral stricture in 19 (3.5%), and bladder neck contracture in 6 (1.1%) patients. CONCLUSIONS PVP with a 120-W HPS laser for benign prostatic hyperplasia has been proved to be a safe and effective procedure for our patients, including those treated with oral anticoagulants. The functional outcome in larger prostates was similar to that in smaller glands. UROLOGY 78: 134-141, 2011. (C) 2011 Elsevier Inc.
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120-W GreenLight Laser Photoselective Vaporization of Prostate for Benign Prostatic Hyperplasia: Midterm Outcomes REPLY
(01.07.2011) Tasci, Ali Ihsan; Sahin, Selcuk; Tugcu, Volkan; Ilbey, Yusuf Ozlem; Luleci, Huseyin; Cicekler, Olcay; Cevik, Cem
OBJECTIVES To evaluate the safety and efficacy of 120-W high-performance system (HPS) laser photoselective vaporization of the prostate (PVP) in the treatment of patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia. METHODS Two experienced surgeons performed 120-W HPS laser PVP. The baseline characteristics, perioperative data, complications, and postoperative outcomes were evaluated at 3, 6, 12, 24, and 36 months postoperatively. RESULTS A total of 550 consecutive patients, with a mean age of 67.6 years, underwent PVP with a 120-W HPS laser. The mean prostate volume was 72.93 cm(3), with a mean prostate-specific antigen level of 3.57 ng/mL. The mean operative duration and the mean applied energy was 61.3 minutes and 164.06 kJ, respectively. No major complication occurred intraoperatively or postoperatively. The mean follow-up was 17.80 months. Significant improvements were observed postoperatively in the mean International Prostate Symptom Score, quality of life score, maximal urinary flow rate, and postvoid residual urine volume. The mean catheterization time was 18.5 hours. The complications included delayed hematuria in 26 (4.8%), recatheterization in 24 (4.4%), reoperation owing to residual prostatic adenoma in 46 (8.5%), urethral stricture in 19 (3.5%), and bladder neck contracture in 6 (1.1%) patients. CONCLUSIONS PVP with a 120-W HPS laser for benign prostatic hyperplasia has been proved to be a safe and effective procedure for our patients, including those treated with oral anticoagulants. The functional outcome in larger prostates was similar to that in smaller glands. UROLOGY 78: 134-141, 2011. (C) 2011 Elsevier Inc.
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16-kDa Prolactin Promotes Cardiac Ischemia/Reperfusion Injury
(22.10.2013) Yamac, Aylin Hatice
The recent discovery that anti-angiogenic, pro-apoptotic and pro-inflammatory N-terminal 16-kDa prolactin subform (16-kDa Prl) is generated under enhanced oxidative stress and yielding adverse cardiac effects, prompted us to investigate the potential role of prolactin and its cleaved 16-kDa form in myocardial ischemia/reperfusion (I/R) injury. In the current study we demonstrate that enhanced levels of serum prolactin (Prl) and cathepsin D (CD) activity in patients with acute myocardial infarction (AMI) were associated with the generation of N-terminal 16-kDa subform. In a murine model of myocardial I/R with previous LAD (left anterior descending artery) ligation for 50 minutes, blockage of endogenous Prl release by the dopamine D2 receptor agonist bromocriptine limited infarct size 24 hours post-reperfusion and preserved left ventricular (LV) function after 14 days of reperfusion. Additionally, we demonstrate that after blockage of endogenous Prl release, the subsequent application of a recombinant mutant, prolactin isoform, which is not cleaved into the 16-kDa subform, significantly limited the extent of cardiac injury compared to the well-cleaved corresponding wildtype prolactin isoform 24 hours post-reperfusion. I/R injury-induced up-regulation of pro-inflammatory mediators (e.g. TNF-α, CCL-2, CXCL2) and extravasation of inflammatory infiltrates were significantly reduced in bromocriptine treated mice than untreated controls. The bromocriptine induced cardiac protection was mainly addicted to inhibition of 16-kDa Prl formation, as myocardium treated with the mutant prolactin isoform displayed substantially less inflammatory cell infiltration and cytokine expression than myocardium treated with the wildtype prolactin isoform. In addition, we discovered that recombinant 16-kDa Prl markedly induced the expression of proinflammatory cytokines via activation of NF-κB signalling in neonatal rat cardiomyocytes.
