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Publication Unknown A Newly Designed Surgical Instrument to Facilitate Osteotomy: The Lightening Osteotome(01.01.2012) Ozalp, Burhan; Karaaltin, Mehmet Veli; Orhan, Kadir SerkanPublication Unknown A retrospective evaluation of the results of the application of MIPPO technique with osteosynthesis on 26 cases of tibial fracture(01.06.2010) Bulbul, M.; Ayanolu, S.; Iret, H.; Gurbuz, H.; Gurkan, V.Aim. This retrospective study aimed to evaluate the use of minimally invasive percutaneous plate osteosynthesis (MIPPO) technique on 26 cases of tibial fractures, which are frequently encountered in orthopedic traumatology. Methods. The study comprised 26 patients with tibial fractures who had been operated on with the MIPPO technique at our clinic between June 2006 and December 2008. Sixteen patients were male and 10 female with a mean age of 36.3 years (range 24-57 yrs). Three of the cases were determined as Grade I open fracture. A low profile 3.5 mm limited contact dynamic compression plate (LCDCP) was used on all cases. On postoperative day 2 all patients were allowed full movement but they were discharged without weight-bearing. Some of the patients commenced weight-bearing in the 6th week in accordance with follow-up radiographs. No patient was allowed full weight-bearing before the fourth month. Results. All the cases achieved clinical and radiological union. At the final follow-up all the cases were seen to be able to continue their lives with unrestricted daily activity. None of the cases developed superficial or deep tissue infection. Within one week postoperative three cases displayed minimal clinical findings of having developed deep vein thrombosis. This was eradicated within 15 days by medical treatment. The mean time to full weight-bearing was 5.6 months. Extirpation was necessary in 11 cases because of skin irritation due to the plate. Conclusion. According to our opinion MIPPO technique for diaphyseal and distal fractures of the tibia is simple to apply, engenders better rehabilitation and has few complications. We believe that MIPPO technique with low profile and LCDCP plate can be applied to selected patients.Publication Unknown A novel candidate therapeutic target for diabetic nephropathy: Gas6(01.06.2011) Erek, A.; Ozakpinar, O.; Karaca, Z.; Uras, F.; Uras, A. R.Gastrointestinal stromal tumors (GISTs) are rare in the childhood period. The authors reported a case who was admitted to the neonatal intensive care unit (NICU) on a suspicion of intestinal obstruction. She was operated and a mass in a size of 6 xx 4.5 xx 4 cm was resected from the ileum. Histologic and immunohistochemical studies showed a GIST. CD34, small muscle actin (SMA), and desmin were positive. The baby was discharged on the 13th day after operation.Publication Unknown A Rare Cause of Calf Pain: Extradigital Glomus Tumor: Case Report(01.06.2012) Saka, Gursel; Durkaya, Salih Murat; Kucukdurmaz, Fatih; Saglam, Necdet; Karabulut, Murat HakanGlomus tumors are rare small benign neoplasms of the dermis or subcutis and originate from the neuromyoarterial glomus body. They most frequently develop in the nail bed of the hands, and their occurrence in other parts of the body is rare. A 25 years old male patient presented to our clinic with calf pain for the last 5 years. Physical examination revealed a 1x1 cm painful, semimobile lesion within the right gastrocnemius muscle. Direct X-rays revealed no pathology. In magnetic resonance imaging, edema was detected in the right gastrocnemius muscle. The mass was excised and histopathologic examination revealed glomus tumor. The patient was cured and no recurrence developed during the 25-month follow-up.Publication Metadata only 120-W GreenLight Laser Photoselective Vaporization of Prostate for Benign Prostatic Hyperplasia: Midterm Outcomes REPLY(01.07.2011) Tasci, Ali Ihsan; Sahin, Selcuk; Tugcu, Volkan; Ilbey, Yusuf Ozlem; Luleci, Huseyin; Cicekler, Olcay; Cevik, CemOBJECTIVES