Welcome to the Open Access System!
This site is Bezmialem Vakif University Academic Open Access System. The system was established in June 2019 in order to store the academic outcomes of Bezmialem Vakif University in digital standards and to provide them with open access. OpenAccess includes academic outputs such as articles, presentations, dissertations, books, book chapters and reports produced by Bezmialem Vakif University.
Recent Submissions
An evaluation of a hepatotoxicity risk induced by the microplastic polymethyl methacrylate (PMMA) using HepG2/THP-1 co-culture model
(2024-04-01) Boran T.; Zengin Ö. S.; Şeker Z.; Günaydın Akyıldız A.; Kara M.; Öztaş E.; Özhan G.; ŞEKER, ZEHRA; GÜNAYDIN AKYILDIZ, AYŞENUR
METABOLOMIC PROFILING IN DISTINCT TYPES OF LEUKEMIA
(2024-02-29) Gül A. Z.; Selek Ş.; Bekiroğlu S.; Demirel M.; Çakır F. B.; Uyanık B.; SELEK, ŞAHABETTİN; DEMİREL, METİN
METABOLIC EFFECTS OF ORAL TITANIUM DIOXIDE IN JUVENILE RATS: INSIGHTS FROM NMR-BASED METABOLOMICS ANALYSIS
(2024-02-29) KÖKTAŞOĞLU F.; DEMİREL M.; GÜLTEKİN F.; GÜLER E. M.; BEKİROĞLU S.; SELEK Ş.; KÖKTAŞOĞLU, FATMANUR; DEMİREL, METİN; SELEK, ŞAHABETTİN
Association Between Articular Eminence Structure and Joint Spaces in Temporomandibular Joints with Anterior Disc Displacement
(2024-03-01) ETÖZ M.; Çabuk D. S.; KÜTÜK N.; ERCAN İ.; KÜTÜK, NÜKHET
Background and Aims: The association among the joint spaces, articular eminence morphology, and disc displacement is not well documented in the literature. This study aims to evaluate and compare the joint spaces and the articular eminence structure (eminence height [E h] and inclination [E i]) using cone-beam computed tomography (CBCT) of temporomandibular joints (TMJs) with anterior disc displacements and joints with normal disc position. Methods: The study groups consisted of 75 TMJs of 39 patients. The disc status of TMJs was diagnosed with magnetic resonance imaging, and the measurements were performed on CBCT. Three groups, that is, normal disc position (NDP) group, anterior disc displacement with reduction (ADDWR) group, and anterior disc displacement without reduction (ADDWoR) group, were established. Anterior, superior, posterior joint spaces (AJS, SJS, and PJS, respectively), articular E h, and articular E i were measured. Statistical Package for the Social Sciences version 22 was used for statistical analysis. Shapiro-Wilk test was used to check the normality of data. Intergroup comparisons of categorical variables were assessed with Fisher-Freeman-Halton test. For comparison of continuous variables parameters, Mann-Whitney U test and Kruskal-Wallis test were used. Statistical significance level was determined as P < 0.05. Results: Significant differences were not found in intergroup comparisons for PJS. However, the difference between groups was found to be significant for AJS, SJS, E h, and E i. Intergroup comparisons were performed for these parameters. No significant difference was found between the NDP group and the ADDWR group for AJS, SJS, E h, and E İ. The mean AJS, SJS, E h, and E i values in ADDWoR were found to be significantly lower compared to the corresponding values in both NDP and ADDWR groups. Conclusion: Decreased AJS and SJS when TMJ is evaluated with CBCT may be an indicator of ADDWoR. Authors suggest that narrowed articular E i and reduced articular E h can be one of the predisposing factors for anterior disc displacement.
Dosing-time, feeding, and sex-dependent variations of everolimus pharmacokinetics in mice
(2024-01-01) ÖZTÜRK CİVELEK D.; ÖZTÜRK SEYHAN N.; AKYEL Y. K.; Gazioglu I.; PALA KARA Z.; Orman M. N.; OKYAR A.; ÖZTÜRK CİVELEK, DİLEK; GAZİOĞLU, IŞIL
Background: Everolimus is an oral mammalian target of rapamycin (mTOR) inhibitor used as an immunosuppressant and anticancer. Its pharmacokinetics is highly variable, it has a narrow therapeutic window and shows chronotoxicity with the best time at ZT13 and worst time at ZT1 (ZT; Zeitgeber time, time after light onset) in the preclinical setting. Objectives: In the present study, we aimed to investigate whether the pharmacokinetics of everolimus vary according to dosing time and whether sex and feeding status interfere with the chronopharmacokinetics. Method: A single dosage of 5 mg/kg everolimus was administered orally to C57BL/6J male and female mice, in fed or fasted states at ZT1-rest and ZT13-activity times and blood and tissue samples were collected at 0.5, 1, 2, 4, 12, and 24 h following drug administration. Ileum, liver, plasma, and thymus concentrations of everolimus were determined. Results: Females had a greater ileum AUC0–24h than males when fed (P = 0.043). Everolimus AUC0–24h in the liver was substantially greater at ZT1 than at ZT13 in a fasted state (P = 0.001). Plasma Cmax, AUC0–24h, and AUCtotal were not statistically significant between the groups (P = 0.098). In one of the target organs of everolimus, the thymus, males had considerably higher amounts at ZT1 than females (P = 0.029). Conclusion: Our findings imply that the pharmacokinetics of everolimus in mice may differ according to dosing time, sex, and feeding. Greater tissue distribution of everolimus at ZT1 may be associated with the worst tolerated time of everolimus. Our research suggests that oral chronomodulated everolimus therapy may be more effective and safer for cancer patients.