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1st International Conference on Natural Products for Cancer Prevention and Therapy 31 August-2 September 2015 Istanbul, Turkey (vol 26, pg e1, 2015)
(2.01.2016) Bektay, M. Yunus; Uckaya, Fatih; Topcu, Gulacti; Esrefoglu, Mukaddes; Bayindir, Nihan
A novel automatic Rapid Diagnostic Test (RDT) reader platform is designed to analyze and diagnose target disease by using existing consumer cameras of a laptop-computer or a tablet. The RDT reader is useable with numerous lateral immunochromatographic assays and similar biomedical tests. The system has two different components, which are 3D-printed, low-cost, tiny, and compact stand and a decision program named RDT-AutoReader 2.0. The program takes the image of RDT, crops the region of interest (ROI), and extracts the features from the control end test lines to classify the results as invalid, positive, or negative. All related patient's personal information, image of ROI, and the e-report are digitally saved and transferred to the related clinician. Condition of the patient and the progress of the disease can be monitored by using the saved data. The reader platform has been tested by taking image from used cassette RDTs of rotavirus (RtV)/adenovirus (AdV) and lateral flow strip RDTs of Helicobacter pylori (H. pylori) before discarding them. The created RDT reader can also supply real-time statistics of various illnesses by using databases and Internet. This can help to inhibit propagation of contagious diseases and to increase readiness against epidemic diseases worldwide.
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2 Kirpinar I, Gormez A, Kurtulmus A. A case of Niemann-Pick type C disease with juvenile onset neuropsychiatric symptoms.
(2016-09-20) KIRPINAR, İSMET; Görmez, Aynur; Kurtulmuş, AYŞE; KIRPINAR, İSMET; KURTULMUŞ, AYŞE
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2012-2017 Yılları Arasında Dispeptik Hastalarda Helicobacter pylori Antijen Prevalansı
(2018-05-13) GÜLTEPE, BİLGE; CEYLAN, AYŞE NUR; SÜMBÜL, BİLGE; CEYLAN, AYŞE NUR
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3D (Three-dimensional) evaluation of ischemic damaged brain area and correlation of them with clinical symptoms
(2015-09-06) ARİFOĞLU, YASİN; ARİFOĞLU, YASİN
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57PD NEOADJUVANT CHEMORADIOTHERAPY FOR LOCALLY ADVANCED NON SMALL CELL LUNG CANCER
(2013-04-01) ZİYADE, SEDAT; ZİYADE, SEDAT
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A
(2019-09-18T00:00:00Z) İçağasıoğlu, Dilara Füsun; İÇAĞASIOĞLU, DİLARA FÜSUN
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A clinical and microbiological comparison of Er: YAG laser and mechanical debridement for the nonsurgical periodontal therapy: a randomized controlled clinical study
(2018-06-01) ZENGİN ÇELİK, TUĞBA; ERCAN, ÇİLEM; AKBAŞ, FAHRİ; SAĞLAM, EBRU; Nazaroğlu, KENAN; TUNALI, MUSTAFA; ZENGİN ÇELİK, TUĞBA; ERCAN, ÇİLEM; AKBAŞ, FAHRİ; TUNALI, MUSTAFA
Open Access
A 13-Year-Old Boy Who Has Kawasaki Disease Shock Syndrome Presents with Parotitis
(2020-03-01T00:00:00Z) YOZGAT, Yılmaz; UZUNER, SELÇUK; Demir, Aysegul Dogan; OĞUR, MUSTAFA; Yozgat, Can Yilmaz; TÜREL, Özden; YOZGAT, YILMAZ; UZUNER, SELÇUK; OĞUR, MUSTAFA; TÜREL, ÖZDEN
We report a 13-year-old boy who (initially) had symptoms of toxic shock-like syndrome and mumps. Then, the patient was hospitalized in the pediatric intensive care unit (PICU) because of his ongoing hemodynamic instability (low blood pressure of 70/30 mm Hg and capillary refill time of > 4 seconds). During his stay in the PICU, the patient was treated with fluid resuscitation and vasoactive infusion and at the same time was diagnosed with Kawasaki disease shock syndrome (KDSS), when giant right coronary artery aneurysms were detected on echocardiographic examination. This case illustrates the risk of KDSS in patient who carries both parotitis and toxic shock-like syndrome. The clinicians should be cautious about detecting any types of coronary artery aneurysms in such patients. This is the first case of KDSS associated with parotitis reported in the literature.
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A 4-year clinical evaluation of direct composite build-ups for space closure after orthodontic treatment
(2015-12-01) Demirci, Mustafa; Tuncer, Safa; Oztas, Evren; TEKÇE, NESLİHAN; Uysal, Omer; UYSAL, ÖMER
To evaluate the medium-term clinical performance of direct composite build-ups for diastema closures and teeth recontouring using a nano and a nanohybrid composite in combination with three- or two-step etch-and-rinse adhesives following treatment with fixed orthodontic appliances.