To evaluate the safety and efficacy of 120-W high-performance system (HPS) laser photoselective vaporization of the prostate (PVP) in the treatment of patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia. METHODS Two experienced surgeons performed 120-W HPS laser PVP. The baseline characteristics, perioperative data, complications, and postoperative outcomes were evaluated at 3, 6, 12, 24, and 36 months postoperatively. RESULTS A total of 550 consecutive patients, with a mean age of 67.6 years, underwent PVP with a 120-W HPS laser. The mean prostate volume was 72.93 cm(3), with a mean prostate-specific antigen level of 3.57 ng/mL. The mean operative duration and the mean applied energy was 61.3 minutes and 164.06 kJ, respectively. No major complication occurred intraoperatively or postoperatively. The mean follow-up was 17.80 months. Significant improvements were observed postoperatively in the mean International Prostate Symptom Score, quality of life score, maximal urinary flow rate, and postvoid residual urine volume. The mean catheterization time was 18.5 hours. The complications included delayed hematuria in 26 (4.8%), recatheterization in 24 (4.4%), reoperation owing to residual prostatic adenoma in 46 (8.5%), urethral stricture in 19 (3.5%), and bladder neck contracture in 6 (1.1%) patients. CONCLUSIONS PVP with a 120-W HPS laser for benign prostatic hyperplasia has been proved to be a safe and effective procedure for our patients, including those treated with oral anticoagulants. The functional outcome in larger prostates was similar to that in smaller glands. UROLOGY 78: 134-141, 2011. (C) 2011 Elsevier Inc.Publication Metadata only A novel technique for the management of advanced uterine/vault prolapse: extraperitoneal sacrocolpopexy(01.07.2011) Onol, Fikret Fatih; Kaya, Erdal; Kose, Osman; Onol, Sinasi YavuzAbdominal sacrocolpopexy is the gold standard for advanced uterovaginal/cuff prolapse repair; however, early and late bowel complications are of concern. We report our experience with extraperitoneal sacrocolpopexy (ESCP). Twenty-three patients who underwent ESCP between 2007 and 2010 were analyzed in this retrospective cohort study. Preoperative assessment included Pelvic Floor Distress Inventory (PFDI-20) and Pelvic Floor Impact (PFIQ-7) questionnaires, and pelvic examination according to Pelvic Organ Prolapse Quantification (POP-Q) system. Pre-operative findings were compared with postoperative values at the last follow-up using the Wilcoxon sign test. Mean operation time was 86 +/- 20 min. Twenty patients were discharged within 24 h. With a mean follow-up of 20 months, objective and subjective cure rates were 91.3% and 86.9%, respectively. No postoperative complications were evident with significant improvement in POP-Q, PFDI-20, and PFIQ-7 scores. ESCP is a safe and effective sacrocolpopexy procedure that can potentially eliminate the risk of gastrointestinal complications.Publication Metadata only 120-W GreenLight Laser Photoselective Vaporization of Prostate for Benign Prostatic Hyperplasia: Midterm Outcomes(01.07.2011) Tasci, Ali Ihsan; Ilbey, Yusuf Ozlem; Luleci, Huseyin; Cicekler, Olcay; Sahin, Selcuk; Cevik, Cem; Tugcu, VolkanOBJECTIVES To evaluate the safety and efficacy of 120-W high-performance system (HPS) laser photoselective vaporization of the prostate (PVP) in the treatment of patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia. METHODS Two experienced surgeons performed 120-W HPS laser PVP. The baseline characteristics, perioperative data, complications, and postoperative outcomes were evaluated at 3, 6, 12, 24, and 36 months postoperatively. RESULTS A total of 550 consecutive patients, with a mean age of 67.6 years, underwent PVP with a 120-W HPS laser. The mean prostate volume was 72.93 cm(3), with a mean prostate-specific antigen level of 3.57 ng/mL. The mean operative duration and the mean applied energy was 61.3 minutes and 164.06 kJ, respectively. No major complication