Welcome to the Open Access System!
This site is Bezmialem Vakif University Academic Open Access System. The system was established in June 2019 in order to store the academic outcomes of Bezmialem Vakif University in digital standards and to provide them with open access. OpenAccess includes academic outputs such as articles, presentations, dissertations, books, book chapters and reports produced by Bezmialem Vakif University.
Recent Submissions
Evaluation of vitamin D levels in children and adolescents after the first year of the COVID-19 pandemic: 1-year results of a secondary-level state hospital
(2024-04-01) Çömlek F. Ö.; TOPRAK A.; BİRBİLEN A. Z.; Dilek S. Ö.; Coşkun F.; TOPRAK, ALİ
Background: The COVID-19 pandemic caused a global public health problem with high morbidity and mortality rates. In this study, we aimed to evaluate the 25-hydroxyvitamin D (25(OH)D) status of patients presenting to the Pediatrics Department of Gaziantep Maternity and Children\"s Hospital in the 1-year period after the onset of the COVID-19 pandemic according to ethnicity, age, and gender. Method: This cross-sectional study included the data of 7640 patients whose 25(OH)D levels were assessed at our hospital between March 2021 and March 2022. Vitamin D levels, age, gender, and the ethnic origin of the patients were retrospectively scanned and recorded from the laboratory results system. Based on the World Health Organization (WHO) classification of vitamin D levels, patients were divided into three groups: <10 ng/mL = vitamin D deficiency; 10–19 ng/mL = vitamin D insufficiency, and 20 ng/mL and over = normal vitamin D status. Results: The mean age of the 7640 patients who presented to the pediatrics department was 7.47 (±5.3) years. Of these patients, 48 % (3665) were male and 52 % (3975) were female. The mean vitamin D level of girls was 18.1 (±15.2) ng/mL, and of boys it was 20.2 (±15.4) ng/mL, with a statistically significant difference (p < 0.001). In total, 21.2 % (1650) of patients had deficient, 43.3 % (3310) of patients had insufficient, and 35.5 % (2710) of patients had normal 25(OH)D levels. Overall, 21.8 % of the patients (1667) were immigrants, and in this group the deficiency was found to be statistically significantly higher at 27.4 % (n = 456; p < 0.001). There was a low negative correlation between the age of the patients and their 25(OH)D levels (r=−0.35; p < 0.001). Conclusions: Vitamin D deficiency remains a serious public health problem. Since the most important production source is exposure to the sun, it must be kept in mind that vitamin D should be supported during lockdown pandemic processes.
Prevalance of Urinary Incontinence and Anal Incontinence: An Internet Based Cross-Sectional Study of Female Turkish University Students
(2023-10-01) GÖKMEN KARASU A. F.; Cetin C.; PASİN Ö.; Karacabay M.; Tanoglu F. B.; Ilhan G.; GÖKMEN KARASU, AYŞE FİLİZ; PASİN, ÖZGE
KAPOSIFORM HEMANGIOENDOTHELIOMA AND REFRACTORY KASABACH-MERRITT PHENOMENON TREATED WITH SIROLIMUS
(2023-11-01) EREN T.; ÇAKIR F. B.; ÇAKIR, FATMA BETÜL
Development of a green high-performance liquid chromatography method for tofacitinib quantification in pharmaceutical formulations and degradation studies
(2024-04-02) TIRIS G.; Genc A. A.; ERK N.; TIRIS, GİZEM
A new high-performance liquid chromatography (HPLC) method was applied for the quantification of the active substance of tofacitinib. Analysis was performed on a Chromasil 100 C18 (100.0 x 4.0 mm, 3.5 mu m) stationary phase. The mobile phase consisted of acetonitrile:0.2% phosphoric acid in water (12:88, v/v). The prepared sample (20.0 mu L) was injected into the system. A detection wavelength of 285.0 nm was chosen for the compound, and the flow rate was 0.8 mL/min. The experiment was completed in 5.0 min. The analysis temperature was set to 40.0 degrees C. The method was evaluated using green chemistry. The method was validated according to the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use guidelines. For linearity studies calibration curves were constructed in the range of 10.0-200.0 mu g/mL. The recovery values were calculated at 97.66% and 105.68%. The method developed for the analysis of the active substance had a short analysis time and was cost-effective. It is an environmentally friendly method due to the mobile phase content used. The technique can be used in laboratory analysis and bioequivalence experiments.
EARTHQUAKE DISASTER AND ITS' ACUTE EFFECT ON PEDIATRIC HEMATOLOGY AND ONCOLOGY.IN TURKIYE; TURKISH PEDIATRIC ONCOLOGY GROUP-TPOG QUESTIONARE STUDY
(2023-11-01) TAÇYILDIZ N.; İNCESOY ÖZDEMİR S.; Kupeli B.; Cemaloglu M.; Acipayam C.; Oncel K.; Akinel A. N.; Karabel N.; Coskun C.; SEZGİN G.; et al.; ÇAKIR, FATMA BETÜL