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A Basic Algorithmic Surgical Approach for Nicolau Syndrome
(2020-04-01T00:00:00Z) Yeniocak, Ali; Güneren, Ethem; Özkan, Mustafa; Temel, Metin; Kelahmetoğlu, Osman; YENİOCAK, ALİ; GÜNEREN, ETHEM; KELAHMETOĞLU, OSMAN
Background: Nicolau syndrome (NS) is a rare complication that develops after the administration of intramuscular diclofenac sodium. The etiology and surgical treatments of 11 patients with NS were evaluated and studies in the literature were examined. The aim of this study was to compose a basic algorithm for surgical approaches to treat NS. Materials and methods: Eleven patients were evaluated for NS between December 2013 and January 2018. Two patients did not accept treatment, and nine patients underwent surgical debridement of necrotic tissues. The tissue defects of five patients were closed with a fasciocutaneous flap and, in four patients, the defects were repaired primarily. Results: No complications, such as wound infection, wound dehiscence, seroma, or flap necrosis, were encountered. Of the seven patients who received concurrent antibiotic therapy, no patient had any problems at their follow-up (2-30 months). The results were satisfactory from an aesthetic and functional point of view. Conclusion: NS was more frequent in women with a high body mass index and high fat in gluteal regions. We considered that any kind of medication could lead to NS. Different methods are discussed for treatment.
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A Candidate Therapeutic Target For Diabetic Nephropathy: Gas6 (Growth Arrest Spesific Protein)
(2010-06-12T00:00:00Z) Çağman, Zeynep; ÇAĞMAN, ZEYNEP
Open Access
A case of Behçet-s disease possibly triggered by β-glucan.
(2016-02-01) Gulsel, BA; IRFAN, KT; ULAS, G; UMIT, T; KIYMET, B; GULIZ, I; BAHALI, ANIL GÜLSEL
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A case of Budd-Chiari syndrom associated with alveolar echinococcosis
(2014-04-01) KARADAS, SEVDEGUL; GÜLTEPE, BİLGE; DULGER, AHMET CUMHUR; BEYAZAL, MEHMET; SÜMBÜL, BİLGE
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A CASE OF CARBON MONOXİDE POİSONİNG RESULTİNG WİTH EKG CHANGİNGS AND NEUROLOGİCAL DEFECTS ARE SHOWN WİTH MRI
(2013-05-24) KARAYEL, EDA; SÖNMEZ, ERTAN; DUR, ALİ; YAMAN, ASLI; KÜÇÜKDAĞLI, OKKEŞ T; LİSAR, HAZAR; ERŞAN, TEZCAN; YILMAZ, CAHİT; MASUR, BETÜL; SÖNMEZ, ERTAN
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A case of cerebral phaeohyphomycosis caused by Fonsecaea monophora, a neurotropic dematiaceous fungus, and a review of the literature
(2015-03-01) Doymaz, Mehmet Z.; Gultepe, Bilge S.; Hakyemez, Ismail; CEVIK, Serdar; ASLAN, Turan; DOYMAZ, MEHMET ZIYA; SEYİTHANOĞLU, MEHMET HAKAN; HAKYEMEZ, İSMAİL NECATİ; SÜMBÜL, BİLGE
The Fonsecaea species, which are the leading causes of chromoblastomycosis, are not considered neurotropic fungal agents. Fonsecaea pedrosoi is the primary species in the genus and is usually isolated from chromoblastomycosis cases. However, the recently distinguished species F. monophora has been reported in a few cerebral phaeohyphomycosis cases. Here, a case of cerebral phaeohyphomycosis caused by Fonsecaea monophora is presented in a 71-year-old female subject with chronic diabetes mellitus and hypertension. The identification of F. monophora was made through mycological and molecular analysis, and an isolate was differentiated from the closely related F.pedrosoi by sequence data on key bases on the ribosomal internal transcribed spacer region. The case was successfully treated with surgical and medical approaches, and the patient has remained healthy and stable after a ten-month follow up. Given the increasing incidence of this type of infection of the central nervous system (CNS), this case provides further support for the consideration that F. monophora might represent a neurotropic agent.
Open Access
A Case of Chronic Lymphocytic Leukemia in Two Brothers
(2017-01-01) GULTEPE, Ilhami; OZKAN, Tuba; Cetin, GÜVEN; ÇETİN, GÜVEN
Monoclonal B-cell lymphocytosis is accepted as an important risk factor for developing lymphocytosis familial chronic lymphocytic leukemia (CLL) but does not meet the criteria for B-cell lymphoproliferative disease, and patients with <5,000 ( but not 0) CLL-phenotype B-cell lymphocytes per mm 3. Individuals with lymphocytosis who have relatives diagnosed with CLL should undergo flow cytometry for early diagnosis. In our study, a 56-year-old patient-s brother had been early diagnosed with CLL and with lymphocytosis, and the patient was diagnosed with class 1-2 CLL after 2 years. We emphasize that individuals having a family history of CLL should be closely monitored.

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