occurred intraoperatively or postoperatively. The mean follow-up was 17.80 months. Significant improvements were observed postoperatively in the mean International Prostate Symptom Score, quality of life score, maximal urinary flow rate, and postvoid residual urine volume. The mean catheterization time was 18.5 hours. The complications included delayed hematuria in 26 (4.8%), recatheterization in 24 (4.4%), reoperation owing to residual prostatic adenoma in 46 (8.5%), urethral stricture in 19 (3.5%), and bladder neck contracture in 6 (1.1%) patients. CONCLUSIONS PVP with a 120-W HPS laser for benign prostatic hyperplasia has been proved to be a safe and effective procedure for our patients, including those treated with oral anticoagulants. The functional outcome in larger prostates was similar to that in smaller glands. UROLOGY 78: 134-141, 2011. (C) 2011 Elsevier Inc.Publication Metadata only A Class of Sulfonamides with Strong Inhibitory Action against the alpha-Carbonic Anhydrase from Trypanosoma cruzi(01.07.2013) Guzel-Akdemir, Ozlen; Akdemir, Atilla; Pan, Peiwen; Vermelho, Alane B.; Parkkila, Seppo; Scozzafava, Andrea; Capasso, Clemente; Supuran, Claudiu T.Trypanosoma cruzi, the causative agent of Chagas disease, encodes for an alpha-carbonic anhydrase (CA, EC 4.2.1.1) possessing high catalytic activity (TcCA) which was recently characterized (Pan et al. J. Med. Chem. 2013, 56, 1761-1771). A new class of sulfonamides possessing low nanomolar/subnanomolar TcCA inhibitory activity is described here. Aromatic/heterocydic sulfonamides incorporating halogeno/methoxyphenacetamido tails inhibited TcCA with K(I)s in the range of 0.5-12.5 nM, being less effective against the human off-target isoforms hCA I and II. A homology model of TcCA helped us to rationalize the excellent inhibition profile of these compounds against the protozoan enzyme, a putative new antitrypanosoma drug target. These compounds were ineffective antitrypanosomal agents in vivo due to penetrability problems of these highly polar molecules that possess sulfonamide moieties.Publication Metadata only A Novel Capsulorhexis Technique in White Cataract Surgery(01.07.2015) Daglioglu, Mutlu Cihan; Coskun, Mesut; Ilhan, Ozgur; Tuzcu, Esra Ayhan; Ilhan, Nilufer; Ayintap, Emre; Taskin, Ibrahim; Oksuz, HuseyinPurpose: To investigate the efficacy and safety of novel capsulorhexis technique in white cataract surgery using the irrigation-aspiration system of a phaco device. Materials and Methods: 53 eyes of 50 patients were included in the study. Patients were randomly divided into two groups. To 27 eyes of 27 patients in Group 1, continuous curvilinear capsulorhexis (CCC) was made using an irrigation-aspiration system by a phaco machine. To 26 eyes of 23 patients in Group 2, CCC was made using an ocular visco-elastic device (OVD) and utrata forceps. Surgical results were compared between two groups. Results: No difference in outcome endothelial cell count or central corneal thickness was noted between the two groups. CCC-2 has been completed totally in Group 1 but only 22 eyes in the other group. Conclusions: Capsulorhexis with described technique is safe in white cataracts. This technique may be an alternative in capsulorhexis to the other method, which is made using OVD and forceps.Publication Metadata only A New Echocardiographic Parameter of Arterial Stiffness in End-Stage Renal Disease(01.10.2013) Sahin, Musa; Simsek, Hakki; Akyol, Aytac; Akdag, Serkan; Yaman, Mehmet; Inan, Bekir; Aydin, Cemalettin; Kul, Seref; Soyoral, Yasemin; Gumrukcuoglu, Hasan AliPublication Metadata only A real-world, retrospective, observational study of dabigatran and rivaroxaban in Turkey: elderly patients receive inappropriately low dose of rivaroxaban(1.01.2017) Yiginer, Omer; Tezcan, Mehmet; Erdal, Emrah; Degirmencioglu, Gokhan; Acar, Gurkan; Ergelen, Mehmet; Cay, Serkan; Cetin, Hande; Ozcelik, Fatih; Dogan, Mehmet; Tokatli, Alptug; Ozmen, Namik; Uz, Omer; Kilicaslan, FethiThromboembolic complications are the most important outcomes of atrial fibrillation (AF). New oral anticoagulants (NOACs) have been presented to protect non-valvular AF patients from thromboembolic complications. In this study, we aimed to evaluate effectiveness and safety of NOACs and also reveal prescribing habits of physicians, retrospectively. NOACs and their effectiveness and safety retrospectively. Patients with non-valvular AF using either rivaroxaban or dabigatran were included in the study in five different tertiary centers. Patients were identified by scanning their medication reports. Appropriate patients were called and face-to-face interviews were done. Follow-ups were carried out on the phone. 183 out of 201 identified patients, taking rivaroxaban and dabigatran, were reached. General clinical characteristics were not significantly different between drug groups. Vascular disease and persistent AF were significantly higher in the rivaroxaban group. The rate of low dose medication in the dabigatran group was higher compared to the rivaroxaban group. Average age of the patients taking low dose medication were prominently higher in both groups. Between high and low dose users of the dabigatran group, creatinine clearance (CrCl) were not differed. Among rivaroxaban group, CrCl of the low dose users were lower than of the high dose users. However, among low-dose-prescribed patients, only 6 out of 38 patients had a CrCl value in the range of 30-49 ml/min, revealing that remaining 32 patients were receiving inappropriately low rivaroxaban dose. The rate of all-cause mortality, thromboembolism and bleeding complications were not statistically significant between the medication groups. While prescribing NOAC for non-valvular AF patients, physicians seem to consider patients' ages rather than CrCl values. In terms of protecting from thromboembolism, rivaroxaban and dabigatran seem to be equally effective and safe.Publication Metadata only A case of multiple dental anomalies: a variant of Ekman-Westborg-Julin trait(1.01.2018) Colakoglu, Gizem; Kazak, Magrur; Buyukbayram, Isil Kaya; Elcin, Mehmet Ali; Bedeloglu, ElcinSimultaneous occurrence of multiple dental anomalies is relatively common and has been reported particularly in cases with systemic alterations or syndromes. However, in 1974, Ekman-Westborg and Julin described a unique case of multiple macrodontia and multituberculism of posterior teeth accompanied by multiple dental malformations without other systemic anomalies. Here we report the case of a 20-year-old female patient who presented with macrodontia affecting her maxillary lateral teeth, mandibular incisors, and impacted multituberculated wisdom teeth accompanied by other dental anomalies that manifested itself as a variant of the Ekman-Westborg-Julin trait.Publication Metadata only A new method that can be used to overcome the condensation risks in radiant cooling systems and thermal comfort examinations(1.01.2018) Koca, AliihsanIn this study, we propose a novel cooling dehumidifying strategy, in which a condensing panel can be hydronically connected in series with the radiant cooling system to overcome condensation risk and improve indoor thermal comfort level. Based on the concept, the sensible heat-load is primarily covered by radiant cooling panels and some amount of latent heat and sensible heat can be treated by the condensing panel, while improving indoor thermal comfort level. Since, the surface temperature of the condensing panel is lower than the dew point temperature, while the radiant surface is higher for same supply water temperatures - condensation occurs only over the condensing plate. This paper evaluates the thermal comfort performance of the proposed novel condensing panel. For these aim, a new experimental chamber was developed. General thermal comfort level and the temperature, relative humidity ratio distribution in the tested room were evaluated for 10 different experimental cases. Multiple tests were conducted by varying surface temperature of the condensing panel and initial relative humidity ratios of air in the room. The results show that proposed simple solution can improve thermal comfort level, for the places where the latent heat loads are not considerable high, and reduce the condensation risk over the radiant cooling panels.Publication Metadata only A Novel Actual Time Cyber Security Approach to Smart Grids(1.01.2018) Buyuk, Oguzhan Oktay; Camurcu, Ali YilmazThe purpose of this paper was to develop a novel actual time cyber security approach to smart grids. The developed way securely backed the smart meters among smart grids against external attacks in a distribution substation. Security is provided using Message Passing Interface (MPI). Newly configured Floyd-Warshall Algorithm was applied to MPI so as to represent a distribution of key pairs which was generated by Homomorphic Encryption. Simulation case studies were conducted on Raspberry Pi 2 Model B in order to illustrate how the mentioned approach can be built to execute the cyber security essentials via parallel programming techniques and Valgrind tools on a virtual distributed mechanism. Simulation results which use real world attack data demonstrated that the developed way is capable of accomplishing cyber security against outer attacks accurately, quickly and real time based sorting of the key pairs into each smart meter node in the demanded area.Publication Metadata only A New Signal Processing Toolbox and Real-Time EMG and ECG Analysis(1.01.2018) Ozkan, Haydar; Ural, Ebrar Selva; Kalender, Aleyna; Tuncer, Fatma ElifBiomedical signals acquisition, processing and visualizing with accurate and high quality play a very important role in the diagnosis of many diseases. For this purpose, in this study, a one-dimensional signal processing toolbox has been designed using the MATLAB Graphical User Interface (GUI). Real-time medical signals can be obtained and analyzed in time and frequency domains. This toolbox can be used to analyze a signal that is pre-recorded or one dimensional that is created by a user. Due to the toolbox developed, the data which are acquired from EMG and ECG cards and digitized in the Arduino microprocessor are displayed in real time on the computer screen. Also, the high-frequency noises in the ECG signal have been eliminated by designing a Parks-McClellan low pass FIR filter. Heart rate has been calculated with high accuracy by counting R peak points per minute from the noise reduced ECG signal automatically. By using the developed signal processing toolbox, any kind of general or medical signals can be analyzed in more detail and fast.Publication Metadata only A rare cause of hypertension in childhood: Answers(1.01.2020) Kucuk, Nuran; Abali, Zehra Yavas; Abali, Saygin; Canpolat, Nur; Yesil, Gozde; Turan, Serap; Bereket, Abdullah; Guran, TulayBackground: A novel rapid, accurate, and stability-indicating reversed-phase high performance liquid chromatographic (RP-HPLC) and first derivative spectrophotometric determination were explained for the assay of vortioxetine (VRT) in bulk and pharmaceutical formulations. For RP-HPLC method, optimal separation and determination of VRT were achieved with a Waters Symmetry C-18, (100 x 4.6 mm, 3.5 mu m) analytical column using a mobile phase consisting of methanol:0.05 M potassium dihydrogen phosphate (pH:3.0 +/- 0.05) (30:70, v/v) in isocratic mode with flow rate of 1.3 mL min(-1). Injection volume was 20 mu L. The maximum absorption wavelength of VRT is 225.0 nm; hence, 225.0 nm was studied as the detection wavelength and column at 50 degrees C temperature. The caffeine was used as the internal standard (IS). On the other hand, the first derivative spectrophotometric method for the analysis of vortioxetine was performed by measuring the amplitude at 251.7 and 272.6 nm. Result: The HPLC method was found to be linear in the concentration ranges of 10.0-70.0 mu g mL(-1) with the coefficient value R-2 of 0.9998, and the mean recovery value was 100.7%. Further stability studies were done through exposure of the analyte solutions to various stress conditions: acid, alkali hydrolysis, chemical oxidation, and exposure to UV radiation. For the first derivative spectrophotometric method, linearity was observed in the concentration range 6.0-30.0 mu g mL(-1) (for 237.7 nm R-2 = 0.9999 and for 257.2 nm R-2 = 0.9997). Conclusion: The methods were validated in accordance with ICH guidelines with respect to linearity, accuracy, specificity, limit of detection, precision, and limit of quantification.Publication Metadata only A Portable Wearable Tele-ECG Monitoring System(1.01.2020) Ozkan, Haydar; Ozhan, Orhan; Karadana, Yasemin; Gulcu, Muhammed; Macit, Samet; Husain, FasahathThis paper introduces a wearable Tele-ECG and heart rate (HR) monitoring system which has a novel architecture including a stretchable singlet redesigned with textile electrodes (TEs), textile threads, snap fasteners, Velcro, sponges, and an ECG circuit. In addition, a Bluetooth low energy (BLE), a smartphone, a server, and a web page have been added to the system for remote monitoring. The TE can be attached to and removed from the singlet by a Velcro, which allows the user to dry-clean the TE easily for long-term use. A new holter-based ECG system has been designed to evaluate the TE-based ECG system and the average correlation between the recorded ECG signals is obtained as 99.23. A filtered digital signal, with a high signal-to-noise ratio of 45.62 dB, is transmitted to the smartphone via BLE. The ECG signal is plotted, the HR is calculated with 1.83 mean absolute percentage error, and displayed. The data are sent to the server, allowing the patient's physician to analyze the signals in real time through the web page or the smartphone. If HR reaches beyond the normal range or user presses the HELP button on the smartphone screen, the physician is informed automatically by an short message service (SMS) with a location pin on the map. The battery lasts approximately 14 days and when it needs replacement, the system automatically alerts the users by an SMS and a flashing LED. This fast and uninterrupted telemonitoring system has the potential to improve the patient's life quality by providing a psychological reassurance.Publication Metadata only A multicenter experience of thrombotic microangiopathies in Turkey: The Turkish Hematology Research and Education Group (ThREG)-TMA01 study(1.02.2018) Tekgunduz, Emre; Yilmaz, Mehmet; Erkurt, Mehmet Ali; Kiki, Ilhami; Kaya, Ali Hakan; Kaynar, Leylagul; Alacacioglu, Inci; Cetin, Guven; Ozarslan, Ibrahim; Kuku, Irfan; Sincan, Gulden; Salim, Ozan; Namdaroglu, Sinem; Karakus, Abdullah; Karakus, Volkan; Altuntas, Fevzi; Sari, Ismail; Ozet, Gulsum; Aydogdu, Ismet; Okan, Vahap; Kaya, Emin; Yildirim, Rahsan; Yildizhan, Esra; Ozgur, Gokhan; Ozcebe, Osman Ilhami; Payzin, Bahriye; Akpinar, Seval; Demirkan, FatihThrombotic microangiopathies (TMAs) are rare, but life-threatening disorders characterized by microangiopathic hemolytic anemia and thrombocytopenia (MAHAT) associated with multiorgan dysfunction as a result of microvascular thrombosis and tissue ischemia. The differentiation of the etiology is of utmost importance as the pathophysiological basis will dictate the choice of appropriate treatment. We retrospectively evaluated 154 (99 females and 55 males) patients who received therapeutic plasma exchange (TPE) due to a presumptive diagnosis of TMA, who had serum ADAMTSI3 activity/antiADAMTS13 antibody analysis at the time of hospital admission. The median age of the study cohort was 36 (14-84). 67 (43.5%), 32 (20.8%), 27 (17.5%) and 28 (18.2%) patients were diagnosed as thrombotic thrombocytopenic purpura (TTP), infection/complement-associated hemolytic uremic syndrome (IA/CAHUS), secondary TMA and TMA-not otherwise specified (TMA-NOS), respectively. Patients received a median of 18 (1-75) plasma volume exchanges for 14 (153) days. 81 (52.6%) patients received concomitant steroid therapy with TPE. Treatment responses could be evaluated in 137 patients. 90 patients (65.7%) achieved clinical remission following TPE, while 47 (34.3%) patients had non-responsive disease. 25 (18.2%) non-responsive patients died during follow-up. Our study present real-life data on the distribution and follow-up of patients with TMAs who were referred to therapeutic apheresis centers for the application of TPE. (C) 2018 Elsevier Ltd. All rights reserved.Publication Metadata only A new dinuclear copper (II) complex of 2,5-Furandicarboxyclic acid with 4(5)-Methylimidazole as a high potential alpha-glucosidase inhibitor: Synthesis, Crystal structure, Cytotoxicity study, and TD/DFT calculations(1.03.2019) Avci, Davut; Alturk, Sumeyye; Sonmez, Fatih; Tamer, Omer; Basoglu, Adil; Atalay, Yusuf; Zengin Kurt, Belma; Ozturk, Dilek; Dege, NecmiA new dinuclear copper (II) complex of 2,5-furandicarboxyclic acid with 4(5)-methylimidazole, [Cu (FDCA)((4(5)MeI)(2)](2)center dot 2H(2)O, was synthesized, and its structure characterized by XRD, FT-IR and UV-Vis spectroscopic techniques. The alpha-glucosidase inhibition and cytotoxicity study of the synthesized Cu (II) complex were determined by IC50 values. The optimized geometry and vibrational harmonic frequencies for the Cu (II) complex were obtained by using Density Functional Theory (DFT) of HSEh1PBE/6-311++G(d,p)/LanL2DZ level. TD-DFT/HSEh1PBE/6-311++G(d,p)/LanL2DZ level with CPCM model was applied to examine the electronic spectral properties and major contributions were determined via Swizard program. To investigate linear and nonlinear optical behavior of the synthesized Cu (II) complex, the alpha, Delta alpha and chi((1))/beta, gamma and chi((3)) parameters called linear/nonlinear optical parameters in gas phase and ethanol solvent were computed at the same level and basis set. Furthermore, molecular electrostatic potential (MEP) surface was determined by using the same level. The docking study of the Cu (II) complex to the binding site of the target protein (the template structure S. cerevisiae isomaltase) is fulfilled. Natural bond orbital (NBO) analysis was used to investigate the hyperconjugative interactions, inter- and intra-molecular bonding and to determine coordination around Cu (II) ion. Finally, present work is the first remarkable scientific report of mixed-ligand (H(2)FDCA and 4(5)MeI) Cu (II) complex as novel drug candidate for DM II. It is also determined that microscopic third-NLO parameters for the Cu (II) complex is remarkable.Publication Open Access A Comparison of Classification Methods for Telediagnosis of Parkinson's Disease(1.04.2016) Ozkan, HaydarParkinson's disease (PD) is a progressive and chronic nervous system disease that impairs the ability of speech, gait, and complex muscle-and-nerve actions. Early diagnosis of PD is quite important for alleviating the symptoms. Cost effective and convenient telemedicine technology helps to distinguish the patients with PD from healthy people using variations of dysphonia, gait or motor skills. In this study, a novel telemedicine technology was developed to detect PD remotely using dysphonia features. Feature transformation and several machine learning (ML) methods with 2-, 5- and 10-fold cross-validations were implemented on the vocal features. It was observed that the combination of principal component analysis (PCA) as a feature transformation (FT) and k-nearest neighbor (k-NN) as a classifier with 10-fold cross-validation has the best accuracy as 99.1%. All ML processes were applied to the prerecorded PD dataset using a newly created program named ParkDet 2.0. Additionally, the blind test interface was created on the ParkDet so that users could detect new patients with PD in future. Clinicians or medical technicians, without any knowledge of ML, will be able to use the blind test interface to detect PD at a clinic or remote location utilizing internet as a telemedicine application.